ISMARA results: gata1a+gata2b

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for gata1a+gata2b

Z-value: 0.18

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Transcription factors associated with gata1a+gata2b

Gene Symbol	Gene ID	Gene Info
gata2b NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000009094	GATA binding protein 2b
gata1a NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000013477	GATA binding protein 1a
gata1a NCBI UniProt ZFIN ENSEMBL Google	ENSDARG00000117116	GATA binding protein 1a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
gata1a	dr11_v1_chr11_-_25418856_25418856	-0.81	4.2e-05	Click!
gata2b	dr11_v1_chr6_+_40794015_40794015	0.45	6.0e-02	Click!

Activity profile of gata1a+gata2b motif

Sorted Z-values of gata1a+gata2b motif

Top targets:

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_35532937 Show fit	0.33	ENSDART00000193209	ctps1b NCBI UniProt ZFIN ENSEMBL Google Show fit	CTP synthase 1b
chr22_+_21398508 Show fit	0.33	ENSDART00000089408 ENSDART00000186091	shdb NCBI UniProt ZFIN ENSEMBL Google Show fit	Src homology 2 domain containing transforming protein D, b
chr18_+_3169579 Show fit	0.26	ENSDART00000164724 ENSDART00000186340 ENSDART00000181247 ENSDART00000168056	pak1 NCBI UniProt ZFIN ENSEMBL Google Show fit	p21 protein (Cdc42/Rac)-activated kinase 1
chr10_+_42589391 Show fit	0.21	ENSDART00000067689 ENSDART00000075259	fgfr1b NCBI UniProt ZFIN ENSEMBL Google Show fit	fibroblast growth factor receptor 1b
chr11_-_40457325 Show fit	0.19	ENSDART00000128442	tnfrsf1b NCBI UniProt ZFIN ENSEMBL Google Show fit	tumor necrosis factor receptor superfamily, member 1B
chr8_-_6825588 Show fit	0.18	ENSDART00000135834	dock5 NCBI UniProt ZFIN ENSEMBL Google Show fit	dedicator of cytokinesis 5
chr10_-_31175744 Show fit	0.17	ENSDART00000191728	pknox2 NCBI UniProt ZFIN ENSEMBL Google Show fit	pbx/knotted 1 homeobox 2
chr4_-_2380173 Show fit	0.12	ENSDART00000177727	nap1l1 NCBI UniProt ZFIN ENSEMBL Google Show fit	nucleosome assembly protein 1-like 1
chr19_-_32710922 Show fit	0.07	ENSDART00000004034	hpca NCBI UniProt ZFIN ENSEMBL Google Show fit	hippocalcin
chr22_-_16270462 Show fit	0.07	ENSDART00000105681	cdc14ab NCBI UniProt ZFIN ENSEMBL Google Show fit	cell division cycle 14Ab
chr6_-_49159207 Show fit	0.07	ENSDART00000041942	tspan2a NCBI UniProt ZFIN ENSEMBL Google Show fit	tetraspanin 2a
chr5_+_18047111 Show fit	0.06	ENSDART00000132164	hira NCBI UniProt ZFIN ENSEMBL Google Show fit	histone cell cycle regulator a
chr22_+_15507218 Show fit	0.03	ENSDART00000125450	gpc1a NCBI UniProt ZFIN ENSEMBL Google Show fit	glypican 1a
chr5_-_7199998 Show fit	0.02	ENSDART00000167316	CABZ01087502.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr21_+_43561650 Show fit	0.02	ENSDART00000085071	gpr185a NCBI UniProt ZFIN ENSEMBL Google Show fit	G protein-coupled receptor 185 a
chr14_+_918287 Show fit	0.01	ENSDART00000167066	CU462913.1 NCBI UniProt ZFIN ENSEMBL Google Show fit
chr15_-_16704417 Show fit	0.00	ENSDART00000155163	caln1 NCBI UniProt ZFIN ENSEMBL Google Show fit	calneuron 1

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1a+gata2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0044210	'de novo' CTP biosynthetic process(GO:0044210)
0.0	0.3	GO:0003232	bulbus arteriosus development(GO:0003232)
0.0	0.2	GO:1901534	positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0097268	cytoophidium(GO:0097268)
0.0	0.1	GO:1902636	kinociliary basal body(GO:1902636)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0003883	CTP synthase activity(GO:0003883)
0.1	0.3	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.3	PID S1P S1P2 PATHWAY	S1P2 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway