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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for foxl1
Z-value: 1.24
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Transcription factors associated with foxl1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxl1 | dr11_v1_chr18_-_17485419_17485419 | -0.98 | 1.0e-12 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr24_-_19719240 Show fit | 4.84 |
ENSDART00000135405
|
cysteine-serine-rich nuclear protein 1b |
|
| chr15_-_37104165 Show fit | 3.72 |
ENSDART00000165867
|
zmp:0000001114 |
|
| chr7_-_71585065 Show fit | 3.55 |
ENSDART00000128678
|
methyltransferase like 4 |
|
| chr7_+_58751504 Show fit | 3.16 |
ENSDART00000024185
|
zgc:56231 |
|
| chr20_+_22799641 Show fit | 2.96 |
ENSDART00000131132
|
sec1 family domain containing 2 |
|
| chr19_-_11315224 Show fit | 2.88 |
ENSDART00000104933
|
endonuclease/exonuclease/phosphatase family domain containing 1 |
|
| chr12_-_1034383 Show fit | 2.81 |
ENSDART00000152455
ENSDART00000152346 |
polymerase (RNA) III (DNA directed) polypeptide E |
|
| chr11_-_10456553 Show fit | 2.67 |
ENSDART00000169509
ENSDART00000185574 ENSDART00000188276 |
epithelial cell transforming 2 |
|
| chr20_+_22799857 Show fit | 2.63 |
ENSDART00000058527
|
sec1 family domain containing 2 |
|
| chr20_-_52882881 Show fit | 2.53 |
ENSDART00000111078
|
wu:fi04e12 |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxl1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.1 | 4.8 | GO:0030901 | midbrain development(GO:0030901) |
| 0.4 | 3.5 | GO:2000273 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273) |
| 0.4 | 3.1 | GO:0033292 | T-tubule organization(GO:0033292) |
| 0.1 | 3.0 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.3 | 2.9 | GO:0040014 | regulation of multicellular organism growth(GO:0040014) |
| 0.1 | 2.9 | GO:1902036 | regulation of hematopoietic stem cell differentiation(GO:1902036) |
| 0.0 | 2.8 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.2 | 2.7 | GO:0000915 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 0.0 | 2.6 | GO:0006096 | glycolytic process(GO:0006096) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 5.0 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 4.5 | GO:0005764 | lysosome(GO:0005764) |
| 0.0 | 4.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 3.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.3 | 3.1 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.1 | 3.0 | GO:0070822 | Sin3-type complex(GO:0070822) |
| 0.0 | 2.9 | GO:0005938 | cell cortex(GO:0005938) |
| 0.1 | 2.8 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.1 | 2.7 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.7 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.1 | 5.6 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 3.9 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.3 | 3.6 | GO:0009008 | DNA-methyltransferase activity(GO:0009008) |
| 0.1 | 3.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 3.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 3.4 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.2 | 3.2 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 3.0 | GO:0043236 | laminin binding(GO:0043236) |
| 0.4 | 2.6 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 2.9 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.4 | 2.4 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 1.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 1.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 1.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 1.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 1.0 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.1 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.1 | 3.5 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 2.7 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 2.1 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 2.1 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 1.5 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 1.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.4 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 1.3 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |