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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for creb3l2

Z-value: 0.38

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Transcription factors associated with creb3l2

Gene Symbol Gene ID Gene Info
creb3l2
ENSDARG00000063563 cAMP responsive element binding protein 3-like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
creb3l2dr11_v1_chr4_-_4751981_47519830.551.8e-02Click!

Activity profile of creb3l2 motif

Sorted Z-values of creb3l2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_17200120 0.82 ENSDART00000147739
gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr22_-_817479 0.57 ENSDART00000123487
zgc:153675
zgc:153675
chr7_+_38716048 0.57 ENSDART00000024590
syt13
synaptotagmin XIII
chr5_-_22130937 0.52 ENSDART00000138606
las1l
LAS1-like, ribosome biogenesis factor
chr5_-_54714525 0.48 ENSDART00000150138
ENSDART00000150070
ccnb1
cyclin B1
chr25_+_34862225 0.44 ENSDART00000149782
CHST6
zgc:194879
chr5_-_54714789 0.44 ENSDART00000063357
ccnb1
cyclin B1
chr18_-_43857089 0.44 ENSDART00000150170
treh
trehalase (brush-border membrane glycoprotein)
chr19_+_7173613 0.43 ENSDART00000001331
hsd17b8
hydroxysteroid (17-beta) dehydrogenase 8
chr16_+_22865942 0.41 ENSDART00000103235
ENSDART00000143957
flad1
flavin adenine dinucleotide synthetase 1
chr5_-_32338866 0.40 ENSDART00000017956
ENSDART00000047670
dab2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr18_-_37252036 0.40 ENSDART00000132230
six5
SIX homeobox 5
chr14_+_22076596 0.39 ENSDART00000106147
ENSDART00000100278
ENSDART00000131489
slc43a1a
solute carrier family 43 (amino acid system L transporter), member 1a
chr15_-_43978141 0.39 ENSDART00000041249
chordc1a
cysteine and histidine-rich domain (CHORD) containing 1a
chr20_-_13140309 0.37 ENSDART00000020703
ENSDART00000188594
ints7
integrator complex subunit 7
chr15_+_32419303 0.37 ENSDART00000162663
si:dkey-285b23.3
si:dkey-285b23.3
chr5_+_69278089 0.36 ENSDART00000136656
selenom
selenoprotein M
chr1_+_2301961 0.35 ENSDART00000108919
ENSDART00000143361
ENSDART00000142944
farp1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr7_-_69352424 0.34 ENSDART00000170714
ap1g1
adaptor-related protein complex 1, gamma 1 subunit
chr20_+_51061695 0.33 ENSDART00000134416
im:7140055
im:7140055
chr16_+_20294976 0.33 ENSDART00000059619
fkbp14
FK506 binding protein 14
chr13_+_36958086 0.32 ENSDART00000024386
frmd6
FERM domain containing 6
chr5_-_63644938 0.32 ENSDART00000050865
surf4l
surfeit gene 4, like
chr5_-_67757188 0.31 ENSDART00000167168
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr16_-_32727199 0.31 ENSDART00000137232
usp45
ubiquitin specific peptidase 45
chr9_+_31222026 0.30 ENSDART00000145573
clybl
citrate lyase beta like
chr25_-_1323623 0.29 ENSDART00000156532
ENSDART00000157163
ENSDART00000156062
ENSDART00000082447
ENSDART00000189175
calml4b
calmodulin-like 4b
chr25_+_3788443 0.28 ENSDART00000189747
chid1
chitinase domain containing 1
chr13_-_25548733 0.28 ENSDART00000168099
ENSDART00000135788
ENSDART00000077655
mcmbp
minichromosome maintenance complex binding protein
chr4_+_77957611 0.27 ENSDART00000156692
arfgap3
ADP-ribosylation factor GTPase activating protein 3
chr25_-_7670616 0.26 ENSDART00000131583
ENSDART00000142794
bet1l
Bet1 golgi vesicular membrane trafficking protein-like
chr16_+_813780 0.26 ENSDART00000162474
ENSDART00000161774
irx1a
iroquois homeobox 1a
chr17_+_44441042 0.26 ENSDART00000142123
ap5m1
adaptor-related protein complex 5, mu 1 subunit
chr8_-_46386024 0.21 ENSDART00000136602
ENSDART00000060919
ENSDART00000137472
qars
glutaminyl-tRNA synthetase
chr4_+_17844013 0.21 ENSDART00000019165
apaf1
apoptotic peptidase activating factor 1
chr12_+_4220353 0.21 ENSDART00000133675
mapk7
mitogen-activated protein kinase 7
chr8_-_46045172 0.20 ENSDART00000135138
si:ch211-119d14.3
si:ch211-119d14.3
chr13_+_1015749 0.20 ENSDART00000190982
prokr1b
prokineticin receptor 1b
chr8_+_7316568 0.20 ENSDART00000140874
selenoh
selenoprotein H
chr6_-_23931442 0.20 ENSDART00000160547
sec16b
SEC16 homolog B, endoplasmic reticulum export factor
chr17_-_44440832 0.18 ENSDART00000148786
exoc5
exocyst complex component 5
chr2_-_11504347 0.17 ENSDART00000019392
sdr16c5a
short chain dehydrogenase/reductase family 16C, member 5a
chr3_+_42923275 0.17 ENSDART00000168228
tmem184a
transmembrane protein 184a
chr2_-_10386738 0.17 ENSDART00000016369
wls
wntless Wnt ligand secretion mediator
chr4_+_17843717 0.17 ENSDART00000113507
apaf1
apoptotic peptidase activating factor 1
chr14_+_16287968 0.17 ENSDART00000106593
prpf19
pre-mRNA processing factor 19
chr8_+_49065348 0.17 ENSDART00000032277
ddx51
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr17_-_28797395 0.16 ENSDART00000134735
scfd1
sec1 family domain containing 1
chr3_+_53773256 0.15 ENSDART00000170461
col5a3a
collagen, type V, alpha 3a
chr12_+_19408373 0.15 ENSDART00000114248
snx29
sorting nexin 29
chr3_-_18384501 0.15 ENSDART00000027630
kdelr2a
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2a
chr2_+_50999675 0.15 ENSDART00000158064
ENSDART00000165746
ENSDART00000163917
ENSDART00000172038
ENSDART00000169048
ENSDART00000164775
eef1da
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)
chr18_-_13056801 0.12 ENSDART00000088908
srgap1a
SLIT-ROBO Rho GTPase activating protein 1a
chr2_+_50999477 0.12 ENSDART00000190111
eef1da
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)
chr20_+_29209767 0.12 ENSDART00000141252
katnbl1
katanin p80 subunit B-like 1
chr22_-_12337781 0.12 ENSDART00000188357
ENSDART00000123574
zranb3
zinc finger, RAN-binding domain containing 3
chr6_+_42693288 0.12 ENSDART00000155010
si:ch211-207d10.2
si:ch211-207d10.2
chr3_+_39568290 0.11 ENSDART00000020741
aldoaa
aldolase a, fructose-bisphosphate, a
chr6_+_42693114 0.11 ENSDART00000154353
si:ch211-207d10.2
si:ch211-207d10.2
chr2_-_39015130 0.11 ENSDART00000044331
copb2
coatomer protein complex, subunit beta 2
chr2_-_44971551 0.11 ENSDART00000018818
mul1a
mitochondrial E3 ubiquitin protein ligase 1a
chr20_+_29209926 0.10 ENSDART00000152949
ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr21_+_44857293 0.10 ENSDART00000134365
ENSDART00000168217
ENSDART00000065083
fstl4
follistatin-like 4
chr22_+_31059919 0.10 ENSDART00000077063
sec13
SEC13 homolog, nuclear pore and COPII coat complex component
chr22_-_25043103 0.10 ENSDART00000015512
polr3f
polymerase (RNA) III (DNA directed) polypeptide F
chr4_-_22749553 0.09 ENSDART00000040033
nup107
nucleoporin 107
chr5_-_28968964 0.09 ENSDART00000184936
ENSDART00000016628
fam129bb
family with sequence similarity 129, member Bb
chr1_-_26444075 0.08 ENSDART00000125690
ints12
integrator complex subunit 12
chr22_+_25841786 0.08 ENSDART00000180863
vasna
vasorin a
chr11_+_25296366 0.08 ENSDART00000065949
top1l
DNA topoisomerase I, like
chr25_-_37084032 0.08 ENSDART00000025494
hprt1l
hypoxanthine phosphoribosyltransferase 1, like
chr20_+_15565926 0.07 ENSDART00000063917
si:dkey-86e18.1
si:dkey-86e18.1
chr8_+_8699085 0.07 ENSDART00000021209
uxt
ubiquitously-expressed, prefoldin-like chaperone
chr21_-_5881344 0.07 ENSDART00000009241
rpl35
ribosomal protein L35
chr21_+_21357309 0.07 ENSDART00000079634
ENSDART00000146102
kcnk12l
potassium channel, subfamily K, member 12 like
chr11_-_7156620 0.07 ENSDART00000172823
ENSDART00000172879
ENSDART00000078916
smim7
small integral membrane protein 7
chr7_+_15308042 0.06 ENSDART00000185170
mespaa
mesoderm posterior aa
chr14_-_3071564 0.06 ENSDART00000166136
ENSDART00000167138
slc35a4
solute carrier family 35, member A4
chr6_+_269204 0.05 ENSDART00000191678
atf4a
activating transcription factor 4a
chr15_+_32249062 0.05 ENSDART00000133867
ENSDART00000152545
ENSDART00000082315
ENSDART00000152513
ENSDART00000152139
arfip2a
ADP-ribosylation factor interacting protein 2a
chr15_-_12229874 0.05 ENSDART00000165159
dscaml1
Down syndrome cell adhesion molecule like 1
chr24_+_32472155 0.04 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr11_+_45323455 0.04 ENSDART00000189249
mafgb
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr22_+_9871238 0.04 ENSDART00000141085
ENSDART00000105939
si:dkey-253d23.4
si:dkey-253d23.4
chr21_-_3613702 0.04 ENSDART00000139194
dym
dymeclin
chr10_-_7913591 0.04 ENSDART00000139661
slc35e4
solute carrier family 35, member E4
chr4_-_77227748 0.03 ENSDART00000171545
si:dkey-172k15.4
si:dkey-172k15.4
chr10_-_1180314 0.03 ENSDART00000114261
bmpr1bb
bone morphogenetic protein receptor, type IBb
chr16_+_33109496 0.03 ENSDART00000162364
cnr2
cannabinoid receptor 2
chr14_-_32016615 0.03 ENSDART00000105761
zic3
zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)
chr7_-_47148440 0.03 ENSDART00000185435
ENSDART00000189719
BX005073.3

chr4_-_17391091 0.02 ENSDART00000056002
th2
tyrosine hydroxylase 2
chr2_+_39618951 0.02 ENSDART00000077108
zgc:136870
zgc:136870
chr14_+_46028003 0.02 ENSDART00000113469
nocta
nocturnin a
chr24_+_12913329 0.01 ENSDART00000141829
si:dkeyp-28d2.4
si:dkeyp-28d2.4
chr15_+_897280 0.01 ENSDART00000155470
znf1012
zinc finger protein 1012
chr4_-_12718103 0.01 ENSDART00000144388
mgst1.1
microsomal glutathione S-transferase 1.1
chr21_+_45685757 0.01 ENSDART00000160530
sec24a
SEC24 homolog A, COPII coat complex component
chr22_-_94352 0.01 ENSDART00000184883
ndufaf3
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr7_-_45990386 0.01 ENSDART00000186008
si:ch211-260e23.7
si:ch211-260e23.7
chr9_+_42095220 0.01 ENSDART00000148317
ENSDART00000134431
pcbp3
poly(rC) binding protein 3
chr13_-_4992395 0.00 ENSDART00000102651
nolc1
nucleolar and coiled-body phosphoprotein 1
chr1_+_17593392 0.00 ENSDART00000078889
helt
helt bHLH transcription factor

Network of associatons between targets according to the STRING database.

First level regulatory network of creb3l2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005991 trehalose metabolic process(GO:0005991)
0.1 0.4 GO:0006747 FAD biosynthetic process(GO:0006747) FAD metabolic process(GO:0046443) flavin adenine dinucleotide metabolic process(GO:0072387) flavin adenine dinucleotide biosynthetic process(GO:0072388)
0.1 0.9 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 0.3 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.2 GO:0061355 Wnt protein secretion(GO:0061355)
0.1 0.4 GO:2000725 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.0 0.2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0 0.2 GO:0070973 positive regulation of protein exit from endoplasmic reticulum(GO:0070863) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.1 GO:0046099 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.8 GO:0050821 protein stabilization(GO:0050821)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.6 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.3 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.5 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478)
0.0 0.2 GO:0030431 sleep(GO:0030431)
0.0 0.3 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.5 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.6 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.4 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.1 GO:0097101 blood vessel endothelial cell fate specification(GO:0097101)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.5 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.3 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.3 GO:0001917 photoreceptor inner segment(GO:0001917)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.4 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.1 0.4 GO:0003919 FMN adenylyltransferase activity(GO:0003919)
0.1 0.3 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.1 0.4 GO:0043531 ADP binding(GO:0043531)
0.1 0.2 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.1 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
0.0 0.3 GO:0008061 chitin binding(GO:0008061)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0048038 quinone binding(GO:0048038)
0.0 0.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.3 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 0.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 0.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.8 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.3 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport