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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for arnt2
Z-value: 1.70
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Transcription factors associated with arnt2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| arnt2 | dr11_v1_chr7_+_10701938_10701938 | 0.96 | 1.8e-10 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_10152092 Show fit | 5.51 |
ENSDART00000066053
|
chromobox homolog 2 (Drosophila Pc class) |
|
| chr1_+_49814461 Show fit | 5.03 |
ENSDART00000132405
|
lymphoid enhancer-binding factor 1 |
|
| chr4_+_9279784 Show fit | 4.32 |
ENSDART00000014897
|
SLIT-ROBO Rho GTPase activating protein 1b |
|
| chr10_-_25217347 Show fit | 4.01 |
ENSDART00000036906
|
karyopherin alpha 7 (importin alpha 8) |
|
| chr3_-_1283247 Show fit | 3.94 |
ENSDART00000149814
|
transcription factor 20 |
|
| chr20_-_48898371 Show fit | 3.86 |
ENSDART00000170617
|
5'-3' exoribonuclease 2 |
|
| chr12_+_38807604 Show fit | 3.77 |
ENSDART00000155563
|
ATP-binding cassette, sub-family A (ABC1), member 5 |
|
| chr2_-_21438492 Show fit | 3.69 |
ENSDART00000046098
|
phospholipase C, delta 1b |
|
| chr8_-_18899427 Show fit | 3.51 |
ENSDART00000079840
|
RAR-related orphan receptor C a |
|
| chr5_+_25733774 Show fit | 3.46 |
ENSDART00000137088
ENSDART00000098467 |
abhydrolase domain containing 17B |
Network of associatons between targets according to the STRING database.
First level regulatory network of arnt2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.2 | GO:0048798 | swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798) |
| 1.5 | 7.3 | GO:0060784 | regulation of cell proliferation involved in tissue homeostasis(GO:0060784) |
| 0.1 | 7.2 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.5 | 6.1 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.6 | 5.6 | GO:0035588 | adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588) |
| 0.4 | 5.4 | GO:0098734 | protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734) |
| 0.2 | 5.4 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.0 | 5.2 | GO:0006869 | lipid transport(GO:0006869) |
| 0.7 | 5.0 | GO:0002931 | response to ischemia(GO:0002931) |
| 0.1 | 4.5 | GO:0048015 | phosphatidylinositol-mediated signaling(GO:0048015) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.1 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.4 | 7.7 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 6.6 | GO:0005764 | lysosome(GO:0005764) |
| 0.0 | 6.4 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.1 | 5.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.3 | 5.5 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.3 | 5.0 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 4.7 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.3 | 4.5 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.0 | 3.5 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 9.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.2 | 8.7 | GO:0004629 | phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629) |
| 0.4 | 7.6 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.3 | 7.3 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.0 | 6.8 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.3 | 6.0 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.2 | 5.9 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.3 | 5.8 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.2 | 5.6 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 6.5 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.2 | 4.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 3.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 3.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 2.8 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 2.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 2.2 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 1.7 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 1.6 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.1 | 5.4 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.6 | 5.0 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 3.9 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 3.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 2.7 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.0 | 2.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 2.3 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 2.1 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.2 | 2.0 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |