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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hnf1ba+hnf1bb

Z-value: 1.16

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Transcription factors associated with hnf1ba+hnf1bb

Gene Symbol Gene ID Gene Info
ENSDARG00000006615 HNF1 homeobox Ba
ENSDARG00000022295 HNF1 homeobox Bb
ENSDARG00000115522 HNF1 homeobox Ba

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hnf1bbdr11_v1_chr21_+_38817785_388178430.409.9e-02Click!
hnf1badr11_v1_chr15_-_16012963_160129630.371.3e-01Click!

Activity profile of hnf1ba+hnf1bb motif

Sorted Z-values of hnf1ba+hnf1bb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr24_-_4765740 3.66 ENSDART00000121576
carboxypeptidase B1 (tissue)
chr16_-_42894628 3.50 ENSDART00000045600
hemochromatosis type 2
chr11_-_37997419 3.49 ENSDART00000102870
solute carrier family 41 (magnesium transporter), member 1
chr20_+_23440632 3.46 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
chr24_+_35787629 3.19 ENSDART00000136721
si:dkeyp-7a3.1
chr7_-_35066457 3.11 ENSDART00000058067
zgc:112160
chr24_-_39610585 3.09 ENSDART00000066506
cytochrome c oxidase subunit VIb polypeptide 1
chr21_+_38002879 2.99 ENSDART00000065183
claudin 2
chr20_-_31075972 2.85 ENSDART00000122927
si:ch211-198b3.4
chr3_+_26734162 2.56 ENSDART00000114552
si:dkey-202l16.5
chr5_-_19394440 2.49 ENSDART00000163771
forkhead box N4
chr25_-_37191929 2.31 ENSDART00000128108
urate (5-hydroxyiso-) hydrolase b
chr2_-_17828279 2.31 ENSDART00000083314
protein tyrosine phosphatase, receptor type, f, b
chr5_-_30715225 2.28 ENSDART00000016758
finTRIM family, member 82
chr3_-_16250527 2.14 ENSDART00000146699
ENSDART00000141181
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr24_+_26345427 2.13 ENSDART00000089756
leucine rich repeat containing 34
chr18_-_48550426 2.02 ENSDART00000145189
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr4_+_7827261 1.95 ENSDART00000129568
phytanoyl-CoA 2-hydroxylase
chr2_+_26647472 1.82 ENSDART00000145415
ENSDART00000157409
tocopherol (alpha) transfer protein
chr25_-_35497055 1.69 ENSDART00000009271
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr5_+_13385837 1.65 ENSDART00000191190
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr1_+_10051763 1.63 ENSDART00000011701
fibrinogen beta chain
chr24_+_26345609 1.54 ENSDART00000186844
leucine rich repeat containing 34
chr1_-_19502322 1.54 ENSDART00000181888
ENSDART00000044030
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr7_-_25895189 1.51 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
CD99 molecule-like 2
chr8_+_26522013 1.45 ENSDART00000046863
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl
chr13_-_36534380 1.43 ENSDART00000177857
ENSDART00000181046
ENSDART00000187243
serine/arginine-rich splicing factor 5a
chr24_+_23791758 1.40 ENSDART00000066655
ENSDART00000146580
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr1_+_34224360 1.21 ENSDART00000192938
ADP-ribosylation factor-like 6
chr4_-_9533345 1.21 ENSDART00000128501
si:ch73-139j3.4
chr18_+_3530769 1.16 ENSDART00000163469
si:ch73-338a16.3
chr20_+_41756996 1.11 ENSDART00000186393
family with sequence similarity 184, member A
chr10_-_41664427 1.09 ENSDART00000150213
gamma-glutamyltransferase 1b
chr20_-_47347962 1.05 ENSDART00000080863
dystrobrevin, beta a
chr25_+_23280220 1.04 ENSDART00000153940
protein tyrosine phosphatase, receptor type, Jb, tandem duplicate 1
chr20_-_23440955 1.03 ENSDART00000153386
solute carrier family 10, member 4
chr6_+_60055168 1.02 ENSDART00000008752
phosphoenolpyruvate carboxykinase 1 (soluble)
chr8_-_47800754 1.02 ENSDART00000115050
ENSDART00000133669
KN motif and ankyrin repeat domains 3
chr5_+_9428876 1.01 ENSDART00000081791
UDP glucuronosyltransferase 2 family, polypeptide A7
chr25_+_3347461 1.00 ENSDART00000104888
solute carrier family 35, member B4
chr20_-_47348116 0.97 ENSDART00000162087
ENSDART00000160769
ENSDART00000164484
dystrobrevin, beta a
chr7_-_72277269 0.90 ENSDART00000161914
ENSDART00000183927
solute carrier family 35 (GDP-fucose transporter), member C1
chr5_+_21225017 0.89 ENSDART00000141573
si:dkey-13n15.11
chr12_+_35067863 0.88 ENSDART00000152849
synaptotagmin XV
chr5_+_45921234 0.86 ENSDART00000134355
ankyrin repeat and death domain containing 1B
chr9_+_29994439 0.83 ENSDART00000012447
transmembrane protein 30C
chr5_+_37854685 0.82 ENSDART00000051222
ENSDART00000185283
preproinsulin
chr24_-_6078222 0.81 ENSDART00000146830
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr15_+_28202170 0.81 ENSDART00000077736
vitronectin a
chr20_+_10538025 0.81 ENSDART00000129762
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like
chr10_-_17159761 0.80 ENSDART00000080449
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr3_+_13559199 0.80 ENSDART00000166547
si:ch73-106n3.1
chr2_-_127945 0.75 ENSDART00000056453
insulin-like growth factor binding protein 1b
chr20_+_10544100 0.74 ENSDART00000113927
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr22_-_23748284 0.73 ENSDART00000162005
complement factor H like 2
chr5_+_32345187 0.73 ENSDART00000147132
complement component 9
chr13_-_23666579 0.73 ENSDART00000192457
ENSDART00000179777
mitogen-activated protein kinase kinase kinase 21
chr17_+_15033822 0.70 ENSDART00000154987
sterile alpha motif domain containing 4A
chr9_+_28688574 0.68 ENSDART00000101319
zgc:162396
chr7_+_27059330 0.67 ENSDART00000173919
pleckstrin homology domain containing, family A member 7b
chr1_-_22851481 0.62 ENSDART00000054386
quinoid dihydropteridine reductase b1
chr5_+_45677781 0.62 ENSDART00000163120
ENSDART00000126537
group-specific component (vitamin D binding protein)
chr14_+_38654300 0.61 ENSDART00000148938
ENSDART00000150107
ribonuclease like 3
chr10_-_42131408 0.60 ENSDART00000076693
STAM binding protein a
chr15_-_41744509 0.60 ENSDART00000176952
ENSDART00000156690
finTRIM family, member 88
chr8_+_15254564 0.59 ENSDART00000024433
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr22_-_23668356 0.59 ENSDART00000167106
ENSDART00000159622
ENSDART00000163228
complement factor H
chr10_+_25369254 0.58 ENSDART00000164375
BTB and CNC homology 1, basic leucine zipper transcription factor 1 b
chr3_-_9722603 0.57 ENSDART00000168234
CREB binding protein b
chr25_+_17920361 0.57 ENSDART00000185644
BLOC-1 related complex subunit 5
chr23_+_27740788 0.57 ENSDART00000053871
desert hedgehog
chr25_+_13406069 0.56 ENSDART00000010495
zinc and ring finger 1
chr6_+_54221654 0.54 ENSDART00000128456
protein kinase C and casein kinase substrate in neurons 1b
chr13_-_40726865 0.53 ENSDART00000099847
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr5_-_41307550 0.52 ENSDART00000143446
natriuretic peptide receptor 3
chr17_-_17948587 0.52 ENSDART00000090447
HHIP-like 1
chr3_-_16760923 0.51 ENSDART00000055855
aspartate dehydrogenase domain containing
chr3_+_40170216 0.51 ENSDART00000011568
synaptogyrin 3a
chr6_+_41039166 0.50 ENSDART00000125659
ectonucleoside triphosphate diphosphohydrolase 8
chr24_-_17039638 0.49 ENSDART00000048823
complement component 8, gamma polypeptide
chr22_+_16555939 0.48 ENSDART00000012604
PDZK1 interacting protein 1
chr6_+_7977611 0.48 ENSDART00000112290
paralemmin 3
chr24_+_23716918 0.48 ENSDART00000080332
COP9 signalosome subunit 5
chr20_-_43723860 0.47 ENSDART00000122051
Mix paired-like homeobox
chr5_-_12063381 0.46 ENSDART00000026749
nipsnap homolog 1 (C. elegans)
chr12_-_3940768 0.46 ENSDART00000134292
zgc:92040
chr8_-_1051438 0.45 ENSDART00000067093
ENSDART00000170737
SET and MYND domain containing 1b
chr22_-_26005894 0.45 ENSDART00000105088
platelet-derived growth factor alpha polypeptide a
chr8_+_30699429 0.44 ENSDART00000005345
ureidopropionase, beta
chr11_+_575665 0.44 ENSDART00000122133
MKRN2 opposite strand, tandem duplicate 1
chr11_-_18601955 0.44 ENSDART00000180565
zinc finger, MYND-type containing 8
chr15_+_35043007 0.44 ENSDART00000086954
sestrin 3
chr6_-_59563597 0.42 ENSDART00000166311
inhibin beta E subunit
chr10_+_21867307 0.42 ENSDART00000126629
cerebellin 17
chr5_-_42904329 0.41 ENSDART00000112807
chemokine (C-X-C motif) ligand 20
chr5_+_28830643 0.39 ENSDART00000051448
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr7_+_27317174 0.39 ENSDART00000193058
SRY (sex determining region Y)-box 6
chr4_+_45484774 0.37 ENSDART00000150573
si:dkey-256i11.6
chr6_+_10094061 0.35 ENSDART00000150998
ENSDART00000162236
ATPase copper transporting beta
chr24_+_14713776 0.35 ENSDART00000134475
ganglioside induced differentiation associated protein 1
chr8_-_53490376 0.34 ENSDART00000158789
choline dehydrogenase
chr4_+_18804317 0.34 ENSDART00000101043
solute carrier family 26 (anion exchanger), member 3, tandem duplicate 2
chr21_-_23308286 0.33 ENSDART00000184419
zinc finger and BTB domain containing 16a
chr8_+_26293673 0.33 ENSDART00000144977
monoglyceride lipase
chr20_-_40755614 0.33 ENSDART00000061247
connexin 32.3
chr22_-_26100282 0.33 ENSDART00000166075
platelet-derived growth factor alpha polypeptide a
chr1_+_22851261 0.32 ENSDART00000193925
general transcription factor IIE, polypeptide 2, beta
chr6_+_28141135 0.32 ENSDART00000113405
ENSDART00000179795
inositol polyphosphate-5-phosphatase D
chr10_+_25369859 0.31 ENSDART00000047541
BTB and CNC homology 1, basic leucine zipper transcription factor 1 b
chr20_-_42534504 0.31 ENSDART00000132310
regulatory factor X, 6
chr6_+_30456788 0.31 ENSDART00000121492

chr22_+_17261801 0.31 ENSDART00000192978
ENSDART00000193187
ENSDART00000179953
ENSDART00000134798
tudor domain containing 5
chr5_+_28830388 0.29 ENSDART00000149150
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr24_+_25913162 0.29 ENSDART00000143099
ENSDART00000184814
mitogen-activated protein kinase kinase kinase 15
chr5_-_67661102 0.29 ENSDART00000013605
zinc finger and BTB domain containing 20
chr21_+_43669943 0.29 ENSDART00000136025
trimethyllysine hydroxylase, epsilon
chr2_-_41942666 0.28 ENSDART00000075673
Epstein-Barr virus induced 3
chr4_-_5317006 0.28 ENSDART00000150867
si:ch211-214j24.15
chr20_+_51006362 0.27 ENSDART00000028084
membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5)
chr23_+_27740592 0.26 ENSDART00000137875
desert hedgehog
chr7_-_59564011 0.26 ENSDART00000186053
zgc:112271
chr17_-_51893123 0.25 ENSDART00000103350
ENSDART00000017329
numb homolog (Drosophila)
chr7_-_29534001 0.25 ENSDART00000124028
annexin A2b
chr20_-_40750953 0.24 ENSDART00000061256
connexin 28.9
chr12_+_5209822 0.23 ENSDART00000152610
si:ch211-197g18.2
chr13_+_23988442 0.23 ENSDART00000010918
angiotensinogen
chr2_-_27609189 0.20 ENSDART00000040555
LYN proto-oncogene, Src family tyrosine kinase
chr19_-_3876877 0.19 ENSDART00000163711
thyroid hormone receptor associated protein 3b
chr5_+_45322734 0.19 ENSDART00000084411
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr4_+_76416268 0.17 ENSDART00000174351
ENSDART00000191591
zgc:113209

chr6_-_49078702 0.17 ENSDART00000135185
solute carrier family 5 (iodide transporter), member 8-like
chr11_+_7432533 0.16 ENSDART00000180977
adhesion G protein-coupled receptor L2a
chr2_+_17055069 0.14 ENSDART00000115078
thrombopoietin
chr12_-_6177894 0.14 ENSDART00000152292
apobec1 complementation factor
chr22_-_24818066 0.13 ENSDART00000143443
vitellogenin 6
chr4_-_32642681 0.12 ENSDART00000188695
ENSDART00000193974
si:dkey-265e7.1
chr6_+_28140816 0.12 ENSDART00000137907
inositol polyphosphate-5-phosphatase D
chr23_+_28770225 0.12 ENSDART00000132179
ENSDART00000142273
mannan-binding lectin serine peptidase 2
chr23_+_32335871 0.12 ENSDART00000149698
solute carrier family 39 (zinc transporter), member 5
chr23_+_33752275 0.09 ENSDART00000007260
si:ch211-210c8.6
chr2_+_1487118 0.09 ENSDART00000147283
complement component 8, alpha polypeptide
chr17_-_50233493 0.09 ENSDART00000172266
v-fos FBJ murine osteosarcoma viral oncogene homolog Aa
chr17_+_5895500 0.08 ENSDART00000019905
fibronectin type III domain containing 4b
chr11_-_45152702 0.08 ENSDART00000168066
arylformamidase
chr6_+_39930825 0.07 ENSDART00000182352
ENSDART00000186643
ENSDART00000190513
ENSDART00000065092
ENSDART00000188645
inositol 1,4,5-trisphosphate receptor, type 1a
chr5_+_1877464 0.07 ENSDART00000050658
zgc:101699
chr7_+_23292133 0.06 ENSDART00000134489
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1
chr2_+_1486822 0.06 ENSDART00000132500
complement component 8, alpha polypeptide
chr6_-_29515709 0.05 ENSDART00000180205
peroxisomal biogenesis factor 5-like a
chr1_+_26667872 0.05 ENSDART00000152803
ENSDART00000152144
ENSDART00000152785
ENSDART00000152393
hemogen
chr4_+_58016732 0.05 ENSDART00000165777

chr5_-_30620625 0.05 ENSDART00000098273
transcobalamin like
chr7_+_19817306 0.05 ENSDART00000044425

chr4_+_54798291 0.04 ENSDART00000165113
ENSDART00000109624
si:dkeyp-82b4.6
chr4_-_32179699 0.04 ENSDART00000124106
ENSDART00000158835
si:dkey-72l17.6
chr15_+_35139457 0.04 ENSDART00000059204
solute carrier family 19 (thiamine transporter), member 3a
chr6_-_43028270 0.04 ENSDART00000149092
ENSDART00000149559
glycerate kinase
chr12_+_27061720 0.03 ENSDART00000153426
Snf2-related CREBBP activator protein
chr19_+_19772765 0.03 ENSDART00000182028
ENSDART00000161019
homeobox A3a
chr16_-_22294265 0.03 ENSDART00000124718
aquaporin 10a
chr7_-_17412559 0.02 ENSDART00000163020
novel immune-type receptor 3a
chr10_+_25726694 0.02 ENSDART00000140308
UDP glucuronosyltransferase 5 family, polypeptide D1
chr2_-_43635777 0.01 ENSDART00000148633
integrin, beta 1b.1

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf1ba+hnf1bb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0035881 amacrine cell differentiation(GO:0035881)
0.4 1.5 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.3 3.5 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.3 2.0 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.3 2.3 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.3 1.0 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
0.2 0.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 0.8 GO:2000252 positive regulation of epithelial cell differentiation(GO:0030858) negative regulation of behavior(GO:0048521) negative regulation of feeding behavior(GO:2000252)
0.2 0.9 GO:0072530 purine-containing compound transmembrane transport(GO:0072530)
0.2 0.8 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.1 1.1 GO:0031179 peptide modification(GO:0031179)
0.1 0.5 GO:0000338 protein deneddylation(GO:0000338)
0.1 0.8 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 1.6 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.1 0.3 GO:0019695 choline metabolic process(GO:0019695)
0.1 0.3 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 1.8 GO:0006775 fat-soluble vitamin metabolic process(GO:0006775)
0.1 2.3 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.1 0.5 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.3 GO:0044320 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.1 0.4 GO:0019483 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
0.1 1.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.4 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1 3.3 GO:0070830 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1 0.4 GO:1902623 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.1 0.4 GO:0071233 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.0 0.2 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.0 1.0 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.3 GO:0006578 amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0 0.4 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 1.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.4 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.5 GO:0009435 NAD biosynthetic process(GO:0009435)
0.0 3.7 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.7 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 1.2 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.3 GO:0043046 DNA methylation involved in gamete generation(GO:0043046)
0.0 0.5 GO:0060038 cardiac muscle cell proliferation(GO:0060038)
0.0 0.5 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.2 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 0.6 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.4 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 2.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 1.0 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.3 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.6 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.9 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.2 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.1 GO:0071578 zinc II ion transmembrane import(GO:0071578)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0005577 fibrinogen complex(GO:0005577)
0.2 0.7 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.1 0.6 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.1 0.3 GO:0033391 chromatoid body(GO:0033391)
0.1 0.3 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.1 0.4 GO:0061700 GATOR2 complex(GO:0061700)
0.1 1.2 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.5 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 3.2 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.4 GO:0031430 M band(GO:0031430)
0.0 0.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.0 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.8 GO:0005770 late endosome(GO:0005770)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.2 1.4 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.2 0.6 GO:0005499 vitamin D binding(GO:0005499)
0.2 1.0 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.2 0.5 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.2 1.0 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 3.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.1 GO:0033691 sialic acid binding(GO:0033691)
0.1 2.3 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 1.1 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.1 0.5 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.4 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.1 1.5 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.5 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 0.8 GO:0005113 patched binding(GO:0005113)
0.1 1.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.8 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.7 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.4 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.7 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.1 0.4 GO:0070728 leucine binding(GO:0070728)
0.1 0.9 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 1.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 2.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 1.8 GO:0019842 vitamin binding(GO:0019842)
0.0 0.8 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.5 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.7 GO:0030371 translation repressor activity(GO:0030371)
0.0 1.0 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 2.3 GO:0008201 heparin binding(GO:0008201)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 2.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.0 1.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.5 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.0 1.8 GO:0019955 cytokine binding(GO:0019955)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 3.5 PID BMP PATHWAY BMP receptor signaling
0.0 1.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID IL27 PATHWAY IL27-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.3 3.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 3.6 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 0.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 0.8 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 1.9 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 0.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 1.5 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 0.4 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.1 3.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 0.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+