ISMARA results: gata1b+gata2a

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for gata1b+gata2a

Z-value: 1.02

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Transcription factors associated with gata1b+gata2a

Gene Symbol	Gene ID	Gene Info
gata1b NCBI UniProt	ENSDARG00000059130	GATA binding protein 1b
gata2a NCBI UniProt	ENSDARG00000059327	GATA binding protein 2a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
gata2a	dr11_v1_chr11_-_3865472_3865472	0.82	2.8e-05	Click!
gata1b	dr11_v1_chr8_-_7474997_7474997	0.78	1.2e-04	Click!

Activity profile of gata1b+gata2a motif

Sorted Z-values of gata1b+gata2a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_55105066 Show fit	5.24	ENSDART00000110848	si:ch211-5k11.8 NCBI UniProt Show fit	si:ch211-5k11.8
chr13_+_2908764 Show fit	3.36	ENSDART00000162362	wu:fj16a03 NCBI UniProt Show fit	wu:fj16a03
chr3_+_55100045 Show fit	3.13	ENSDART00000113098	hbaa1 NCBI UniProt Show fit	hemoglobin, alpha adult 1
chr10_-_29236860 Show fit	2.76	ENSDART00000111620	ccdc83 NCBI UniProt Show fit	coiled-coil domain containing 83
chr23_-_23401305 Show fit	2.69	ENSDART00000078936	her9 NCBI UniProt Show fit	hairy-related 9
chr7_+_35075847 Show fit	2.59	ENSDART00000193469 ENSDART00000037346	ctrb1 NCBI UniProt Show fit	chymotrypsinogen B1
chr23_+_7379728 Show fit	2.58	ENSDART00000012194	gata5 NCBI UniProt Show fit	GATA binding protein 5
chr16_-_24815091 Show fit	2.50	ENSDART00000154269 ENSDART00000131025	kcnn4 NCBI UniProt Show fit	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr2_+_33051730 Show fit	2.44	ENSDART00000177902 ENSDART00000187903	rnf220a NCBI UniProt Show fit	ring finger protein 220a
chr24_+_2843268 Show fit	2.36	ENSDART00000170529	si:ch211-152c8.2 NCBI UniProt Show fit	si:ch211-152c8.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1b+gata2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	9.8	GO:0015671	oxygen transport(GO:0015671)
0.0	8.5	GO:0016567	protein ubiquitination(GO:0016567)
0.8	3.9	GO:0001773	myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.1	3.1	GO:0032474	otolith morphogenesis(GO:0032474)
0.1	2.6	GO:0046686	response to cadmium ion(GO:0046686)
0.0	2.4	GO:0071466	cellular response to xenobiotic stimulus(GO:0071466)
0.2	2.3	GO:0046314	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0	2.0	GO:0018298	protein-chromophore linkage(GO:0018298)
0.1	1.8	GO:0031397	negative regulation of protein ubiquitination(GO:0031397)
0.5	1.6	GO:0035971	peptidyl-histidine dephosphorylation(GO:0035971)

Showing 1 to 10 of 81 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	9.8	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	2.5	GO:0043025	neuronal cell body(GO:0043025)
0.0	2.3	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.0	2.0	GO:0005930	axoneme(GO:0005930)
0.0	1.6	GO:0043204	perikaryon(GO:0043204)
0.3	1.5	GO:0098645	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	1.5	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	1.5	GO:0048786	presynaptic active zone(GO:0048786)
0.0	1.3	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	1.3	GO:0099569	presynaptic cytoskeleton(GO:0099569)

Showing 1 to 10 of 29 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	9.8	GO:0031720	haptoglobin binding(GO:0031720)
0.0	5.7	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.0	4.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	3.9	GO:0042802	identical protein binding(GO:0042802)
0.3	2.5	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	2.5	GO:0008013	beta-catenin binding(GO:0008013)
0.2	2.3	GO:0016775	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1	2.1	GO:0005518	collagen binding(GO:0005518)
0.5	2.0	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.1	2.0	GO:0048306	calcium-dependent protein binding(GO:0048306)

Showing 1 to 10 of 73 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	2.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	2.0	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	1.7	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	1.2	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	1.0	PID CDC42 PATHWAY	CDC42 signaling events
0.0	0.5	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.5	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.4	2.6	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	2.6	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	2.5	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.2	2.0	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	1.5	REACTOME EXTRACELLULAR MATRIX ORGANIZATION	Genes involved in Extracellular matrix organization
0.0	1.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	1.2	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	1.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.7	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity

Showing 1 to 10 of 21 entries

Results for gata1b+gata2a

Z-value: 1.02

Motif logo

Transcription factors associated with gata1b+gata2a

Activity-expression correlation:

Activity profile of gata1b+gata2a motif

Sorted Z-values of gata1b+gata2a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1b+gata2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: