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PRJNA207719: Tissue specific transcriptome profiling
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Results for tfap4
Z-value: 1.75
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Transcription factors associated with tfap4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tfap4 | dr11_v1_chr3_-_12227359_12227359 | 0.43 | 4.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_-_4482449 Show fit | 1.74 |
ENSDART00000056278
ENSDART00000149425 |
solute carrier family 25 member 22a |
|
| chr13_+_36764715 Show fit | 1.49 |
ENSDART00000111832
ENSDART00000085230 |
atlastin GTPase 1 |
|
| chr23_+_35714574 Show fit | 1.29 |
ENSDART00000164616
|
tubulin, alpha 1c |
|
| chr5_+_71999996 Show fit | 1.22 |
ENSDART00000179933
ENSDART00000187070 |
phospholipid phosphatase 7 (inactive) |
|
| chr21_-_43952958 Show fit | 1.17 |
ENSDART00000039571
|
calcium/calmodulin-dependent protein kinase II alpha |
|
| chr15_+_40188076 Show fit | 1.08 |
ENSDART00000063779
|
EF-hand domain family, member D1 |
|
| chr1_-_14233815 Show fit | 1.07 |
ENSDART00000044896
|
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2 |
|
| chr20_-_29864390 Show fit | 1.06 |
ENSDART00000161834
ENSDART00000132278 |
ring finger protein 144ab |
|
| chr1_+_25801648 Show fit | 1.03 |
ENSDART00000129471
|
guanylate cyclase 1 soluble subunit beta 1 |
|
| chr20_+_35382482 Show fit | 1.03 |
ENSDART00000135284
|
visinin-like 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of tfap4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.7 | GO:1903964 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 0.2 | 1.7 | GO:0015800 | acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490) |
| 0.1 | 1.6 | GO:0048263 | determination of dorsal identity(GO:0048263) |
| 0.0 | 1.6 | GO:0099515 | vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515) |
| 0.2 | 1.5 | GO:0060036 | notochord cell vacuolation(GO:0060036) |
| 0.0 | 1.5 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.0 | 1.2 | GO:0032012 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 1.1 | GO:0010996 | response to auditory stimulus(GO:0010996) |
| 0.0 | 1.1 | GO:1901800 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800) |
| 0.0 | 1.1 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0005912 | adherens junction(GO:0005912) |
| 0.0 | 2.6 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 1.7 | GO:0043197 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.0 | 1.3 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 1.1 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 1.1 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 1.0 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 1.0 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) |
| 0.1 | 0.9 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.1 | 0.9 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.2 | 2.7 | GO:0015172 | L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172) |
| 0.1 | 2.7 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.4 | 1.7 | GO:0032896 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896) |
| 0.0 | 1.6 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 1.6 | GO:0101005 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 1.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 1.4 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 1.4 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 1.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.0 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.9 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 0.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.7 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 0.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.5 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.4 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.4 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.4 | 1.2 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 0.9 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 0.9 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 0.8 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 0.7 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.1 | 0.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 0.7 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.7 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.7 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |