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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for VDR+nr1i2_vdrb

Z-value: 1.18

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Transcription factors associated with VDR+nr1i2_vdrb

Gene Symbol Gene ID Gene Info
ENSDARG00000029766 nuclear receptor subfamily 1, group I, member 2
ENSDARG00000112923 vitamin D receptor
ENSDARG00000070721 vitamin D receptor b
ENSDARG00000114864 vitamin D receptor b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
vdrbdr11_v1_chr6_-_39005133_39005133-0.831.7e-05Click!
CABZ01088036.1dr11_v1_chr23_+_45785563_45785563-0.571.4e-02Click!
nr1i2dr11_v1_chr9_+_9502610_95026100.107.0e-01Click!

Activity profile of VDR+nr1i2_vdrb motif

Sorted Z-values of VDR+nr1i2_vdrb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_42544522 6.59 ENSDART00000157968

chr5_-_36949476 6.04 ENSDART00000047269
H3 histone, family 3C
chr6_+_9893554 5.54 ENSDART00000064979
Pim proto-oncogene, serine/threonine kinase, related 74
chr12_+_20506197 5.00 ENSDART00000153010
si:zfos-754c12.2
chr12_+_18663154 4.62 ENSDART00000057918
si:ch211-147h1.4
chr1_+_54626491 4.30 ENSDART00000136063
si:ch211-202h22.9
chr21_-_18972206 3.73 ENSDART00000146743
Pim proto-oncogene, serine/threonine kinase, related 72
chr6_-_9922266 3.71 ENSDART00000151549
Pim proto-oncogene, serine/threonine kinase, related 73
chr3_+_39922602 3.37 ENSDART00000193937
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr19_-_4010263 3.30 ENSDART00000159605
ENSDART00000165541
MAP7 domain containing 1b
chr25_-_4148719 3.29 ENSDART00000112880
ENSDART00000023278
fatty acid desaturase 2
chr7_+_65673885 3.28 ENSDART00000169182
parvin, alpha b
chr20_+_263056 3.05 ENSDART00000132669
tubulin, epsilon 1
chr23_-_38054 2.73 ENSDART00000170393

chr16_+_53685812 2.55 ENSDART00000014098
gamma-glutamylcyclotransferase b
chr1_-_56223913 2.35 ENSDART00000019573
zgc:65894
chr11_+_25112269 2.35 ENSDART00000147546
ndrg family member 3a
chr19_-_32600138 2.30 ENSDART00000052101
zgc:91944
chr12_+_10134366 2.01 ENSDART00000127343
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
chr25_-_13188214 1.99 ENSDART00000187298
si:ch211-147m6.1
chr11_+_25111846 1.84 ENSDART00000128705
ENSDART00000190058
ndrg family member 3a
chr2_+_33051730 1.60 ENSDART00000177902
ENSDART00000187903
ring finger protein 220a
chr5_-_11271209 1.60 ENSDART00000122084
proline dehydrogenase (oxidase) 1b
chr16_-_22781446 1.60 ENSDART00000144107
lens epithelial protein
chr14_-_858985 1.58 ENSDART00000148687
ENSDART00000149375
solute carrier family 34 (type II sodium/phosphate cotransporter), member 1a
chr4_-_13921185 1.53 ENSDART00000143202
ENSDART00000080334
YY1 associated factor 2
chr17_-_12385308 1.44 ENSDART00000080927
synaptosomal-associated protein, 25b
chr2_-_24898226 1.38 ENSDART00000134936
si:dkey-149i17.9
chr16_+_32995882 1.30 ENSDART00000170157
protease, serine, 35
chr21_-_25756119 1.30 ENSDART00000002341
claudin c
chr11_+_2642013 1.27 ENSDART00000111324
zgc:193807
chr11_-_25734417 1.27 ENSDART00000103570
bromodomain and PHD finger containing, 3a
chr20_+_48100261 1.24 ENSDART00000158604
XK related 5a
chr21_+_30470809 1.21 ENSDART00000171648
ENSDART00000126678
ENSDART00000003335
ENSDART00000133478
ENSDART00000140811
ENSDART00000147375
sorting nexin 12
chr6_+_50451337 1.21 ENSDART00000155051
myelocytomatosis oncogene homolog
chr16_-_12787029 1.17 ENSDART00000139916
forkhead box J2
chr18_+_33788340 1.14 ENSDART00000136950
si:dkey-145c18.2
chr19_+_58954 1.08 ENSDART00000162379
collagen, type XIV, alpha 1b
chr12_-_13556536 1.05 ENSDART00000166396

chr19_+_29798064 1.05 ENSDART00000167803
ENSDART00000051804
MARCKS-like 1b
chr16_-_35329803 1.01 ENSDART00000161729
ENSDART00000157700
ENSDART00000184584
ENSDART00000174713
ENSDART00000162518
protein tyrosine phosphatase, receptor type, U, b
chr23_-_28808480 1.00 ENSDART00000078167
DNA fragmentation factor, alpha polypeptide
chr14_-_21064199 1.00 ENSDART00000172099
si:dkey-74k8.3
chr25_+_12494079 0.98 ENSDART00000163508
microtubule-associated protein 1 light chain 3 beta
chr4_-_14915268 0.98 ENSDART00000067040
si:dkey-180p18.9
chr21_-_32289356 0.96 ENSDART00000183050
CDC-like kinase 4b
chr2_+_33052169 0.95 ENSDART00000180008
ring finger protein 220a
chr11_-_18800299 0.94 ENSDART00000156276
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr17_+_20923691 0.92 ENSDART00000122407
cyclin-dependent kinase 1
chr14_-_21063977 0.91 ENSDART00000164373
si:dkey-74k8.3
chr11_-_25324534 0.90 ENSDART00000158598
si:ch211-232b12.5
chr13_-_36418921 0.89 ENSDART00000135804
ddb1 and cul4 associated factor 5
chr22_-_20733822 0.89 ENSDART00000133780
si:dkey-3k20.1
chr23_+_35672542 0.88 ENSDART00000046268
premelanosome protein b
chr14_+_45732081 0.88 ENSDART00000110103
coiled-coil domain containing 88B
chr8_+_20918207 0.87 ENSDART00000144039
si:ch73-196i15.5
chr3_+_62356578 0.86 ENSDART00000157030
IQ motif containing K
chr15_+_2421432 0.85 ENSDART00000193772
hephaestin-like 1a
chr4_+_12013642 0.84 ENSDART00000067281
cryptochrome circadian clock 1aa
chr3_-_29977495 0.82 ENSDART00000077111
hydroxysteroid (17-beta) dehydrogenase 14
chr14_-_33872092 0.81 ENSDART00000111903
si:ch73-335m24.2
chr7_-_24236364 0.81 ENSDART00000010124
solute carrier family 7 (amino acid transporter light chain, L system), member 8a
chr10_+_428269 0.81 ENSDART00000140715
zinc finger, DHHC-type containing 8a
chr5_-_34609337 0.80 ENSDART00000145792
hexosaminidase B (beta polypeptide)
chr19_-_10043142 0.79 ENSDART00000193016
glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a
chr25_+_13191615 0.78 ENSDART00000168849
si:ch211-147m6.2
chr25_+_23777469 0.76 ENSDART00000067179
mitochondrial ribosomal protein L23
chr25_+_17871089 0.73 ENSDART00000133725
BTB (POZ) domain containing 10a
chr18_+_50089000 0.73 ENSDART00000058936
secretory carrier membrane protein 5b
chr12_+_14214755 0.73 ENSDART00000078052
mitochondrial tRNA translation optimization 1
chr25_+_17870799 0.72 ENSDART00000136797
BTB (POZ) domain containing 10a
chr1_-_25679339 0.72 ENSDART00000161703
ENSDART00000054230
fibrinogen gamma chain
chr12_+_20336070 0.71 ENSDART00000066385
zgc:163057
chr2_+_10134345 0.70 ENSDART00000100725
alpha-2-HS-glycoprotein 2
chr19_-_32600638 0.68 ENSDART00000143497
zgc:91944
chr5_+_22459087 0.68 ENSDART00000134781

chr2_-_22575851 0.68 ENSDART00000182932

chr20_+_218886 0.67 ENSDART00000002661
laminin, alpha 4
chr19_+_177455 0.67 ENSDART00000111580
transmembrane protein 65
chr3_+_52473670 0.67 ENSDART00000154310
si:ch211-191c10.3
chr12_+_16967715 0.67 ENSDART00000138174
solute carrier family 16, member 12b
chr5_-_27867657 0.66 ENSDART00000112495
transcriptional and immune response regulator a
chr16_+_16969060 0.64 ENSDART00000182819
ENSDART00000191876
si:ch211-120k19.1
ribosomal protein L18
chr22_-_13857729 0.62 ENSDART00000177971
S100 calcium binding protein, beta (neural)
chr10_+_42691210 0.61 ENSDART00000193813
Rho-related BTB domain containing 2b
chr16_-_45001842 0.60 ENSDART00000037797
sulfotransferase family 2, cytosolic sulfotransferase 3
chr10_-_22803740 0.60 ENSDART00000079469
ENSDART00000187968
ENSDART00000122543
procollagen C-endopeptidase enhancer a
chr7_-_38183331 0.59 ENSDART00000149382
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
chr11_-_36263886 0.58 ENSDART00000140397
nuclear transcription factor Y, alpha
chr6_-_9630081 0.58 ENSDART00000013066
excision repair cross-complementation group 3
chr19_+_56351 0.58 ENSDART00000168334
collagen, type XIV, alpha 1b
chr7_-_52842007 0.57 ENSDART00000182710
microtubule-associated protein 1Aa
chr17_-_25563847 0.55 ENSDART00000040032
reticulon 4 interacting protein 1
chr14_-_29799993 0.55 ENSDART00000133775
ENSDART00000005568
PDZ and LIM domain 3b
chr9_-_10778615 0.52 ENSDART00000182577

chr4_-_11737939 0.51 ENSDART00000150299
podocalyxin-like
chr25_+_4541211 0.51 ENSDART00000129978
patatin-like phospholipase domain containing 2
chr25_-_18125769 0.50 ENSDART00000140484
kit ligand a
chr22_+_34694217 0.50 ENSDART00000111793
hydroxylysine kinase, tandem duplicate 1
chr5_+_38276582 0.50 ENSDART00000158532
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr18_+_33762090 0.49 ENSDART00000147605
si:dkey-145c18.4
chrM_+_11299 0.49 ENSDART00000093618
NADH dehydrogenase 4, mitochondrial
chr4_-_76370630 0.49 ENSDART00000168831
ENSDART00000174313
si:ch73-158p21.3
chr10_+_2899108 0.48 ENSDART00000147031
endoplasmic reticulum aminopeptidase 1a
chr20_+_17581881 0.48 ENSDART00000182832
cadherin 2, type 1, N-cadherin (neuronal)
chr22_+_39058269 0.48 ENSDART00000113362
inositol hexakisphosphate kinase 1
chr1_+_23783349 0.48 ENSDART00000007531
slit homolog 2 (Drosophila)
chr14_-_31856819 0.47 ENSDART00000003345
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr16_+_5901835 0.46 ENSDART00000060519
unc-51 like kinase 4
chr7_-_24995631 0.46 ENSDART00000173955
ENSDART00000173791
REST corepressor 2
chr8_-_15991801 0.46 ENSDART00000132005
ATP/GTP binding protein-like 4
chr18_+_18879733 0.45 ENSDART00000019581
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)
chr6_-_43677125 0.45 ENSDART00000150128
forkhead box P1b
chr9_-_28616436 0.45 ENSDART00000136985
si:ch73-7i4.2
chr14_-_17588345 0.44 ENSDART00000143486
selenoprotein T, 2
chr14_+_35383267 0.44 ENSDART00000143818
clathrin interactor 1a
chr4_-_43388943 0.43 ENSDART00000150796
si:dkey-29j8.2
chr17_+_41302660 0.42 ENSDART00000059480
fos-like antigen 2
chr19_+_2896188 0.42 ENSDART00000151421
si:ch211-251g8.5
chr25_+_13191391 0.42 ENSDART00000109937
si:ch211-147m6.2
chr8_-_44015210 0.40 ENSDART00000186879
ENSDART00000188965
ENSDART00000001313
ENSDART00000188902
ENSDART00000185935
ENSDART00000147869
RIMS binding protein 2
RIMS binding protein 2
chr15_+_2421729 0.40 ENSDART00000082294
ENSDART00000156428
hephaestin-like 1a
chr15_-_23699737 0.39 ENSDART00000078311
zgc:154093
chr24_-_21498802 0.39 ENSDART00000181235
ENSDART00000153695
ATPase phospholipid transporting 8A2
chr12_-_30359031 0.38 ENSDART00000192628
tudor domain containing 1
chr24_-_1021318 0.38 ENSDART00000181403
v-ral simian leukemia viral oncogene homolog Aa (ras related)
chr12_+_48581588 0.38 ENSDART00000114996

chr5_+_64856666 0.38 ENSDART00000050863
zgc:101858
chr25_+_27923846 0.37 ENSDART00000047007
solute carrier family 13 member 1
chr25_+_23591990 0.37 ENSDART00000151938
ENSDART00000089199
carnitine palmitoyltransferase 1Ab (liver)
chr24_-_22702017 0.35 ENSDART00000179403
catenin (cadherin-associated protein), delta 2a
chr5_+_39875646 0.35 ENSDART00000097608
si:ch73-138i16.1
chr11_-_18799827 0.34 ENSDART00000185438
ENSDART00000189116
ENSDART00000180504
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr1_+_54687616 0.34 ENSDART00000146677
lysine-rich nucleolar protein 1
chr8_+_20956078 0.34 ENSDART00000136397
si:dkeyp-82a1.2
chr17_-_31058664 0.33 ENSDART00000126414
echinoderm microtubule associated protein like 1
chr1_-_30689004 0.33 ENSDART00000018827
dachshund c
chr14_+_8715527 0.31 ENSDART00000170754
potassium channel, subfamily K, member 4a
chr5_+_45921234 0.30 ENSDART00000134355
ankyrin repeat and death domain containing 1B
chr5_+_29160132 0.30 ENSDART00000088827
dipeptidyl-peptidase 7
chr22_+_26798853 0.30 ENSDART00000087576
ENSDART00000179780
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
chr20_+_37661229 0.28 ENSDART00000138539
androgen-induced 1 (H. sapiens)
chr19_-_35400819 0.26 ENSDART00000148080
ring finger protein 19B
chr10_-_373575 0.26 ENSDART00000114487
DM1 protein kinase
chr3_+_14768364 0.26 ENSDART00000090235
ENSDART00000139001
nuclear factor I/Xb
chr24_+_17345521 0.26 ENSDART00000024722
ENSDART00000154250
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr6_-_48087152 0.26 ENSDART00000180614
solute carrier family 2 (facilitated glucose transporter), member 1b
chr10_+_7563755 0.25 ENSDART00000165877
purine-rich element binding protein G
chr14_-_25309058 0.23 ENSDART00000159569
5-hydroxytryptamine receptor 4
chr14_-_33872616 0.23 ENSDART00000162840
si:ch73-335m24.2
chr8_-_53108207 0.23 ENSDART00000111023
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
chr22_+_24389135 0.23 ENSDART00000157861
prolyl 3-hydroxylase 2
chr7_+_24069421 0.22 ENSDART00000034218
apoptotic chromatin condensation inducer 1b
chr21_+_261490 0.21 ENSDART00000177919
Janus kinase 2a
chr19_+_37701450 0.21 ENSDART00000087694
thrombospondin, type I, domain containing 7Aa
chr11_-_26040594 0.21 ENSDART00000144115
kazrin, periplakin interacting protein b
chr22_-_4878012 0.21 ENSDART00000110947
ENSDART00000147431
si:ch73-256j6.5
chr13_-_31866276 0.20 ENSDART00000140164
synaptotagmin XIVa
chr14_+_22297257 0.20 ENSDART00000113676
ATPase phospholipid transporting 10B
chr6_+_27624023 0.20 ENSDART00000147789
solute carrier organic anion transporter family, member 2A1
chr10_+_25369859 0.19 ENSDART00000047541
BTB and CNC homology 1, basic leucine zipper transcription factor 1 b
chr20_+_49081967 0.19 ENSDART00000112689
crooked neck pre-mRNA splicing factor 1
chr8_+_23245596 0.19 ENSDART00000143313
si:ch211-196c10.11
chr17_-_37054959 0.19 ENSDART00000151921
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr14_-_11529311 0.19 ENSDART00000127208
si:ch211-153b23.7
chr9_-_23944470 0.18 ENSDART00000138754
collagen, type VI, alpha 3
chr12_+_18542954 0.17 ENSDART00000178845
ENSDART00000185149
ENSDART00000012743
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr4_-_18454591 0.17 ENSDART00000185200
SCO2 cytochrome c oxidase assembly protein
chr11_+_77526 0.17 ENSDART00000193521

chr21_+_29179887 0.16 ENSDART00000161941
si:ch211-57b15.1
chr4_+_29967255 0.15 ENSDART00000150383
zinc finger protein 1128
chr2_+_30916188 0.14 ENSDART00000137012
myomesin 1a (skelemin)
chr23_-_46040618 0.13 ENSDART00000161415

chr21_+_5589923 0.13 ENSDART00000160885
starch binding domain 1
chr6_+_9155271 0.12 ENSDART00000168727
zgc:64065
chr20_+_33744065 0.12 ENSDART00000015000
HEN methyltransferase 1
chr21_-_1012269 0.11 ENSDART00000159835

chr10_+_7564106 0.10 ENSDART00000159042
purine-rich element binding protein G
chr8_-_48674930 0.09 ENSDART00000165905
Pim proto-oncogene, serine/threonine kinase, related 183
chr4_+_37406676 0.09 ENSDART00000130981
si:ch73-134f24.1
chr2_+_23222939 0.09 ENSDART00000026800
kinesin-associated protein 3b
chr17_-_45155181 0.08 ENSDART00000185274
transmembrane p24 trafficking protein 8
chr24_+_37410403 0.08 ENSDART00000186282
si:ch211-183d21.1
chr5_+_51079504 0.08 ENSDART00000097466
family with sequence similarity 169, member Aa
chr7_+_23457803 0.08 ENSDART00000024191
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1
chr1_-_40914752 0.07 ENSDART00000113087
H6 family homeobox 1
chr1_+_41609676 0.07 ENSDART00000183675
mannosyl-oligosaccharide glucosidase
chr3_-_1859198 0.07 ENSDART00000121870
MICAL like 1b, duplicate 2
chr5_+_69716458 0.06 ENSDART00000159594
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr8_+_25295160 0.06 ENSDART00000049793
glutathione S-transferase mu, tandem duplicate 1
chr12_+_18543783 0.06 ENSDART00000148326
ENSDART00000134530
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr16_+_13822137 0.06 ENSDART00000163251
folliculin
chr14_+_9583588 0.06 ENSDART00000164101
transmembrane protein 129, E3 ubiquitin protein ligase
chr20_-_27864964 0.05 ENSDART00000153311
synapse differentiation inducing 1-like
chr1_-_22512063 0.05 ENSDART00000031546
ENSDART00000190987
cholinergic receptor, nicotinic, alpha 6
chr23_-_10831995 0.05 ENSDART00000142533
PDZ domain containing RING finger 3a
chr17_-_31058900 0.04 ENSDART00000134998
ENSDART00000104307
ENSDART00000172721
echinoderm microtubule associated protein like 1
chr9_-_6208067 0.04 ENSDART00000032368
teleost multiple tissue opsin 2b
chr22_-_4880603 0.04 ENSDART00000134055
si:ch73-256j6.5
chr8_-_3336273 0.04 ENSDART00000081160
zgc:173737

Network of associatons between targets according to the STRING database.

First level regulatory network of VDR+nr1i2_vdrb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.3 1.6 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.3 1.6 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.2 2.0 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.2 0.7 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.2 3.4 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.2 0.9 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.2 0.7 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.2 0.5 GO:0033632 cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.2 0.5 GO:0090248 hindbrain structural organization(GO:0021577) dorsal fin morphogenesis(GO:0035142) cell motility involved in somitogenic axis elongation(GO:0090247) cell migration involved in somitogenic axis elongation(GO:0090248)
0.2 0.5 GO:0007414 axonal defasciculation(GO:0007414)
0.1 1.0 GO:0030262 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.1 0.5 GO:0010898 regulation of triglyceride catabolic process(GO:0010896) positive regulation of triglyceride catabolic process(GO:0010898)
0.1 0.5 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.1 1.2 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 1.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 1.3 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 0.8 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.6 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.1 1.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.3 GO:0061010 gall bladder development(GO:0061010)
0.1 3.5 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 1.4 GO:0006825 copper ion transport(GO:0006825)
0.1 3.3 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.1 24.4 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 0.4 GO:2000725 regulation of cardiocyte differentiation(GO:1905207) regulation of cardiac muscle cell differentiation(GO:2000725)
0.1 1.0 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.7 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.5 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.3 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.0 0.9 GO:0032438 melanosome organization(GO:0032438)
0.0 0.8 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 1.0 GO:0001757 somite specification(GO:0001757)
0.0 0.4 GO:0043046 DNA methylation involved in gamete generation(GO:0043046)
0.0 0.7 GO:0016203 muscle attachment(GO:0016203)
0.0 0.4 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 0.4 GO:0036368 cone photoresponse recovery(GO:0036368)
0.0 0.7 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:0045682 regulation of epidermis development(GO:0045682)
0.0 1.3 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.6 GO:1901654 response to ketone(GO:1901654)
0.0 0.6 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.5 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.1 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.6 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.2 GO:0071715 icosanoid transport(GO:0071715) fatty acid derivative transport(GO:1901571)
0.0 0.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.6 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.4 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.2 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.6 GO:0050773 regulation of dendrite development(GO:0050773)
0.0 0.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.8 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.4 GO:0008272 sulfate transport(GO:0008272)
0.0 0.7 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 2.3 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.4 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.2 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.2 GO:1904894 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.2 0.7 GO:0005577 fibrinogen complex(GO:0005577)
0.1 3.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.2 GO:0030904 retromer complex(GO:0030904)
0.1 1.6 GO:0005903 brush border(GO:0005903)
0.1 1.3 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.5 GO:0031464 inclusion body(GO:0016234) Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 0.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 2.0 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 0.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.3 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.0 0.4 GO:0071546 pi-body(GO:0071546)
0.0 1.0 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.5 GO:0014704 intercalated disc(GO:0014704)
0.0 0.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 4.1 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.7 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 3.3 GO:0005925 focal adhesion(GO:0005925)
0.0 0.2 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.4 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.5 3.4 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.4 1.6 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.3 3.0 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.3 1.6 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.2 0.6 GO:0044548 S100 protein binding(GO:0044548)
0.1 0.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 5.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 1.3 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 0.8 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.5 GO:0019202 amino acid kinase activity(GO:0019202)
0.1 0.7 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.1 0.9 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.7 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.2 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.1 0.5 GO:0048039 ubiquinone binding(GO:0048039)
0.1 0.8 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 0.4 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.3 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.4 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.4 GO:0034584 piRNA binding(GO:0034584)
0.0 0.8 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 1.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.1 GO:2001070 starch binding(GO:2001070)
0.0 0.5 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.5 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)
0.0 0.5 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 24.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.6 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.4 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 2.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.2 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 2.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0022842 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 0.4 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.0 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID NCADHERIN PATHWAY N-cadherin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.2 1.0 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 0.9 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.1 0.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 0.8 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 0.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.6 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions