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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for emx2+emx3

Z-value: 1.19

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Transcription factors associated with emx2+emx3

Gene Symbol Gene ID Gene Info
ENSDARG00000020417 empty spiracles homeobox 3
ENSDARG00000039701 empty spiracles homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
emx3dr11_v1_chr14_-_26377044_26377044-0.933.3e-08Click!
emx2dr11_v1_chr13_+_19322686_19322686-0.744.7e-04Click!

Activity profile of emx2+emx3 motif

Sorted Z-values of emx2+emx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_6452444 5.59 ENSDART00000137879
ENSDART00000134957
ENSDART00000004483
La ribonucleoprotein domain family, member 6b
chr25_+_22320738 4.10 ENSDART00000073566
cytochrome P450, family 11, subfamily A, polypeptide 1
chr8_-_23780334 3.85 ENSDART00000145179
ENSDART00000145894
zgc:195245
chr9_+_54039006 3.71 ENSDART00000112441
toll-like receptor 7
chr1_-_18811517 3.60 ENSDART00000142026
si:dkey-167i21.2
chr23_+_36460239 3.43 ENSDART00000172441
LIM domain and actin binding 1a
chr20_+_54299419 3.35 ENSDART00000056089
ENSDART00000193107
si:zfos-1505d6.3
chr20_+_54309148 3.31 ENSDART00000099360
zona pellucida glycoprotein 2, tandem duplicate 1
chr17_-_4245902 3.19 ENSDART00000151851
growth differentiation factor 3
chr4_+_9467049 3.16 ENSDART00000012659
zgc:55888
chr20_+_54304800 2.76 ENSDART00000121661
zona pellucida glycoprotein 2, tandem duplicate 6
chr18_-_40708537 2.75 ENSDART00000077577
si:ch211-132b12.8
chr10_-_34916208 2.47 ENSDART00000187371
cyclin A1
chr19_-_10330778 2.37 ENSDART00000081465
ENSDART00000136653
ENSDART00000171232
coiled-coil domain containing 106b
chr19_-_25149034 2.07 ENSDART00000148432
ENSDART00000175266
protein tyrosine phosphatase type IVA, member 3
chr3_+_7808459 2.03 ENSDART00000162374
hook microtubule-tethering protein 2
chr21_+_13387965 2.00 ENSDART00000134347
zgc:113162
chr5_+_37903790 1.93 ENSDART00000162470
transmembrane protease, serine 4b
chr16_-_41646164 1.92 ENSDART00000184257
ATPase secretory pathway Ca2+ transporting 1
chr19_-_25149598 1.86 ENSDART00000162917
protein tyrosine phosphatase type IVA, member 3
chr8_-_39884359 1.86 ENSDART00000131372
malectin
chr19_+_14351560 1.85 ENSDART00000182732
AT rich interactive domain 1Ab (SWI-like)
chr14_-_25935167 1.83 ENSDART00000139855
GTPase activating protein (SH3 domain) binding protein 1
chr10_+_26990095 1.75 ENSDART00000064111
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed b
chr21_+_21743599 1.70 ENSDART00000101700
polymerase (DNA-directed), delta 3, accessory subunit
chr21_-_4849029 1.68 ENSDART00000168930
ENSDART00000151019
notch 1a
chr10_-_44560165 1.62 ENSDART00000181217
ENSDART00000076084
nucleophosmin/nucleoplasmin, 2b
chr15_+_34934568 1.55 ENSDART00000165210
zgc:66024
chr11_-_44979281 1.55 ENSDART00000190972
LIM-domain binding 1b
chr23_-_14766902 1.52 ENSDART00000168113
glutathione synthetase
chr12_-_3978306 1.50 ENSDART00000149473
ENSDART00000114857
protein phosphatase 4, catalytic subunit b
chr6_-_46742455 1.50 ENSDART00000011970
zgc:66479
chr13_+_30035253 1.49 ENSDART00000181303
ENSDART00000057525
ENSDART00000136622
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr15_+_34946779 1.48 ENSDART00000192661
ENSDART00000188800
ENSDART00000156515
si:ch73-95l15.5
zgc:55621
chr22_-_22337382 1.46 ENSDART00000144684
si:ch211-129c21.1
chr9_+_24065855 1.44 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
leucine rich repeat (in FLII) interacting protein 1a
chr12_-_35386910 1.44 ENSDART00000153453
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr2_+_42871831 1.41 ENSDART00000171393
EFR3 homolog A (S. cerevisiae)
chr6_+_7533601 1.40 ENSDART00000057823
proliferation-associated 2G4, a
chr12_-_48188928 1.39 ENSDART00000184384
phosphatase domain containing, paladin 1a
chr1_+_31658011 1.38 ENSDART00000192203
polymerase (DNA directed), lambda
chr12_-_314899 1.34 ENSDART00000066579
6-pyruvoyltetrahydropterin synthase
chr8_+_42917515 1.34 ENSDART00000021715
solute carrier family 23 (ascorbic acid transporter), member 2
chr4_-_5108844 1.31 ENSDART00000132666
ENSDART00000136096
transmembrane protein 209
chr13_-_46687097 1.30 ENSDART00000169106
ENSDART00000158202

chr14_-_1200854 1.30 ENSDART00000106672
ADP-ribosylation factor-like 9
chr2_+_15100742 1.29 ENSDART00000027171
coagulation factor IIIb
chr3_+_32416948 1.28 ENSDART00000157324
ENSDART00000154267
ENSDART00000186094
ENSDART00000155860
ENSDART00000156986
proline rich Gla (G-carboxyglutamic acid) 2
chr16_+_25068576 1.28 ENSDART00000125838
im:7147486
chr10_-_28380919 1.28 ENSDART00000183409
ENSDART00000183105
ENSDART00000100207
ENSDART00000185392
ENSDART00000131220
B-cell translocation gene 3
chr21_-_32060993 1.27 ENSDART00000131651
si:ch211-160j14.2
chr3_+_23029934 1.26 ENSDART00000110343
N-acetylglutamate synthase
chr8_-_2616326 1.25 ENSDART00000027214
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a
chr2_+_30182431 1.24 ENSDART00000004903
retinol dehydrogenase 10b
chr10_+_5268054 1.24 ENSDART00000114491
receptor tyrosine kinase-like orphan receptor 2
chr23_+_26026383 1.23 ENSDART00000141553
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr24_+_26329018 1.23 ENSDART00000145752
myoneurin
chr21_-_44081540 1.22 ENSDART00000130833

chr11_-_45171139 1.21 ENSDART00000167036
ENSDART00000161712
ENSDART00000158156
synaptogyrin 2b
chr3_+_40164129 1.21 ENSDART00000102526
growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)
chr3_+_23029484 1.20 ENSDART00000187900
N-acetylglutamate synthase
chr21_-_2185600 1.20 ENSDART00000169897
zgc:171220
chr23_+_12160900 1.19 ENSDART00000136046
protein phosphatase 1, regulatory subunit 3Da
chr11_-_10456387 1.19 ENSDART00000011087
ENSDART00000081827
epithelial cell transforming 2
chr3_+_26342768 1.18 ENSDART00000163832
si:ch211-156b7.4
chr14_-_33858214 1.18 ENSDART00000112268
oculocerebrorenal syndrome of Lowe
chr9_-_32300783 1.15 ENSDART00000078596
heat shock 60 protein 1
chr9_-_32300611 1.13 ENSDART00000127938
heat shock 60 protein 1
chr11_-_10456553 1.13 ENSDART00000169509
ENSDART00000185574
ENSDART00000188276
epithelial cell transforming 2
chr24_+_26328787 1.12 ENSDART00000003884
myoneurin
chr7_+_69459759 1.12 ENSDART00000160500
CTD nuclear envelope phosphatase 1b
chr16_-_7793457 1.12 ENSDART00000113483
tripartite motif containing 71, E3 ubiquitin protein ligase
chr13_-_15082024 1.12 ENSDART00000157482
sideroflexin 5a
chr23_-_40536017 1.11 ENSDART00000153751
ENSDART00000140623
ENSDART00000133356
ring finger protein 146
chr22_+_2751887 1.10 ENSDART00000133652
si:dkey-20i20.11
chr9_-_5318873 1.10 ENSDART00000129308
activin A receptor type 1C
chr2_-_17392799 1.08 ENSDART00000136470
ENSDART00000141188
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr19_-_42045372 1.07 ENSDART00000144275
trio Rho guanine nucleotide exchange factor a
chr13_-_35761266 1.06 ENSDART00000190217
endoplasmic reticulum lectin 1
chr7_+_59033902 1.06 ENSDART00000168888
FAST kinase domains 3
chr10_+_45089820 1.05 ENSDART00000175481
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr20_+_32552912 1.04 ENSDART00000009691
Scm polycomb group protein like 4
chr7_+_22313533 1.03 ENSDART00000123457
si:dkey-11f12.2
chr9_-_41040492 1.03 ENSDART00000163164
adenosine deaminase, tRNA-specific 3
chr11_+_45110865 1.03 ENSDART00000158188
meningioma expressed antigen 5 (hyaluronidase) like
chr16_+_32736588 1.03 ENSDART00000075191
ENSDART00000168358
zgc:172323
chr12_+_45238292 1.03 ENSDART00000057983
mitochondrial ribosomal protein L38
chr18_+_22416051 1.01 ENSDART00000115388
craniofacial development protein 1
chr15_+_34592215 0.99 ENSDART00000099776
tetraspanin 13a
chr25_-_35101673 0.99 ENSDART00000140864
zgc:162611
chr17_+_6469419 0.99 ENSDART00000191729
si:dkey-36g24.3
chr2_-_9989919 0.99 ENSDART00000180213
ENSDART00000184369
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr5_-_25733745 0.98 ENSDART00000051566
zgc:101016
chr13_+_7665890 0.98 ENSDART00000046792
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr5_-_9824908 0.97 ENSDART00000169698
zgc:158343
chr23_-_25135046 0.97 ENSDART00000184844
ENSDART00000103989
isocitrate dehydrogenase 3 (NAD+) gamma
chr25_+_2263857 0.97 ENSDART00000076439
tyrosyl-tRNA synthetase 2, mitochondrial
chr5_-_52010122 0.95 ENSDART00000073627
ENSDART00000163898
ENSDART00000051003
cyclin-dependent kinase 7
chr20_-_38801981 0.94 ENSDART00000125333
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr9_+_38314466 0.92 ENSDART00000048753
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr7_-_23894879 0.91 ENSDART00000123203
von Hippel-Lindau binding protein 1
chr1_+_54124209 0.91 ENSDART00000187730

chr13_+_33268657 0.90 ENSDART00000002095
transmembrane protein 39B
chr14_-_33521071 0.90 ENSDART00000052789
C1GALT1-specific chaperone 1
chr25_+_20694177 0.89 ENSDART00000073648
KxDL motif containing 1
chr1_+_45002971 0.88 ENSDART00000021336
DnaJ (Hsp40) homolog, subfamily A, member 1
chr12_-_45238759 0.88 ENSDART00000154859
tripartite motif containing 65
chr11_-_6877973 0.88 ENSDART00000160271
DEAD (Asp-Glu-Ala-Asp) box polypeptide 49
chr12_+_1609563 0.87 ENSDART00000163559
solute carrier family 39 member 11
chr16_+_24733741 0.87 ENSDART00000155217
si:dkey-79d12.4
chr21_+_21195487 0.86 ENSDART00000181746
ENSDART00000184832
RPTOR independent companion of MTOR, complex 2b
chr21_-_38618540 0.85 ENSDART00000036600
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr16_-_10223741 0.83 ENSDART00000188099
si:rp71-15i12.1
chr22_+_2769236 0.83 ENSDART00000141836
si:dkey-20i20.10
chr2_-_31833347 0.83 ENSDART00000109460
nucleolar protein 7
chr3_-_15496551 0.82 ENSDART00000124063
ENSDART00000007726
SAGA complex associated factor 29
chr20_+_28803977 0.82 ENSDART00000153351
ENSDART00000038149
farnesyltransferase, CAAX box, beta
chr19_-_2822372 0.81 ENSDART00000109130
ENSDART00000122385
RecQ helicase-like 4
chr6_-_39005133 0.80 ENSDART00000104116
ENSDART00000151750
vitamin D receptor b
chr23_+_29966466 0.79 ENSDART00000143583
dishevelled segment polarity protein 1a
chr21_-_4250682 0.79 ENSDART00000099389
DNL-type zinc finger
chr2_-_37743834 0.78 ENSDART00000088040
ENSDART00000191057
myosin IXb
chr4_+_2482046 0.78 ENSDART00000103371
zinc finger, DHHC-type containing 17
chr16_-_36064143 0.77 ENSDART00000158358
ENSDART00000182584
serine/threonine kinase 40
chr21_+_6394929 0.77 ENSDART00000138600
si:ch211-225g23.1
chr24_+_19415124 0.77 ENSDART00000186931
sulfatase 1
chr2_-_17393216 0.77 ENSDART00000123137
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr1_+_6225493 0.77 ENSDART00000145378
FAST kinase domains 2
chr6_-_7686594 0.76 ENSDART00000091836
ENSDART00000151697
ubinuclein 2a
chr2_-_40890264 0.76 ENSDART00000123886
UDP-glucose glycoprotein glucosyltransferase 1
chr11_+_31323746 0.76 ENSDART00000180220
ENSDART00000189937
signal-induced proliferation-associated 1 like 2
chr2_-_40890004 0.76 ENSDART00000191746
UDP-glucose glycoprotein glucosyltransferase 1
chr2_+_1988036 0.76 ENSDART00000155956
synovial sarcoma, X breakpoint 2 interacting protein a
chr20_+_26943072 0.76 ENSDART00000153215
cell division cycle associated 4
chr25_-_27621268 0.75 ENSDART00000146205
ENSDART00000073511
hyaluronoglucosaminidase 6
chr9_+_29643036 0.75 ENSDART00000023210
ENSDART00000175160
tripartite motif containing 13
chr16_+_54209504 0.74 ENSDART00000020033
X-ray repair complementing defective repair in Chinese hamster cells 1
chr24_+_42004640 0.74 ENSDART00000171380
DNA topoisomerase I mitochondrial
chr9_-_7390388 0.74 ENSDART00000132392
solute carrier family 23, member 3
chr11_-_18020258 0.74 ENSDART00000156116
glutamine-rich 1
chr4_-_5019113 0.73 ENSDART00000189321
ENSDART00000081990
striatin interacting protein 2
chr10_-_35257458 0.73 ENSDART00000143890
ENSDART00000139107
ENSDART00000082445
proline rich 11
chr1_-_513762 0.72 ENSDART00000148162
ENSDART00000144606
tRNA methyltransferase 10C, mitochondrial RNase P subunit
chr18_+_16750080 0.72 ENSDART00000136320
ring finger protein 141
chr13_-_31008275 0.71 ENSDART00000139394
WDFY family member 4
chr11_+_13642157 0.71 ENSDART00000060251
WD repeat domain 18
chr23_+_32101202 0.71 ENSDART00000000992
zgc:56699
chr21_+_31253048 0.71 ENSDART00000178521
ENSDART00000132317
ENSDART00000040190
argininosuccinate lyase
chr18_+_8833251 0.70 ENSDART00000143519
IMP (inosine 5'-monophosphate) dehydrogenase 1a
chr7_-_50410524 0.70 ENSDART00000083346
huntingtin interacting protein K
chr15_-_17813680 0.70 ENSDART00000158556

chr19_+_15485287 0.69 ENSDART00000182797
PDLIM1 interacting kinase 1 like
chr20_+_22799641 0.68 ENSDART00000131132
sec1 family domain containing 2
chr11_+_42474694 0.68 ENSDART00000056048
ENSDART00000184710
si:ch1073-165f9.2
chr1_-_25144439 0.68 ENSDART00000132355
F-box and WD repeat domain containing 7
chr1_+_45663727 0.68 ENSDART00000038574
ENSDART00000141144
ENSDART00000149565
trafficking protein particle complex 5
chr6_+_30533504 0.67 ENSDART00000155842
WWC family member 3
chr7_+_15659280 0.67 ENSDART00000173414
myocyte enhancer factor 2ab
chr20_+_474288 0.67 ENSDART00000026794
5'-nucleotidase domain containing 1
chr14_+_29941266 0.66 ENSDART00000112757
family with sequence similarity 149 member A
chr21_+_43702016 0.66 ENSDART00000017176
dyskeratosis congenita 1, dyskerin
chr18_+_45958375 0.66 ENSDART00000108636
adaptor-related protein complex 2, mu 1 subunit, b
chr25_+_3217419 0.65 ENSDART00000104859
RCC1 domain containing 1
chr25_-_25058508 0.65 ENSDART00000087570
ENSDART00000178891

chr12_-_3773869 0.65 ENSDART00000092983
si:ch211-166g5.4
chr16_-_30869732 0.64 ENSDART00000042716
ENSDART00000190168
protein tyrosine kinase 2ab
chr12_+_1139690 0.64 ENSDART00000160442

chr14_-_26425416 0.64 ENSDART00000088690
lectin, mannose-binding 2
chr19_+_2685779 0.62 ENSDART00000160533
ENSDART00000097531
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr6_-_39218609 0.61 ENSDART00000133305
osteosarcoma amplified 9, endoplasmic reticulum lectin
chr8_-_43835603 0.61 ENSDART00000134073
adhesion G protein-coupled receptor D1
chr9_-_21825913 0.61 ENSDART00000101986
mitochondrial ribosomal protein L30
chr17_+_49281597 0.61 ENSDART00000155599
zgc:113176
chr5_-_11809710 0.60 ENSDART00000186998
ENSDART00000181363
ENSDART00000180681
neurofibromin 2a (merlin)
chr11_-_34478225 0.60 ENSDART00000189604
xyloside xylosyltransferase 1
chr11_+_17984354 0.60 ENSDART00000179986
RNA pseudouridylate synthase domain containing 4
chr22_-_20812822 0.60 ENSDART00000193778
DOT1-like histone H3K79 methyltransferase
chr7_+_36898850 0.59 ENSDART00000113342
TOX high mobility group box family member 3
chr25_-_6011034 0.59 ENSDART00000075197
ENSDART00000136054
sorting nexin 22
chr3_+_32118670 0.58 ENSDART00000055287
ENSDART00000111688
zgc:109934
chr21_-_25395223 0.57 ENSDART00000016219
protein phosphatase methylesterase 1
chr12_+_1492641 0.57 ENSDART00000152411
ubiquitin specific peptidase 22
chr17_+_8799661 0.56 ENSDART00000105326
tonsoku-like, DNA repair protein
chr7_+_66884291 0.55 ENSDART00000187499
SET binding factor 2
chr18_-_2222128 0.55 ENSDART00000171402
phosphatidylinositol glycan anchor biosynthesis, class B
chr11_-_38533505 0.54 ENSDART00000113894
solute carrier family 45, member 3
chr9_+_48761455 0.53 ENSDART00000139631
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
chr1_+_27977297 0.53 ENSDART00000180692
ENSDART00000166819
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr21_-_31210749 0.53 ENSDART00000185356
zgc:152891
chr13_+_6219551 0.53 ENSDART00000025910
adipocyte plasma membrane associated protein
chr23_+_42254960 0.52 ENSDART00000102980
zinc finger, CCHC domain containing 11
chr4_+_5255041 0.52 ENSDART00000137966
coiled-coil domain containing 167
chr2_-_37632896 0.52 ENSDART00000008302
insulin receptor a
chr8_+_53080515 0.52 ENSDART00000143009
WD repeat domain 46
chr7_+_36898622 0.52 ENSDART00000190773
TOX high mobility group box family member 3
chr19_+_20274491 0.51 ENSDART00000090860
ENSDART00000151693
oxidoreductase NAD-binding domain containing 1
chr3_+_54553931 0.50 ENSDART00000029387
peter pan homolog (Drosophila)
chr23_+_25135858 0.49 ENSDART00000103986
family with sequence similarity 3, member A
chr23_-_900795 0.48 ENSDART00000190517
ENSDART00000182849
ENSDART00000111456
ENSDART00000185430
RNA binding motif protein 10
chr22_-_11954861 0.48 ENSDART00000131611
si:dkeyp-4h4.1

Network of associatons between targets according to the STRING database.

First level regulatory network of emx2+emx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.8 4.1 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.8 3.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.6 2.3 GO:0045041 positive regulation of interleukin-6 production(GO:0032755) protein import into mitochondrial intermembrane space(GO:0045041)
0.6 1.7 GO:0070914 UV-damage excision repair(GO:0070914)
0.6 1.7 GO:0021531 spinal cord radial glial cell differentiation(GO:0021531)
0.5 2.6 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.4 1.3 GO:0015882 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.4 1.9 GO:0055071 manganese ion homeostasis(GO:0055071)
0.4 1.5 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.3 0.9 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.3 1.2 GO:0071869 response to monoamine(GO:0071867) response to catecholamine(GO:0071869) response to epinephrine(GO:0071871)
0.3 1.5 GO:0010692 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.2 1.1 GO:0000012 single strand break repair(GO:0000012)
0.2 1.8 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.2 0.7 GO:0031645 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
0.2 0.9 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.2 1.1 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.2 1.1 GO:0010586 miRNA metabolic process(GO:0010586)
0.2 0.7 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.2 0.8 GO:0018343 protein farnesylation(GO:0018343)
0.2 0.6 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.2 0.6 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.2 2.3 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.2 0.8 GO:0015744 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.1 0.6 GO:2000677 histone H3-K79 methylation(GO:0034729) regulation of transcription regulatory region DNA binding(GO:2000677)
0.1 0.7 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 0.4 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.1 1.3 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.1 0.5 GO:0015722 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.1 3.0 GO:0071218 response to misfolded protein(GO:0051788) cellular response to misfolded protein(GO:0071218)
0.1 0.8 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.1 0.6 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 1.0 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.8 GO:0090178 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 0.3 GO:0019062 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.1 1.1 GO:0006842 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.1 0.4 GO:0070084 protein initiator methionine removal(GO:0070084)
0.1 1.6 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.1 1.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 0.6 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.1 0.8 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 0.4 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.1 1.2 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.3 GO:0032847 regulation of cellular pH reduction(GO:0032847) synaptic vesicle lumen acidification(GO:0097401) regulation of synaptic vesicle lumen acidification(GO:1901546)
0.1 0.4 GO:0031650 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.1 0.3 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.1 0.5 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.3 GO:0090386 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.1 1.4 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.1 0.3 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.1 0.4 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 1.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.2 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.1 0.3 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902165)
0.1 0.3 GO:1903385 dendrite guidance(GO:0070983) regulation of homophilic cell adhesion(GO:1903385)
0.1 1.1 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.1 0.7 GO:0090329 regulation of DNA-dependent DNA replication(GO:0090329)
0.1 0.7 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1 0.3 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 1.2 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.1 0.4 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 1.0 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 2.0 GO:0050821 protein stabilization(GO:0050821)
0.1 0.3 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.1 0.6 GO:0070309 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.1 0.7 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 0.4 GO:0015809 arginine transport(GO:0015809)
0.1 0.7 GO:0099639 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.1 1.6 GO:0048264 determination of ventral identity(GO:0048264)
0.1 1.2 GO:0010962 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.1 0.9 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 0.8 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.4 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 1.4 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.9 GO:0009408 response to heat(GO:0009408)
0.0 2.5 GO:0003146 heart jogging(GO:0003146)
0.0 0.3 GO:0006921 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.0 0.5 GO:0043651 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 3.7 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.7 GO:0006265 DNA topological change(GO:0006265)
0.0 0.3 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.0 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 1.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.8 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.6 GO:0045005 replication fork processing(GO:0031297) DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.0 0.1 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.0 0.3 GO:0060753 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 2.0 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.3 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0042421 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.0 0.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.3 GO:0032264 IMP salvage(GO:0032264)
0.0 0.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 1.7 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.4 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.3 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.8 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.4 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.8 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.8 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.1 GO:1990575 mitochondrial ornithine transport(GO:0000066) ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.0 0.1 GO:1902745 regulation of macrophage chemotaxis(GO:0010758) positive regulation of macrophage chemotaxis(GO:0010759) mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675) positive regulation of lamellipodium organization(GO:1902745)
0.0 0.3 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.1 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.0 0.1 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.1 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.6 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.4 GO:0098781 ncRNA transcription(GO:0098781)
0.0 0.1 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.1 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.0 0.2 GO:0098787 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 1.3 GO:0007596 blood coagulation(GO:0007596)
0.0 0.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.3 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.2 GO:0090481 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.2 GO:0001881 receptor recycling(GO:0001881)
0.0 0.1 GO:0032475 otolith formation(GO:0032475)
0.0 1.3 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 0.1 GO:2001287 optomotor response(GO:0071632) caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 1.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.3 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.5 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.5 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.2 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.1 GO:0035065 regulation of histone acetylation(GO:0035065)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.8 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.3 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.3 GO:0001878 response to yeast(GO:0001878)
0.0 0.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.4 GO:0071222 cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222)
0.0 0.4 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.1 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.0 0.1 GO:0051601 exocyst localization(GO:0051601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.4 2.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 1.0 GO:0034457 Mpp10 complex(GO:0034457)
0.3 1.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 1.8 GO:0035060 brahma complex(GO:0035060)
0.2 0.7 GO:1990072 TRAPPIII protein complex(GO:1990072)
0.2 1.1 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.2 0.8 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.2 0.7 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.1 1.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 0.5 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.1 0.5 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.9 GO:0016272 prefoldin complex(GO:0016272)
0.1 1.1 GO:0000124 SAGA complex(GO:0000124)
0.1 0.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.0 GO:0005675 holo TFIIH complex(GO:0005675)
0.1 0.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.3 GO:0043291 RAVE complex(GO:0043291)
0.1 0.7 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.2 GO:0016460 myosin II complex(GO:0016460)
0.1 0.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.7 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 1.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0030689 Noc complex(GO:0030689)
0.0 6.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.9 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686)
0.0 1.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.8 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.5 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.1 GO:0031085 BLOC-3 complex(GO:0031085)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 5.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.0 GO:0098753 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) anchored component of the cytoplasmic side of the plasma membrane(GO:0098753)
0.0 0.4 GO:0035861 site of double-strand break(GO:0035861)
0.0 3.9 GO:0005730 nucleolus(GO:0005730)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.4 GO:0005876 spindle microtubule(GO:0005876)
0.0 1.0 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.9 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.2 GO:0005795 Golgi stack(GO:0005795)
0.0 0.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.2 GO:0070822 Sin3-type complex(GO:0070822)
0.0 1.1 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.8 2.5 GO:0034618 arginine binding(GO:0034618)
0.4 1.2 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.3 1.0 GO:0052717 tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.3 1.9 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.3 0.9 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.3 1.5 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.3 1.8 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.2 0.9 GO:0048531 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531)
0.2 1.5 GO:0030274 LIM domain binding(GO:0030274)
0.2 0.8 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.2 1.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.2 1.1 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.2 0.7 GO:0033149 FFAT motif binding(GO:0033149)
0.2 0.7 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.2 0.7 GO:0016842 amidine-lyase activity(GO:0016842)
0.2 0.5 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.2 0.8 GO:0015131 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140) succinate transmembrane transporter activity(GO:0015141)
0.2 0.8 GO:0070644 vitamin D response element binding(GO:0070644)
0.2 0.8 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.2 0.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.6 GO:0031151 histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.1 3.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.7 GO:0043295 glutathione binding(GO:0043295)
0.1 0.4 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.5 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.1 0.4 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.1 0.6 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.1 1.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.1 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.1 0.7 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 1.1 GO:0035198 miRNA binding(GO:0035198)
0.1 0.5 GO:0043560 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.1 1.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.4 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 3.1 GO:0051087 chaperone binding(GO:0051087)
0.1 1.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.6 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.1 1.2 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.1 0.2 GO:0004061 arylformamidase activity(GO:0004061)
0.1 1.2 GO:2001069 glycogen binding(GO:2001069)
0.1 0.5 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.1 1.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.5 GO:0008506 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 1.7 GO:0005112 Notch binding(GO:0005112)
0.1 1.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.2 GO:0032028 myosin head/neck binding(GO:0032028) myosin II head/neck binding(GO:0032034) myosin II heavy chain binding(GO:0032038)
0.1 0.7 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 2.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 3.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 0.5 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 1.0 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.6 GO:0005537 mannose binding(GO:0005537)
0.0 0.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.0 1.8 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0098809 nitrite reductase activity(GO:0098809)
0.0 0.2 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.8 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 2.0 GO:0031491 nucleosome binding(GO:0031491)
0.0 1.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.0 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.5 GO:0019843 rRNA binding(GO:0019843)
0.0 3.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.7 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 0.2 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.7 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.1 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.0 0.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 1.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.9 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 1.2 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.7 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.3 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.2 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 1.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.5 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.6 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0050218 propionate-CoA ligase activity(GO:0050218)
0.0 0.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.5 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 2.3 GO:0005125 cytokine activity(GO:0005125)
0.0 0.2 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.4 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.1 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.0 0.1 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 2.5 GO:0042393 histone binding(GO:0042393)
0.0 0.3 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 1.7 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.3 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.7 GO:0000146 microfilament motor activity(GO:0000146)
0.0 2.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.0 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.1 GO:0032052 bile acid binding(GO:0032052)
0.0 0.2 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 2.1 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 3.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 2.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 1.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 3.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 1.3 PID ARF 3PATHWAY Arf1 pathway
0.1 1.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.7 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.7 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.3 PID MYC PATHWAY C-MYC pathway
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.6 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.7 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.1 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.3 3.7 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 3.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 1.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2 3.4 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.2 2.0 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 5.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.0 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 1.2 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.7 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.0 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 1.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.9 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.4 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.4 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 0.3 REACTOME G PROTEIN BETA GAMMA SIGNALLING Genes involved in G-protein beta:gamma signalling
0.0 0.5 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation