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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hoxa9a+hoxa9b

Z-value: 0.94

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Transcription factors associated with hoxa9a+hoxa9b

Gene Symbol Gene ID Gene Info
ENSDARG00000056819 homeobox A9b
ENSDARG00000105013 homeobox A9a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxa9bdr11_v1_chr16_+_20915319_20915319-0.911.5e-07Click!
hoxa9adr11_v1_chr19_+_19747430_19747430-0.904.6e-07Click!

Activity profile of hoxa9a+hoxa9b motif

Sorted Z-values of hoxa9a+hoxa9b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_33647138 3.86 ENSDART00000142111
ENSDART00000015547
claudin g
chr17_-_4245902 3.00 ENSDART00000151851
growth differentiation factor 3
chr16_+_29509133 2.38 ENSDART00000112116
cathepsin S, ortholog2, tandem duplicate 1
chr19_-_27550768 2.30 ENSDART00000142313
si:dkeyp-46h3.8
chr21_-_13690712 2.22 ENSDART00000065817
POU domain, class 5, transcription factor 3
chr17_-_4245311 2.11 ENSDART00000055379
growth differentiation factor 3
chr17_-_2595736 2.10 ENSDART00000128797
zona pellucida glycoprotein 3, tandem duplicate 2
chr7_+_30626378 2.04 ENSDART00000173533
ENSDART00000052541
cyclin B2
chr10_-_8053753 2.04 ENSDART00000162289
si:ch211-251f6.7
chr19_-_31042570 1.96 ENSDART00000144337
ENSDART00000136213
ENSDART00000133101
ENSDART00000190949
basic leucine zipper and W2 domains 2
chr6_-_42388608 1.94 ENSDART00000049425
Sec61 translocon alpha 1 subunit, like
chr8_+_21229718 1.91 ENSDART00000100222
cryptochrome circadian clock 1ba
chr17_-_2590222 1.90 ENSDART00000185711

chr5_-_29514689 1.89 ENSDART00000126018
ENSDART00000125175
euchromatic histone-lysine N-methyltransferase 1a
chr7_+_1473929 1.86 ENSDART00000050687
lysophosphatidylcholine acyltransferase 4
chr9_-_34937025 1.80 ENSDART00000137888
cell division cycle 16 homolog (S. cerevisiae)
chr7_+_26545911 1.78 ENSDART00000135313
tyrosine kinase, non-receptor, 1
chr10_-_8046764 1.72 ENSDART00000099031
zgc:136254
chr5_+_41476443 1.71 ENSDART00000145228
ENSDART00000137981
ENSDART00000142538
protein inhibitor of activated STAT, 2
chr6_-_53144336 1.67 ENSDART00000154429
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr2_-_32738535 1.65 ENSDART00000135293
nuclear receptor binding protein 2a
chr7_-_33684632 1.64 ENSDART00000130553
transducin-like enhancer of split 3b
chr17_+_19626479 1.62 ENSDART00000044993
ENSDART00000131863
regulator of G protein signaling 7a
chr10_+_44699734 1.54 ENSDART00000167952
ENSDART00000158681
ENSDART00000190188
ENSDART00000168276
scavenger receptor class B, member 1
chr19_-_27830818 1.51 ENSDART00000131767
PAP associated domain containing 7
chr3_-_40232615 1.48 ENSDART00000155969
flightless I actin binding protein
chr1_+_36771954 1.44 ENSDART00000149022
Rho GTPase activating protein 10
chr1_+_31658011 1.36 ENSDART00000192203
polymerase (DNA directed), lambda
chr7_+_51795667 1.35 ENSDART00000174201
ENSDART00000073839
solute carrier family 38, member 7
chr8_-_2616326 1.35 ENSDART00000027214
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a
chr20_-_49889111 1.33 ENSDART00000058858
kinesin family member 13Bb
chr8_+_3431671 1.30 ENSDART00000017850
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr4_-_4261673 1.26 ENSDART00000150694
CD9 molecule b
chr22_-_20695237 1.26 ENSDART00000112722
oogenesis-related gene
chr3_+_58472305 1.26 ENSDART00000154122
si:ch211-165g14.1
chr10_+_44700103 1.26 ENSDART00000165999
scavenger receptor class B, member 1
chr22_-_11493236 1.26 ENSDART00000002691
tetraspanin 7b
chr8_+_15269423 1.25 ENSDART00000020386
glutamate-cysteine ligase, modifier subunit
chr7_+_30779761 1.25 ENSDART00000066806
ENSDART00000173671
methylmalonyl CoA epimerase
chr17_-_30652738 1.23 ENSDART00000154960
SH3 and SYLF domain containing 1
chr7_+_26545502 1.22 ENSDART00000140528
tyrosine kinase, non-receptor, 1
chr8_+_12951155 1.22 ENSDART00000081601
choline/ethanolamine phosphotransferase 1a
chr18_+_27515640 1.22 ENSDART00000181593
tumor protein p53 inducible protein 11b
chr10_-_8053385 1.22 ENSDART00000142714
si:ch211-251f6.7
chr9_-_23807032 1.20 ENSDART00000027443
extended synaptotagmin-like protein 3
chr17_+_25833947 1.18 ENSDART00000044328
ENSDART00000154604
acyl-CoA synthetase short chain family member 1
chr9_+_50175366 1.18 ENSDART00000170352
cordon-bleu WH2 repeat protein-like 1b
chr14_+_22132896 1.18 ENSDART00000138274
cyclin G1
chr25_+_15997957 1.17 ENSDART00000140047
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr8_-_38355555 1.17 ENSDART00000134283
ENSDART00000132077
ENSDART00000146378
sorbin and SH3 domain containing 3
chr5_+_872299 1.16 ENSDART00000130042
far upstream element (FUSE) binding protein 3
chr8_-_38355268 1.15 ENSDART00000129597
sorbin and SH3 domain containing 3
chr22_-_10541712 1.15 ENSDART00000013933
si:dkey-42i9.4
chr6_+_38626926 1.14 ENSDART00000190339
ATPase phospholipid transporting 10A
chr2_+_22409249 1.10 ENSDART00000182915
zgc:56628
chr9_+_492459 1.10 ENSDART00000112635

chr19_+_32321797 1.09 ENSDART00000167664
ataxin 1a
chr18_-_35407289 1.08 ENSDART00000012018
small nuclear ribonucleoprotein polypeptide A
chr17_+_32622933 1.07 ENSDART00000077418
cathepsin Ba
chr18_-_35407695 1.06 ENSDART00000191845
ENSDART00000141703
small nuclear ribonucleoprotein polypeptide A
chr14_+_34490445 1.04 ENSDART00000132193
ENSDART00000148044
wingless-type MMTV integration site family, member 8a
chr4_+_2482046 1.04 ENSDART00000103371
zinc finger, DHHC-type containing 17
chr18_-_35407530 1.04 ENSDART00000137663
small nuclear ribonucleoprotein polypeptide A
chr24_-_21903588 1.03 ENSDART00000180991
spermatogenesis associated 13
chr24_-_40901410 1.02 ENSDART00000170688
WD repeat domain 48a
chr5_-_36597612 1.02 ENSDART00000031270
ENSDART00000122098
ras homolog gene family, member Gc
chr11_-_35171768 1.02 ENSDART00000192896
TRAF-interacting protein
chr9_-_30259295 1.01 ENSDART00000139106
si:dkey-100n23.5
chr9_-_30259447 1.00 ENSDART00000140585
ENSDART00000145052
ENSDART00000129926
si:dkey-100n23.5
chr18_+_11858397 1.00 ENSDART00000133762
transmembrane and tetratricopeptide repeat containing 2b
chr22_-_10541372 1.00 ENSDART00000179708
si:dkey-42i9.4
chr20_-_16548912 0.98 ENSDART00000137601
checkpoint suppressor 1
chr19_+_27858866 0.98 ENSDART00000140336
NOP2/Sun RNA methyltransferase family, member 2
chr8_-_31416403 0.98 ENSDART00000098912
zinc finger protein 131
chr3_+_40255408 0.97 ENSDART00000074746
Smith-Magenis syndrome chromosome region, candidate 8a
chr20_-_51814080 0.97 ENSDART00000041476
melanoma inhibitory activity family, member 3
chr20_-_51831657 0.96 ENSDART00000165076
melanoma inhibitory activity family, member 3
chr3_+_28502419 0.96 ENSDART00000151081
septin 12
chr7_+_24881680 0.95 ENSDART00000058843
kelch repeat-containing protein
chr25_+_16880990 0.93 ENSDART00000020259
zgc:77158
chr24_+_36317544 0.93 ENSDART00000048640
ENSDART00000156096
pseudouridylate synthase 3
chr12_+_36428052 0.93 ENSDART00000131300
unkempt family zinc finger
chr14_+_25505468 0.93 ENSDART00000079016
THO complex 3
chr13_-_35907768 0.92 ENSDART00000147522
MYCL proto-oncogene, bHLH transcription factor a
chr19_+_4968947 0.92 ENSDART00000003634
ENSDART00000134808
StAR-related lipid transfer (START) domain containing 3
chr13_-_22961605 0.92 ENSDART00000143112
ENSDART00000057641
tetraspanin 15
chr9_+_28232522 0.92 ENSDART00000031761
frizzled class receptor 5
chr9_-_30258957 0.91 ENSDART00000144259
si:dkey-100n23.5
chr20_-_51831816 0.91 ENSDART00000060505
melanoma inhibitory activity family, member 3
chr17_+_26718648 0.90 ENSDART00000154492
NRDE-2, necessary for RNA interference, domain containing
chr22_+_10713713 0.90 ENSDART00000122349
hippocampus abundant transcript 1b
chr9_-_14137295 0.90 ENSDART00000127640
ENSDART00000189018
ENSDART00000188985
tubulin tyrosine ligase-like family, member 4
chr13_-_35908275 0.89 ENSDART00000013961
MYCL proto-oncogene, bHLH transcription factor a
chr1_+_11107688 0.89 ENSDART00000109858
kinetochore-localized astrin/SPAG5 binding protein
chr9_-_12575776 0.88 ENSDART00000128931
ENSDART00000182695
insulin-like growth factor 2 mRNA binding protein 2a
chr2_+_34967022 0.87 ENSDART00000134926
astrotactin 1
chr25_+_16214854 0.87 ENSDART00000109672
ENSDART00000190093
microtubule associated monooxygenase, calponin and LIM domain containing 2b
chr8_-_30424182 0.87 ENSDART00000099021
dedicator of cytokinesis 8
chr5_+_25733774 0.87 ENSDART00000137088
ENSDART00000098467
abhydrolase domain containing 17B
chr4_+_10754802 0.87 ENSDART00000181470
stabilin 2
chr20_+_2642855 0.87 ENSDART00000058775
zgc:101562
chr15_-_10341048 0.87 ENSDART00000171013
teneurin transmembrane protein 4
chr6_+_1724889 0.86 ENSDART00000157415
activin A receptor type 2Ab
chr1_-_681116 0.86 ENSDART00000165894
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr10_-_1961930 0.85 ENSDART00000122446
teratocarcinoma-derived growth factor 1
chr23_-_3758637 0.85 ENSDART00000131536
ENSDART00000139408
ENSDART00000137826
high mobility group AT-hook 1a
chr12_+_22404108 0.84 ENSDART00000153055
high density lipoprotein binding protein b
chr24_-_33801668 0.84 ENSDART00000079202
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr1_-_51038885 0.83 ENSDART00000035150
spastin
chr23_+_43718115 0.81 ENSDART00000149266
ENSDART00000149503
anaphase promoting complex subunit 10
chr19_-_30447611 0.81 ENSDART00000073705
ENSDART00000048977
ENSDART00000191237
ATP-binding cassette, sub-family F (GCN20), member 1
chr10_-_1961576 0.81 ENSDART00000042441
teratocarcinoma-derived growth factor 1
chr24_+_39211288 0.81 ENSDART00000061540
im:7160594
chr22_+_21549419 0.81 ENSDART00000139411
phospholipid phosphatase 2b
chr7_+_59033902 0.81 ENSDART00000168888
FAST kinase domains 3
chr23_-_3759345 0.80 ENSDART00000132205
ENSDART00000137707
ENSDART00000189382
high mobility group AT-hook 1a
chr1_+_12177195 0.80 ENSDART00000146842
ENSDART00000142081
STRA6-like
chr16_+_55078477 0.79 ENSDART00000170074
5-azacytidine induced 2
chr10_-_9961488 0.79 ENSDART00000191023
spermatid perinuclear RNA binding protein
chr9_-_30502010 0.79 ENSDART00000149483
si:dkey-229b18.3
chr14_-_24110062 0.78 ENSDART00000177062
cytoplasmic polyadenylation element binding protein 4a
chr19_-_82504 0.78 ENSDART00000027864
ENSDART00000160560
heterogeneous nuclear ribonucleoprotein R
chr17_+_13031497 0.77 ENSDART00000115208
F-box protein 33
chr11_-_26832685 0.77 ENSDART00000153519
IQ motif and Sec7 domain 1b
chr5_-_8682590 0.77 ENSDART00000142762
zgc:153352
chr3_-_11922713 0.77 ENSDART00000150575
coronin 7
chr18_-_13121983 0.77 ENSDART00000092648
ribitol xylosyltransferase 1
chr5_-_66823750 0.76 ENSDART00000041441
ENSDART00000112488
stress-induced phosphoprotein 1
chr6_+_20954400 0.76 ENSDART00000143248
ENSDART00000165806
serine/threonine kinase 11 interacting protein
chr13_+_13945218 0.75 ENSDART00000089501
ENSDART00000142997
eukaryotic translation initiation factor 2-alpha kinase 3
chr2_-_37277626 0.75 ENSDART00000135340
NAD kinase b
chr1_-_52201266 0.74 ENSDART00000143805
ENSDART00000023757
RAB3D, member RAS oncogene family, a
chr5_-_41124241 0.74 ENSDART00000083561
myotubularin related protein 12
chr7_-_19369002 0.74 ENSDART00000165680
netrin 4
chr17_-_51262430 0.74 ENSDART00000163222
trafficking protein particle complex 12
chr20_-_20821783 0.73 ENSDART00000152577
ENSDART00000027603
ENSDART00000145601
creatine kinase, brain b
chr4_+_13586689 0.73 ENSDART00000067161
ENSDART00000138201
transportin 3
chr2_-_44777592 0.72 ENSDART00000113351
ENSDART00000169310
non-SMC condensin I complex, subunit D2
chr14_+_30795559 0.72 ENSDART00000006132
cofilin 1
chr13_+_49727333 0.71 ENSDART00000168799
ENSDART00000037559
geranylgeranyl diphosphate synthase 1
chr20_-_51186524 0.71 ENSDART00000027836
ENSDART00000114407
RNA binding motif protein 25b
chr2_+_59041081 0.71 ENSDART00000067736
serine/threonine kinase 11
chr2_-_37797577 0.70 ENSDART00000110781
nuclear factor of activated T cells 4
chr18_-_39288894 0.70 ENSDART00000186216
mitogen-activated protein kinase 6
chr23_-_20051369 0.69 ENSDART00000049836
biglycan b
chr6_+_12527725 0.69 ENSDART00000149328
serine/threonine kinase 24b (STE20 homolog, yeast)
chr8_-_32803227 0.69 ENSDART00000110079
zgc:194839
chr23_+_39963599 0.68 ENSDART00000166539
FYVE and coiled-coil domain containing 1a
chr11_-_22916641 0.67 ENSDART00000080201
ENSDART00000154813
MDM4, p53 regulator
chr4_+_1761029 0.67 ENSDART00000026963
peptidase (mitochondrial processing) beta
chr16_+_32014552 0.67 ENSDART00000047570
membrane bound O-acyltransferase domain containing 7
chr17_-_25630822 0.66 ENSDART00000126201
ENSDART00000105503
ENSDART00000151878
RAB3 GTPase activating protein subunit 2 (non-catalytic)
chr17_-_8592824 0.66 ENSDART00000127022

chr10_-_33251876 0.66 ENSDART00000184565
BCL tumor suppressor 7Ba
chr9_-_51563575 0.66 ENSDART00000167034
ENSDART00000148918
TRAF family member-associated NFKB activator
chr6_+_27992886 0.66 ENSDART00000160354
angiomotin like 2a
chr1_-_58900851 0.66 ENSDART00000183085
ENSDART00000188855
ENSDART00000182567
Danio rerio microfibril-associated glycoprotein 4-like (LOC100334800), transcript variant 2, mRNA.
chr2_+_21185903 0.65 ENSDART00000131369
si:dkey-29d8.3
chr9_+_6009077 0.65 ENSDART00000057484
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr4_-_13255700 0.64 ENSDART00000162277
ENSDART00000026593
glutamate receptor interacting protein 1
chr16_-_17586883 0.64 ENSDART00000017142
mannose-6-phosphate receptor (cation dependent)
chr21_+_39100289 0.64 ENSDART00000075958
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr11_-_40457325 0.64 ENSDART00000128442
tumor necrosis factor receptor superfamily, member 1B
chr22_-_14272699 0.64 ENSDART00000190121
si:ch211-246m6.5
chr22_+_22437561 0.64 ENSDART00000089622
kinesin family member 14
chr1_+_35985813 0.64 ENSDART00000179634
ENSDART00000139636
ENSDART00000175902
zgc:152968
chr10_+_39199547 0.63 ENSDART00000075943
etoposide induced 2.4
chr15_-_1843831 0.63 ENSDART00000156718
ENSDART00000154175
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_-_49854432 0.62 ENSDART00000180731
biliverdin reductase A
chr12_-_22238004 0.62 ENSDART00000038310
ORMDL sphingolipid biosynthesis regulator 3
chr8_-_38201415 0.61 ENSDART00000155189
PDZ and LIM domain 2 (mystique)
chr22_-_31517300 0.60 ENSDART00000164799
solute carrier family 6 (neurotransmitter transporter), member 6b
chr5_-_62940851 0.60 ENSDART00000137052
sperm antigen with calponin homology and coiled-coil domains 1
chr17_+_25331576 0.60 ENSDART00000157309
transmembrane protein 54a
chr18_+_22138924 0.59 ENSDART00000183961
RHO family interacting cell polarization regulator 1
chr11_-_13341051 0.59 ENSDART00000121872
microtubule associated serine/threonine kinase 3b
chr10_+_22034477 0.58 ENSDART00000133304
ENSDART00000134189
ENSDART00000021240
ENSDART00000100526
nucleophosmin 1a
chr17_+_50701748 0.58 ENSDART00000191938
ENSDART00000183220
ENSDART00000049464
fermitin family member 2
chr7_-_14446512 0.57 ENSDART00000041577
kinesin family member 7
chr16_+_3185541 0.57 ENSDART00000024088
WD repeat domain 21
chr20_+_38458084 0.56 ENSDART00000020153
ENSDART00000135912
coenzyme Q8A
chr11_-_40147032 0.56 ENSDART00000052918
si:dkey-264d12.4
chr21_-_9769500 0.56 ENSDART00000170710
Rho GTPase activating protein 24
chr7_+_29863548 0.56 ENSDART00000136555
ENSDART00000134068
talin 2a
chr21_+_11749097 0.56 ENSDART00000102408
ENSDART00000102404
elongation factor, RNA polymerase II, 2
chr11_+_45153104 0.56 ENSDART00000159204
ENSDART00000177585
thymidine kinase 1, soluble
chr15_+_24704798 0.55 ENSDART00000192470
si:dkey-151p21.7
chr23_-_43718067 0.55 ENSDART00000015777
ATP-binding cassette, sub-family E (OABP), member 1
chr6_-_7123210 0.55 ENSDART00000041304
autophagy related 3
chr1_+_24557414 0.54 ENSDART00000076519
dCTP pyrophosphatase 1
chr20_-_43811023 0.54 ENSDART00000153134
MAP/microtubule affinity-regulating kinase 3b
chr9_+_25840720 0.54 ENSDART00000024572
glycosyltransferase-like domain containing 1
chr2_+_2168547 0.54 ENSDART00000029347
HIG1 hypoxia inducible domain family, member 1A
chr3_+_21200763 0.54 ENSDART00000067841
zgc:112038
chr23_+_5631381 0.54 ENSDART00000149143
plakophilin 1a
chr13_-_479129 0.54 ENSDART00000159803
ENSDART00000082127
HEAT repeat containing 5B
chr3_+_52545400 0.53 ENSDART00000184183
solute carrier family 27 (fatty acid transporter), member 1a
chr21_+_20903244 0.53 ENSDART00000186193
complement component 7b
chr4_+_28374628 0.52 ENSDART00000076037
asparagine-linked glycosylation 10
chr1_+_38142354 0.51 ENSDART00000179352
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa9a+hoxa9b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.1 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.9 2.8 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.8 3.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.6 1.7 GO:0090008 hypoblast development(GO:0090008)
0.3 1.0 GO:0039015 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.3 1.0 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.3 1.2 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.3 0.8 GO:0034214 protein hexamerization(GO:0034214) mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.3 2.2 GO:0035284 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.3 1.9 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.2 0.7 GO:0030043 actin filament fragmentation(GO:0030043)
0.2 0.9 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.2 1.3 GO:0032447 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.2 1.0 GO:0071071 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.2 2.0 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.2 1.2 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.2 0.9 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.2 0.6 GO:0046125 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.2 0.5 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.2 0.7 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 0.9 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2 1.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 1.0 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.2 0.7 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.2 0.8 GO:0071939 vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.2 0.6 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.2 1.7 GO:0001973 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.2 1.8 GO:0045842 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.1 0.9 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.9 GO:0045687 positive regulation of glial cell differentiation(GO:0045687) positive regulation of oligodendrocyte differentiation(GO:0048714)
0.1 2.6 GO:0035459 cargo loading into vesicle(GO:0035459)
0.1 0.7 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 2.1 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.5 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.8 GO:0002931 response to ischemia(GO:0002931)
0.1 0.7 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.4 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.1 0.8 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.1 0.3 GO:0019677 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
0.1 0.3 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229)
0.1 0.7 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.1 0.7 GO:0035909 aorta morphogenesis(GO:0035909) dorsal aorta morphogenesis(GO:0035912)
0.1 0.6 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.1 0.5 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 0.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.5 GO:0000012 single strand break repair(GO:0000012)
0.1 0.9 GO:0016246 RNA interference(GO:0016246)
0.1 0.5 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.1 0.3 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.1 0.7 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.1 0.5 GO:0048795 swim bladder morphogenesis(GO:0048795)
0.1 0.4 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 0.2 GO:0006600 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.1 0.6 GO:0046149 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1 0.2 GO:0001112 DNA-templated transcriptional open complex formation(GO:0001112) transcriptional open complex formation at RNA polymerase II promoter(GO:0001113) protein-DNA complex remodeling(GO:0001120)
0.1 0.7 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.1 0.5 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.1 0.9 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 1.2 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.1 3.2 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 0.4 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.8 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.1 1.7 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.6 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 0.7 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 0.2 GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.1 0.3 GO:1901909 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 1.5 GO:0051014 actin filament severing(GO:0051014)
0.1 0.5 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.8 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.9 GO:0000054 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.9 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.3 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.7 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 1.0 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 1.4 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.2 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.0 0.2 GO:0048855 adenohypophysis morphogenesis(GO:0048855)
0.0 0.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.6 GO:1901534 positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.6 GO:0060325 face morphogenesis(GO:0060325)
0.0 1.7 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.1 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.0 0.2 GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 2.6 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 0.6 GO:0097324 melanocyte migration(GO:0097324)
0.0 0.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.3 GO:0060561 apoptotic process involved in morphogenesis(GO:0060561)
0.0 2.0 GO:0034968 histone lysine methylation(GO:0034968)
0.0 1.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.3 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.0 0.4 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 2.3 GO:0051028 mRNA transport(GO:0051028)
0.0 0.5 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.4 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 1.2 GO:0006354 DNA-templated transcription, elongation(GO:0006354)
0.0 0.3 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.2 GO:0045840 positive regulation of mitotic nuclear division(GO:0045840) positive regulation of nuclear division(GO:0051785)
0.0 0.9 GO:0030301 cholesterol transport(GO:0030301)
0.0 0.4 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.7 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.6 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 0.9 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 0.1 GO:0071380 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.0 0.1 GO:0035777 pronephric distal tubule development(GO:0035777)
0.0 0.1 GO:0061641 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 1.5 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 1.2 GO:0001764 neuron migration(GO:0001764)
0.0 1.6 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 2.0 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 2.5 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0021767 mammillary body development(GO:0021767)
0.0 0.1 GO:0090280 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) positive regulation of calcium ion import(GO:0090280)
0.0 0.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.9 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.2 GO:0009303 rRNA transcription(GO:0009303)
0.0 1.1 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.6 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 1.3 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.3 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.4 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.4 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.4 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.2 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 1.1 GO:0031101 fin regeneration(GO:0031101)
0.0 0.9 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.4 GO:0007338 single fertilization(GO:0007338)
0.0 0.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0097189 apoptotic body(GO:0097189)
0.3 1.9 GO:0005784 Sec61 translocon complex(GO:0005784)
0.2 1.6 GO:0044232 organelle membrane contact site(GO:0044232)
0.2 0.7 GO:0044609 DBIRD complex(GO:0044609)
0.2 0.5 GO:0034457 Mpp10 complex(GO:0034457)
0.2 0.6 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.6 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.1 3.2 GO:0005685 U1 snRNP(GO:0005685)
0.1 5.0 GO:0000421 autophagosome membrane(GO:0000421)
0.1 0.9 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 1.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 2.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 2.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.1 3.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.2 GO:0010369 chromocenter(GO:0010369)
0.1 0.9 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.3 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.4 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 2.5 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 0.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.4 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.2 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.2 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.0 0.7 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.5 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 5.0 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.3 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.1 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.2 GO:0005845 mRNA cap binding complex(GO:0005845)
0.0 0.2 GO:0043198 dendritic shaft(GO:0043198)
0.0 4.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.3 GO:0030904 retromer complex(GO:0030904)
0.0 1.2 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 1.2 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.0 0.7 GO:0005776 autophagosome(GO:0005776)
0.0 1.2 GO:0031941 filamentous actin(GO:0031941)
0.0 0.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)
0.0 0.1 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.8 GO:0030496 midbody(GO:0030496)
0.0 0.4 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.9 GO:0000779 condensed chromosome, centromeric region(GO:0000779)
0.0 3.4 GO:0005764 lysosome(GO:0005764)
0.0 0.6 GO:0016528 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.6 GO:0008023 transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.5 1.4 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.4 3.2 GO:0030619 U1 snRNA binding(GO:0030619)
0.3 0.9 GO:1990715 mRNA CDS binding(GO:1990715)
0.2 1.2 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.2 1.0 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.2 0.8 GO:0048487 beta-tubulin binding(GO:0048487)
0.2 1.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 2.1 GO:0035804 structural constituent of egg coat(GO:0035804)
0.2 0.8 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2 0.5 GO:0019777 Atg12 transferase activity(GO:0019777)
0.2 2.9 GO:0030552 cAMP binding(GO:0030552)
0.2 5.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 0.5 GO:0008119 thiopurine S-methyltransferase activity(GO:0008119)
0.1 0.9 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.1 1.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.7 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 1.9 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 1.7 GO:0070697 activin receptor binding(GO:0070697)
0.1 0.9 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 1.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.1 1.9 GO:0002039 p53 binding(GO:0002039)
0.1 0.3 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 0.4 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.1 0.3 GO:0030975 thiamine diphosphokinase activity(GO:0004788) thiamine binding(GO:0030975)
0.1 0.5 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 0.7 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.1 0.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.6 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 0.5 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.1 0.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 1.0 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.9 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.1 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.2 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.7 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.2 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.1 1.2 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 0.9 GO:0017002 activin-activated receptor activity(GO:0017002)
0.1 0.3 GO:0008486 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.1 0.3 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.1 1.0 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 3.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.8 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.8 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.5 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.4 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.9 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 3.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.3 GO:0000049 tRNA binding(GO:0000049)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.0 0.8 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.7 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.6 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.7 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 4.8 GO:0008083 growth factor activity(GO:0008083)
0.0 0.7 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 2.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.3 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.5 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 5.7 GO:0042802 identical protein binding(GO:0042802)
0.0 1.3 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 3.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.6 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 2.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0016415 octanoyltransferase activity(GO:0016415)
0.0 1.1 GO:0005178 integrin binding(GO:0005178)
0.0 0.7 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.4 GO:0071617 lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.6 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 0.1 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 0.1 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 3.5 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.1 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 1.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.0 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.0 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.4 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 1.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 0.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 0.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.7 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 1.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 0.9 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 2.2 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.7 PID AURORA B PATHWAY Aurora B signaling
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.9 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 5.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.2 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.0 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.2 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.3 0.7 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.2 1.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 2.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 1.7 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 2.6 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 2.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 0.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 0.7 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 0.7 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.1 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.5 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.8 REACTOME PERK REGULATED GENE EXPRESSION Genes involved in PERK regulated gene expression
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 3.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.4 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.0 0.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.1 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening