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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for gfi1aa+gfi1ab
Z-value: 0.81
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Transcription factors associated with gfi1aa+gfi1ab
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000020746 | growth factor independent 1A transcription repressor a | |
| ENSDARG00000044457 | growth factor independent 1A transcription repressor b | |
| ENSDARG00000114140 | growth factor independent 1A transcription repressor b |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| gfi1aa | dr11_v1_chr2_+_10766744_10766744 | -0.64 | 4.0e-03 | Click! |
| gfi1ab | dr11_v1_chr6_-_29007493_29007493 | -0.57 | 1.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_35252761 Show fit | 1.84 |
ENSDART00000051278
|
transportin 1 |
|
| chr11_-_10456387 Show fit | 1.78 |
ENSDART00000011087
ENSDART00000081827 |
epithelial cell transforming 2 |
|
| chr14_-_49110280 Show fit | 1.70 |
ENSDART00000023654
|
sideroflexin 1 |
|
| chr11_-_10456553 Show fit | 1.69 |
ENSDART00000169509
ENSDART00000185574 ENSDART00000188276 |
epithelial cell transforming 2 |
|
| chr6_-_53143667 Show fit | 1.63 |
ENSDART00000079694
|
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b |
|
| chr20_+_26940178 Show fit | 1.60 |
ENSDART00000190888
|
cell division cycle associated 4 |
|
| chr2_-_9915814 Show fit | 1.54 |
ENSDART00000091644
ENSDART00000177556 |
abl-interactor 1b |
|
| chr2_+_23007675 Show fit | 1.52 |
ENSDART00000163649
|
MAP kinase interacting serine/threonine kinase 2a |
|
| chr7_-_26603743 Show fit | 1.50 |
ENSDART00000099003
|
phospholipid scramblase 3b |
|
| chr5_+_57328535 Show fit | 1.43 |
ENSDART00000149646
|
solute carrier family 31 (copper transporter), member 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of gfi1aa+gfi1ab
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.3 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.3 | 3.6 | GO:0000912 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 0.4 | 3.2 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.2 | 2.9 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.1 | 2.5 | GO:0090279 | regulation of calcium ion import(GO:0090279) |
| 0.0 | 2.5 | GO:0031047 | gene silencing by RNA(GO:0031047) |
| 0.0 | 2.4 | GO:1990542 | mitochondrial transmembrane transport(GO:1990542) |
| 0.0 | 2.4 | GO:0051170 | nuclear import(GO:0051170) |
| 0.0 | 2.4 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 2.1 | GO:0009648 | photoperiodism(GO:0009648) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 1.1 | 3.2 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.0 | 2.9 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.1 | 2.8 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 2.4 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 2.3 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 2.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 1.8 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 1.7 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 1.6 | GO:0030175 | filopodium(GO:0030175) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 3.1 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 3.0 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629) |
| 0.5 | 2.8 | GO:0022889 | serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 2.6 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 2.0 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.1 | 1.9 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 1.9 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 1.9 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.1 | 1.8 | GO:0061608 | nuclear import signal receptor activity(GO:0061608) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 2.5 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 2.3 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 2.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 1.7 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 1.5 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.3 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 1.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 1.1 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.3 | 3.0 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.3 | 2.5 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 1.7 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 1.6 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.1 | 1.4 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 1.3 | REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |
| 0.1 | 1.0 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 1.0 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 1.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |