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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for gsx2+pnx
Z-value: 1.35
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Transcription factors associated with gsx2+pnx
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pnx | dr11_v1_chr10_+_2799285_2799285 | 0.97 | 8.6e-11 | Click! |
| gsx2 | dr11_v1_chr20_-_22484621_22484621 | 0.64 | 4.3e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_33865312 Show fit | 6.56 |
ENSDART00000166141
|
tektin 1 |
|
| chr7_-_1504382 Show fit | 5.25 |
ENSDART00000172770
|
si:zfos-405g10.4 |
|
| chr10_-_17083180 Show fit | 4.61 |
ENSDART00000170083
|
family with sequence similarity 166, member B |
|
| chr11_-_40728380 Show fit | 4.57 |
ENSDART00000023745
|
coiled-coil domain containing 114 |
|
| chr6_-_40352215 Show fit | 4.39 |
ENSDART00000103992
|
tubulin tyrosine ligase-like family, member 3 |
|
| chr2_-_2957970 Show fit | 4.35 |
ENSDART00000162505
|
si:ch1073-82l19.1 |
|
| chr4_+_306036 Show fit | 4.17 |
ENSDART00000103659
|
mesogenin 1 |
|
| chr6_+_40354424 Show fit | 4.00 |
ENSDART00000047416
|
solute carrier family 4, sodium bicarbonate cotransporter, member 8 |
|
| chr5_+_42308955 Show fit | 3.58 |
ENSDART00000136683
|
Pim proto-oncogene, serine/threonine kinase, related 201 |
|
| chr18_+_1154189 Show fit | 3.35 |
ENSDART00000135090
|
si:ch1073-75f15.2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of gsx2+pnx
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.6 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 0.3 | 6.1 | GO:0098884 | postsynaptic neurotransmitter receptor internalization(GO:0098884) |
| 0.0 | 5.7 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.1 | 5.0 | GO:0070121 | Kupffer's vesicle development(GO:0070121) |
| 1.4 | 4.2 | GO:0048340 | paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341) |
| 0.2 | 4.0 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 3.8 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.4 | 3.0 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.3 | 2.6 | GO:0097477 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 0.1 | 2.6 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | GO:0031514 | motile cilium(GO:0031514) |
| 0.3 | 6.1 | GO:0098844 | postsynaptic endocytic zone membrane(GO:0098844) |
| 0.3 | 4.4 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.1 | 4.4 | GO:0005930 | axoneme(GO:0005930) |
| 0.1 | 3.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 2.8 | GO:0005604 | collagen trimer(GO:0005581) basement membrane(GO:0005604) |
| 0.0 | 2.6 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 2.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 1.9 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 1.9 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 5.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.5 | 4.4 | GO:0070738 | protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738) |
| 0.3 | 4.0 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 3.9 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 3.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 2.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 2.6 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 2.6 | GO:0043236 | laminin binding(GO:0043236) |
| 0.0 | 2.2 | GO:0003724 | RNA helicase activity(GO:0003724) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 1.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 1.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 1.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.9 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 0.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.9 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 0.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 3.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 2.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 2.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 1.9 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 1.9 | REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM | Genes involved in Chondroitin sulfate/dermatan sulfate metabolism |
| 0.1 | 1.7 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.5 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 1.5 | REACTOME SHC1 EVENTS IN EGFR SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.1 | 1.3 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |