ISMARA results: barx2

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for barx2

Z-value: 1.42

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Transcription factors associated with barx2

Gene Symbol	Gene ID	Gene Info
barx2 NCBI UniProt	ENSDARG00000041098	BARX homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
barx2	dr11_v1_chr18_+_47313899_47313899	0.65	3.4e-03	Click!

Activity profile of barx2 motif

Sorted Z-values of barx2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_54209504 Show fit	1.91	ENSDART00000020033	xrcc1 NCBI UniProt Show fit	X-ray repair complementing defective repair in Chinese hamster cells 1
chr10_-_29236860 Show fit	1.68	ENSDART00000111620	ccdc83 NCBI UniProt Show fit	coiled-coil domain containing 83
chr3_+_26145013 Show fit	1.58	ENSDART00000162546 ENSDART00000129561	atp2a1 NCBI UniProt Show fit	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr13_-_33683889 Show fit	1.57	ENSDART00000136820 ENSDART00000065435	cst3 NCBI UniProt Show fit	cystatin C (amyloid angiopathy and cerebral hemorrhage)
chr24_+_3478871 Show fit	1.44	ENSDART00000111491 ENSDART00000134598 ENSDART00000142407	wdr37 NCBI UniProt Show fit	WD repeat domain 37
chr23_+_7710447 Show fit	1.43	ENSDART00000168199	kif3b NCBI UniProt Show fit	kinesin family member 3B
chr4_+_17279966 Show fit	1.42	ENSDART00000067005 ENSDART00000137487	bcat1 NCBI UniProt Show fit	branched chain amino-acid transaminase 1, cytosolic
chr17_-_39772999 Show fit	1.38	ENSDART00000155727	pimr60 NCBI UniProt Show fit	Pim proto-oncogene, serine/threonine kinase, related 60
chr21_-_26490186 Show fit	1.37	ENSDART00000009889	zgc:110540 NCBI UniProt Show fit	zgc:110540
chr15_+_34988148 Show fit	1.36	ENSDART00000076269	ccdc105 NCBI UniProt Show fit	coiled-coil domain containing 105

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of barx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	13.2	GO:0046777	protein autophosphorylation(GO:0046777)
0.3	2.7	GO:0043584	nose development(GO:0043584)
0.0	2.6	GO:0031047	gene silencing by RNA(GO:0031047)
0.1	2.5	GO:0071910	determination of liver left/right asymmetry(GO:0071910)
0.3	1.7	GO:0000012	single strand break repair(GO:0000012)
0.4	1.6	GO:0031446	regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.4	1.4	GO:0009098	leucine biosynthetic process(GO:0009098)
0.1	1.4	GO:0042073	intraciliary transport(GO:0042073)
0.0	1.4	GO:0030814	regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of adenylate cyclase activity(GO:0045761)
0.1	1.3	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)

Showing 1 to 10 of 120 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0005871	kinesin complex(GO:0005871)
0.1	2.5	GO:0030286	dynein complex(GO:0030286)
0.0	2.0	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	1.8	GO:0043025	neuronal cell body(GO:0043025)
0.4	1.6	GO:0031673	H zone(GO:0031673)
0.0	1.5	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1	1.4	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.1	1.4	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.0	1.3	GO:0016605	PML body(GO:0016605)
0.0	1.3	GO:0005814	centriole(GO:0005814)

Showing 1 to 10 of 56 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	14.4	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
0.0	2.7	GO:0003777	microtubule motor activity(GO:0003777)
0.1	2.5	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1	1.9	GO:0003684	damaged DNA binding(GO:0003684)
0.1	1.6	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.4	1.4	GO:0052655	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2	1.4	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.1	1.4	GO:0045503	dynein light chain binding(GO:0045503)
0.1	1.3	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.4	1.1	GO:0033897	ribonuclease T2 activity(GO:0033897)

Showing 1 to 10 of 79 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.6	PID BARD1 PATHWAY	BARD1 signaling events
0.1	1.5	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.4	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	1.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	1.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	0.8	PID BMP PATHWAY	BMP receptor signaling
0.0	0.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	0.5	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.5	PID ILK PATHWAY	Integrin-linked kinase signaling

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	REACTOME KINESINS	Genes involved in Kinesins
0.1	1.9	REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.1	1.6	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.1	1.5	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	1.4	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	1.3	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	1.3	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.1	1.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.9	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	0.8	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse

Showing 1 to 10 of 27 entries

Results for barx2

Z-value: 1.42

Motif logo

Transcription factors associated with barx2

Activity-expression correlation:

Activity profile of barx2 motif

Sorted Z-values of barx2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of barx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: