ISMARA results: egr2a+egr2b

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for egr2a+egr2b

Z-value: 0.99

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Transcription factors associated with egr2a+egr2b

Gene Symbol	Gene ID	Gene Info
egr2b NCBI UniProt	ENSDARG00000042826	early growth response 2b
egr2a NCBI UniProt	ENSDARG00000044098	early growth response 2a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
egr2a	dr11_v1_chr17_-_43666166_43666166	0.97	1.8e-11	Click!
egr2b	dr11_v1_chr12_-_8486330_8486330	0.45	6.1e-02	Click!

Activity profile of egr2a+egr2b motif

Sorted Z-values of egr2a+egr2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_-_10560964 Show fit	4.58	ENSDART00000172761 ENSDART00000170476	mthfs NCBI UniProt Show fit	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chr16_+_10963602 Show fit	3.40	ENSDART00000141032	pou2f2a NCBI UniProt Show fit	POU class 2 homeobox 2a
chr16_-_54405976 Show fit	3.20	ENSDART00000055395	osr2 NCBI UniProt Show fit	odd-skipped related transciption factor 2
chr16_+_23978978 Show fit	2.99	ENSDART00000058964 ENSDART00000135084	apoa2 NCBI UniProt Show fit	apolipoprotein A-II
chr15_-_20939579 Show fit	2.98	ENSDART00000152371	usp2a NCBI UniProt Show fit	ubiquitin specific peptidase 2a
chr23_+_39606108 Show fit	2.82	ENSDART00000109464	g0s2 NCBI UniProt Show fit	G0/G1 switch 2
chr14_+_80685 Show fit	2.68	ENSDART00000188443	stag3 NCBI UniProt Show fit	stromal antigen 3
chr20_-_22778394 Show fit	2.61	ENSDART00000152645	fip1l1a NCBI UniProt Show fit	FIP1 like 1a (S. cerevisiae)
chr3_+_60007703 Show fit	2.61	ENSDART00000157351 ENSDART00000153928 ENSDART00000155876	si:ch211-110e21.3 NCBI UniProt Show fit	si:ch211-110e21.3
chr15_+_31526225 Show fit	2.31	ENSDART00000154456	wdr95 NCBI UniProt Show fit	WD40 repeat domain 95

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of egr2a+egr2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	4.6	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	4.5	GO:0016579	protein deubiquitination(GO:0016579)
0.0	3.5	GO:0055113	epiboly involved in gastrulation with mouth forming second(GO:0055113)
0.3	3.0	GO:0098787	mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1	2.7	GO:0002574	thrombocyte differentiation(GO:0002574)
0.3	2.6	GO:0097374	sensory neuron axon guidance(GO:0097374)
0.2	2.4	GO:0043248	proteasome assembly(GO:0043248)
0.0	2.4	GO:0001946	lymphangiogenesis(GO:0001946)
0.1	2.3	GO:0006094	gluconeogenesis(GO:0006094)
0.1	2.1	GO:2000601	positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)

Showing 1 to 10 of 137 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.3	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2	2.4	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1	2.1	GO:0031209	SCAR complex(GO:0031209)
0.0	1.8	GO:0005861	troponin complex(GO:0005861)
0.2	1.7	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.1	1.7	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	1.7	GO:0005814	centriole(GO:0005814)
0.1	1.6	GO:0008278	cohesin complex(GO:0008278)
0.0	1.6	GO:0042470	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	1.5	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)

Showing 1 to 10 of 44 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.6	GO:0016879	ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.0	4.5	GO:0036459	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1	3.2	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	3.1	GO:0008201	heparin binding(GO:0008201)
0.4	2.4	GO:0061133	endopeptidase activator activity(GO:0061133)
0.2	2.3	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3	2.2	GO:0016803	ether hydrolase activity(GO:0016803)
0.0	2.2	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2	2.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.1	2.1	GO:0031492	nucleosomal DNA binding(GO:0031492)

Showing 1 to 10 of 111 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.4	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.1	1.3	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	1.2	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	1.2	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	1.1	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	1.0	PID SHP2 PATHWAY	SHP2 signaling
0.0	0.8	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.7	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.7	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.0	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	2.7	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	1.9	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1	1.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	1.4	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0	1.4	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.2	1.3	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	1.3	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	1.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	1.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle

Showing 1 to 10 of 29 entries

Results for egr2a+egr2b

Z-value: 0.99

Motif logo

Transcription factors associated with egr2a+egr2b

Activity-expression correlation:

Activity profile of egr2a+egr2b motif

Sorted Z-values of egr2a+egr2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of egr2a+egr2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: