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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for gata1b+gata2a

Z-value: 1.02

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Transcription factors associated with gata1b+gata2a

Gene Symbol Gene ID Gene Info
ENSDARG00000059130 GATA binding protein 1b
ENSDARG00000059327 GATA binding protein 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gata2adr11_v1_chr11_-_3865472_38654720.822.8e-05Click!
gata1bdr11_v1_chr8_-_7474997_74749970.781.2e-04Click!

Activity profile of gata1b+gata2a motif

Sorted Z-values of gata1b+gata2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_55105066 5.24 ENSDART00000110848
si:ch211-5k11.8
chr13_+_2908764 3.36 ENSDART00000162362
wu:fj16a03
chr3_+_55100045 3.13 ENSDART00000113098
hemoglobin, alpha adult 1
chr10_-_29236860 2.76 ENSDART00000111620
coiled-coil domain containing 83
chr23_-_23401305 2.69 ENSDART00000078936
hairy-related 9
chr7_+_35075847 2.59 ENSDART00000193469
ENSDART00000037346
chymotrypsinogen B1
chr23_+_7379728 2.58 ENSDART00000012194
GATA binding protein 5
chr16_-_24815091 2.50 ENSDART00000154269
ENSDART00000131025
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr2_+_33051730 2.44 ENSDART00000177902
ENSDART00000187903
ring finger protein 220a
chr24_+_2843268 2.36 ENSDART00000170529
si:ch211-152c8.2
chr23_-_35483163 2.34 ENSDART00000138660
ENSDART00000113643
ENSDART00000189269
F-box protein 25
chr25_+_21829777 2.32 ENSDART00000027393
creatine kinase, mitochondrial 1
chr16_+_25126935 2.14 ENSDART00000058945
zgc:92590
chr20_+_15552657 1.97 ENSDART00000063912
Jun proto-oncogene, AP-1 transcription factor subunit
chr13_+_24679674 1.97 ENSDART00000033090
ENSDART00000139854
zgc:66426
chr2_+_33052360 1.92 ENSDART00000134651
ring finger protein 220a
chr12_+_47945664 1.75 ENSDART00000189824
ENSDART00000055743
ENSDART00000188936

chr7_-_51102479 1.65 ENSDART00000174023
collagen, type IV, alpha 6
chr20_+_33981946 1.63 ENSDART00000131775
si:dkey-51e6.1
chr16_+_51180938 1.56 ENSDART00000169022
high mobility group nucleosomal binding domain 2
chr15_+_19838458 1.53 ENSDART00000101204
activated leukocyte cell adhesion molecule b
chr19_+_8606883 1.53 ENSDART00000054469
ENSDART00000185264
S100 calcium binding protein A10a
chr2_+_33052169 1.51 ENSDART00000180008
ring finger protein 220a
chr13_+_33304187 1.50 ENSDART00000075826
ENSDART00000145295
doublecortin domain containing 2B
chr6_-_49078263 1.50 ENSDART00000032982
solute carrier family 5 (iodide transporter), member 8-like
chr8_-_49431939 1.48 ENSDART00000011453
ENSDART00000088240
ENSDART00000114173
synaptophysin b
chr21_-_25756119 1.46 ENSDART00000002341
claudin c
chr12_-_20350629 1.39 ENSDART00000066384
hemoglobin beta embryonic-2
chr2_+_4207209 1.33 ENSDART00000157903
ENSDART00000166476
GATA binding protein 6
chr7_+_46368520 1.33 ENSDART00000192821
zinc finger protein 536
chr14_+_30568961 1.31 ENSDART00000184303
mitochondrial ribosomal protein L11
chr11_+_33818179 1.30 ENSDART00000109418
speckle-type POZ protein-like b
chr1_+_52563298 1.30 ENSDART00000142465
ATP-binding cassette, sub-family A (ABC1), member 1A
chr17_+_30894431 1.28 ENSDART00000127996
delta(4)-desaturase, sphingolipid 2
chr1_-_45636362 1.26 ENSDART00000181757
septin 3
chr6_+_58915889 1.24 ENSDART00000083628
DNA-damage-inducible transcript 3
chr1_-_8651718 1.23 ENSDART00000133319
actin, beta 1
chr13_-_29406534 1.22 ENSDART00000100877
zgc:153142
chr8_-_39654669 1.22 ENSDART00000145677
si:dkey-63d15.12
chr11_-_6265574 1.18 ENSDART00000181974
ENSDART00000104405
chemokine (C-C motif) ligand 25b
chr8_+_16004551 1.18 ENSDART00000165141
ELAV like neuron-specific RNA binding protein 4
chr1_-_9109699 1.16 ENSDART00000147833
vascular associated protein
chr14_-_25949713 1.14 ENSDART00000181455
secreted protein, acidic, cysteine-rich (osteonectin)
chr19_+_4912817 1.12 ENSDART00000101658
ENSDART00000165082
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr11_-_28614608 1.12 ENSDART00000065853
dehydrogenase/reductase (SDR family) member 3b
chr14_+_17197132 1.10 ENSDART00000054598
reticulon 4 receptor-like 2b
chr20_+_33875256 1.10 ENSDART00000002554
retinoid X receptor, gamma b
chr5_+_15203421 1.06 ENSDART00000040826
T-box 1
chr10_+_10801564 1.02 ENSDART00000027026
alpha-1-microglobulin/bikunin precursor
chr5_+_34622320 1.01 ENSDART00000141338
ectodermal-neural cortex 1
chr24_-_39858710 1.00 ENSDART00000134251
solute carrier family 12 (potassium/chloride transporter), member 7b
chr15_-_21877726 0.97 ENSDART00000127819
ENSDART00000145646
ENSDART00000100897
ENSDART00000144739
zgc:162608
chr14_-_25949951 0.97 ENSDART00000141304
secreted protein, acidic, cysteine-rich (osteonectin)
chr3_+_40809892 0.96 ENSDART00000190803
actin related protein 2/3 complex, subunit 1B
chr8_-_40327397 0.95 ENSDART00000074125
apelin receptor a
chr20_-_25533739 0.94 ENSDART00000063064
cytochrome P450, family 2, subfamily AD, polypeptide 6
chr23_+_26079467 0.91 ENSDART00000129617
ATPase H+ transporting accessory protein 1b
chr2_-_51794472 0.89 ENSDART00000186652

chr19_+_20778011 0.88 ENSDART00000024208
nuclear transport factor 2, like
chr13_-_4848889 0.87 ENSDART00000165259
mitochondrial calcium uniporter
chr16_-_36834505 0.86 ENSDART00000141275
ENSDART00000139588
ENSDART00000041993
purine nucleoside phosphorylase 4b
chr8_+_31872992 0.84 ENSDART00000146933
complement component 7a
chr2_+_21486529 0.82 ENSDART00000047468
inhibin, beta Ab
chr10_-_17484762 0.81 ENSDART00000137905
ENSDART00000007961
5'-nucleotidase, cytosolic II, like 1
chr2_+_38261748 0.80 ENSDART00000076478
dehydrogenase/reductase (SDR family) member 1
chr25_-_7974494 0.80 ENSDART00000171446
histidine ammonia-lyase
chr10_+_10801719 0.80 ENSDART00000193648
alpha-1-microglobulin/bikunin precursor
chr23_+_25708787 0.76 ENSDART00000060059
RNA binding motif, single stranded interacting protein 2b
chr19_-_40985308 0.76 ENSDART00000132986
ENSDART00000142360
si:ch211-120e1.7
chr3_-_12026741 0.74 ENSDART00000132238
cilia and flagella associated protein 70
chr14_-_28052474 0.73 ENSDART00000172948
ENSDART00000135337
si:ch211-220e11.3
zgc:64189
chr9_+_2522797 0.73 ENSDART00000186786
ENSDART00000147034
G protein-coupled receptor 155a
chr20_-_26420939 0.72 ENSDART00000110883
A kinase (PRKA) anchor protein 12b
chr24_-_2843107 0.69 ENSDART00000165290
cytochrome b5 type A (microsomal)
chr8_-_43574935 0.68 ENSDART00000051139
nuclear receptor corepressor 2
chr23_-_6920107 0.68 ENSDART00000149230
ENSDART00000182946
si:ch211-117c9.2
chr13_+_844150 0.67 ENSDART00000058260
glutathione S-transferase, alpha tandem duplicate 1
chr7_+_34290051 0.65 ENSDART00000123498
fin bud initiation factor b
chr20_-_26421112 0.65 ENSDART00000183767
ENSDART00000182330
A kinase (PRKA) anchor protein 12b
chr3_+_32492467 0.64 ENSDART00000151329
transient receptor potential cation channel, subfamily M, member 4a
chr5_-_13645995 0.63 ENSDART00000099665
ENSDART00000166957
purine-rich element binding protein Ba
chr9_+_29585943 0.63 ENSDART00000185989
ENSDART00000115290
mcf.2 cell line derived transforming sequence-like b
chr19_+_7124337 0.61 ENSDART00000031380
transporter associated with antigen processing, subunit type a
chr16_+_26449615 0.60 ENSDART00000039746
erythrocyte membrane protein band 4.1b
chr21_-_11834452 0.60 ENSDART00000081652
Rieske (Fe-S) domain containing
chr7_+_17120811 0.60 ENSDART00000147140
protein arginine methyltransferase 3
chr25_-_13728111 0.60 ENSDART00000169865
lecithin-cholesterol acyltransferase
chr9_-_45149695 0.59 ENSDART00000162033

chr6_-_40697585 0.59 ENSDART00000113196
si:ch211-157b11.14
chr21_+_27336550 0.56 ENSDART00000139634
dipeptidyl-peptidase 3
chr3_-_35602233 0.55 ENSDART00000055269
guanine nucleotide binding protein (G protein), gamma 13b
chr11_-_13126969 0.54 ENSDART00000169052
ENSDART00000190120
ELOVL fatty acid elongase 1b
chr22_+_16535575 0.53 ENSDART00000083063
T-cell acute lymphocytic leukemia 1
chr20_+_34870517 0.53 ENSDART00000191797
ankyrin repeat and EF-hand domain containing 1a
chr20_-_26066020 0.53 ENSDART00000078559
myc target 1a
chr25_-_16826219 0.52 ENSDART00000191299
ENSDART00000188504
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr25_+_18564266 0.52 ENSDART00000172338
caveolin 1
chr13_-_20381485 0.51 ENSDART00000131351
si:ch211-270n8.1
chr3_-_26204867 0.51 ENSDART00000103748
glycerophosphodiester phosphodiesterase domain containing 3a
chr14_+_36738069 0.51 ENSDART00000105590
tryptophan 2,3-dioxygenase a
chr18_+_48428713 0.50 ENSDART00000076861
Fli-1 proto-oncogene, ETS transcription factor a
chr7_-_50604626 0.50 ENSDART00000073903
ENSDART00000174031
CREB regulated transcription coactivator 3
chr6_+_8176486 0.50 ENSDART00000193308
nuclear factor, interleukin 3 regulated, member 5
chr1_+_41854298 0.48 ENSDART00000192672
spermine oxidase
chr22_-_36856405 0.48 ENSDART00000029588
kininogen 1
chr6_-_49078702 0.47 ENSDART00000135185
solute carrier family 5 (iodide transporter), member 8-like
chr24_-_10917243 0.47 ENSDART00000144372
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b
chr24_+_29381946 0.47 ENSDART00000189551
netrin g1a
chr1_-_38816685 0.47 ENSDART00000075230
ankyrin repeat and SOCS box containing 5b
chr22_-_11626014 0.47 ENSDART00000063133
ENSDART00000160085
glucagon a
chr18_+_18405992 0.46 ENSDART00000080174
nedd4 binding protein 1
chr10_+_26612321 0.46 ENSDART00000134322
four and a half LIM domains 1b
chr18_-_16795262 0.45 ENSDART00000048722
adenosine monophosphate deaminase 3b
chr5_-_42272517 0.45 ENSDART00000137692
ENSDART00000164363
si:ch211-207c6.2
chr11_-_1400507 0.45 ENSDART00000173029
ENSDART00000172953
ENSDART00000111140
ribosomal protein L29
chr5_-_66301142 0.44 ENSDART00000067541
prolactin receptor b
chr23_-_33750307 0.44 ENSDART00000162772
bridging integrator 2a
chr23_-_33750135 0.44 ENSDART00000187641
bridging integrator 2a
chr4_-_23858900 0.44 ENSDART00000123199
USP6 N-terminal like
chr15_-_43164591 0.44 ENSDART00000171305
adaptor-related protein complex 1, sigma 3 subunit, a
chr16_+_13424534 0.43 ENSDART00000114944
zgc:101640
chr9_+_343062 0.42 ENSDART00000164012
ENSDART00000164365
BPI fold containing family C, like
chr19_+_37509638 0.42 ENSDART00000139999
si:ch211-250g4.3
chr8_+_4838114 0.42 ENSDART00000146667
es1 protein
chr5_+_45921234 0.41 ENSDART00000134355
ankyrin repeat and death domain containing 1B
chr8_-_14151051 0.41 ENSDART00000090427
si:dkey-6n6.1
chr10_-_43029001 0.41 ENSDART00000171494
single-stranded DNA binding protein 2
chr14_-_41556720 0.41 ENSDART00000149244
integrin, alpha 6, like
chr1_+_36674584 0.40 ENSDART00000186772
ENSDART00000192274
endothelin receptor type Aa
chr8_+_16004154 0.40 ENSDART00000134787
ENSDART00000172510
ENSDART00000141173
ELAV like neuron-specific RNA binding protein 4
chr21_-_11820379 0.38 ENSDART00000126640
si:dkey-6b12.5
chr15_+_26600611 0.38 ENSDART00000155352
solute carrier family 47 (multidrug and toxin extrusion), member 3
chr10_+_40624702 0.37 ENSDART00000109129
zgc:172131
chr16_-_24668620 0.37 ENSDART00000012807
paraoxonase 3, tandem duplicate 2
chr1_-_11291324 0.37 ENSDART00000091205
sidekick cell adhesion molecule 1b
chr24_-_21258945 0.37 ENSDART00000111025
BOC cell adhesion associated, oncogene regulated
chr14_+_35691889 0.36 ENSDART00000074685
glycine receptor, beta b
chr8_+_20994433 0.36 ENSDART00000141736
si:dkeyp-82a1.8
chr13_+_22480496 0.36 ENSDART00000136863
ENSDART00000131870
ENSDART00000078720
ENSDART00000078740
ENSDART00000139218
LIM domain binding 3a
chr19_+_5146460 0.34 ENSDART00000150740
si:dkey-89b17.4
chr2_-_6482240 0.34 ENSDART00000132623
regulator of G protein signaling 13
chr24_+_29382109 0.34 ENSDART00000184620
ENSDART00000188414
ENSDART00000186132
ENSDART00000191489
netrin g1a
chr11_-_25418856 0.34 ENSDART00000013714
GATA binding protein 1a
chr20_+_51813432 0.32 ENSDART00000127444
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A
chr24_+_29449690 0.31 ENSDART00000105743
ENSDART00000193556
ENSDART00000145816
netrin g1a
chr25_+_35134393 0.31 ENSDART00000185379

chr23_-_24682244 0.31 ENSDART00000104035
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr1_-_17569793 0.30 ENSDART00000125125
acyl-CoA synthetase long chain family member 1a
chr5_-_16425781 0.30 ENSDART00000185624
ENSDART00000180617
solute carrier family 39 (zinc transporter), member 14
chr16_-_5612480 0.29 ENSDART00000157944

chr6_-_6673813 0.28 ENSDART00000150995
si:dkey-261j15.2
chr5_-_51166025 0.28 ENSDART00000097471
caspase recruitment domain family, member 9
chr3_+_24275766 0.27 ENSDART00000055607
platelet-derived growth factor beta polypeptide b
chr13_+_23677949 0.27 ENSDART00000144215
pecanex-like 2 (Drosophila)
chr23_+_20408227 0.27 ENSDART00000134727
si:rp71-17i16.4
chr2_+_47927026 0.26 ENSDART00000143023
finTRIM family, member 25
chr6_-_38418862 0.26 ENSDART00000104135
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr10_+_19525839 0.26 ENSDART00000162912
ENSDART00000158512
V-set and immunoglobulin domain containing 8a
chr7_+_44445595 0.26 ENSDART00000108766
cadherin 5
chr18_+_27732285 0.26 ENSDART00000141835
tetraspanin 18b
chr8_-_50287949 0.25 ENSDART00000023639
NK2 transcription factor related 7
chr11_+_31285127 0.25 ENSDART00000160154
si:dkey-238i5.2
chr17_-_29736019 0.25 ENSDART00000183483
Usher syndrome 2A (autosomal recessive, mild)
chr15_-_568645 0.25 ENSDART00000156744
cerebellin 18
chr2_+_35240764 0.24 ENSDART00000015827
tenascin R (restrictin, janusin)
chr11_-_13126505 0.24 ENSDART00000158377
ELOVL fatty acid elongase 1b
chr23_+_36115541 0.24 ENSDART00000130090
homeobox C6a
chr13_+_10945337 0.24 ENSDART00000091845
ATP-binding cassette, sub-family G (WHITE), member 5
chr12_-_32421046 0.23 ENSDART00000075567
ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 1
chr8_+_24861264 0.22 ENSDART00000099607
solute carrier family 6 (neutral amino acid transporter), member 17
chr18_+_17959681 0.22 ENSDART00000142700
zinc finger protein 423
chr14_+_26546175 0.21 ENSDART00000105932
si:dkeyp-110e4.11
chr17_+_8175998 0.20 ENSDART00000131200
myc target 1b
chr6_-_13308813 0.20 ENSDART00000065372
potassium inwardly-rectifying channel, subfamily J, member 3b
chr21_-_40880317 0.20 ENSDART00000100054
ENSDART00000137696
elastin b
chr20_-_27390258 0.19 ENSDART00000010584
peripherin 2, like
chr23_+_42272588 0.19 ENSDART00000164907

chr17_-_26867725 0.19 ENSDART00000153590
si:dkey-221l4.10
chr1_+_9954489 0.18 ENSDART00000005895
ENSDART00000183003
protein disulfide isomerase family A, member 2
chr5_+_21211135 0.18 ENSDART00000088492
bone morphogenetic protein 10
chr16_-_30564319 0.18 ENSDART00000145087
lamin A
chr17_+_39242437 0.18 ENSDART00000156138
ENSDART00000128863
zgc:174356
chr13_+_835390 0.17 ENSDART00000171329
glutathione S-transferase, alpha tandem duplicate 1
chr10_+_21650828 0.17 ENSDART00000160754
protocadherin 1 gamma 1
chr18_+_45228691 0.17 ENSDART00000127953
LARGE xylosyl- and glucuronyltransferase 2
chr8_+_23709280 0.17 ENSDART00000185842
peroxisome proliferator-activated receptor delta b
chr16_-_12953739 0.17 ENSDART00000103894
calcium channel, voltage-dependent, gamma subunit 8b
chr24_-_25691020 0.17 ENSDART00000015391
cholinergic receptor, nicotinic, delta (muscle)
chr6_-_609880 0.17 ENSDART00000149248
ENSDART00000148867
ENSDART00000149414
ENSDART00000148552
ENSDART00000148391
lectin, galactoside-binding, soluble, 2b
chr8_-_40555340 0.17 ENSDART00000163348
NPC1 like intracellular cholesterol transporter 1
chr7_-_41851605 0.17 ENSDART00000142981
myosin light chain kinase 3
chr19_+_7567763 0.16 ENSDART00000140411
S100 calcium binding protein A11
chr4_+_1530287 0.16 ENSDART00000067446
solute carrier family 38, member 4
chr9_+_32978302 0.16 ENSDART00000007630
nescient helix loop helix 2
chr4_-_20118468 0.16 ENSDART00000078587
si:dkey-159a18.1
chr12_-_36070473 0.15 ENSDART00000165720
G protein-coupled receptor 142
chr6_-_38419318 0.15 ENSDART00000138026
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr10_-_43718914 0.15 ENSDART00000189277
centrin 3
chr7_-_31938938 0.15 ENSDART00000132353
brain-derived neurotrophic factor
chr18_+_33550667 0.14 ENSDART00000141246
ENSDART00000136070
si:dkey-47k20.1

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1b+gata2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.9 GO:0001773 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.5 1.6 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
0.5 9.8 GO:0015671 oxygen transport(GO:0015671)
0.5 1.4 GO:0032060 bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
0.4 1.2 GO:2000471 regulation of hematopoietic stem cell migration(GO:2000471)
0.4 1.1 GO:0003156 regulation of organ formation(GO:0003156)
0.3 1.3 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.3 1.2 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.3 0.8 GO:0019556 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.3 1.5 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.2 1.0 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903589)
0.2 1.5 GO:0021885 forebrain cell migration(GO:0021885)
0.2 0.6 GO:0002369 T cell cytokine production(GO:0002369)
0.2 1.0 GO:0010873 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
0.2 0.9 GO:1901207 regulation of heart looping(GO:1901207)
0.2 2.3 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2 0.5 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.1 0.9 GO:0071800 podosome assembly(GO:0071800)
0.1 0.9 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.1 2.6 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.4 GO:1903392 epicardial cell to mesenchymal cell transition(GO:0003347) negative regulation of adherens junction organization(GO:1903392)
0.1 0.4 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 3.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 0.5 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 0.3 GO:0033212 iron assimilation(GO:0033212)
0.1 1.8 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.1 1.3 GO:0034311 diol metabolic process(GO:0034311)
0.1 1.1 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.3 GO:0030224 monocyte differentiation(GO:0030224)
0.1 0.2 GO:0015824 proline transport(GO:0015824)
0.1 0.5 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.1 0.5 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 0.5 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 0.4 GO:0051703 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.1 0.4 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 1.5 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.1 0.3 GO:0009826 unidimensional cell growth(GO:0009826)
0.1 1.2 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.0 1.2 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.6 GO:0050909 sensory perception of taste(GO:0050909)
0.0 1.0 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 1.3 GO:0070831 basement membrane assembly(GO:0070831)
0.0 2.0 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.0 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 1.1 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.6 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.0 0.7 GO:0030225 macrophage differentiation(GO:0030225)
0.0 0.2 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.6 GO:0014823 response to activity(GO:0014823)
0.0 0.5 GO:0032264 IMP salvage(GO:0032264)
0.0 0.5 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.2 GO:0090342 regulation of cell aging(GO:0090342)
0.0 0.8 GO:0019835 cytolysis(GO:0019835)
0.0 0.4 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 2.4 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0048901 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) anterior lateral line neuromast development(GO:0048901) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.1 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.0 0.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.0 0.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.0 0.3 GO:0003207 cardiac chamber formation(GO:0003207)
0.0 1.0 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.2 GO:0010996 response to auditory stimulus(GO:0010996)
0.0 0.4 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.6 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.0 0.4 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.1 GO:0007624 ultradian rhythm(GO:0007624)
0.0 1.6 GO:0050768 negative regulation of neurogenesis(GO:0050768)
0.0 0.3 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.1 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
0.0 0.5 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 8.5 GO:0016567 protein ubiquitination(GO:0016567)
0.0 1.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.3 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.2 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 1.5 GO:0098645 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 1.2 GO:0097433 dense body(GO:0097433)
0.2 0.9 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.3 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.9 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 1.0 GO:0042627 chylomicron(GO:0042627)
0.1 0.9 GO:1990246 uniplex complex(GO:1990246)
0.1 1.0 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.8 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.1 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.1 GO:0043218 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.3 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.0 1.6 GO:0043204 perikaryon(GO:0043204)
0.0 1.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 2.5 GO:0043025 neuronal cell body(GO:0043025)
0.0 2.0 GO:0005930 axoneme(GO:0005930)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.4 GO:0032589 neuron projection membrane(GO:0032589) dendrite membrane(GO:0032590)
0.0 0.5 GO:0005901 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.5 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.8 GO:0031720 haptoglobin binding(GO:0031720)
0.5 2.0 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.4 1.6 GO:0101006 protein histidine phosphatase activity(GO:0101006)
0.3 2.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.3 1.3 GO:0090554 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 1.2 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.2 1.3 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.2 1.0 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.2 1.0 GO:0060182 apelin receptor activity(GO:0060182)
0.2 2.3 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2 0.5 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.2 0.8 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 1.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 1.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 0.6 GO:0031769 glucagon receptor binding(GO:0031769)
0.1 0.4 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 0.4 GO:0070052 collagen V binding(GO:0070052)
0.1 0.3 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
0.1 0.5 GO:0046592 polyamine oxidase activity(GO:0046592)
0.1 0.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.4 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 2.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 2.1 GO:0005518 collagen binding(GO:0005518)
0.1 0.4 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 2.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.5 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.4 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 1.0 GO:0015377 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.8 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.6 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 1.1 GO:0098631 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.4 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237) benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.6 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.3 GO:0050700 CARD domain binding(GO:0050700)
0.0 1.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.1 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 4.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.1 GO:0016803 ether hydrolase activity(GO:0016803)
0.0 3.9 GO:0042802 identical protein binding(GO:0042802)
0.0 0.1 GO:0045735 nutrient reservoir activity(GO:0045735)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 0.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.9 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.2 GO:0042285 xylosyltransferase activity(GO:0042285)
0.0 0.2 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 1.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 5.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.7 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.7 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.1 2.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.5 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 2.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 2.0 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 0.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 3.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.7 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.5 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 1.5 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.0 0.5 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.1 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)