ISMARA results: e2f8

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for e2f8

Z-value: 0.96

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Transcription factors associated with e2f8

Gene Symbol	Gene ID	Gene Info
e2f8 NCBI UniProt	ENSDARG00000057323	E2F transcription factor 8

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
e2f8	dr11_v1_chr7_-_16582187_16582187	-0.96	1.2e-10	Click!

Activity profile of e2f8 motif

Sorted Z-values of e2f8 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_+_33220342 Show fit	3.81	ENSDART00000100893 ENSDART00000113451	si:ch211-125e6.13 NCBI UniProt Show fit	si:ch211-125e6.13
chr6_+_21005725 Show fit	3.56	ENSDART00000041370	cx44.2 NCBI UniProt Show fit	connexin 44.2
chr3_+_43086548 Show fit	2.70	ENSDART00000163579	si:dkey-43p13.5 NCBI UniProt Show fit	si:dkey-43p13.5
chr7_+_28724919 Show fit	2.34	ENSDART00000011324	ccdc102a NCBI UniProt Show fit	coiled-coil domain containing 102A
chr6_-_33916756 Show fit	2.29	ENSDART00000137447 ENSDART00000138488	nasp NCBI UniProt Show fit	nuclear autoantigenic sperm protein (histone-binding)
chr7_+_41812636 Show fit	2.13	ENSDART00000174333	orc6 NCBI UniProt Show fit	origin recognition complex, subunit 6
chr17_+_11372531 Show fit	1.98	ENSDART00000130975 ENSDART00000149366	timm9 NCBI UniProt Show fit	translocase of inner mitochondrial membrane 9 homolog
chr7_+_41812817 Show fit	1.87	ENSDART00000174165	orc6 NCBI UniProt Show fit	origin recognition complex, subunit 6
chr11_-_26576754 Show fit	1.84	ENSDART00000191733 ENSDART00000002846	st3gal8 NCBI UniProt Show fit	ST3 beta-galactoside alpha-2,3-sialyltransferase 8
chr7_+_41812190 Show fit	1.79	ENSDART00000113732 ENSDART00000174137	orc6 NCBI UniProt Show fit	origin recognition complex, subunit 6

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.8	GO:0006270	DNA replication initiation(GO:0006270)
0.3	3.4	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.8	3.3	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	2.7	GO:0048484	enteric nervous system development(GO:0048484)
0.1	2.3	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0	2.0	GO:0006119	oxidative phosphorylation(GO:0006119)
0.2	1.9	GO:0044030	regulation of DNA methylation(GO:0044030)
0.4	1.6	GO:1904667	negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2	1.6	GO:0072425	signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.0	1.5	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)

Showing 1 to 10 of 57 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.0	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.5	5.8	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	2.5	GO:0016459	myosin complex(GO:0016459)
0.3	2.3	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
0.5	1.6	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.5	1.5	GO:0030906	retromer, cargo-selective complex(GO:0030906)
0.0	1.5	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	1.4	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3	1.3	GO:0031298	replication fork protection complex(GO:0031298)
0.2	1.3	GO:0035060	brahma complex(GO:0035060)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.9	GO:0042393	histone binding(GO:0042393)
0.0	1.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2	1.8	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	1.6	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1	1.4	GO:0030515	snoRNA binding(GO:0030515)
0.0	1.4	GO:0071949	FAD binding(GO:0071949)
0.0	1.3	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0	1.3	GO:0031490	chromatin DNA binding(GO:0031490)
0.2	1.2	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.2	1.2	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)

Showing 1 to 10 of 47 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	PID PLK1 PATHWAY	PLK1 signaling events
0.0	1.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	1.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.0	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.9	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	0.8	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.8	PID ATR PATHWAY	ATR signaling pathway
0.0	0.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.4	PID P53 REGULATION PATHWAY	p53 pathway
0.0	0.3	PID BARD1 PATHWAY	BARD1 signaling events

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	6.6	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.1	2.5	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	2.0	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	1.2	REACTOME TRANSLATION	Genes involved in Translation
0.1	1.1	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.1	1.1	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	1.1	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.1	1.0	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	0.8	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.8	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis

Showing 1 to 10 of 23 entries

Results for e2f8

Z-value: 0.96

Motif logo

Transcription factors associated with e2f8

Activity-expression correlation:

Activity profile of e2f8 motif

Sorted Z-values of e2f8 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: