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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for bhlhe40

Z-value: 0.51

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Transcription factors associated with bhlhe40

Gene Symbol Gene ID Gene Info
bhlhe40
ENSDARG00000004060 basic helix-loop-helix family, member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
bhlhe40dr11_v1_chr11_-_35763323_35763323-0.994.0e-14Click!

Activity profile of bhlhe40 motif

Sorted Z-values of bhlhe40 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_32622933 1.77 ENSDART00000077418
ctsba
cathepsin Ba
chr17_-_25331439 1.26 ENSDART00000155422
ENSDART00000082324
zpcx
zona pellucida protein C
chr9_-_34269066 1.20 ENSDART00000059955
ildr1b
immunoglobulin-like domain containing receptor 1b
chr19_+_791538 1.13 ENSDART00000146554
ENSDART00000138406
tmem79a
transmembrane protein 79a
chr8_+_13700605 1.04 ENSDART00000144516
lonrf1l
LON peptidase N-terminal domain and ring finger 1, like
chr11_+_5499661 1.03 ENSDART00000027850
slc35e1
solute carrier family 35, member E1
chr5_-_22130937 1.01 ENSDART00000138606
las1l
LAS1-like, ribosome biogenesis factor
chr12_+_19958845 1.00 ENSDART00000193248
ercc4
excision repair cross-complementation group 4
chr6_-_49547680 0.94 ENSDART00000169678
ppp4r1l
protein phosphatase 4, regulatory subunit 1-like
chr5_+_41476443 0.89 ENSDART00000145228
ENSDART00000137981
ENSDART00000142538
pias2
protein inhibitor of activated STAT, 2
chr10_+_32050906 0.88 ENSDART00000137373
si:ch211-266i6.3
si:ch211-266i6.3
chr7_+_51795667 0.85 ENSDART00000174201
ENSDART00000073839
slc38a7
solute carrier family 38, member 7
chr6_+_149405 0.85 ENSDART00000161154
fdx1l
ferredoxin 1-like
chr10_+_5268054 0.83 ENSDART00000114491
ror2
receptor tyrosine kinase-like orphan receptor 2
chr25_+_3788074 0.80 ENSDART00000154008
chid1
chitinase domain containing 1
chr9_-_10804796 0.79 ENSDART00000134911
si:ch1073-416j23.1
si:ch1073-416j23.1
chr9_-_27868267 0.77 ENSDART00000079502
dbr1
debranching RNA lariats 1
chr24_-_6024466 0.77 ENSDART00000040865
pdss1
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr13_-_12389748 0.76 ENSDART00000141606
commd8
COMM domain containing 8
chr17_+_30843881 0.75 ENSDART00000149600
ENSDART00000148547
tpp1
tripeptidyl peptidase I
chr19_+_15441022 0.75 ENSDART00000098970
ENSDART00000140276
lin28a
lin-28 homolog A (C. elegans)
chr19_+_9111550 0.74 ENSDART00000088336
setdb1a
SET domain, bifurcated 1a
chr14_-_16810401 0.73 ENSDART00000158396
ENSDART00000170758
tcirg1b
T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b
chr4_-_9196291 0.73 ENSDART00000153963
hcfc2
host cell factor C2
chr24_+_33462800 0.72 ENSDART00000166666
ENSDART00000050826
rmc1
regulator of MON1-CCZ1
chr7_-_41881177 0.72 ENSDART00000174258
ENSDART00000018972
zgc:92818
zgc:92818
chr5_+_26204561 0.70 ENSDART00000137178
marveld2b
MARVEL domain containing 2b
chr25_+_3788443 0.67 ENSDART00000189747
chid1
chitinase domain containing 1
chr23_-_10786400 0.67 ENSDART00000055038
rybpa
RING1 and YY1 binding protein a
chr19_+_15440841 0.64 ENSDART00000182329
lin28a
lin-28 homolog A (C. elegans)
chr1_-_47114310 0.61 ENSDART00000144899
ENSDART00000053157
setd4
SET domain containing 4
chr20_-_40766387 0.59 ENSDART00000061173
hsdl1
hydroxysteroid dehydrogenase like 1
chr9_+_16854121 0.59 ENSDART00000110866
cln5
CLN5, intracellular trafficking protein
chr16_+_33143503 0.59 ENSDART00000058471
ENSDART00000179385
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr25_-_19608382 0.58 ENSDART00000022279
ENSDART00000135201
ENSDART00000147223
ENSDART00000190220
ENSDART00000184242
ENSDART00000166824
gtse1
G-2 and S-phase expressed 1
chr22_+_16759010 0.58 ENSDART00000079638
ENSDART00000113099
tm2d1
TM2 domain containing 1
chr15_+_1534644 0.57 ENSDART00000130413
smc4
structural maintenance of chromosomes 4
chr16_+_25296389 0.50 ENSDART00000114528
tbc1d31
TBC1 domain family, member 31
chr23_-_2901167 0.50 ENSDART00000165955
ENSDART00000190616
zhx3
zinc fingers and homeoboxes 3
chr24_-_42072886 0.48 ENSDART00000171389
CABZ01095370.1

chr14_-_36345175 0.48 ENSDART00000077823
lrit3a
info leucine-rich repeat, immunoglobulin-like and transmembrane domains 3a
chr12_+_18529228 0.47 ENSDART00000193931
ENSDART00000146260
meiob
msrb1b
meiosis specific with OB domains
methionine sulfoxide reductase B1b
chr15_-_44077937 0.47 ENSDART00000110112
lamtor1
late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
chr14_-_36437249 0.46 ENSDART00000016728
aga
aspartylglucosaminidase
chr17_+_25331576 0.46 ENSDART00000157309
tmem54a
transmembrane protein 54a
chr15_+_34939906 0.46 ENSDART00000131182
si:ch73-95l15.3
si:ch73-95l15.3
chr9_-_10805231 0.46 ENSDART00000193913
ENSDART00000078348
si:ch1073-416j23.1
si:ch1073-416j23.1
chr23_+_32028574 0.44 ENSDART00000145501
ENSDART00000143121
ENSDART00000111877
tpx2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr22_-_16758973 0.43 ENSDART00000145208
patj
PATJ, crumbs cell polarity complex component
chr20_-_45040916 0.41 ENSDART00000190001
klhl29
kelch-like family member 29
chr10_-_24724388 0.40 ENSDART00000148582
smpd1
sphingomyelin phosphodiesterase 1, acid lysosomal
chr23_-_22130778 0.39 ENSDART00000079212
phc2a
polyhomeotic homolog 2a (Drosophila)
chr4_+_17655872 0.39 ENSDART00000066999
washc3
WASH complex subunit 3
chr8_-_25817106 0.37 ENSDART00000099364
taf10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr25_+_10547228 0.36 ENSDART00000067678
zgc:110339
zgc:110339
chr21_+_43178831 0.35 ENSDART00000151512
aff4
AF4/FMR2 family, member 4
chr16_+_19029297 0.33 ENSDART00000115263
ENSDART00000114954
rapgef5b
Rap guanine nucleotide exchange factor (GEF) 5b
chr20_+_13969414 0.33 ENSDART00000049864
rd3
retinal degeneration 3
chr21_-_4539899 0.32 ENSDART00000112460
dolk
dolichol kinase
chr17_-_15229787 0.31 ENSDART00000039165
styx
serine/threonine/tyrosine interacting protein
chr5_-_4532516 0.30 ENSDART00000192398
cst14b.1
cystatin 14b, tandem duplicate 1
chr1_+_50639416 0.30 ENSDART00000141977
herc3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr19_+_40379771 0.29 ENSDART00000017917
ENSDART00000110699
vps50
vps50
VPS50 EARP/GARPII complex subunit
VPS50 EARP/GARPII complex subunit
chr3_-_4501026 0.28 ENSDART00000163052
zgc:162198
zgc:162198
chr17_-_44440832 0.28 ENSDART00000148786
exoc5
exocyst complex component 5
chr7_-_14446512 0.28 ENSDART00000041577
kif7
kinesin family member 7
chr15_-_26570948 0.27 ENSDART00000156621
wdr81
WD repeat domain 81
chr22_-_16759151 0.27 ENSDART00000191880
patj
PATJ, crumbs cell polarity complex component
chr12_+_34891529 0.27 ENSDART00000015643
tbcc
tubulin folding cofactor C
chr23_+_35847200 0.26 ENSDART00000129222
rarga
retinoic acid receptor gamma a
chr1_+_17695426 0.23 ENSDART00000103236
ankrd37
ankyrin repeat domain 37
chr14_-_45595711 0.23 ENSDART00000074038
scyl1
SCY1-like, kinase-like 1
chr12_+_17933775 0.22 ENSDART00000186047
ENSDART00000160586
trrap
transformation/transcription domain-associated protein
chr20_-_29683754 0.21 ENSDART00000130599
ENSDART00000015928
ENSDART00000131219
si:ch211-195d17.2
si:ch211-195d17.2
chr20_-_13140309 0.21 ENSDART00000020703
ENSDART00000188594
ints7
integrator complex subunit 7
chr16_+_7985886 0.21 ENSDART00000126041
ano10a
anoctamin 10a
chr3_+_16922226 0.20 ENSDART00000017646
atp6v0a1a
ATPase H+ transporting V0 subunit a1a
chr3_-_25420931 0.20 ENSDART00000109601
ENSDART00000182184
bptf
bromodomain PHD finger transcription factor
chr12_-_7280551 0.18 ENSDART00000061633
zgc:171971
zgc:171971
chr24_+_32472155 0.17 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr4_+_13696537 0.16 ENSDART00000109195
ENSDART00000122041
ENSDART00000192554
nrcama
neuronal cell adhesion molecule a
chr16_-_7228276 0.16 ENSDART00000149030
nt5c3a
5'-nucleotidase, cytosolic IIIA
chr14_+_44804326 0.15 ENSDART00000079866
ENSDART00000172974
slc30a9
solute carrier family 30 (zinc transporter), member 9
chr5_-_9540641 0.15 ENSDART00000124384
ENSDART00000160079
gak
cyclin G associated kinase
chr15_-_41807371 0.15 ENSDART00000156819
slc25a36b
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36b
chr9_-_1200187 0.15 ENSDART00000158760
ino80da
INO80 complex subunit Da
chr13_+_40692804 0.14 ENSDART00000109822
hps1
Hermansky-Pudlak syndrome 1
chr13_+_12389849 0.14 ENSDART00000086525
atp10d
ATPase phospholipid transporting 10D
chr15_-_34418525 0.12 ENSDART00000147582
agmo
alkylglycerol monooxygenase
chr17_-_37299394 0.12 ENSDART00000154414
ptgr2
prostaglandin reductase 2
chr13_+_7164345 0.11 ENSDART00000022051
gins1
GINS complex subunit 1 (Psf1 homolog)
chr10_+_22890791 0.11 ENSDART00000176011
arrb2a
arrestin, beta 2a
chr7_+_1442059 0.10 ENSDART00000173391
si:cabz01090193.1
si:cabz01090193.1
chr5_+_61839707 0.09 ENSDART00000163051
CR759879.1
Danio rerio interferon-induced protein with tetratricopeptide repeats 5 (LOC572297), mRNA.
chr18_+_31280984 0.09 ENSDART00000170285
ENSDART00000150608
ENSDART00000159720
def8
differentially expressed in FDCP 8 homolog (mouse)
chr20_-_211920 0.09 ENSDART00000104790
znf292b
zinc finger protein 292b
chr19_-_38830582 0.09 ENSDART00000189966
ENSDART00000183055
adgrb2
adhesion G protein-coupled receptor B2
chr23_+_42131509 0.09 ENSDART00000184544
SHISAL2A
shisa like 2A
chr4_+_17353714 0.08 ENSDART00000136299
nup37
nucleoporin 37
chr8_+_41229233 0.08 ENSDART00000131135
zgc:152830
zgc:152830
chr2_-_32486080 0.07 ENSDART00000110821
ttc19
tetratricopeptide repeat domain 19
chr14_-_3071564 0.07 ENSDART00000166136
ENSDART00000167138
slc35a4
solute carrier family 35, member A4
chr22_+_8800432 0.06 ENSDART00000139940
si:dkey-182g1.6
si:dkey-182g1.6
chr2_+_50967947 0.06 ENSDART00000162288
si:ch211-249o11.5
si:ch211-249o11.5
chr24_+_3307857 0.06 ENSDART00000106527
gyg1b
glycogenin 1b
chr4_+_13640903 0.05 ENSDART00000155349
pnpla8
patatin-like phospholipase domain containing 8
chr25_-_1323623 0.05 ENSDART00000156532
ENSDART00000157163
ENSDART00000156062
ENSDART00000082447
ENSDART00000189175
calml4b
calmodulin-like 4b
chr14_-_25452503 0.04 ENSDART00000148652
slc26a2
solute carrier family 26 (anion exchanger), member 2
chr20_-_51386511 0.04 ENSDART00000151429
ENSDART00000066072
rnf8
ring finger protein 8, E3 ubiquitin protein ligase
chr21_-_14251306 0.04 ENSDART00000114715
ENSDART00000181380
man1b1a
mannosidase, alpha, class 1B, member 1a
chr11_-_44945636 0.04 ENSDART00000157658
orc2
origin recognition complex, subunit 2
chr9_+_54686686 0.03 ENSDART00000066198
rab9a
RAB9A, member RAS oncogene family
chr12_-_43438148 0.03 ENSDART00000004122
ptprea
protein tyrosine phosphatase, receptor type, E, a
chr3_+_12784460 0.03 ENSDART00000168382
cyp2k8
cytochrome P450, family 2, subfamily K, polypeptide 8
chr3_-_25421504 0.03 ENSDART00000154200
bptf
bromodomain PHD finger transcription factor
chr4_-_17353972 0.02 ENSDART00000041529
parpbp
PARP1 binding protein
chr5_+_57210237 0.01 ENSDART00000167660
pja2
praja ring finger ubiquitin ligase 2
chr18_+_39074139 0.01 ENSDART00000142390
gnb5b
guanine nucleotide binding protein (G protein), beta 5b
chr1_-_54765262 0.01 ENSDART00000150362
si:ch211-197k17.3
si:ch211-197k17.3
chr23_+_26079467 0.01 ENSDART00000129617
atp6ap1b
ATPase H+ transporting accessory protein 1b
chr21_+_45816030 0.01 ENSDART00000187056
pitx1
paired-like homeodomain 1
chr25_-_35599887 0.00 ENSDART00000153827
clpxb
caseinolytic mitochondrial matrix peptidase chaperone subunit b

Network of associatons between targets according to the STRING database.

First level regulatory network of bhlhe40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair(GO:1901255)
0.3 0.3 GO:0043393 regulation of protein binding(GO:0043393)
0.1 0.3 GO:0035973 aggrephagy(GO:0035973)
0.1 0.5 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 0.6 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 1.3 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 1.2 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.1 0.9 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.7 GO:0090309 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 0.2 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0 0.5 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.2 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.6 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.8 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.1 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.8 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.4 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.9 GO:0016925 protein sumoylation(GO:0016925)
0.0 1.0 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.2 GO:0072318 clathrin coat disassembly(GO:0072318) vesicle uncoating(GO:0072319)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0046485 ether lipid metabolic process(GO:0046485)
0.0 0.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.6 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.6 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 1.8 GO:0031101 fin regeneration(GO:0031101)
0.0 0.9 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:0097033 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0035675 neuromast hair cell development(GO:0035675)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.4 GO:0005880 nuclear microtubule(GO:0005880)
0.1 0.3 GO:1990745 EARP complex(GO:1990745)
0.1 0.9 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.5 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.4 GO:0071203 WASH complex(GO:0071203)
0.1 0.3 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.1 1.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.3 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 1.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0031085 BLOC-3 complex(GO:0031085)
0.0 0.7 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.7 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 5.5 GO:0005764 lysosome(GO:0005764)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.9 GO:1903293 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 1.4 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.3 GO:0000145 exocyst(GO:0000145)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.2 1.0 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.5 GO:0033745 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.1 1.3 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 1.5 GO:0008061 chitin binding(GO:0008061)
0.1 0.3 GO:0043621 protein self-association(GO:0043621)
0.1 0.7 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.9 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.9 GO:0051117 ATPase binding(GO:0051117)
0.1 0.2 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 0.8 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.8 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 0.6 GO:0016229 steroid dehydrogenase activity(GO:0016229)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.0 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 1.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.0 GO:0004519 endonuclease activity(GO:0004519)
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID AURORA A PATHWAY Aurora A signaling
0.0 0.6 PID AURORA B PATHWAY Aurora B signaling
0.0 0.4 PID TRAIL PATHWAY TRAIL signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening