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PRJNA207719: Tissue specific transcriptome profiling
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Results for vsx2
Z-value: 1.45
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Transcription factors associated with vsx2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| vsx2 | dr11_v1_chr17_-_31659670_31659670 | 0.82 | 8.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr23_+_28731379 Show fit | 2.47 |
ENSDART00000047378
|
cortistatin |
|
| chr4_+_21129752 Show fit | 2.30 |
ENSDART00000169764
|
synaptotagmin Ia |
|
| chr3_-_46817499 Show fit | 2.25 |
ENSDART00000013717
|
ELAV like neuron-specific RNA binding protein 3 |
|
| chr15_-_16098531 Show fit | 1.94 |
ENSDART00000080377
|
aldolase C, fructose-bisphosphate, a |
|
| chr16_+_46111849 Show fit | 1.76 |
ENSDART00000172232
|
synaptic vesicle glycoprotein 2A |
|
| chr20_+_35382482 Show fit | 1.48 |
ENSDART00000135284
|
visinin-like 1a |
|
| chr21_-_27185915 Show fit | 1.42 |
ENSDART00000135052
|
solute carrier family 8 (sodium/calcium exchanger), member 4a |
|
| chr18_-_1185772 Show fit | 1.42 |
ENSDART00000143245
|
neuroplastin b |
|
| chr5_-_16996482 Show fit | 1.40 |
ENSDART00000144501
|
polypeptide N-acetylgalactosaminyltransferase 9 |
|
| chr21_+_28958471 Show fit | 1.38 |
ENSDART00000144331
ENSDART00000005929 |
protein phosphatase 3, catalytic subunit, alpha isozyme |
Network of associatons between targets according to the STRING database.
First level regulatory network of vsx2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.2 | 1.9 | GO:0061588 | calcium activated phospholipid scrambling(GO:0061588) |
| 0.1 | 1.9 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.0 | 1.8 | GO:0006836 | neurotransmitter transport(GO:0006836) |
| 0.1 | 1.4 | GO:0042044 | fluid transport(GO:0042044) |
| 0.1 | 1.4 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.0 | 1.4 | GO:0070593 | dendrite self-avoidance(GO:0070593) |
| 0.2 | 1.2 | GO:0071881 | adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881) |
| 0.0 | 1.1 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 1.0 | GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway(GO:0060158) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.3 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.0 | 1.8 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.3 | 1.4 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.2 | 1.4 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 1.4 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.1 | 1.0 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 0.9 | GO:0033181 | plasma membrane proton-transporting V-type ATPase complex(GO:0033181) |
| 0.0 | 0.9 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.0 | 0.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.7 | GO:0032591 | dendritic spine membrane(GO:0032591) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 2.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 2.3 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.2 | 1.9 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.2 | 1.4 | GO:0033192 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.1 | 1.4 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.1 | 1.4 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.0 | 1.4 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
| 0.2 | 1.2 | GO:0004938 | alpha2-adrenergic receptor activity(GO:0004938) |
| 0.2 | 1.0 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.4 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 1.4 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.7 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.4 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.0 | 0.2 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |