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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hoxa11a

Z-value: 0.39

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Transcription factors associated with hoxa11a

Gene Symbol Gene ID Gene Info
ENSDARG00000104162 homeobox A11a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxa11adr11_v1_chr19_+_19737214_197373000.097.2e-01Click!

Activity profile of hoxa11a motif

Sorted Z-values of hoxa11a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_20108833 0.52 ENSDART00000100867
family with sequence similarity 3, member C
chr16_-_10316359 0.44 ENSDART00000104025
flotillin 1b
chr21_+_13128180 0.43 ENSDART00000081426
outer dense fiber of sperm tails 2a
chr2_-_37874647 0.42 ENSDART00000039386
zgc:66427
chr1_+_31019165 0.40 ENSDART00000102210
integrin, alpha 6b
chr19_+_7424347 0.36 ENSDART00000004622
splicing factor 3b, subunit 4
chr16_-_47426482 0.33 ENSDART00000148631
ENSDART00000149723
septin 7b
chr9_+_20483846 0.33 ENSDART00000192067
ENSDART00000145111
poly (ADP-ribose) polymerase family, member 4
chr8_-_33154677 0.29 ENSDART00000133300
zinc finger and BTB domain containing 34
chr20_+_34671386 0.29 ENSDART00000152836
ENSDART00000138226
elongator acetyltransferase complex subunit 3
chr2_+_54696042 0.28 ENSDART00000074270
ankyrin repeat domain 12
chr24_-_21090447 0.27 ENSDART00000136507
ENSDART00000140786
ENSDART00000184841
queuine tRNA-ribosyltransferase accessory subunit 2
chr17_+_44463230 0.25 ENSDART00000130311
N(alpha)-acetyltransferase 30, NatC catalytic subunit
chr15_+_44093286 0.22 ENSDART00000114352
zgc:112998
chr21_-_25618175 0.21 ENSDART00000133512
FOS-like antigen 1b
chr13_+_42309688 0.21 ENSDART00000158367
insulin-degrading enzyme
chr7_+_9308625 0.21 ENSDART00000084598
selenoprotein S
chr21_+_13127742 0.18 ENSDART00000179221
outer dense fiber of sperm tails 2a
chr4_-_6373735 0.18 ENSDART00000140100
si:ch73-156e19.1
chr10_+_2587234 0.18 ENSDART00000126937
wu:fb59d01
chr7_-_30624435 0.17 ENSDART00000173828
ring finger protein 111
chr12_-_11560794 0.17 ENSDART00000149098
ENSDART00000169975
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b
chr7_-_30280934 0.16 ENSDART00000126741
small EDRK-rich factor 2
chr1_+_36722122 0.16 ENSDART00000111566
transmembrane protein 184C
chr5_-_32489796 0.16 ENSDART00000168870
G protein-coupled receptor 107
chr13_+_29925397 0.15 ENSDART00000123482
CUE domain containing 2
chr25_-_18002937 0.14 ENSDART00000149696
centrosomal protein 290
chr3_-_40254634 0.14 ENSDART00000154562
DNA topoisomerase III alpha
chr6_-_40744720 0.14 ENSDART00000154916
ENSDART00000186922
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr25_-_18002498 0.13 ENSDART00000158688
centrosomal protein 290
chr6_+_42338309 0.13 ENSDART00000015277
glutathione peroxidase 1b
chr16_-_6205790 0.12 ENSDART00000038495
catenin (cadherin-associated protein), beta 1
chr23_+_33752275 0.11 ENSDART00000007260
si:ch211-210c8.6
chr1_+_45056371 0.11 ENSDART00000073689
ENSDART00000167309
bloodthirsty-related gene family, member 1
chr18_-_17087138 0.10 ENSDART00000135597
zinc finger CCCH-type containing 18
chr11_-_26832685 0.10 ENSDART00000153519
IQ motif and Sec7 domain 1b
chr3_+_24190207 0.10 ENSDART00000034762
proline rich 15-like a
chr12_+_33361948 0.10 ENSDART00000124982
fatty acid synthase
chr12_-_26851726 0.10 ENSDART00000047724
zinc finger E-box binding homeobox 1b
chr12_+_27117609 0.09 ENSDART00000076154
homeobox B8b
chr11_+_24716837 0.09 ENSDART00000145217
zgc:153953
chr22_-_33916620 0.09 ENSDART00000191276

chr5_+_36611128 0.08 ENSDART00000097684
neuro-oncological ventral antigen 1
chr8_+_23861461 0.08 ENSDART00000037109
SRSF protein kinase 1a
chr5_+_59397739 0.06 ENSDART00000148659
CAP-GLY domain containing linker protein 2
chr15_-_734203 0.06 ENSDART00000177867
ENSDART00000154918
si:dkey-7i4.21

chr11_+_43751263 0.06 ENSDART00000163843
zgc:153431
chr11_+_25560072 0.06 ENSDART00000124131
ENSDART00000147179
methyl-CpG binding domain protein 1b
chr17_-_23727978 0.05 ENSDART00000079600
multiple inositol-polyphosphate phosphatase 1a
chr17_+_17764979 0.05 ENSDART00000105013
alkB homolog 1, histone H2A dioxygenase
chr9_-_39005317 0.05 ENSDART00000014207
myosin, light chain 1, alkali; skeletal, fast
chr4_+_39368978 0.05 ENSDART00000160640
si:dkey-261o4.1
chr11_+_25560632 0.05 ENSDART00000033914
methyl-CpG binding domain protein 1b
chr17_-_31695217 0.04 ENSDART00000104332
ENSDART00000143090
lin-52 DREAM MuvB core complex component
chr6_+_49551614 0.04 ENSDART00000022581
RAB22A, member RAS oncogene family
chr8_-_12432604 0.04 ENSDART00000133350
ENSDART00000140699
ENSDART00000101174
TNF receptor-associated factor 1
chr9_-_23922011 0.04 ENSDART00000145734
collagen, type VI, alpha 3
chr10_+_33990572 0.04 ENSDART00000138547
furry homolog b (Drosophila)
chr23_-_33750307 0.03 ENSDART00000162772
bridging integrator 2a
chr23_-_33750135 0.03 ENSDART00000187641
bridging integrator 2a
chr9_-_3671911 0.03 ENSDART00000102900
Sp5 transcription factor a
chr6_-_53334259 0.03 ENSDART00000172465
guanine nucleotide binding protein (G protein), beta polypeptide 1b
chr7_-_18508815 0.03 ENSDART00000173539
regulator of G protein signaling 12a
chr10_-_25561751 0.03 ENSDART00000147089
glutamate receptor, ionotropic, kainate 1a
chr13_-_25196758 0.03 ENSDART00000184722
adenosine kinase a
chr5_+_59397348 0.03 ENSDART00000175642
CAP-GLY domain containing linker protein 2
chr9_-_2892250 0.03 ENSDART00000140695
cell division cycle associated 7a
chr21_+_11865972 0.02 ENSDART00000081676
ubiquitin associated protein 1
chr14_-_48348973 0.02 ENSDART00000185822

chr9_-_2892045 0.02 ENSDART00000137201
cell division cycle associated 7a
chr18_-_2433011 0.02 ENSDART00000181922
ENSDART00000193276

chr3_-_18737126 0.02 ENSDART00000055767
E4F transcription factor 1
chr1_-_56213723 0.02 ENSDART00000142505
ENSDART00000137237
si:dkey-76b14.2
chr17_+_4368859 0.01 ENSDART00000055385
cardiolipin synthase 1
chr20_+_43379029 0.01 ENSDART00000142486
ENSDART00000186486
unc-93 homolog A
chr13_-_9875538 0.01 ENSDART00000041609
transmembrane 9 superfamily member 3
chr7_+_31879649 0.01 ENSDART00000099789
myosin binding protein C, cardiac
chr22_+_2239974 0.00 ENSDART00000141993
zinc finger protein 1144
chr12_-_34713888 0.00 ENSDART00000153272
BAH domain and coiled-coil containing 1b
chr7_+_31879986 0.00 ENSDART00000138491
myosin binding protein C, cardiac

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa11a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1901890 positive regulation of cell junction assembly(GO:1901890)
0.1 0.3 GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.(GO:0002926)
0.1 0.5 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.3 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.2 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.1 GO:2000055 positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000055)
0.0 0.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.2 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.1 GO:0071800 podosome assembly(GO:0071800)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0016600 flotillin complex(GO:0016600)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.1 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.0 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.0 GO:0035516 oxidative DNA demethylase activity(GO:0035516)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins