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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for hnf1ba+hnf1bb
Z-value: 1.16
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Transcription factors associated with hnf1ba+hnf1bb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hnf1bb | dr11_v1_chr21_+_38817785_38817843 | 0.40 | 9.9e-02 | Click! |
| hnf1ba | dr11_v1_chr15_-_16012963_16012963 | 0.37 | 1.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr24_-_4765740 Show fit | 3.66 |
ENSDART00000121576
|
carboxypeptidase B1 (tissue) |
|
| chr16_-_42894628 Show fit | 3.50 |
ENSDART00000045600
|
hemochromatosis type 2 |
|
| chr11_-_37997419 Show fit | 3.49 |
ENSDART00000102870
|
solute carrier family 41 (magnesium transporter), member 1 |
|
| chr20_+_23440632 Show fit | 3.46 |
ENSDART00000180685
ENSDART00000042820 |
si:dkey-90m5.4 |
|
| chr24_+_35787629 Show fit | 3.19 |
ENSDART00000136721
|
si:dkeyp-7a3.1 |
|
| chr7_-_35066457 Show fit | 3.11 |
ENSDART00000058067
|
zgc:112160 |
|
| chr24_-_39610585 Show fit | 3.09 |
ENSDART00000066506
|
cytochrome c oxidase subunit VIb polypeptide 1 |
|
| chr21_+_38002879 Show fit | 2.99 |
ENSDART00000065183
|
claudin 2 |
|
| chr20_-_31075972 Show fit | 2.85 |
ENSDART00000122927
|
si:ch211-198b3.4 |
|
| chr3_+_26734162 Show fit | 2.56 |
ENSDART00000114552
|
si:dkey-202l16.5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of hnf1ba+hnf1bb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0071466 | cellular response to xenobiotic stimulus(GO:0071466) |
| 0.3 | 3.5 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.1 | 3.3 | GO:0070830 | apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830) |
| 0.4 | 2.5 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.3 | 2.3 | GO:0097374 | sensory neuron axon guidance(GO:0097374) |
| 0.1 | 2.3 | GO:0006144 | purine nucleobase metabolic process(GO:0006144) |
| 0.0 | 2.1 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.3 | 2.0 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.1 | 1.8 | GO:0006775 | fat-soluble vitamin metabolic process(GO:0006775) |
| 0.1 | 1.6 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 1.8 | GO:0005770 | late endosome(GO:0005770) |
| 0.5 | 1.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 1.2 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 1.0 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.2 | 0.7 | GO:0044215 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.1 | 0.6 | GO:0098574 | cytoplasmic side of lysosomal membrane(GO:0098574) |
| 0.0 | 0.5 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.5 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 0.4 | GO:0061700 | GATOR2 complex(GO:0061700) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 2.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 2.3 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.0 | 2.3 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 2.2 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.1 | 2.1 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 2.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.5 | 1.9 | GO:0015355 | secondary active monocarboxylate transmembrane transporter activity(GO:0015355) |
| 0.0 | 1.8 | GO:0019842 | vitamin binding(GO:0019842) |
| 0.0 | 1.8 | GO:0019955 | cytokine binding(GO:0019955) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 1.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 1.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.5 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.3 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 3.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 3.0 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.9 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 1.8 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 1.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.5 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.3 | 1.0 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 1.0 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 0.8 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |