ISMARA results: atf2+atf7a+atf7b

Project

PRJNA438478: RNAseq of wild type zebrafish germline

Navigation

Downloads

Results for atf2+atf7a+atf7b_creb5a+creb5b

Z-value: 0.88

Motif logo

Transcription factors associated with atf2+atf7a+atf7b_creb5a+creb5b

Gene Symbol	Gene ID	Gene Info
atf7a NCBI UniProt	ENSDARG00000011298	activating transcription factor 7a
atf2 NCBI UniProt	ENSDARG00000023903	activating transcription factor 2
atf7b NCBI UniProt	ENSDARG00000055481	activating transcription factor 7b
atf7b NCBI UniProt	ENSDARG00000114492	activating transcription factor 7b
atf7b NCBI UniProt	ENSDARG00000115171	activating transcription factor 7b
creb5b NCBI UniProt	ENSDARG00000070536	cAMP responsive element binding protein 5b
creb5a NCBI UniProt	ENSDARG00000099002	cAMP responsive element binding protein 5a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
atf7b	dr11_v1_chr6_-_39631164_39631181	0.97	7.4e-12	Click!
creb5b	dr11_v1_chr16_-_20707742_20707742	-0.59	9.6e-03	Click!
creb5a	dr11_v1_chr19_-_19505167_19505167	-0.56	1.5e-02	Click!
atf7a	dr11_v1_chr23_-_27479558_27479558	0.50	3.6e-02	Click!
atf2	dr11_v1_chr9_+_2343096_2343172	-0.29	2.5e-01	Click!

Activity profile of atf2+atf7a+atf7b_creb5a+creb5b motif

Sorted Z-values of atf2+atf7a+atf7b_creb5a+creb5b motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_35603637 Show fit	8.12	ENSDART00000147278	plk3 NCBI UniProt Show fit	polo-like kinase 3 (Drosophila)
chr16_-_29387215 Show fit	3.85	ENSDART00000148787	s100a1 NCBI UniProt Show fit	S100 calcium binding protein A1
chr11_-_44801968 Show fit	3.47	ENSDART00000161846	map1lc3c NCBI UniProt Show fit	microtubule-associated protein 1 light chain 3 gamma
chr2_+_12255568 Show fit	3.33	ENSDART00000184164 ENSDART00000013454	prtfdc1 NCBI UniProt Show fit	phosphoribosyl transferase domain containing 1
chr7_-_51773166 Show fit	3.25	ENSDART00000054591	bmp15 NCBI UniProt Show fit	bone morphogenetic protein 15
chr25_-_6447835 Show fit	2.89	ENSDART00000012820	snupn NCBI UniProt Show fit	snurportin 1
chr14_+_30285613 Show fit	2.89	ENSDART00000173090	mtus1a NCBI UniProt Show fit	microtubule associated tumor suppressor 1a
chr24_-_19718077 Show fit	2.69	ENSDART00000109107 ENSDART00000056082	csrnp1b NCBI UniProt Show fit	cysteine-serine-rich nuclear protein 1b
chr25_-_6448050 Show fit	2.60	ENSDART00000180616	snupn NCBI UniProt Show fit	snurportin 1
chr8_-_410199 Show fit	2.39	ENSDART00000091177 ENSDART00000122979 ENSDART00000151331 ENSDART00000151155	trim36 NCBI UniProt Show fit	tripartite motif containing 36

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of atf2+atf7a+atf7b_creb5a+creb5b

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.0	8.1	GO:0048313	organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.1	5.7	GO:0008016	regulation of heart contraction(GO:0008016)
1.4	5.5	GO:0006404	RNA import into nucleus(GO:0006404) snRNA import into nucleus(GO:0061015)
0.3	5.1	GO:0006995	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
1.1	4.2	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.8	3.3	GO:0060283	negative regulation of oocyte development(GO:0060283)
0.0	3.1	GO:0090263	positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.1	2.8	GO:0072114	pronephros morphogenesis(GO:0072114)
0.1	2.7	GO:0030901	midbrain development(GO:0030901)
0.0	2.6	GO:0006892	post-Golgi vesicle-mediated transport(GO:0006892)

Showing 1 to 10 of 125 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.9	GO:0000922	spindle pole(GO:0000922)
0.1	5.1	GO:0000421	autophagosome membrane(GO:0000421)
0.1	4.6	GO:0032432	actin filament bundle(GO:0032432)
0.0	4.6	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.1	3.8	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	2.6	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	2.2	GO:0005657	replication fork(GO:0005657)
0.2	2.0	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.1	2.0	GO:0005876	spindle microtubule(GO:0005876)
0.1	1.8	GO:0044665	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.8	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
0.3	5.5	GO:0061608	nuclear import signal receptor activity(GO:0061608)
0.1	5.5	GO:0031625	ubiquitin protein ligase binding(GO:0031625)
1.1	4.2	GO:0004419	hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.1	3.9	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	3.7	GO:0008017	microtubule binding(GO:0008017)
0.0	2.8	GO:0003714	transcription corepressor activity(GO:0003714)
0.2	2.7	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.4	2.6	GO:0070698	type I activin receptor binding(GO:0070698)
0.1	2.6	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)

Showing 1 to 10 of 87 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.4	PID P73PATHWAY	p73 transcription factor network
0.0	7.0	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	2.4	PID AURORA B PATHWAY	Aurora B signaling
0.0	2.2	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	1.7	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	1.6	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	1.4	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	1.3	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	1.0	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	0.6	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.6	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	4.4	REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0	3.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	2.6	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	2.0	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	2.0	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	1.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	1.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	1.0	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.9	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases

Showing 1 to 10 of 20 entries

Results for atf2+atf7a+atf7b_creb5a+creb5b

Z-value: 0.88

Motif logo

Transcription factors associated with atf2+atf7a+atf7b_creb5a+creb5b

Activity-expression correlation:

Activity profile of atf2+atf7a+atf7b_creb5a+creb5b motif

Sorted Z-values of atf2+atf7a+atf7b_creb5a+creb5b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of atf2+atf7a+atf7b_creb5a+creb5b

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: