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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for ets2
Z-value: 1.07
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Transcription factors associated with ets2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ets2 | dr11_v1_chr10_+_187760_187764 | -0.19 | 4.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_50135492 Show fit | 3.31 |
ENSDART00000149398
|
si:ch73-132k15.2 |
|
| chr11_+_18183220 Show fit | 3.09 |
ENSDART00000113468
|
|
|
| chr12_-_42368296 Show fit | 2.84 |
ENSDART00000171075
|
zgc:111868 |
|
| chr20_+_54304800 Show fit | 2.76 |
ENSDART00000121661
|
zona pellucida glycoprotein 2, tandem duplicate 6 |
|
| chr11_+_18130300 Show fit | 2.72 |
ENSDART00000169146
|
zgc:175135 |
|
| chr11_+_18037729 Show fit | 2.72 |
ENSDART00000111624
|
zgc:175135 |
|
| chr10_-_8046764 Show fit | 2.71 |
ENSDART00000099031
|
zgc:136254 |
|
| chr11_+_18053333 Show fit | 2.68 |
ENSDART00000075750
|
zgc:175135 |
|
| chr11_+_18157260 Show fit | 2.63 |
ENSDART00000144659
|
zgc:173545 |
|
| chr11_+_18175893 Show fit | 2.61 |
ENSDART00000177625
|
zgc:173545 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ets2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | GO:0048545 | response to steroid hormone(GO:0048545) |
| 0.1 | 5.2 | GO:0070098 | chemokine-mediated signaling pathway(GO:0070098) |
| 0.2 | 4.2 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.3 | 2.8 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.0 | 2.0 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.1 | 1.8 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 1.8 | GO:0034976 | response to endoplasmic reticulum stress(GO:0034976) |
| 0.2 | 1.7 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.0 | 1.6 | GO:0030178 | negative regulation of Wnt signaling pathway(GO:0030178) |
| 0.0 | 1.5 | GO:0051014 | actin filament severing(GO:0051014) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.4 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 4.2 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 3.4 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 3.2 | GO:0005764 | lysosome(GO:0005764) |
| 0.6 | 2.4 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 1.5 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.2 | 1.3 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.1 | 1.3 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 1.3 | GO:0043197 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.2 | 1.2 | GO:0097433 | dense body(GO:0097433) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.8 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.3 | 5.2 | GO:0031729 | CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729) |
| 0.2 | 2.7 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.5 | 2.4 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.1 | 2.3 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 2.1 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 1.9 | GO:0034062 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
| 0.1 | 1.8 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 1.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 1.7 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 1.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 0.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.6 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 0.5 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.5 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.5 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.2 | 2.4 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.1 | 2.4 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 2.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.9 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.2 | 1.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 1.0 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.1 | 1.0 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 1.0 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.0 | 1.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |