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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for foxb1b+foxb2
Z-value: 1.07
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Transcription factors associated with foxb1b+foxb2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxb2 | dr11_v1_chr8_-_38506339_38506339 | -0.51 | 2.9e-02 | Click! |
| foxb1b | dr11_v1_chr7_+_29461060_29461060 | 0.10 | 6.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxb1b+foxb2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.4 | GO:0008078 | mesodermal cell migration(GO:0008078) |
| 0.2 | 4.3 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 0.1 | 3.8 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.1 | 3.8 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 0.1 | 3.8 | GO:0034968 | histone lysine methylation(GO:0034968) |
| 0.1 | 3.6 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.2 | 3.5 | GO:0035268 | protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502) |
| 0.0 | 3.5 | GO:0048916 | posterior lateral line development(GO:0048916) |
| 0.0 | 3.5 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.5 | 3.2 | GO:0032287 | peripheral nervous system myelin maintenance(GO:0032287) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0005768 | endosome(GO:0005768) |
| 0.0 | 5.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 4.3 | GO:0005764 | lysosome(GO:0005764) |
| 0.0 | 4.1 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 3.5 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 3.2 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 3.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 2.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.7 | 2.8 | GO:0097134 | cyclin E1-CDK2 complex(GO:0097134) |
| 0.0 | 2.4 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 5.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 5.8 | GO:0003712 | transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712) |
| 1.1 | 4.4 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.2 | 4.3 | GO:0015379 | cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379) |
| 0.0 | 3.9 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.4 | 3.4 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 2.9 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.2 | 2.8 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.0 | 2.8 | GO:0005319 | lipid transporter activity(GO:0005319) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.2 | 3.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.2 | 3.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 2.3 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 2.0 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 1.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 1.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 1.3 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 1.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 2.7 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 2.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.1 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 1.9 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 1.7 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.1 | 1.5 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.1 | 1.3 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 1.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 1.2 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |