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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for foxk1_foxj3

Z-value: 1.03

Motif logo

Transcription factors associated with foxk1_foxj3

Gene Symbol Gene ID Gene Info
ENSDARG00000037872 forkhead box K1
ENSDARG00000075774 forkhead box J3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
foxk1dr11_v1_chr3_-_40933415_409334150.591.0e-02Click!
foxj3dr11_v1_chr11_-_26362294_263623340.262.9e-01Click!

Activity profile of foxk1_foxj3 motif

Sorted Z-values of foxk1_foxj3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_21295132 4.12 ENSDART00000103845
enolase family member 4
chr9_+_52411530 3.30 ENSDART00000163684
NME/NM23 family member 8
chr5_+_44944778 3.26 ENSDART00000130428
ENSDART00000044361
ENSDART00000128825
ENSDART00000124637
ENSDART00000126066
ENSDART00000177635
doublesex and mab-3 related transcription factor 1
chr25_+_13662606 3.18 ENSDART00000008989
coiled-coil domain containing 113
chr5_-_54672763 2.80 ENSDART00000159009
sperm associated antigen 8
chr16_-_49646625 2.30 ENSDART00000101629
EF-hand domain family, member B
chr1_+_50538839 2.05 ENSDART00000020412
polycystic kidney disease 2
chr10_+_39084354 1.95 ENSDART00000158245
si:ch73-1a9.3
chr14_+_26439227 1.94 ENSDART00000054183
G protein-coupled receptor 137
chr25_-_35360096 1.86 ENSDART00000154053
ENSDART00000171917
si:ch73-147o17.1
chr12_+_19188542 1.79 ENSDART00000134726
ENSDART00000148011
ENSDART00000109541
chibby homolog 1 (Drosophila)
chr24_-_6678640 1.75 ENSDART00000042478
enkurin, TRPC channel interacting protein
chr14_-_30960470 1.61 ENSDART00000129989
si:ch211-191o15.6
chr16_-_6944927 1.59 ENSDART00000149620
phosphomevalonate kinase
chr1_-_44901163 1.57 ENSDART00000145354
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3a
chr7_+_20110336 1.47 ENSDART00000179395
zgc:114045
chr4_-_12795030 1.45 ENSDART00000150427
beta-2-microglobulin
chr20_-_13640598 1.42 ENSDART00000128823
ENSDART00000103394
radial spoke 3 homolog
chr25_+_19149241 1.38 ENSDART00000184982
ENSDART00000067324
milk fat globule-EGF factor 8 protein b
chr18_+_26899316 1.37 ENSDART00000050230
tetraspanin 3a
chr11_+_25257022 1.34 ENSDART00000156052
tumor protein p53 inducible nuclear protein 2
chr2_-_11662851 1.34 ENSDART00000145108
zgc:110130
chr5_-_42661012 1.24 ENSDART00000158339
Pim proto-oncogene, serine/threonine kinase, related 58
chr5_+_49744713 1.22 ENSDART00000133384
nuclear receptor subfamily 2, group F, member 1a
chr4_-_12795436 1.22 ENSDART00000131026
ENSDART00000075127
beta-2-microglobulin
chr5_+_42400777 1.20 ENSDART00000183114

chr16_+_6944564 1.16 ENSDART00000104252
ELL associated factor 1
chr13_+_35635672 1.15 ENSDART00000148481
thrombospondin 2a
chr24_+_35787629 1.11 ENSDART00000136721
si:dkeyp-7a3.1
chr17_+_24632440 1.07 ENSDART00000157092
mitogen-activated protein kinase kinase kinase kinase 3b
chr2_+_49572059 1.06 ENSDART00000108861
semaphorin 4e
chr17_+_4325693 1.03 ENSDART00000154264
minichromosome maintenance 8 homologous recombination repair factor
chr24_+_17269849 1.03 ENSDART00000017605
sperm associated antigen 6
chr5_+_26913120 0.98 ENSDART00000126609
T-box 3b
chr14_-_17576391 0.97 ENSDART00000161355
ENSDART00000168959
ring finger protein 4
chr16_-_41131578 0.96 ENSDART00000102649
ENSDART00000145956
protein tyrosine phosphatase, non-receptor type 23, a
chr4_-_6373735 0.94 ENSDART00000140100
si:ch73-156e19.1
chr8_-_23783633 0.92 ENSDART00000132657
si:ch211-163l21.7
chr21_-_13661631 0.90 ENSDART00000184408
patatin-like phospholipase domain containing 7a
chr8_+_37755099 0.90 ENSDART00000075708
ENSDART00000140966
glutamic-oxaloacetic transaminase 1 like 1
chr25_-_3470910 0.89 ENSDART00000029067
ENSDART00000186737
HMG-box transcription factor 1
chr21_+_5800306 0.88 ENSDART00000020603
cyclin G2
chr12_-_11457625 0.87 ENSDART00000012318
HtrA serine peptidase 1b
chr14_-_36799280 0.87 ENSDART00000168615
ring finger protein 130
chr21_+_28502340 0.85 ENSDART00000077897
ENSDART00000140229
OTU deubiquitinase, ubiquitin aldehyde binding 1a
chr4_-_22472653 0.83 ENSDART00000066903
ENSDART00000130072
ENSDART00000123369
lysine (K)-specific methyltransferase 2E
chr24_-_23758003 0.81 ENSDART00000178085
Danio rerio minichromosome maintenance domain containing 2 (mcmdc2), mRNA.
chr23_-_21957383 0.81 ENSDART00000145780
si:dkey-68l7.2
chr21_-_32301109 0.81 ENSDART00000139890
CDC-like kinase 4b
chr3_+_24618012 0.80 ENSDART00000111997
zgc:171506
chr12_+_34763795 0.80 ENSDART00000153097
solute carrier family 38, member 10
chr16_+_6944311 0.79 ENSDART00000144763
ELL associated factor 1
chr4_-_17725008 0.79 ENSDART00000016658
choline phosphotransferase 1
chr15_+_25681044 0.79 ENSDART00000077853
hypermethylated in cancer 1
chr18_+_21122818 0.79 ENSDART00000060015
ENSDART00000060184
choline kinase alpha
chr2_+_19633493 0.79 ENSDART00000147989
Pim proto-oncogene, serine/threonine kinase, related 54
chr10_+_6641514 0.78 ENSDART00000150003
si:ch211-57m13.5
chr19_-_32600823 0.78 ENSDART00000134149
ENSDART00000187858
zgc:91944
chr2_+_55365727 0.77 ENSDART00000162943

chr1_-_9940494 0.77 ENSDART00000138726
transmembrane protein 8A
chr3_-_60711127 0.77 ENSDART00000184119
UBA-like domain containing 2
chr5_-_40190949 0.76 ENSDART00000175588
WD repeat and FYVE domain containing 3
chr12_+_8822717 0.74 ENSDART00000021628
receptor accessory protein 3b
chr3_+_19207176 0.74 ENSDART00000087803
relaxin 3a
chr13_+_22119798 0.73 ENSDART00000173206
ENSDART00000078652
ENSDART00000165842
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2
chr2_+_24786765 0.73 ENSDART00000141030
phosphodiesterase 4C, cAMP-specific a
chr16_+_28578648 0.71 ENSDART00000149566
N-myristoyltransferase 2
chr21_-_28920245 0.70 ENSDART00000132884
CXXC finger protein 5a
chr11_+_6819050 0.69 ENSDART00000104289
RAB3A, member RAS oncogene family, b
chr23_+_24085531 0.68 ENSDART00000139710
tubulin tyrosine ligase-like family, member 10
chr19_-_28367413 0.68 ENSDART00000079092
si:dkey-261i16.5
chr21_-_11855828 0.68 ENSDART00000081666
ubiquitin-conjugating enzyme E2R 2
chr5_-_4931266 0.67 ENSDART00000067600
zinc finger and BTB domain containing 43
chr14_-_25599002 0.67 ENSDART00000040955
solute carrier family 25, member 48
chr24_-_31306724 0.66 ENSDART00000165399
acid phosphatase 5b, tartrate resistant
chr8_+_4803906 0.65 ENSDART00000045533
transmembrane protein 127
chr11_+_6295370 0.65 ENSDART00000139882
RAN binding protein 3a
chr9_-_33785093 0.65 ENSDART00000140779
ENSDART00000059837
FUN14 domain containing 1
chr5_-_38384289 0.64 ENSDART00000135260
misshapen-like kinase 1
chr14_+_94946 0.64 ENSDART00000165766
ENSDART00000163778
minichromosome maintenance complex component 7
chr7_-_13906409 0.64 ENSDART00000062257
solute carrier family 39 (zinc transporter), member 1
chr21_-_11856143 0.63 ENSDART00000151204
ubiquitin-conjugating enzyme E2R 2
chr6_-_39160422 0.63 ENSDART00000148661
signal transducer and activator of transcription 2
chr16_-_12097558 0.62 ENSDART00000123142
peroxisomal biogenesis factor 5
chr22_+_4707663 0.62 ENSDART00000042194
ceramide synthase 4a
chr13_+_22675802 0.61 ENSDART00000145538
ENSDART00000143312
zgc:193505
chr13_+_9368621 0.60 ENSDART00000109126
Alstrom syndrome protein 1
chr11_+_16153207 0.59 ENSDART00000192356
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr7_-_24828296 0.59 ENSDART00000138193
OTU deubiquitinase, ubiquitin aldehyde binding 1b
chr11_+_16152316 0.58 ENSDART00000081054
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr10_+_2529037 0.58 ENSDART00000123467
zmp:0000001301
chr13_+_28854438 0.57 ENSDART00000193407
ENSDART00000189554

chr7_+_52761841 0.57 ENSDART00000111444
diphosphoinositol pentakisphosphate kinase 1a
chr8_-_30791266 0.56 ENSDART00000062220
glutathione S-transferase theta 1a
chr3_-_20063671 0.56 ENSDART00000056614
ENSDART00000126915
upstream binding transcription factor, RNA polymerase I
chr25_+_18953756 0.55 ENSDART00000154291
thymine DNA glycosylase, tandem duplicate 2
chr23_-_28025943 0.54 ENSDART00000181146
Sp5 transcription factor-like
chr14_+_36226243 0.54 ENSDART00000052569
paired-like homeodomain 2
chr16_-_12097394 0.53 ENSDART00000103944
peroxisomal biogenesis factor 5
chr3_-_45298487 0.53 ENSDART00000102245
3-phosphoinositide dependent protein kinase 1a
chr13_-_23665580 0.53 ENSDART00000144282
mitogen-activated protein kinase kinase kinase 21
chr9_+_2343096 0.52 ENSDART00000062292
ENSDART00000191722
ENSDART00000135180
activating transcription factor 2
chr2_-_19576640 0.52 ENSDART00000141021
Pim proto-oncogene, serine/threonine kinase, related 51
chr17_-_13026634 0.52 ENSDART00000113713
family with sequence similarity 177, member A1
chr17_+_43843536 0.52 ENSDART00000164097

chr9_-_7640692 0.52 ENSDART00000135616
DnaJ (Hsp40) homolog, subfamily B, member 2
chr25_+_18953575 0.51 ENSDART00000155610
thymine DNA glycosylase, tandem duplicate 2
chr15_+_3284684 0.50 ENSDART00000179778
forkhead box O1 a
chr4_-_14926637 0.50 ENSDART00000110199
PR domain containing 4
chr20_-_19590378 0.49 ENSDART00000152588
brain and acute leukemia, cytoplasmic b
chr14_-_38843690 0.49 ENSDART00000183629
spindle apparatus coiled-coil protein 1
chr16_+_29492937 0.49 ENSDART00000011497
cathepsin K
chr25_+_3677650 0.49 ENSDART00000154348
prion protein, related sequence 3
chr8_+_8893535 0.49 ENSDART00000139150
OTU deubiquitinase 5a
chr25_-_11088839 0.48 ENSDART00000154748
synaptic vesicle glycoprotein 2Bb
chr15_+_3284416 0.47 ENSDART00000187665
ENSDART00000171723
forkhead box O1 a
chr18_-_48550426 0.47 ENSDART00000145189
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr4_-_20135919 0.47 ENSDART00000172230
centrosomal protein 83
chr8_-_30791089 0.47 ENSDART00000147332
glutathione S-transferase theta 1a
chr17_-_2690083 0.47 ENSDART00000135374
protein tyrosine phosphatase, non-receptor type 21
chr5_+_13549603 0.47 ENSDART00000171270
cytoskeleton associated protein 2-like
chr6_-_43792179 0.46 ENSDART00000160849
forkhead box P1b
chr20_+_52774730 0.45 ENSDART00000014606
phosphatase and actin regulator 1
chr16_-_24605969 0.45 ENSDART00000163305
ENSDART00000167121
FXYD domain containing ion transport regulator 6 like
chr6_-_9565526 0.45 ENSDART00000151470
mitogen-activated protein kinase kinase kinase 2
chr17_+_32500387 0.44 ENSDART00000018423
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b
chr16_+_29492749 0.44 ENSDART00000179680
cathepsin K
chr21_+_30502002 0.43 ENSDART00000043727
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3a
chr23_-_30787932 0.43 ENSDART00000135771
myelin transcription factor 1a
chr19_-_19339285 0.42 ENSDART00000158413
ENSDART00000170479
chondroitin sulfate proteoglycan 5b
chr7_+_22849657 0.42 ENSDART00000173483
phosphorylase, glycogen, muscle b
chr25_+_18954189 0.42 ENSDART00000123207
thymine DNA glycosylase, tandem duplicate 2
chr20_-_23171430 0.42 ENSDART00000109234
spermatogenesis associated 18
chr11_+_18612421 0.42 ENSDART00000110621
nuclear receptor coactivator 3
chr9_+_38163876 0.42 ENSDART00000137955
cytoplasmic linker associated protein 1a
chr11_-_12051805 0.41 ENSDART00000110117
ENSDART00000182744
suppressor of cytokine signaling 7
chr21_+_11415224 0.40 ENSDART00000049036
zgc:92275
chr4_-_20135406 0.40 ENSDART00000161343
centrosomal protein 83
chr19_-_4851411 0.40 ENSDART00000110398
F-box and leucine-rich repeat protein 20
chr4_+_7391110 0.40 ENSDART00000160708
ENSDART00000187823
troponin I4a
chr3_+_20012891 0.39 ENSDART00000078974
transmembrane and ubiquitin-like domain containing 2
chr1_+_25801648 0.39 ENSDART00000129471
guanylate cyclase 1 soluble subunit beta 1
chr9_+_14291932 0.39 ENSDART00000183119

chr12_+_30234209 0.38 ENSDART00000102081
actin filament associated protein 1-like 2
chr8_-_29822527 0.37 ENSDART00000167487
solute carrier family 20 (phosphate transporter), member 2
chr7_-_51102479 0.36 ENSDART00000174023
collagen, type IV, alpha 6
chr6_-_30839763 0.36 ENSDART00000154228
SH3-domain GRB2-like (endophilin) interacting protein 1a
chr1_-_30689004 0.36 ENSDART00000018827
dachshund c
chr20_+_25552057 0.36 ENSDART00000102913
cytochrome P450, family 2, subfamily V, polypeptide 1
chr14_-_33177935 0.35 ENSDART00000180583
ENSDART00000078856
discs, large homolog 3 (Drosophila)
chr15_-_36533322 0.35 ENSDART00000156466
ENSDART00000121755
si:dkey-262k9.4
chr5_-_23485161 0.34 ENSDART00000170293
ENSDART00000134069
si:dkeyp-20g2.1
si:dkeyp-20g2.3
chr23_-_16682186 0.33 ENSDART00000020810
syndecan binding protein (syntenin) 2
chr21_-_280769 0.33 ENSDART00000157753
plasminogen receptor, C-terminal lysine transmembrane protein
chr5_+_36611128 0.32 ENSDART00000097684
neuro-oncological ventral antigen 1
chr11_-_21586157 0.32 ENSDART00000190095
SLIT-ROBO Rho GTPase activating protein 2
chr25_+_17920361 0.32 ENSDART00000185644
BLOC-1 related complex subunit 5
chr1_+_41886830 0.32 ENSDART00000185887
ENSDART00000084735
si:dkey-37g12.1
chr21_-_20765338 0.32 ENSDART00000135940
growth hormone receptor b
chr3_+_55031685 0.31 ENSDART00000132587
N-methylpurine DNA glycosylase
chr16_-_19373310 0.31 ENSDART00000148294
dynein, axonemal, heavy chain 11
chr14_-_34044369 0.31 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cytoplasmic FMR1 interacting protein 2
chr15_+_23784842 0.31 ENSDART00000192889
ENSDART00000138375
intraflagellar transport 20 homolog (Chlamydomonas)
chr19_-_32600638 0.31 ENSDART00000143497
zgc:91944
chr21_-_13662237 0.30 ENSDART00000091647
ENSDART00000151547
patatin-like phospholipase domain containing 7a
chr20_-_1314537 0.30 ENSDART00000144288
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr16_-_15263099 0.30 ENSDART00000125691
syntrophin, basic 1
chr20_+_40457599 0.30 ENSDART00000017553
serine incorporator 1
chr21_-_22951604 0.30 ENSDART00000083449
ENSDART00000180129
duboraya
chr11_+_7264457 0.29 ENSDART00000154182
receptor accessory protein 6
chr17_+_8324345 0.29 ENSDART00000172443
CDC42 binding protein kinase alpha (DMPK-like) a
chr13_-_45155284 0.29 ENSDART00000161144
runt-related transcription factor 3
chr10_+_31951338 0.29 ENSDART00000019416
LHFPL tetraspan subfamily member 6
chr15_+_19990068 0.29 ENSDART00000154033
ENSDART00000054428
zgc:112083
chr3_-_16039619 0.28 ENSDART00000143324
splA/ryanodine receptor domain and SOCS box containing 3a
chr1_+_53945934 0.28 ENSDART00000052838
actin, alpha 1a, skeletal muscle
chr8_+_23093155 0.28 ENSDART00000063075
zgc:100920
chr2_-_8017579 0.28 ENSDART00000040209
eph receptor B3a
chr23_-_27608257 0.27 ENSDART00000026314
PHD finger protein 8
chr13_+_18471546 0.27 ENSDART00000090712
ENSDART00000127962
storkhead box 1
chr2_+_38161318 0.27 ENSDART00000044264
matrix metallopeptidase 14b (membrane-inserted)
chr2_-_54054225 0.27 ENSDART00000167239

chr20_-_16849306 0.27 ENSDART00000131395
ENSDART00000027582
breast cancer metastasis-suppressor 1-like b
chr19_+_40337457 0.27 ENSDART00000089547
ENSDART00000140857
family with sequence similarity 133, member B
chr13_+_45980163 0.26 ENSDART00000074547
ENSDART00000005195
BSD domain containing 1
chr13_+_42602406 0.26 ENSDART00000133388
ENSDART00000147996
mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
chr25_-_16826219 0.26 ENSDART00000191299
ENSDART00000188504
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr4_-_49312747 0.26 ENSDART00000181057

chr16_+_43152727 0.25 ENSDART00000125590
ENSDART00000154493
ADAM metallopeptidase domain 22
chr12_-_32013125 0.25 ENSDART00000153355
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr9_+_41459759 0.25 ENSDART00000132501
ENSDART00000100265
nuclear envelope integral membrane protein 2
chr1_+_52130213 0.24 ENSDART00000018817
ring finger protein 11a
chr12_-_22509069 0.24 ENSDART00000179755
ENSDART00000109707
neuralized E3 ubiquitin protein ligase 4
chr24_+_11381400 0.24 ENSDART00000058703
atypical chemokine receptor 4b
chr19_-_10395683 0.23 ENSDART00000109488
zgc:194578
chr5_-_16351306 0.23 ENSDART00000168643

chr6_-_8244474 0.22 ENSDART00000151358
ral guanine nucleotide dissociation stimulator-like 3a
chr22_+_26798853 0.22 ENSDART00000087576
ENSDART00000179780
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
chr6_+_49021703 0.22 ENSDART00000149394
solute carrier family 16 (monocarboxylate transporter), member 1a
chr19_+_1878500 0.21 ENSDART00000113392
gamma-glutamylcyclotransferase a

Network of associatons between targets according to the STRING database.

First level regulatory network of foxk1_foxj3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0030238 male sex determination(GO:0030238)
0.7 2.1 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.6 1.9 GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903069)
0.5 4.1 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.4 1.6 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.2 1.4 GO:1900044 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.2 0.7 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.2 0.9 GO:0006531 aspartate metabolic process(GO:0006531)
0.2 1.1 GO:0010692 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.2 0.8 GO:0018008 N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
0.2 2.7 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122) negative regulation of innate immune response(GO:0045824)
0.2 0.7 GO:0006844 acyl carnitine transport(GO:0006844)
0.1 0.4 GO:0052576 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.1 1.0 GO:0048745 smooth muscle tissue development(GO:0048745)
0.1 1.2 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011)
0.1 0.4 GO:0032637 interleukin-8 production(GO:0032637) regulation of interleukin-8 production(GO:0032677) positive regulation of interleukin-8 production(GO:0032757)
0.1 0.6 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.1 1.2 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 1.4 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.1 1.6 GO:0045851 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.5 GO:0061072 iris morphogenesis(GO:0061072)
0.1 0.3 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.1 0.4 GO:0099543 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 0.5 GO:0021731 trigeminal motor nucleus development(GO:0021731)
0.1 0.3 GO:0090131 mesenchyme migration(GO:0090131)
0.1 0.3 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.6 GO:0071357 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 2.0 GO:0014812 muscle cell migration(GO:0014812)
0.1 0.3 GO:0051026 chiasma assembly(GO:0051026)
0.1 0.7 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.3 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.1 0.3 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640) platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583)
0.1 0.9 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.1 0.7 GO:0045453 bone resorption(GO:0045453)
0.1 0.4 GO:1902837 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.1 0.3 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.1 0.4 GO:0071800 podosome assembly(GO:0071800)
0.1 0.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 0.6 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.5 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.2 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.1 0.5 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 0.2 GO:0061010 gall bladder development(GO:0061010)
0.0 0.4 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.0 1.0 GO:0032392 DNA geometric change(GO:0032392) DNA duplex unwinding(GO:0032508)
0.0 0.1 GO:0010312 detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
0.0 1.2 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 0.1 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.0 0.6 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 1.4 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.6 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.3 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.7 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.0 0.2 GO:0097033 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 1.0 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.5 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 1.1 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.3 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.1 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.5 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 1.1 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.1 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.0 1.0 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 1.1 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.3 GO:0001964 startle response(GO:0001964)
0.0 0.5 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.1 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.8 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.8 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0 0.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.9 GO:0003205 cardiac chamber development(GO:0003205)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.1 GO:0044273 sulfur compound catabolic process(GO:0044273)
0.0 0.3 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 1.3 GO:0001666 response to hypoxia(GO:0001666)
0.0 0.7 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.0 GO:2000392 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
0.0 0.3 GO:0006284 base-excision repair(GO:0006284)
0.0 0.4 GO:0040001 establishment of mitotic spindle localization(GO:0040001)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.7 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.8 GO:0009612 response to mechanical stimulus(GO:0009612)
0.0 0.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 2.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.3 3.2 GO:0034451 centriolar satellite(GO:0034451)
0.2 2.0 GO:0032783 ELL-EAF complex(GO:0032783)
0.2 1.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 1.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 2.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.5 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.1 1.7 GO:0042555 MCM complex(GO:0042555)
0.1 0.3 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 0.4 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 0.7 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.2 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.0 0.5 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.3 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 1.3 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.1 GO:0005814 centriole(GO:0005814)
0.0 0.3 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.5 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0033010 paranodal junction(GO:0033010)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 2.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.3 1.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.2 0.9 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.2 0.6 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 0.8 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379)
0.2 1.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 0.7 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.2 1.5 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.2 0.8 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.1 1.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.6 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 2.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 0.6 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140) single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity(GO:1990518)
0.1 0.3 GO:0045545 syndecan binding(GO:0045545)
0.1 1.6 GO:0051117 ATPase binding(GO:0051117)
0.1 0.9 GO:0043515 kinetochore binding(GO:0043515)
0.1 1.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 2.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.4 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.1 0.5 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 0.7 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.3 GO:0004903 growth hormone receptor activity(GO:0004903)
0.1 0.3 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.4 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.4 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.1 0.5 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 1.0 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.3 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 1.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.6 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0031544 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.4 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.2 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.0 0.1 GO:0019202 amino acid kinase activity(GO:0019202)
0.0 0.6 GO:0000339 RNA cap binding(GO:0000339)
0.0 1.2 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.1 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.0 0.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 1.1 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 2.7 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 1.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 PID ATR PATHWAY ATR signaling pathway
0.0 0.3 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.5 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.6 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.6 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 1.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.1 1.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 0.9 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 0.6 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 0.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 1.1 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.6 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors