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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for arxa
Z-value: 0.80
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Transcription factors associated with arxa
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| arxa | dr11_v1_chr24_-_23942722_23942722 | -0.91 | 1.6e-07 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_37903790 Show fit | 3.43 |
ENSDART00000162470
|
transmembrane protease, serine 4b |
|
| chr25_+_22320738 Show fit | 2.59 |
ENSDART00000073566
|
cytochrome P450, family 11, subfamily A, polypeptide 1 |
|
| chr11_-_39118882 Show fit | 1.94 |
ENSDART00000113185
ENSDART00000156526 |
adaptor-related protein complex 5, beta 1 subunit |
|
| chr8_-_53044300 Show fit | 1.88 |
ENSDART00000191653
|
nuclear receptor subfamily 6, group A, member 1a |
|
| chr3_+_7808459 Show fit | 1.79 |
ENSDART00000162374
|
hook microtubule-tethering protein 2 |
|
| chr12_-_33357655 Show fit | 1.71 |
ENSDART00000066233
ENSDART00000148165 |
solute carrier family 16 (monocarboxylate transporter), member 3 |
|
| chr20_+_29209767 Show fit | 1.71 |
ENSDART00000141252
|
katanin p80 subunit B-like 1 |
|
| chr7_-_51727760 Show fit | 1.68 |
ENSDART00000174180
|
histone deacetylase 8 |
|
| chr6_+_36839509 Show fit | 1.62 |
ENSDART00000190605
ENSDART00000104160 |
zgc:110788 |
|
| chr20_+_29209926 Show fit | 1.60 |
ENSDART00000152949
ENSDART00000153016 |
katanin p80 subunit B-like 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of arxa
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0030917 | midbrain-hindbrain boundary development(GO:0030917) |
| 0.5 | 2.6 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
| 0.1 | 2.0 | GO:0016233 | telomere capping(GO:0016233) |
| 0.0 | 1.8 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.0 | 1.8 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.2 | 1.7 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.1 | 1.6 | GO:0006382 | adenosine to inosine editing(GO:0006382) |
| 0.0 | 1.6 | GO:0050821 | protein stabilization(GO:0050821) |
| 0.0 | 1.6 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.1 | 1.5 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.0 | 1.8 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 1.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 1.7 | GO:0030141 | secretory granule(GO:0030141) |
| 0.5 | 1.5 | GO:0031310 | integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310) |
| 0.1 | 1.5 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 1.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.3 | GO:0031211 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
| 0.0 | 1.3 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 1.3 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.1 | 3.4 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.9 | 2.6 | GO:0008386 | cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713) |
| 0.0 | 2.4 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.3 | 1.8 | GO:0008118 | N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118) |
| 0.0 | 1.8 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.1 | 1.7 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 1.7 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 1.6 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.0 | 1.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 1.1 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 0.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.7 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.6 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.6 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 1.7 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 1.7 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 1.4 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 1.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 1.1 | REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway |
| 0.1 | 1.1 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.1 | 1.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.0 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |