ISMARA results: cux2b

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for cux2b

Z-value: 1.04

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Transcription factors associated with cux2b

Gene Symbol	Gene ID	Gene Info
cux2b NCBI UniProt	ENSDARG00000086345	cut-like homeobox 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
cux2b	dr11_v1_chr8_-_4327473_4327473	-0.44	7.0e-02	Click!

Activity profile of cux2b motif

Sorted Z-values of cux2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_60721342 Show fit	4.44	ENSDART00000157772	foxj1a NCBI UniProt Show fit	forkhead box J1a
chr8_+_21376290 Show fit	4.00	ENSDART00000136765	ela2 NCBI UniProt Show fit	elastase 2
chr2_-_38000276 Show fit	3.12	ENSDART00000034790	pcp4l1 NCBI UniProt Show fit	Purkinje cell protein 4 like 1
chr14_-_34512859 Show fit	2.89	ENSDART00000140368	si:ch211-232m8.3 NCBI UniProt Show fit	si:ch211-232m8.3
chr1_-_54158902 Show fit	2.69	ENSDART00000193267	CABZ01067151.1 NCBI UniProt Show fit
chr13_+_50375800 Show fit	2.59	ENSDART00000099537	cox5b2 NCBI UniProt Show fit	cytochrome c oxidase subunit Vb 2
chr8_-_21372446 Show fit	2.43	ENSDART00000061481 ENSDART00000079293	ela2l NCBI UniProt Show fit	elastase 2 like
chr19_+_34274504 Show fit	2.38	ENSDART00000132046	si:ch211-9n13.3 NCBI UniProt Show fit	si:ch211-9n13.3
chr25_-_5119162 Show fit	2.29	ENSDART00000153961	shisal1b NCBI UniProt Show fit	shisa like 1b
chr22_+_110158 Show fit	2.14	ENSDART00000143698	prkar2ab NCBI UniProt Show fit	protein kinase, cAMP-dependent, regulatory, type II, alpha, B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of cux2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.5	GO:0046777	protein autophosphorylation(GO:0046777)
0.9	4.4	GO:1902019	regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.1	3.0	GO:0055078	sodium ion homeostasis(GO:0055078)
0.7	2.9	GO:0033301	cell cycle comprising mitosis without cytokinesis(GO:0033301)
0.2	2.6	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2	2.6	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.1	2.5	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	2.3	GO:0030177	positive regulation of Wnt signaling pathway(GO:0030177)
0.0	2.2	GO:0007602	phototransduction(GO:0007602)
0.1	2.1	GO:0036158	outer dynein arm assembly(GO:0036158)

Showing 1 to 10 of 204 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.8	GO:0005840	ribosome(GO:0005840)
0.0	3.3	GO:0005930	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.3	2.6	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	2.6	GO:0031970	mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0	2.2	GO:0001750	photoreceptor outer segment(GO:0001750)
0.2	2.1	GO:0036157	outer dynein arm(GO:0036157)
0.0	2.1	GO:0016324	apical plasma membrane(GO:0016324)
0.0	2.0	GO:0005761	organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.1	1.7	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.3	1.6	GO:0005797	Golgi medial cisterna(GO:0005797)

Showing 1 to 10 of 78 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	5.0	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	3.9	GO:0016675	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	3.7	GO:0005249	voltage-gated potassium channel activity(GO:0005249)
0.3	3.6	GO:0045503	dynein light chain binding(GO:0045503)
0.0	3.6	GO:0005085	guanyl-nucleotide exchange factor activity(GO:0005085)
0.1	3.2	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.4	2.9	GO:0001217	bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.4	2.6	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.2	2.5	GO:0070739	protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)

Showing 1 to 10 of 139 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	1.8	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	1.5	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	1.2	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	1.0	PID EPHB FWD PATHWAY	EPHB forward signaling
0.1	0.9	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.9	PID ATR PATHWAY	ATR signaling pathway
0.0	0.8	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	0.6	PID RHOA REG PATHWAY	Regulation of RhoA activity

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	1.8	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.1	1.7	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	1.7	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	1.6	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.1	1.5	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.2	1.4	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	1.4	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	1.2	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

Showing 1 to 10 of 44 entries

Results for cux2b

Z-value: 1.04

Motif logo

Transcription factors associated with cux2b

Activity-expression correlation:

Activity profile of cux2b motif

Sorted Z-values of cux2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of cux2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: