ISMARA results: cebpa

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for cebpa

Z-value: 1.05

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Transcription factors associated with cebpa

Gene Symbol	Gene ID	Gene Info
cebpa NCBI UniProt	ENSDARG00000036074	CCAAT enhancer binding protein alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
cebpa	dr11_v1_chr7_-_38087865_38087865	0.89	6.0e-07	Click!

Activity profile of cebpa motif

Sorted Z-values of cebpa motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_1702648 Show fit	3.72	ENSDART00000102934	hnrnpa3 NCBI UniProt Show fit	heterogeneous nuclear ribonucleoprotein A3
chr8_-_50147948 Show fit	2.88	ENSDART00000149010	hp NCBI UniProt Show fit	haptoglobin
chr23_-_28692581 Show fit	2.67	ENSDART00000078141	ribc1 NCBI UniProt Show fit	RIB43A domain with coiled-coils 1
chr4_-_41209037 Show fit	2.53	ENSDART00000151948	si:ch211-73m21.1 NCBI UniProt Show fit	si:ch211-73m21.1
chr1_-_29139141 Show fit	2.38	ENSDART00000075546 ENSDART00000133246	hsf2bp NCBI UniProt Show fit	heat shock transcription factor 2 binding protein
chr7_-_10560964 Show fit	2.14	ENSDART00000172761 ENSDART00000170476	mthfs NCBI UniProt Show fit	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chr25_+_1732838 Show fit	2.11	ENSDART00000159555 ENSDART00000168161	FBLN1 NCBI UniProt Show fit	fibulin 1
chr4_-_5652030 Show fit	2.10	ENSDART00000010903	rsph9 NCBI UniProt Show fit	radial spoke head 9 homolog
chr11_-_6265574 Show fit	2.08	ENSDART00000181974 ENSDART00000104405	ccl25b NCBI UniProt Show fit	chemokine (C-C motif) ligand 25b
chr7_+_22616212 Show fit	2.04	ENSDART00000052844	cldn7a NCBI UniProt Show fit	claudin 7a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of cebpa

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	GO:0070830	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0	3.0	GO:0006821	chloride transport(GO:0006821)
0.2	2.5	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.7	2.1	GO:1904158	axonemal central apparatus assembly(GO:1904158)
0.7	2.1	GO:2000471	regulation of hematopoietic stem cell migration(GO:2000471)
0.3	2.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.1	2.1	GO:0051904	melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.2	1.9	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.6	1.8	GO:0070197	telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240)
0.0	1.8	GO:0090090	negative regulation of canonical Wnt signaling pathway(GO:0090090)

Showing 1 to 10 of 175 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	23.9	GO:0005615	extracellular space(GO:0005615)
0.0	6.7	GO:0005576	extracellular region(GO:0005576)
0.1	2.2	GO:0005637	nuclear inner membrane(GO:0005637)
0.7	2.1	GO:0001534	radial spoke(GO:0001534)
0.3	2.1	GO:0016586	RSC complex(GO:0016586)
0.1	2.0	GO:0005605	basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0	1.7	GO:0097014	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.5	1.6	GO:0005577	fibrinogen complex(GO:0005577)
0.0	1.6	GO:0030018	Z disc(GO:0030018)
0.0	1.6	GO:0005770	late endosome(GO:0005770)

Showing 1 to 10 of 77 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.9	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	4.6	GO:0004866	endopeptidase inhibitor activity(GO:0004866)
0.0	3.9	GO:0005198	structural molecule activity(GO:0005198)
0.1	3.1	GO:0003823	antigen binding(GO:0003823)
0.1	2.7	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	2.4	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.6	2.2	GO:0005153	interleukin-8 receptor binding(GO:0005153)
0.1	2.1	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	2.1	GO:0046982	protein heterodimerization activity(GO:0046982)
0.1	2.0	GO:0005247	voltage-gated chloride channel activity(GO:0005247)

Showing 1 to 10 of 138 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	3.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	2.5	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	2.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	2.0	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	2.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	1.1	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	1.0	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	0.9	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.8	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport

Showing 1 to 10 of 25 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.3	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	3.2	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	2.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1	2.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	1.9	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.2	1.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	1.6	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	1.5	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.2	1.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	1.4	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP

Showing 1 to 10 of 50 entries

Results for cebpa

Z-value: 1.05

Motif logo

Transcription factors associated with cebpa

Activity-expression correlation:

Activity profile of cebpa motif

Sorted Z-values of cebpa motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of cebpa

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: