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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for egr4

Z-value: 0.29

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Transcription factors associated with egr4

Gene Symbol Gene ID Gene Info
ENSDARG00000077799 early growth response 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
egr4dr11_v1_chr23_+_45579497_455794970.625.6e-03Click!

Activity profile of egr4 motif

Sorted Z-values of egr4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_30298377 0.53 ENSDART00000153622
chromosome 11 open reading frame 96
chr3_-_32180796 0.51 ENSDART00000133191
ENSDART00000055308
PIH1 domain containing 1
chr24_+_24831727 0.45 ENSDART00000080969
tripartite motif containing 55b
chr16_-_12784373 0.43 ENSDART00000080396
forkhead box J2
chr13_-_44834895 0.41 ENSDART00000135573
si:dkeyp-2e4.5
chr2_+_16710889 0.39 ENSDART00000017852
UBX domain protein 7
chr16_-_54405976 0.38 ENSDART00000055395
odd-skipped related transciption factor 2
chr16_-_40508624 0.37 ENSDART00000075718
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr23_+_39606108 0.37 ENSDART00000109464
G0/G1 switch 2
chr4_+_842010 0.36 ENSDART00000067461
si:ch211-152c2.3
chr13_-_36418921 0.35 ENSDART00000135804
ddb1 and cul4 associated factor 5
chr12_-_23129453 0.32 ENSDART00000077453
armadillo repeat containing 4
chr2_-_48753873 0.28 ENSDART00000189556

chr18_+_20481982 0.28 ENSDART00000128139
kelch repeat and BTB (POZ) domain containing 4
chr11_-_165288 0.28 ENSDART00000108703
ENSDART00000173151
testis enhanced gene transcript (BAX inhibitor 1)
chr18_+_20482369 0.28 ENSDART00000100668
kelch repeat and BTB (POZ) domain containing 4
chr3_+_31897029 0.27 ENSDART00000146275
ste20-related kinase adaptor alpha
chr21_-_31238244 0.26 ENSDART00000159678
tyrosylprotein sulfotransferase 1, like
chr17_-_10025234 0.26 ENSDART00000008355
cofilin 2 (muscle)
chr17_-_2584423 0.25 ENSDART00000013506
zona pellucida glycoprotein 3, tandem duplicate 2
chr21_-_41838284 0.23 ENSDART00000141067
chaperonin containing TCP1, subunit 6A (zeta 1)
chr11_-_236984 0.23 ENSDART00000170778
dual specificity phosphatase 7
chr2_+_105748 0.22 ENSDART00000169601

chr18_-_45617146 0.21 ENSDART00000146543
wilms tumor 1b
chr11_-_236766 0.21 ENSDART00000163978
dual specificity phosphatase 7
chr7_+_41340520 0.20 ENSDART00000005127
GRB2 associated, regulator of MAPK1
chr22_+_20720808 0.19 ENSDART00000171321
si:dkey-211f22.5
chr23_-_524780 0.19 ENSDART00000055139
collagen, type IX, alpha 3
chr22_-_16180849 0.18 ENSDART00000090390
vascular cell adhesion molecule 1b
chr17_+_15297398 0.17 ENSDART00000156574
si:ch211-270g19.5
chr19_+_390298 0.17 ENSDART00000136361
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr20_+_6659770 0.16 ENSDART00000192135
tensin 3, tandem duplicate 2
chr5_-_2689753 0.16 ENSDART00000172699
guanine nucleotide binding protein (G protein), gamma 10
chr19_-_11237125 0.16 ENSDART00000163921
signal sequence receptor, beta
chr8_-_52859301 0.15 ENSDART00000162004
nuclear receptor subfamily 5, group A, member 1a
chr3_+_29469283 0.15 ENSDART00000103592
family with sequence similarity 83, member Fa
chr19_+_5480327 0.14 ENSDART00000148794
junction plakoglobin b
chr22_-_10591876 0.14 ENSDART00000105846
si:dkey-42i9.8
chr2_+_38924975 0.13 ENSDART00000109219
RAS (RAD and GEM)-like GTP binding 2
chr5_-_43819663 0.13 ENSDART00000022481
methylcrotonoyl-CoA carboxylase 2 (beta)
chr14_-_21218891 0.12 ENSDART00000158294
protein phosphatase 2, regulatory subunit B, gamma b
chr24_-_24146875 0.11 ENSDART00000173052
MAP7 domain containing 2b
chr22_-_20720427 0.11 ENSDART00000105532
ornithine decarboxylase antizyme 1a
chr24_+_26895748 0.11 ENSDART00000089351
neutral cholesterol ester hydrolase 1b, tandem duplicate 1
chr21_+_33172526 0.11 ENSDART00000183532
ADP-ribosylation factor-like 3, like 1
chr23_+_44049509 0.11 ENSDART00000102003
TXK tyrosine kinase
chr1_-_411331 0.10 ENSDART00000092524
RAS p21 protein activator 3
chr14_+_36220479 0.10 ENSDART00000148319
paired-like homeodomain 2
chr4_+_70556298 0.10 ENSDART00000170985
si:dkey-11d20.1
chr10_+_19554604 0.09 ENSDART00000063806
ATPase H+ transporting V1 subunit B2
chr20_+_27427112 0.09 ENSDART00000153459
si:dkey-22l1.1
chr5_+_51443009 0.09 ENSDART00000083350
Ras protein-specific guanine nucleotide-releasing factor 2b
chr3_+_24537023 0.09 ENSDART00000077702
SP110 nuclear body protein, tandem duplicate 1
chr13_+_35925490 0.09 ENSDART00000046115
major facilitator superfamily domain containing 2aa
chr6_+_40661703 0.07 ENSDART00000142492
enolase 1b, (alpha)
chr13_-_31397987 0.07 ENSDART00000008287
phosphoglycerate mutase 1a
chr4_+_332709 0.07 ENSDART00000067486
tubby like protein 4a
chr23_+_41800052 0.06 ENSDART00000141484
prodynorphin
chr10_-_15919839 0.06 ENSDART00000065032
phosphatidylinositol-4-phosphate 5-kinase, type I, beta a
chr19_+_31061718 0.05 ENSDART00000145971
sclerostin domain containing 1b
chr20_+_9211237 0.05 ENSDART00000139527
si:ch211-59d15.4
chr5_-_49012569 0.05 ENSDART00000184690
si:dkey-172m14.2
chr1_-_47431453 0.05 ENSDART00000101104
gap junction protein, alpha 5b
chr22_-_34872533 0.05 ENSDART00000167176
slit homolog 1b (Drosophila)
chr25_+_13406069 0.05 ENSDART00000010495
zinc and ring finger 1
chr23_+_40460333 0.05 ENSDART00000184658
SOGA family member 3b
chr11_+_14049131 0.04 ENSDART00000172471
glutamate receptor, ionotropic, N-methyl-D-aspartate 3Bb
chr22_-_9839003 0.04 ENSDART00000193573
si:dkey-253d23.2
chr12_+_499881 0.04 ENSDART00000167527
myosin phosphatase Rho interacting protein
chr23_+_9067131 0.04 ENSDART00000144533
cerebral cavernous malformation 2-like
chr21_-_26114886 0.04 ENSDART00000139320
NIPA-like domain containing 4
chr17_+_48164536 0.04 ENSDART00000161750
ENSDART00000156923
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr17_+_20639180 0.03 ENSDART00000063624
neuropeptide Y receptor Y4
chr3_+_23737795 0.03 ENSDART00000182247
homeobox B3a
chr7_-_2039060 0.03 ENSDART00000173879
si:cabz01007794.1
chr16_+_19029297 0.03 ENSDART00000115263
ENSDART00000114954
Rap guanine nucleotide exchange factor (GEF) 5b
chr23_+_41799748 0.03 ENSDART00000144257
prodynorphin
chr19_+_164013 0.03 ENSDART00000167379
capping protein regulator and myosin 1 linker 1
chr13_-_9886579 0.03 ENSDART00000101926
si:ch211-117n7.7
chr5_-_21030934 0.03 ENSDART00000133461
ENSDART00000098667
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
chr14_+_40641350 0.02 ENSDART00000074506
tenomodulin
chr15_+_9294620 0.02 ENSDART00000133588
ENSDART00000140009
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr5_+_42136359 0.02 ENSDART00000083731
transient receptor potential cation channel, subfamily V, member 1
chr8_+_22438398 0.02 ENSDART00000135145
zgc:153759
chr3_-_7106678 0.02 ENSDART00000175293
ENSDART00000187732
ENSDART00000158652
zgc:113102

chr22_+_6757741 0.02 ENSDART00000140815

chr9_-_30363770 0.02 ENSDART00000147030
synaptotagmin-like 5
chr23_+_16910071 0.02 ENSDART00000104793
si:dkey-147f3.8
chr5_+_61941610 0.02 ENSDART00000168808
si:dkeyp-117b8.4
chr17_+_27456804 0.01 ENSDART00000017756
ENSDART00000181461
ENSDART00000180178
cathepsin L.1
chr22_-_14309817 0.01 ENSDART00000171625
si:ch73-338d8.5
chr25_-_36827491 0.01 ENSDART00000170941

chr7_-_41014773 0.01 ENSDART00000013785
insulin induced gene 1
chr5_-_14390445 0.01 ENSDART00000026120
adaptor-related protein complex 3, mu 2 subunit
chr4_+_30785713 0.01 ENSDART00000165945
si:dkey-178j11.5
chr5_+_64739762 0.01 ENSDART00000161112
ENSDART00000135610
ENSDART00000002908
olfactomedin 1a
chr2_+_47906240 0.01 ENSDART00000122206
finTRIM family, member 23
chr19_-_1920613 0.01 ENSDART00000186176
si:ch211-149a19.3
chr20_-_4407228 0.01 ENSDART00000166997

chr2_+_51194657 0.00 ENSDART00000161381
leucine rich repeat containing 24
chr17_-_15657029 0.00 ENSDART00000153925
fucosyltransferase 9a
chr22_-_6991514 0.00 ENSDART00000148233
fibroblast growth factor receptor 1b, like
chr23_+_804119 0.00 ENSDART00000148163
FERM domain containing 4Bb
chr4_+_28997595 0.00 ENSDART00000133357
si:dkey-13e3.1

Network of associatons between targets according to the STRING database.

First level regulatory network of egr4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.5 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.3 GO:0006478 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.0 0.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.1 GO:0061072 iris morphogenesis(GO:0061072)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.4 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.3 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.2 GO:0043462 regulation of ATPase activity(GO:0043462)
0.0 0.1 GO:0043363 nucleate erythrocyte differentiation(GO:0043363)
0.0 0.1 GO:0030325 adrenal gland development(GO:0030325)
0.0 0.0 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097255 R2TP complex(GO:0097255)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.3 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.3 GO:0035804 structural constituent of egg coat(GO:0035804)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.3 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.3 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation