ISMARA results: hnf4a+hnf4b

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hnf4a+hnf4b

Z-value: 1.37

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Transcription factors associated with hnf4a+hnf4b

Gene Symbol	Gene ID	Gene Info
hnf4a NCBI UniProt	ENSDARG00000021494	hepatocyte nuclear factor 4, alpha
hnf4b NCBI UniProt	ENSDARG00000104742	hepatic nuclear factor 4, beta
hnf4a NCBI UniProt	ENSDARG00000112985	hepatocyte nuclear factor 4, alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
hnf4a	dr11_v1_chr23_+_25856541_25856641	-0.79	8.2e-05	Click!
CABZ01057488.1	dr11_v1_chr7_+_69019851_69019851	0.67	2.3e-03	Click!

Activity profile of hnf4a+hnf4b motif

Sorted Z-values of hnf4a+hnf4b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_2584423 Show fit	5.54	ENSDART00000013506	zp3.2 NCBI UniProt Show fit	zona pellucida glycoprotein 3, tandem duplicate 2
chr20_+_54304800 Show fit	5.29	ENSDART00000121661	zp2.6 NCBI UniProt Show fit	zona pellucida glycoprotein 2, tandem duplicate 6
chr19_-_27564458 Show fit	4.46	ENSDART00000123155	si:dkeyp-46h3.6 NCBI UniProt Show fit	si:dkeyp-46h3.6
chr9_+_8380728 Show fit	4.45	ENSDART00000133501	si:ch1073-75o15.4 NCBI UniProt Show fit	si:ch1073-75o15.4
chr20_-_43741159 Show fit	4.34	ENSDART00000192621	si:dkeyp-50f7.2 NCBI UniProt Show fit	si:dkeyp-50f7.2
chr16_-_17197546 Show fit	4.33	ENSDART00000139939 ENSDART00000135146 ENSDART00000063800 ENSDART00000163606	gapdh NCBI UniProt Show fit	glyceraldehyde-3-phosphate dehydrogenase
chr1_+_24387659 Show fit	4.18	ENSDART00000130356	qdprb2 NCBI UniProt Show fit	quinoid dihydropteridine reductase b2
chr23_+_2740741 Show fit	4.17	ENSDART00000134938	zgc:114123 NCBI UniProt Show fit	zgc:114123
chr17_-_2590222 Show fit	4.13	ENSDART00000185711	CR759892.1 NCBI UniProt Show fit
chr17_-_2578026 Show fit	4.06	ENSDART00000065821	zp3.2 NCBI UniProt Show fit	zona pellucida glycoprotein 3, tandem duplicate 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf4a+hnf4b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	17.4	GO:2000344	binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2	8.3	GO:0050821	protein stabilization(GO:0050821)
0.5	4.2	GO:0033206	meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.4	4.2	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.5	3.7	GO:0042760	very long-chain fatty acid catabolic process(GO:0042760)
0.5	2.7	GO:0070986	left/right axis specification(GO:0070986)
0.1	2.7	GO:0016601	Rac protein signal transduction(GO:0016601)
0.1	2.5	GO:0006635	fatty acid beta-oxidation(GO:0006635)
0.1	2.4	GO:0015693	magnesium ion transport(GO:0015693)
0.0	2.4	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)

Showing 1 to 10 of 67 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	15.1	GO:0031012	extracellular matrix(GO:0031012)
0.0	4.5	GO:0005938	cell cortex(GO:0005938)
0.1	3.1	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0	2.8	GO:0010008	endosome membrane(GO:0010008)
0.6	2.3	GO:0043291	RAVE complex(GO:0043291)
0.0	2.0	GO:0072686	mitotic spindle(GO:0072686)
0.1	1.9	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.0	1.7	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.2	1.5	GO:0035517	PR-DUB complex(GO:0035517)
0.0	1.4	GO:0031105	septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)

Showing 1 to 10 of 30 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	17.4	GO:0035804	structural constituent of egg coat(GO:0035804)
0.1	16.4	GO:0030246	carbohydrate binding(GO:0030246)
2.1	8.3	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.0	4.2	GO:0070404	6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
0.2	3.7	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	3.0	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.3	2.5	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.4	2.4	GO:0030331	estrogen receptor binding(GO:0030331)
0.1	2.4	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	2.2	GO:0030170	pyridoxal phosphate binding(GO:0030170)

Showing 1 to 10 of 59 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	2.0	PID PLK1 PATHWAY	PLK1 signaling events
0.0	1.7	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	1.5	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	1.5	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	1.1	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	1.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.8	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	0.7	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.6	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.6	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	2.3	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.4	2.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.1	2.1	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1	1.9	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.3	1.8	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.1	1.7	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	1.6	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	1.2	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.3	1.1	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI

Showing 1 to 10 of 20 entries

Results for hnf4a+hnf4b

Z-value: 1.37

Motif logo

Transcription factors associated with hnf4a+hnf4b

Activity-expression correlation:

Activity profile of hnf4a+hnf4b motif

Sorted Z-values of hnf4a+hnf4b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf4a+hnf4b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: