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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hoxb2a

Z-value: 0.53

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Transcription factors associated with hoxb2a

Gene Symbol Gene ID Gene Info
ENSDARG00000000175 homeobox B2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb2adr11_v1_chr3_+_23752150_237521500.029.3e-01Click!

Activity profile of hoxb2a motif

Sorted Z-values of hoxb2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_25777425 2.65 ENSDART00000021620
claudin d
chr5_+_29794058 1.87 ENSDART00000045410
Thy-1 cell surface antigen
chr6_+_21001264 1.78 ENSDART00000044519
ENSDART00000151278
connexin 44.2
chr6_+_28208973 1.70 ENSDART00000171216
ENSDART00000171377
ENSDART00000167389
ENSDART00000166988
si:ch73-14h10.2
chr20_-_38787047 1.51 ENSDART00000152913
ENSDART00000153430
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma a
chr20_-_38787341 1.46 ENSDART00000136771
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma a
chr10_-_21362071 1.44 ENSDART00000125167
avidin
chr10_-_25217347 1.42 ENSDART00000036906
karyopherin alpha 7 (importin alpha 8)
chr19_-_18313303 1.36 ENSDART00000164644
ENSDART00000167480
ENSDART00000163104
si:dkey-208k4.2
chr10_-_21362320 1.33 ENSDART00000189789
avidin
chr2_+_41526904 1.33 ENSDART00000127520
activin A receptor, type 1 like
chr16_+_29509133 1.29 ENSDART00000112116
cathepsin S, ortholog2, tandem duplicate 1
chr2_-_57076687 1.26 ENSDART00000161523
solute carrier family 25, member 42
chr24_-_10014512 1.24 ENSDART00000124341
ENSDART00000191630
zgc:171474
chr14_-_33481428 1.24 ENSDART00000147059
ENSDART00000140001
ENSDART00000124242
ENSDART00000164836
ENSDART00000190104
ENSDART00000186833
ENSDART00000180873
lysosomal-associated membrane protein 2
chr11_-_1550709 1.23 ENSDART00000110097
si:ch73-303b9.1
chr18_+_20560616 1.20 ENSDART00000136710
ENSDART00000151974
ENSDART00000121699
ENSDART00000040074
WEE1 homolog 2 (S. pombe)
chr8_-_25034411 1.18 ENSDART00000135973
nuclear transcription factor Y, alpha, like
chr17_+_16046132 1.13 ENSDART00000155005
si:ch73-204p21.2
chr11_-_35171768 1.11 ENSDART00000192896
TRAF-interacting protein
chr21_-_19918286 1.08 ENSDART00000180816
protein phosphatase 1, regulatory subunit 3B
chr17_+_16046314 1.05 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
chr8_+_11425048 1.02 ENSDART00000018739
tight junction protein 2b (zona occludens 2)
chr1_-_55248496 1.01 ENSDART00000098615
nanos homolog 3
chr4_-_77125693 1.00 ENSDART00000174256

chr12_-_33817114 1.00 ENSDART00000161265
twinkle mtDNA helicase
chr22_-_22337382 0.98 ENSDART00000144684
si:ch211-129c21.1
chr14_+_24845941 0.93 ENSDART00000187513
Rho guanine nucleotide exchange factor (GEF) 37
chr10_+_16036246 0.93 ENSDART00000141586
ENSDART00000135868
ENSDART00000065037
ENSDART00000124502
lamin B1
chr3_-_26244256 0.92 ENSDART00000103741
protein phosphatase 4, catalytic subunit a
chr14_-_33945692 0.91 ENSDART00000168546
ENSDART00000189778
zinc finger, DHHC-type containing 24
chr10_+_1849874 0.89 ENSDART00000158897
ENSDART00000149956
adenomatous polyposis coli
chr21_+_34088377 0.89 ENSDART00000170070
myotubularin related protein 1b
chr10_+_7709724 0.89 ENSDART00000097670
gamma-glutamyl carboxylase
chr3_+_26244353 0.88 ENSDART00000103733
ATPase family, AAA domain containing 5a
chr14_+_8940326 0.85 ENSDART00000159920
ribosomal protein S6 kinase a, like
chr21_+_34088110 0.85 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
myotubularin related protein 1b
chr20_-_48898371 0.85 ENSDART00000170617
5'-3' exoribonuclease 2
chr13_+_15838151 0.83 ENSDART00000008987
kinesin light chain 1a
chr10_-_35257458 0.83 ENSDART00000143890
ENSDART00000139107
ENSDART00000082445
proline rich 11
chr22_-_881725 0.82 ENSDART00000035514
choline/ethanolamine phosphotransferase 1b
chr10_+_15255198 0.82 ENSDART00000139047
ENSDART00000172107
ENSDART00000183413
ENSDART00000185314
very low density lipoprotein receptor
chr15_-_17169935 0.81 ENSDART00000110111
cullin 5a
chr19_+_31585917 0.80 ENSDART00000132182
geminin, DNA replication inhibitor
chr21_-_32060993 0.79 ENSDART00000131651
si:ch211-160j14.2
chr21_-_30994577 0.79 ENSDART00000065503
post-GPI attachment to proteins 2
chr17_-_40956035 0.77 ENSDART00000124715
si:dkey-16j16.4
chr22_-_38800173 0.76 ENSDART00000190725
si:ch211-262h13.3
chr9_-_38021889 0.74 ENSDART00000183482
ENSDART00000124333
adenylate cyclase 5
chr12_-_18577983 0.73 ENSDART00000193262
zinc finger, DHHC-type containing 4
chr20_+_34671386 0.72 ENSDART00000152836
ENSDART00000138226
elongator acetyltransferase complex subunit 3
chr12_+_23912074 0.71 ENSDART00000152864
supervillin a
chr5_-_19006290 0.71 ENSDART00000137022
golgin A3
chr15_+_17345609 0.70 ENSDART00000111753
vacuole membrane protein 1
chr16_+_47207691 0.70 ENSDART00000062507
islet cell autoantigen 1
chr6_-_40922971 0.69 ENSDART00000155363
SFI1 centrin binding protein
chr8_+_23355484 0.69 ENSDART00000085361
ENSDART00000125729
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
chr1_+_513986 0.68 ENSDART00000109083
ENSDART00000081945
thioredoxin-like 4B
chr2_+_41524238 0.68 ENSDART00000122860
ENSDART00000017977
activin A receptor, type 1 like
chr24_-_2450597 0.68 ENSDART00000188080
ENSDART00000093331
ras responsive element binding protein 1a
chr18_+_18000887 0.68 ENSDART00000147797
si:ch211-212o1.2
chr1_+_40613297 0.68 ENSDART00000040798
ENSDART00000168067
ENSDART00000130490
N(alpha)-acetyltransferase 15, NatA auxiliary subunit b
chr5_-_11809710 0.67 ENSDART00000186998
ENSDART00000181363
ENSDART00000180681
neurofibromin 2a (merlin)
chr22_-_17671348 0.66 ENSDART00000137995
tight junction protein 3
chr15_-_44052927 0.66 ENSDART00000166209
wu:fb44b02
chr9_-_7287128 0.65 ENSDART00000176281
ENSDART00000065803
MIT, microtubule interacting and transport, domain containing 1
chr8_-_1838315 0.64 ENSDART00000114476
ENSDART00000140077
phosphatidylinositol 4-kinase, catalytic, alpha b
chr3_+_22035863 0.64 ENSDART00000177169
cell division cycle 27
chr3_+_18807006 0.63 ENSDART00000180091
transportin 2 (importin 3, karyopherin beta 2b)
chr19_-_82504 0.62 ENSDART00000027864
ENSDART00000160560
heterogeneous nuclear ribonucleoprotein R
chr5_+_40837539 0.62 ENSDART00000188279
si:dkey-3h3.3
chr24_-_34680956 0.61 ENSDART00000171009
catenin (cadherin-associated protein), alpha 1
chr7_-_64589920 0.61 ENSDART00000172619
ENSDART00000184113

chr18_+_18000695 0.61 ENSDART00000146898
si:ch211-212o1.2
chr12_+_16087077 0.60 ENSDART00000141898
zinc finger protein 281b
chr15_+_1534644 0.60 ENSDART00000130413
structural maintenance of chromosomes 4
chr14_-_25935167 0.60 ENSDART00000139855
GTPase activating protein (SH3 domain) binding protein 1
chr16_-_17347727 0.59 ENSDART00000144392
zyxin
chr18_+_44532199 0.59 ENSDART00000135386
suppression of tumorigenicity 14 (colon carcinoma) a
chr23_-_36446307 0.58 ENSDART00000136623
zgc:174906
chr19_+_366034 0.58 ENSDART00000093383
vacuolar protein sorting 72 homolog (S. cerevisiae)
chr1_+_5422439 0.58 ENSDART00000055047
ENSDART00000142248
serine/threonine kinase 16
chr14_+_12178915 0.57 ENSDART00000054626
histone deacetylase 3
chr15_-_43978141 0.56 ENSDART00000041249
cysteine and histidine-rich domain (CHORD) containing 1a
chr19_-_32914227 0.56 ENSDART00000186115
ENSDART00000124246
metadherin a
chr23_+_32028574 0.56 ENSDART00000145501
ENSDART00000143121
ENSDART00000111877
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr3_+_32832538 0.56 ENSDART00000139410
CD2 (cytoplasmic tail) binding protein 2
chr8_-_30338872 0.55 ENSDART00000137583
dedicator of cytokinesis 8
chr12_-_3077395 0.55 ENSDART00000002867
ENSDART00000126315
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr5_-_63302944 0.55 ENSDART00000047110
gelsolin b
chr5_+_27137473 0.54 ENSDART00000181833
unc-5 netrin receptor Db
chr14_-_38889311 0.54 ENSDART00000186978
zgc:101583
chr3_+_16663373 0.54 ENSDART00000100961
zgc:55558
chr6_-_3982783 0.54 ENSDART00000171944
solute carrier family 25 (aspartate/glutamate carrier), member 12
chr10_-_44560165 0.54 ENSDART00000181217
ENSDART00000076084
nucleophosmin/nucleoplasmin, 2b
chr1_+_21937201 0.54 ENSDART00000087729
lysine (K)-specific demethylase 4C
chr5_-_26765188 0.54 ENSDART00000029450
ring finger protein 181
chr20_-_23426339 0.53 ENSDART00000004625
zygote arrest 1
chr17_+_26722904 0.53 ENSDART00000114927
NRDE-2, necessary for RNA interference, domain containing
chr6_-_41138854 0.52 ENSDART00000128723
ENSDART00000151055
ENSDART00000132484
solute carrier family 6 member 22, tandem duplicate 1
chr5_-_26247973 0.51 ENSDART00000098527
endoplasmic reticulum aminopeptidase 1b
chr16_+_46410520 0.51 ENSDART00000131072
rapunzel 2
chr4_+_9177997 0.50 ENSDART00000057254
ENSDART00000154614
nuclear transcription factor Y, beta a
chr8_-_50888806 0.50 ENSDART00000053750
acyl-CoA synthetase long chain family member 2
chr12_-_4408828 0.49 ENSDART00000152447
si:ch211-173d10.1
chr15_+_29662401 0.49 ENSDART00000135540
nuclear receptor interacting protein 1a
chr25_-_21031007 0.49 ENSDART00000138985
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr1_-_18811517 0.49 ENSDART00000142026
si:dkey-167i21.2
chr6_+_40922572 0.49 ENSDART00000133599
ENSDART00000002728
ENSDART00000145153
eukaryotic translation initiation factor 4E nuclear import factor 1
chr17_-_41798856 0.48 ENSDART00000156031
ENSDART00000192801
ENSDART00000180172
ENSDART00000084745
ENSDART00000175577
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr7_-_7764287 0.48 ENSDART00000173021
ENSDART00000113131
inturned planar cell polarity protein
chr4_-_16833518 0.48 ENSDART00000179867
lactate dehydrogenase Ba
chr23_-_20051369 0.47 ENSDART00000049836
biglycan b
chr16_-_42965192 0.47 ENSDART00000113714
metaxin 1a
chr11_+_45153104 0.47 ENSDART00000159204
ENSDART00000177585
thymidine kinase 1, soluble
chr6_+_50393047 0.47 ENSDART00000055502
ENSDART00000055511
ERGIC and golgi 3
chr5_-_16734060 0.47 ENSDART00000035859
ENSDART00000190457
ENSDART00000179244
ATPase family, AAA domain containing 1a
chr6_-_1591002 0.47 ENSDART00000087039
zgc:123305
chr11_+_31864921 0.46 ENSDART00000180252
diaphanous-related formin 3
chr24_+_39518774 0.45 ENSDART00000132939
defective in cullin neddylation 1 domain containing 3
chr2_-_50272077 0.45 ENSDART00000127623
cullin 1a
chr19_+_40069524 0.45 ENSDART00000151365
ENSDART00000140926
zinc finger, MYM-type 4
chr16_+_54209504 0.44 ENSDART00000020033
X-ray repair complementing defective repair in Chinese hamster cells 1
chr20_-_25445237 0.44 ENSDART00000145034
ENSDART00000018049
mitochondrial ribosomal protein L19
chr5_-_68093169 0.44 ENSDART00000051849
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
chr22_+_14836040 0.44 ENSDART00000180951
GTP binding protein 1, like
chr15_-_34408777 0.44 ENSDART00000139934
alkylglycerol monooxygenase
chr5_+_63302660 0.43 ENSDART00000142131
si:ch73-376l24.2
chr21_-_39177564 0.43 ENSDART00000065143
unc-119 homolog b (C. elegans)
chr24_-_26981848 0.42 ENSDART00000183198
stromal antigen 1b
chr8_+_28452738 0.42 ENSDART00000062706
transmembrane protein 189
chr3_+_45364849 0.41 ENSDART00000153974
ubiquitin-conjugating enzyme E2Ia
chr24_+_19415124 0.41 ENSDART00000186931
sulfatase 1
chr19_+_42227400 0.41 ENSDART00000131574
ENSDART00000135436
jumping translocation breakpoint
chr9_+_21146862 0.41 ENSDART00000136365
hydroxyacid oxidase 2 (long chain)
chr5_+_19314574 0.41 ENSDART00000133247
RUN and SH3 domain containing 2
chr4_+_4849789 0.40 ENSDART00000130818
ENSDART00000127751
protein tyrosine phosphatase, receptor-type, Z polypeptide 1b
chr17_+_49500820 0.40 ENSDART00000170306
apoptosis resistant E3 ubiquitin protein ligase 1
chr25_+_35891342 0.40 ENSDART00000147093
LSM14A mRNA processing body assembly factor a
chr23_+_33963619 0.40 ENSDART00000140666
ENSDART00000084792
pyridoxal phosphate binding protein
chr24_-_25004553 0.40 ENSDART00000080997
ENSDART00000136860
zinc finger, DHHC-type containing 20b
chr18_-_20458840 0.40 ENSDART00000177125
kinesin family member 23
chr12_-_34258384 0.40 ENSDART00000109196
phosphatidylglycerophosphate synthase 1
chr16_+_13818743 0.39 ENSDART00000090191
folliculin
chr23_+_2906031 0.39 ENSDART00000109304
c23h20orf24 homolog (H. sapiens)
chr5_-_26764880 0.38 ENSDART00000140392
ENSDART00000134728
ring finger protein 181
chr15_-_1844048 0.38 ENSDART00000102410
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr23_+_4741543 0.38 ENSDART00000144761
Raf-1 proto-oncogene, serine/threonine kinase a
chr14_+_30795559 0.38 ENSDART00000006132
cofilin 1
chr5_-_30074332 0.37 ENSDART00000147963
beta-carotene oxygenase 2a
chr20_+_38458084 0.37 ENSDART00000020153
ENSDART00000135912
coenzyme Q8A
chr15_-_9272328 0.36 ENSDART00000172114
calmodulin 2a (phosphorylase kinase, delta)
chr16_+_9400661 0.36 ENSDART00000146174
KIAA0947-like (H. sapiens)
chr23_-_32100106 0.36 ENSDART00000044658
LETM1 domain containing 1
chr13_+_24750078 0.35 ENSDART00000021053
collagen, type XVII, alpha 1b
chr19_-_5805923 0.35 ENSDART00000134340
si:ch211-264f5.8
chr7_+_37742299 0.35 ENSDART00000143300
bromodomain containing 7
chr23_-_2901167 0.35 ENSDART00000165955
ENSDART00000190616
zinc fingers and homeoboxes 3
chr25_+_2415131 0.34 ENSDART00000162210
zmp:0000000932
chr22_-_881080 0.34 ENSDART00000185489
choline/ethanolamine phosphotransferase 1b
chr23_-_14990865 0.34 ENSDART00000147799
ndrg family member 3b
chr19_-_19871211 0.34 ENSDART00000170980
even-skipped homeobox 1
chr6_-_2134581 0.34 ENSDART00000175478
V-set and transmembrane domain containing 2 like
chr21_-_40398932 0.33 ENSDART00000162500
nucleoporin 98
chr21_-_3853204 0.33 ENSDART00000188829
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr20_+_25879826 0.33 ENSDART00000018519
zgc:153896
chr14_-_8940499 0.32 ENSDART00000129030
zgc:153681
chr2_+_23352302 0.32 ENSDART00000187760
ring finger protein 2
chr25_-_27722614 0.32 ENSDART00000190154
zgc:153935
chr20_+_41021054 0.32 ENSDART00000146052
mannosidase, alpha, class 1A, member 1
chr3_+_45365098 0.31 ENSDART00000052746
ENSDART00000156555
ubiquitin-conjugating enzyme E2Ia
chr1_-_55068941 0.30 ENSDART00000152143
ENSDART00000152590
pellino E3 ubiquitin protein ligase 1a
chr11_+_34523132 0.30 ENSDART00000192257
zinc finger, matrin-type 3
chr11_+_35171406 0.30 ENSDART00000110839
MON1 secretory trafficking family member A
chr18_+_6558338 0.30 ENSDART00000110892
beta-1,4-N-acetyl-galactosaminyl transferase 3b
chr11_+_2855430 0.30 ENSDART00000172837
kinesin family member 21B
chr3_+_28860283 0.29 ENSDART00000077235
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr11_-_34219211 0.29 ENSDART00000098472
transmembrane protein 44
chr5_-_55933420 0.29 ENSDART00000050966
solute carrier family 25, member 46
chr25_-_37262220 0.28 ENSDART00000153789
ENSDART00000155182
ring finger and WD repeat domain 3
chr14_+_7377552 0.28 ENSDART00000142158
ENSDART00000141471
histidyl-tRNA synthetase
chr6_-_43283122 0.28 ENSDART00000186022
FERM domain containing 4Ba
chr7_+_67749251 0.27 ENSDART00000167562
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr17_-_21162821 0.27 ENSDART00000157283
abhydrolase domain containing 12
chr21_+_1647990 0.27 ENSDART00000148540
ferrochelatase
chr15_-_44601331 0.27 ENSDART00000161514
zgc:165508
chr12_+_48803098 0.27 ENSDART00000074768
peptidylprolyl isomerase Fb
chr3_+_27786601 0.27 ENSDART00000086994
N-acetyltransferase 15 (GCN5-related, putative)
chr23_-_31913069 0.27 ENSDART00000135526
mitochondrial fission regulator 2
chr5_-_9625459 0.26 ENSDART00000143347
SH2B adaptor protein 3
chr2_+_6253246 0.26 ENSDART00000058256
ENSDART00000076700
zona pellucida glycoprotein 3b
chr25_+_459901 0.25 ENSDART00000154895
protogenin homolog b (Gallus gallus)
chr22_+_1170294 0.25 ENSDART00000159761
ENSDART00000169809
interferon regulatory factor 6
chr23_-_900795 0.25 ENSDART00000190517
ENSDART00000182849
ENSDART00000111456
ENSDART00000185430
RNA binding motif protein 10
chr19_-_30510259 0.24 ENSDART00000135128
ENSDART00000186169
ENSDART00000182974
ENSDART00000187797
BCL2 associated athanogene 6, like
chr25_-_27722309 0.24 ENSDART00000148121
zgc:153935
chr7_-_17816175 0.24 ENSDART00000091272
ENSDART00000173757
ECSIT signalling integrator
chr9_+_38983895 0.24 ENSDART00000144893
microtubule-associated protein 2
chr13_+_36923052 0.24 ENSDART00000026313
thioredoxin-related transmembrane protein 1
chr12_-_42214 0.24 ENSDART00000045071
forkhead box K2

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.5 2.0 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.4 1.1 GO:0060631 regulation of meiosis I(GO:0060631)
0.4 1.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.3 1.0 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.2 0.7 GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.(GO:0002926)
0.2 0.9 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031) Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.2 1.0 GO:0010692 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.2 0.7 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.2 0.9 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.2 0.5 GO:0046104 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 0.9 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.9 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 0.4 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin biosynthetic process(GO:0032049)
0.1 0.4 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 1.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 1.0 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 1.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.5 GO:0000012 single strand break repair(GO:0000012)
0.1 0.4 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.1 0.4 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.5 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.1 1.7 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 0.6 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 0.3 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 1.1 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.1 0.4 GO:0040016 embryonic cleavage(GO:0040016)
0.1 0.4 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 0.3 GO:0006660 phosphatidylserine catabolic process(GO:0006660) monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 0.5 GO:0015740 C4-dicarboxylate transport(GO:0015740) acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1 0.4 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.4 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.0 0.5 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.5 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 1.7 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.7 GO:0045471 response to ethanol(GO:0045471)
0.0 0.6 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.6 GO:0021592 fourth ventricle development(GO:0021592)
0.0 1.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.5 GO:1902101 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.4 GO:0016119 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.6 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.5 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.0 0.4 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.9 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.3 GO:0072498 embryonic skeletal joint development(GO:0072498)
0.0 0.4 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.5 GO:0015693 magnesium ion transport(GO:0015693)
0.0 1.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.5 GO:0045116 protein neddylation(GO:0045116)
0.0 0.1 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.6 GO:0050796 regulation of insulin secretion(GO:0050796)
0.0 0.4 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.3 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.7 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.2 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.2 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.3 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0 0.1 GO:0048785 hatching gland development(GO:0048785)
0.0 0.1 GO:1902946 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.0 0.5 GO:0060173 limb development(GO:0060173)
0.0 0.8 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)
0.0 0.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.3 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 0.6 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.5 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 0.2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) maintenance of protein localization in organelle(GO:0072595)
0.0 0.2 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0 0.7 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.6 GO:0051298 centrosome duplication(GO:0051298)
0.0 0.3 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.1 GO:0099638 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 0.2 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.2 GO:0051383 kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.0 0.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.3 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.2 GO:0031297 replication fork processing(GO:0031297)
0.0 0.1 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.8 GO:0034504 protein localization to nucleus(GO:0034504)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.8 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 0.0 GO:0032290 peripheral nervous system myelin formation(GO:0032290) semicircular canal fusion(GO:0060879)
0.0 0.6 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.1 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.0 0.0 GO:0021742 abducens nucleus development(GO:0021742)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.4 2.0 GO:0070724 BMP receptor complex(GO:0070724)
0.3 0.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 1.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.6 GO:0005880 nuclear microtubule(GO:0005880)
0.1 0.7 GO:0031415 NatA complex(GO:0031415)
0.1 0.9 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.2 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.7 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 1.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.5 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.8 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.0 0.2 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.0 1.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.4 GO:0045171 intercellular bridge(GO:0045171)
0.0 4.7 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.7 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.7 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.4 GO:0008278 cohesin complex(GO:0008278)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.1 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.4 GO:0030496 midbody(GO:0030496)
0.0 0.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0043186 P granule(GO:0043186)
0.0 0.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.3 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0009374 biotin binding(GO:0009374)
0.4 1.3 GO:0071077 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.2 1.2 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.2 0.9 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.2 0.8 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.2 0.8 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.2 0.4 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.2 0.7 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.2 1.7 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 2.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 2.1 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.1 0.6 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.4 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.1 0.2 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 0.9 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.1 GO:2001069 glycogen binding(GO:2001069)
0.1 0.9 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.1 0.5 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 0.3 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.1 0.5 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.7 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 0.2 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.4 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.2 GO:0050699 WW domain binding(GO:0050699)
0.0 0.5 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.5 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.3 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.4 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.5 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 1.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 1.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.7 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.0 0.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 1.2 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.3 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.3 GO:0035804 structural constituent of egg coat(GO:0035804)
0.0 0.1 GO:0004061 arylformamidase activity(GO:0004061)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 1.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0032977 membrane insertase activity(GO:0032977)
0.0 0.4 GO:0010181 FMN binding(GO:0010181)
0.0 0.1 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.7 GO:0000049 tRNA binding(GO:0000049)
0.0 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.3 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.5 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.3 GO:0031267 small GTPase binding(GO:0031267)
0.0 1.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.4 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 3.5 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.3 GO:0042802 identical protein binding(GO:0042802)
0.0 0.3 GO:0098632 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 0.8 PID REELIN PATHWAY Reelin signaling pathway
0.1 0.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 0.9 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 1.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.4 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.0 PID AURORA B PATHWAY Aurora B signaling
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.6 PID AURORA A PATHWAY Aurora A signaling
0.0 0.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.3 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.9 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.7 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.8 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 1.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.6 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 1.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.3 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing