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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for creb1a+creb1b+crema+cremb

Z-value: 2.06

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Transcription factors associated with creb1a+creb1b+crema+cremb

Gene Symbol Gene ID Gene Info
ENSDARG00000023217 cAMP responsive element modulator a
ENSDARG00000053586 cAMP responsive element binding protein 1a
ENSDARG00000093420 cAMP responsive element binding protein 1b
ENSDARG00000102899 cAMP responsive element modulator b
ENSDARG00000109505 cAMP responsive element modulator b
ENSDARG00000116064 cAMP responsive element modulator b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
cremadr11_v1_chr2_-_43196595_43196595-0.904.6e-07Click!
creb1bdr11_v1_chr9_-_28275600_28275600-0.644.3e-03Click!
crembdr11_v1_chr24_+_31348595_31348735-0.465.4e-02Click!
creb1adr11_v1_chr1_-_33557915_33557915-0.341.7e-01Click!

Activity profile of creb1a+creb1b+crema+cremb motif

Sorted Z-values of creb1a+creb1b+crema+cremb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_26985231 3.41 ENSDART00000050585
zinc finger, HIT-type containing 2
chr4_+_73651053 2.98 ENSDART00000150532
ENSDART00000172536
zinc finger protein 989
chr11_-_11331052 2.96 ENSDART00000081765
ENSDART00000160247
mitochondrial ribosomal protein L4
chr13_-_36141486 2.93 ENSDART00000044115
mediator complex subunit 6
chr12_-_25201576 2.90 ENSDART00000077188
cytochrome c oxidase subunit VIIa polypeptide 3
chr18_+_5850837 2.80 ENSDART00000013150
component of oligomeric golgi complex 8
chr17_-_13007484 2.62 ENSDART00000156812
si:dkeyp-33b5.4
chr10_-_9346360 2.46 ENSDART00000039536
mitochondrial ribosome recycling factor
chr1_-_53714885 2.41 ENSDART00000026409
chaperonin containing TCP1, subunit 4 (delta)
chr1_+_16073887 2.38 ENSDART00000160270
tumor suppressor candidate 3
chr22_+_38914983 2.38 ENSDART00000085701
SUMO1/sentrin specific peptidase 5
chr20_-_36679233 2.29 ENSDART00000062908
ribosomal protein L7-like 1
chr3_-_62194512 2.28 ENSDART00000074174
transducin (beta)-like 3
chr10_-_23099809 2.27 ENSDART00000148333
ENSDART00000079703
ENSDART00000162444
notchless homolog 1 (Drosophila)
chr15_+_25635326 2.23 ENSDART00000135409
ENSDART00000162240
ENSDART00000052645
TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
chr9_+_145093 2.22 ENSDART00000162764
ribosomal RNA processing 1
chr19_-_26923273 2.18 ENSDART00000089609
SKI2 homolog, superkiller viralicidic activity 2-like
chr19_+_2876106 2.16 ENSDART00000189309
HGH1 homolog (S. cerevisiae)
chr4_-_73562122 2.14 ENSDART00000174096

chr5_+_69950882 2.11 ENSDART00000097359
DnaJ (Hsp40) homolog, subfamily C , member 25
chr5_+_1089600 2.10 ENSDART00000183128

chr23_-_1571682 2.04 ENSDART00000013635
F-box protein 30b
chr13_-_31370184 2.02 ENSDART00000034829
ribosomal RNA processing 12 homolog
chr15_+_823437 1.98 ENSDART00000155608
si:dkey-7i4.7
chr4_-_73561848 1.95 ENSDART00000174210

chr17_-_12058171 1.94 ENSDART00000105236
SET and MYND domain containing 3
chr6_+_15127507 1.93 ENSDART00000063644
diphthamide biosynthesis 3
chr4_-_72643171 1.93 ENSDART00000130126

chr25_-_8660726 1.93 ENSDART00000168010
ENSDART00000171709
ENSDART00000163426
unc-45 myosin chaperone A
chr4_+_76336061 1.92 ENSDART00000174362
zgc:171673
chr4_+_73651452 1.92 ENSDART00000174164
zinc finger protein 989
chr15_-_1031511 1.85 ENSDART00000153569
si:dkey-77f5.4
chr5_+_54555567 1.84 ENSDART00000171159
anaphase promoting complex subunit 2
chr7_+_34963748 1.80 ENSDART00000085087
DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
chr1_+_53714734 1.74 ENSDART00000114689
pseudouridylate synthase 10
chr4_+_76336370 1.71 ENSDART00000170520
zgc:171673
chr4_-_4932619 1.68 ENSDART00000103293
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr15_-_739229 1.66 ENSDART00000153874
si:dkey-7i4.19
chr18_-_5850683 1.63 ENSDART00000082087
NIP7, nucleolar pre-rRNA processing protein
chr4_-_4834347 1.62 ENSDART00000141803
cytochrome c oxidase assembly factor 6
chr3_+_4502066 1.60 ENSDART00000088610
RAN GTPase activating protein 1a
chr17_-_49481672 1.59 ENSDART00000166394
FCF1 rRNA-processing protein
chr7_+_40094081 1.59 ENSDART00000186054
si:ch73-174h16.4
chr7_-_40657831 1.57 ENSDART00000084153
nucleolar protein with MIF4G domain 1
chr13_+_42676202 1.54 ENSDART00000099782
mitochondrial ribosomal protein L14
chr19_-_3056235 1.53 ENSDART00000137020
block of proliferation 1
chr15_-_931815 1.53 ENSDART00000106627
ENSDART00000102239
ENSDART00000184754
ENSDART00000186733
zgc:162936
chr4_+_76416268 1.51 ENSDART00000174351
ENSDART00000191591
zgc:113209

chr10_+_23099890 1.49 ENSDART00000135890
si:dkey-175g6.5
chr15_+_816556 1.47 ENSDART00000046783
zgc:113294
chr20_+_17667 1.46 ENSDART00000150100
si:ch73-57f22.2
chr17_+_15213496 1.44 ENSDART00000058351
ENSDART00000131663
glucosamine-phosphate N-acetyltransferase 1
chr3_+_25990052 1.42 ENSDART00000007398
glycine C-acetyltransferase
chr1_+_19083501 1.41 ENSDART00000002886
ENSDART00000131948
exosome component 9
chr6_-_49898881 1.39 ENSDART00000150204
ATP synthase F1 subunit epsilon
chr3_+_9588705 1.36 ENSDART00000172543
ENSDART00000104875
TNF receptor-associated protein 1
chr7_+_40093662 1.36 ENSDART00000053011
si:ch73-174h16.4
chr4_-_4834617 1.34 ENSDART00000141539
cytochrome c oxidase assembly factor 6
chr4_-_77218637 1.34 ENSDART00000174325
proteasome subunit beta 10
chr14_-_21932403 1.30 ENSDART00000054420
RAD9 checkpoint clamp component A
chr23_-_43424510 1.29 ENSDART00000055564
regulation of nuclear pre-mRNA domain containing 1B
chr5_+_67971627 1.27 ENSDART00000144879
mitochondrial translational initiation factor 3
chr4_-_73548389 1.27 ENSDART00000174327
ENSDART00000150753
ENSDART00000170775
si:ch73-266f23.1
chr3_-_60027255 1.25 ENSDART00000189252
ENSDART00000154684
RecQ helicase-like 5
chr1_-_23268569 1.24 ENSDART00000143948
replication factor C (activator 1) 1
chr12_-_31794908 1.24 ENSDART00000105583
ENSDART00000153449
N-acetyltransferase 9 (GCN5-related, putative)
chr21_-_45891262 1.19 ENSDART00000169816
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr7_+_52949847 1.18 ENSDART00000174216
ENSDART00000174055
ENSDART00000052030
ENSDART00000174240
CDKN2A interacting protein
chr5_+_26199537 1.17 ENSDART00000144303
zgc:86811
chr15_+_1653779 1.16 ENSDART00000021299
NMD3 ribosome export adaptor
chr5_+_56277866 1.15 ENSDART00000170610
ENSDART00000028854
ENSDART00000148749
apoptosis antagonizing transcription factor
chr15_-_1765098 1.13 ENSDART00000149980
ENSDART00000093074
BUD23, rRNA methyltransferase and ribosome maturation factor
chr8_-_32354677 1.12 ENSDART00000138268
ENSDART00000133245
ENSDART00000179677
ENSDART00000174450
importin 11
chr4_-_1839192 1.11 ENSDART00000003790
PWP1 homolog (S. cerevisiae)
chr5_+_50869091 1.11 ENSDART00000083294
nucleolar protein 6 (RNA-associated)
chr14_+_20351 1.05 ENSDART00000051893
syntaxin 18
chr4_-_1839352 1.04 ENSDART00000189215
PWP1 homolog (S. cerevisiae)
chr9_-_52490579 1.04 ENSDART00000161667
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
chr22_+_3184500 1.01 ENSDART00000176409
ENSDART00000160604
FtsJ RNA methyltransferase homolog 3
chr4_+_77060861 1.00 ENSDART00000174271
ENSDART00000174393
ENSDART00000150450
si:dkey-240n22.8
chr25_-_30357027 0.99 ENSDART00000171137
protein disulfide isomerase family A, member 3
chr7_-_73843720 0.97 ENSDART00000111622
caspase activity and apoptosis inhibitor 1
chr3_+_32651697 0.94 ENSDART00000055338
THO complex 6
chr21_-_11199366 0.94 ENSDART00000167666
DnaJ (Hsp40) homolog, subfamily C, member 21
chr4_-_73650074 0.91 ENSDART00000150704
si:ch73-266f23.3
chr11_-_45434959 0.91 ENSDART00000173106
ENSDART00000172767
ENSDART00000172933
ENSDART00000172986
replication factor C (activator 1) 4
chr12_-_1406480 0.90 ENSDART00000152308
si:ch73-105m5.1
chr11_+_12744575 0.89 ENSDART00000131059
ENSDART00000081335
ENSDART00000142481
retinoblastoma binding protein 4, like
chr6_-_10715027 0.88 ENSDART00000151488
ENSDART00000108656
si:dkey-34m19.3
chr4_+_76466751 0.87 ENSDART00000164709
zgc:153116
chr7_-_52709759 0.86 ENSDART00000136745
ENSDART00000131282
ENSDART00000073766
ENSDART00000161387
ENSDART00000174117
ENSDART00000174355
transcription factor 12
chr18_+_8917766 0.81 ENSDART00000145226
si:ch211-233h19.2
chr3_-_16413606 0.81 ENSDART00000127309
ENSDART00000017172
ENSDART00000136465
elongation factor Tu GTP binding domain containing 2
chr9_+_3282369 0.79 ENSDART00000044128
histone acetyltransferase 1
chr1_+_59007536 0.79 ENSDART00000165339
cell division cycle 37
chr14_-_9056066 0.79 ENSDART00000139669
ENSDART00000138758
ENSDART00000041099
synaptobrevin-like 1
chr22_-_17606575 0.79 ENSDART00000183951
glutathione peroxidase 4a
chr5_-_50869494 0.78 ENSDART00000100800
tetratricopeptide repeat domain 37
chr25_+_14398650 0.78 ENSDART00000130548
cytokine induced apoptosis inhibitor 1
chr4_-_73587205 0.76 ENSDART00000150837
zinc finger protein 1015
chr16_+_3068080 0.75 ENSDART00000160092
cytochrome b5 reductase 4
chr2_+_52232630 0.75 ENSDART00000006216
phospholipid phosphatase 2a
chr8_+_49065348 0.75 ENSDART00000032277
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr4_-_73709502 0.75 ENSDART00000170308

chr4_-_73773908 0.74 ENSDART00000159313
si:dkey-262g12.10
chr10_+_1681518 0.74 ENSDART00000018532
TP53 regulated inhibitor of apoptosis 1
chr10_-_41302841 0.73 ENSDART00000020297
ENSDART00000160174
ENSDART00000183850
ENSDART00000169493
BRF2, RNA polymerase III transcription initiation factor
chr10_+_28306749 0.73 ENSDART00000142016
peptidyl-tRNA hydrolase 2
chr6_-_60020385 0.73 ENSDART00000169990
ENSDART00000167740
ENSDART00000098247
WW domain binding protein 4
chr22_+_33362552 0.72 ENSDART00000101580
nicolin 1
chr20_+_263056 0.71 ENSDART00000132669
tubulin, epsilon 1
chr5_-_8096232 0.69 ENSDART00000158447
nipped-B homolog a (Drosophila)
chr4_+_77160027 0.65 ENSDART00000174060
ENSDART00000174364
zinc finger protein 1009
chr18_+_808911 0.65 ENSDART00000172518
cytochrome c oxidase subunit Vab
chr7_-_69185124 0.64 ENSDART00000182217
ENSDART00000191359
ubiquitin specific peptidase 10
chr11_-_486532 0.64 ENSDART00000093148
ISY1 splicing factor homolog
chr25_+_18711804 0.62 ENSDART00000011149
family with sequence similarity 185, member A
chr5_-_33287691 0.62 ENSDART00000004238
ribosomal protein L7a
chr25_-_14398281 0.59 ENSDART00000046934
coenzyme Q9 homolog (S. cerevisiae)
chr11_-_45433419 0.58 ENSDART00000163923
ENSDART00000075612
replication factor C (activator 1) 4
chr2_-_6051836 0.57 ENSDART00000092479
si:ch211-284b7.3
chr15_-_679478 0.57 ENSDART00000115375
ENSDART00000156148
zgc:171901
chr1_+_29862074 0.54 ENSDART00000133905
ENSDART00000136786
ENSDART00000135252
propionyl CoA carboxylase, alpha polypeptide
chr2_+_935952 0.53 ENSDART00000137477
si:ch211-241e1.5
chr4_+_69375564 0.53 ENSDART00000150334
si:dkey-246j6.1
chr22_+_2801464 0.52 ENSDART00000132419
si:dkey-20i20.7
chr21_-_19906786 0.52 ENSDART00000136084
malignant fibrous histiocytoma amplified sequence 1
chr3_-_10582384 0.52 ENSDART00000048095
ENSDART00000155152
elaC ribonuclease Z 2
chr2_-_45135591 0.51 ENSDART00000014691
ENSDART00000123916
eukaryotic translation initiation factor 4E family member 2
chr5_-_26199505 0.50 ENSDART00000132950
RAD17 checkpoint clamp loader component
chr4_+_28442223 0.48 ENSDART00000150879
zinc finger protein 1067
chr4_+_63992019 0.47 ENSDART00000158645

chr21_-_2955181 0.47 ENSDART00000158991
ENSDART00000174052
zinc finger protein 971
chr12_+_35203091 0.47 ENSDART00000153022
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2b
chr2_-_58374842 0.46 ENSDART00000111651

chr5_-_36924509 0.46 ENSDART00000025013
kaptin (actin binding protein)
chr1_+_35473397 0.45 ENSDART00000158799
ubiquitin specific peptidase 38
chr1_+_35473219 0.45 ENSDART00000109678
ENSDART00000181635
ubiquitin specific peptidase 38
chr15_+_850829 0.45 ENSDART00000157374
si:dkey-77f5.11
chr24_-_12689571 0.45 ENSDART00000015517
programmed cell death 6
chr8_-_13678415 0.44 ENSDART00000134153
ENSDART00000143331
si:dkey-258f14.3
chr7_-_52949944 0.44 ENSDART00000174289
tubulin, gamma complex associated protein 4
chr4_-_72555545 0.43 ENSDART00000172315
si:ch211-161m3.4
chr19_-_2876321 0.43 ENSDART00000159253
exosome component 7
chr12_-_30043809 0.43 ENSDART00000150220
ENSDART00000075889
ENSDART00000148847
TruB pseudouridine (psi) synthase family member 1
chr18_-_21105968 0.42 ENSDART00000100791
si:dkey-12e7.1
chr5_+_26921033 0.41 ENSDART00000051483
TM2 domain containing 2
chr25_+_17920668 0.41 ENSDART00000093358
BLOC-1 related complex subunit 5
chr6_-_6673813 0.40 ENSDART00000150995
si:dkey-261j15.2
chr4_+_76426308 0.40 ENSDART00000180424
ENSDART00000159789

zgc:172128
chr11_-_26701611 0.39 ENSDART00000083010
acyl-CoA dehydrogenase family, member 9
chr19_-_27339670 0.38 ENSDART00000139323
zinc ribbon domain containing 1
chr4_+_33525559 0.37 ENSDART00000140480

chr21_+_3928947 0.37 ENSDART00000149777
senataxin
chr15_-_917274 0.36 ENSDART00000156624
si:dkey-77f5.15
chr15_-_704408 0.36 ENSDART00000156200
ENSDART00000166404
ENSDART00000131040
zgc:174574
chr19_-_27339844 0.35 ENSDART00000052358
ENSDART00000148238
ENSDART00000147661
ENSDART00000137346
zinc ribbon domain containing 1
chr15_+_846768 0.34 ENSDART00000155633
ENSDART00000191235
si:dkey-7i4.5
si:dkey-77f5.8
chr22_+_1930589 0.34 ENSDART00000159807
zinc finger protein 1153
chr4_+_62431132 0.32 ENSDART00000160226
si:ch211-79g12.1
chr4_-_43185261 0.31 ENSDART00000150380
si:dkey-16p6.2
chr18_-_6151793 0.31 ENSDART00000122307
glycine cleavage system protein H (aminomethyl carrier), a
chr10_-_7913591 0.31 ENSDART00000139661
solute carrier family 35, member E4
chr10_-_8672820 0.31 ENSDART00000080763
si:dkey-27b3.2
chr17_+_13007307 0.30 ENSDART00000064554
protein phosphatase 2, regulatory subunit B'', gamma
chr4_-_73448588 0.29 ENSDART00000138333
si:ch73-120g24.4
chr5_+_72194444 0.28 ENSDART00000165436
DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
chr15_+_847077 0.28 ENSDART00000188586
si:dkey-7i4.5
chr10_+_3428194 0.27 ENSDART00000081599
protein tyrosine phosphatase, non-receptor type 11, a
chr4_-_30528239 0.27 ENSDART00000169290
zinc finger protein 1052
chr12_+_36109071 0.26 ENSDART00000171268
mitogen-activated protein kinase kinase 6
chr23_+_45845159 0.26 ENSDART00000023944
lamin L3
chr22_-_10604526 0.26 ENSDART00000091777
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr4_+_73973242 0.25 ENSDART00000182529

chr10_+_9346383 0.25 ENSDART00000064975
ENSDART00000141869
RNA binding motif protein 18
chr2_+_21605547 0.25 ENSDART00000112014
M-phase specific PLK1 interacting protein
chr21_+_19418563 0.24 ENSDART00000181113
ENSDART00000080110
alpha-methylacyl-CoA racemase
chr4_+_42175261 0.24 ENSDART00000162193
si:ch211-142b24.2
chr18_+_49411417 0.24 ENSDART00000028944
zmp:0000001073
chr23_-_35396845 0.24 ENSDART00000142038
ENSDART00000049373
ENSDART00000181978
ENSDART00000171357
cap methyltransferase 1
chr3_-_8873716 0.23 ENSDART00000171798
zinc finger protein 1150
chr15_+_2498496 0.23 ENSDART00000153497
WD repeat domain 53
chr4_-_61691066 0.22 ENSDART00000159114
zinc finger protein 1129
chr4_+_49506359 0.22 ENSDART00000154478
si:dkey-5i16.5
chr4_+_35900918 0.21 ENSDART00000162245
zinc finger protein 1088
chr7_-_52950123 0.21 ENSDART00000009649
tubulin, gamma complex associated protein 4
chr6_-_10988741 0.21 ENSDART00000090709
coenzyme Q7 homolog, ubiquinone (yeast)
chr4_-_59057046 0.20 ENSDART00000150249
zinc finger protein 1132
chr4_+_40063572 0.20 ENSDART00000146710

chr4_-_33525219 0.20 ENSDART00000150491

chr23_+_45845423 0.20 ENSDART00000183404
lamin L3
chr4_-_40883162 0.20 ENSDART00000151978
zinc finger protein 1102
chr4_+_71819777 0.19 ENSDART00000171070
zinc finger protein 1017
chr4_-_73572030 0.19 ENSDART00000121652
zinc finger protein 1015
chr4_+_72578191 0.18 ENSDART00000182434
si:cabz01054394.5
chr4_+_64147241 0.18 ENSDART00000163509
zinc finger protein 1089
chr12_+_36109507 0.18 ENSDART00000175409
mitogen-activated protein kinase kinase 6
chr4_-_54969773 0.18 ENSDART00000133535
si:dkey-56m15.6
chr7_-_32598383 0.17 ENSDART00000111055
potassium voltage-gated channel, shaker-related subfamily, member 4
chr4_+_61865790 0.17 ENSDART00000166793
si:dkey-146c18.5

Network of associatons between targets according to the STRING database.

First level regulatory network of creb1a+creb1b+crema+cremb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.6 1.8 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.5 1.6 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.4 1.8 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.4 1.1 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.3 1.9 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.3 1.3 GO:0032790 ribosome disassembly(GO:0032790)
0.3 2.2 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.3 3.0 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.3 1.2 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.3 1.7 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.3 1.1 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.3 4.8 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.2 0.7 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 0.4 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.2 0.6 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.2 1.2 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.2 0.7 GO:0090202 establishment of mitotic sister chromatid cohesion(GO:0034087) establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169) transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.2 1.4 GO:0006566 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.1 2.4 GO:0016926 protein desumoylation(GO:0016926)
0.1 1.0 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 2.9 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 2.4 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.5 GO:0042779 tRNA 3'-trailer cleavage(GO:0042779)
0.1 1.8 GO:0000076 DNA replication checkpoint(GO:0000076)
0.1 1.4 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 1.2 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 2.3 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.3 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.1 0.6 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.1 0.8 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 2.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 0.3 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 1.0 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 0.5 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.3 GO:0035521 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 1.6 GO:0042255 ribosome assembly(GO:0042255)
0.1 1.4 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.4 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.2 GO:0010259 multicellular organism aging(GO:0010259)
0.0 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 7.6 GO:0006457 protein folding(GO:0006457)
0.0 6.5 GO:0006364 rRNA processing(GO:0006364)
0.0 0.2 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 1.3 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.8 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.1 GO:0033212 iron assimilation(GO:0033212)
0.0 0.6 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 1.9 GO:0034968 histone lysine methylation(GO:0034968)
0.0 1.0 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 1.7 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.8 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 1.3 GO:0031124 mRNA 3'-end processing(GO:0031124)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.4 GO:0030330 DNA damage response, signal transduction by p53 class mediator(GO:0030330)
0.0 0.8 GO:0008333 endosome to lysosome transport(GO:0008333)
0.0 1.1 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 1.4 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 6.3 GO:0006412 translation(GO:0006412)
0.0 1.2 GO:0031101 fin regeneration(GO:0031101)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.0 GO:0055087 Ski complex(GO:0055087)
0.5 1.5 GO:0070545 PeBoW complex(GO:0070545)
0.5 5.5 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.4 2.9 GO:0070847 core mediator complex(GO:0070847)
0.4 1.1 GO:0034456 CURI complex(GO:0032545) UTP-C complex(GO:0034456)
0.3 1.4 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.3 1.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 2.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.2 2.8 GO:0017119 Golgi transport complex(GO:0017119)
0.2 1.5 GO:0005663 DNA replication factor C complex(GO:0005663)
0.2 2.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 1.8 GO:0000176 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.5 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.1 0.3 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 2.3 GO:0030686 90S preribosome(GO:0030686)
0.1 4.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.8 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.1 0.7 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 1.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.6 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.1 0.6 GO:0000974 Prp19 complex(GO:0000974)
0.1 1.2 GO:0015030 Cajal body(GO:0015030)
0.1 0.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.1 GO:0032040 small-subunit processome(GO:0032040)
0.1 1.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.3 GO:0005839 proteasome core complex(GO:0005839)
0.0 2.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0035517 PR-DUB complex(GO:0035517)
0.0 9.2 GO:0005730 nucleolus(GO:0005730)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 0.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0070209 ASTRA complex(GO:0070209)
0.0 0.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 1.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.8 GO:0031201 SNARE complex(GO:0031201)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.3 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.5 GO:0034511 U3 snoRNA binding(GO:0034511)
0.6 3.6 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.4 1.4 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.3 1.0 GO:0036310 annealing helicase activity(GO:0036310)
0.3 1.0 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.3 0.8 GO:0030623 U5 snRNA binding(GO:0030623)
0.2 2.0 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 1.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 0.5 GO:0042781 3'-tRNA processing endoribonuclease activity(GO:0042781)
0.2 0.8 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 2.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 0.4 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1 1.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 1.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 0.4 GO:0001147 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.1 2.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 0.8 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.7 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 0.7 GO:0000992 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 3 promoter sequence-specific DNA binding(GO:0001006) RNA polymerase III regulatory region DNA binding(GO:0001016) RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.1 1.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.8 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 1.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.0 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 1.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.5 GO:0016421 CoA carboxylase activity(GO:0016421)
0.1 0.5 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 1.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.6 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 3.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 6.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.2 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.1 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.0 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.2 GO:0008410 CoA-transferase activity(GO:0008410)
0.0 0.1 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.8 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 2.3 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 2.0 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 1.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 1.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 1.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.4 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.1 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
0.0 1.3 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 1.7 GO:0003724 RNA helicase activity(GO:0003724)
0.0 2.5 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.2 GO:0030955 potassium ion binding(GO:0030955) alkali metal ion binding(GO:0031420)
0.0 1.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 PID ATR PATHWAY ATR signaling pathway
0.0 0.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.2 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.2 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 2.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 1.5 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.1 1.8 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 1.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.0 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 3.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.8 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 0.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.8 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.3 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 1.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.7 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 1.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.3 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation