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PRJNA207719: Tissue specific transcriptome profiling
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Results for zic2a+zic2b
Z-value: 2.05
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Transcription factors associated with zic2a+zic2b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000015554 | zic family member 2 (odd-paired homolog, Drosophila), a | |
| ENSDARG00000037178 | zic family member 2 (odd-paired homolog, Drosophila) b | |
| ENSDARG00000112354 | zic family member 2 (odd-paired homolog, Drosophila) b |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zic2a | dr11_v1_chr9_+_31282161_31282161 | 0.88 | 4.9e-02 | Click! |
| zic2b | dr11_v1_chr1_+_29858032_29858032 | 0.79 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_83873 Show fit | 7.95 |
ENSDART00000162145
|
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
|
| chr12_+_47162456 Show fit | 2.60 |
ENSDART00000186272
ENSDART00000180811 |
ryanodine receptor 2 |
|
| chr19_+_23982466 Show fit | 2.53 |
ENSDART00000080673
|
synaptotagmin XIa |
|
| chr12_+_47162761 Show fit | 2.47 |
ENSDART00000192339
ENSDART00000167726 |
ryanodine receptor 2 |
|
| chr8_+_31119548 Show fit | 2.35 |
ENSDART00000136578
|
synapsin I |
|
| chr20_-_915234 Show fit | 1.82 |
ENSDART00000164816
|
cannabinoid receptor 1 |
|
| chr11_+_14147913 Show fit | 1.77 |
ENSDART00000022823
ENSDART00000154329 |
phospholipid phosphatase related 3b |
|
| chr3_-_30118856 Show fit | 1.70 |
ENSDART00000109953
|
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 |
|
| chr15_+_29085955 Show fit | 1.70 |
ENSDART00000156799
|
si:ch211-137a8.4 |
|
| chr6_+_36942966 Show fit | 1.66 |
ENSDART00000028895
|
neuronal growth regulator 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of zic2a+zic2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0099643 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
| 0.0 | 3.5 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.1 | 3.3 | GO:0014059 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.3 | 2.2 | GO:0038171 | cannabinoid signaling pathway(GO:0038171) |
| 0.0 | 1.8 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 0.0 | 1.6 | GO:0051017 | actin filament bundle assembly(GO:0051017) |
| 0.3 | 1.5 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.1 | 1.4 | GO:0060079 | excitatory postsynaptic potential(GO:0060079) |
| 0.0 | 1.4 | GO:0006171 | cAMP biosynthetic process(GO:0006171) |
| 0.0 | 1.4 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.2 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 2.8 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 2.3 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 1.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 1.6 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 1.5 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 1.5 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.1 | 1.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 1.4 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.1 | 1.3 | GO:0098982 | GABA-ergic synapse(GO:0098982) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.4 | 2.6 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 2.5 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.5 | 1.8 | GO:0004949 | cannabinoid receptor activity(GO:0004949) |
| 0.1 | 1.8 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.2 | 1.6 | GO:0008515 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157) |
| 0.1 | 1.5 | GO:0022851 | benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851) |
| 0.1 | 1.4 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 1.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 1.3 | GO:0098882 | structural constituent of presynaptic active zone(GO:0098882) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.9 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 2.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.6 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 1.4 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 1.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.8 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.8 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.4 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 2.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.5 | 2.3 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.1 | 1.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 1.4 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.2 | 1.1 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 1.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.9 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.0 | 0.8 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 0.6 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |