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PRJNA207719: Tissue specific transcriptome profiling
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Results for tgif1
Z-value: 2.77
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Transcription factors associated with tgif1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tgif1 | dr11_v1_chr24_-_9300160_9300160 | 0.42 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_36378494 Show fit | 2.41 |
ENSDART00000058503
|
glycoprotein M6Aa |
|
| chr15_-_4415917 Show fit | 2.01 |
ENSDART00000062874
|
ATPase Na+/K+ transporting subunit beta 3b |
|
| chr4_-_815871 Show fit | 1.77 |
ENSDART00000067455
|
dihydropyrimidinase-like 5b |
|
| chr20_+_34933183 Show fit | 1.74 |
ENSDART00000062738
|
synaptosomal-associated protein, 25a |
|
| chr19_+_43439457 Show fit | 1.62 |
ENSDART00000151571
|
AT hook, DNA binding motif, containing 1 |
|
| chr11_+_1796426 Show fit | 1.54 |
ENSDART00000173330
|
low density lipoprotein receptor-related protein 1Aa |
|
| chr1_-_12278056 Show fit | 1.51 |
ENSDART00000139336
ENSDART00000137463 |
complexin 2, like |
|
| chr16_-_19890303 Show fit | 1.47 |
ENSDART00000147161
ENSDART00000079159 |
histone deacetylase 9b |
|
| chr11_-_1131569 Show fit | 1.44 |
ENSDART00000173228
|
solute carrier family 6 (neurotransmitter transporter), member 11b |
|
| chr2_-_44283554 Show fit | 1.44 |
ENSDART00000184684
|
myelin protein zero |
Network of associatons between targets according to the STRING database.
First level regulatory network of tgif1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | GO:0006821 | chloride transport(GO:0006821) |
| 0.2 | 4.9 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.0 | 4.4 | GO:0071805 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 2.7 | GO:1901342 | regulation of vasculature development(GO:1901342) |
| 0.9 | 2.6 | GO:0018315 | establishment of synaptic specificity at neuromuscular junction(GO:0007529) molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579) |
| 0.1 | 2.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 2.3 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
| 0.1 | 2.2 | GO:0060319 | primitive erythrocyte differentiation(GO:0060319) |
| 0.0 | 2.2 | GO:0006073 | glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042) |
| 0.0 | 2.1 | GO:0019722 | calcium-mediated signaling(GO:0019722) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.5 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 7.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 4.5 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.0 | 4.0 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.1 | 3.6 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.3 | 3.1 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) |
| 0.0 | 3.0 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 2.6 | GO:0016342 | catenin complex(GO:0016342) |
| 0.2 | 2.4 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.3 | 2.3 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 4.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 3.8 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 3.4 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 3.0 | GO:0019900 | kinase binding(GO:0019900) |
| 0.1 | 2.9 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.9 | 2.6 | GO:0061598 | molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599) |
| 0.0 | 2.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.3 | 2.5 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.4 | 2.2 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 1.6 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 1.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.3 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.1 | 1.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 0.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 0.8 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.8 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 2.3 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 1.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 1.4 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.1 | 1.1 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.1 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 1.1 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.0 | 1.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |