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PRJNA207719: Tissue specific transcriptome profiling

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Results for tfap2e

Z-value: 0.63

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Transcription factors associated with tfap2e

Gene Symbol Gene ID Gene Info
tfap2e
ENSDARG00000008861 transcription factor AP-2 epsilon

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
tfap2edr11_v1_chr19_-_47452874_474528741.002.3e-04Click!

Activity profile of tfap2e motif

Sorted Z-values of tfap2e motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_16098531 1.15 ENSDART00000080377
aldoca
aldolase C, fructose-bisphosphate, a
chr19_-_9472893 1.08 ENSDART00000045565
ENSDART00000137505
vamp1
vesicle-associated membrane protein 1
chr23_+_37323962 0.86 ENSDART00000102881
fam43b
family with sequence similarity 43, member B
chr7_-_23563092 0.80 ENSDART00000132275
gpr185b
G protein-coupled receptor 185 b
chr9_+_32358514 0.65 ENSDART00000144608
plcl1
phospholipase C like 1
chr2_+_24199276 0.62 ENSDART00000140575
map4l
microtubule associated protein 4 like
chr24_-_6898302 0.60 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr10_-_2526526 0.59 ENSDART00000191726
ENSDART00000192767
CU856539.1

chr15_-_44512461 0.59 ENSDART00000155456
gria4a
glutamate receptor, ionotropic, AMPA 4a
chr2_+_27010439 0.55 ENSDART00000030547
cdh7a
cadherin 7a
chr16_-_29458806 0.55 ENSDART00000047931
lingo4b
leucine rich repeat and Ig domain containing 4b
chr16_+_45571956 0.48 ENSDART00000143867
syngap1b
synaptic Ras GTPase activating protein 1b
chr6_-_10320676 0.45 ENSDART00000151247
scn1lab
sodium channel, voltage-gated, type I like, alpha b
chr21_-_21089781 0.45 ENSDART00000144361
ank1b
ankyrin 1, erythrocytic b
chr19_+_1184878 0.44 ENSDART00000163539
scrt1a
scratch family zinc finger 1a
chr7_-_51476276 0.41 ENSDART00000082464
nhsl2
NHS-like 2
chr14_+_29609245 0.38 ENSDART00000043058
TENM2
si:dkey-34l15.2
chr19_-_10395683 0.37 ENSDART00000109488
zgc:194578
zgc:194578
chr2_+_24199073 0.36 ENSDART00000144110
map4l
microtubule associated protein 4 like
chr19_+_32979331 0.36 ENSDART00000078066
spire1a
spire-type actin nucleation factor 1a
chr16_+_36906693 0.35 ENSDART00000160645
si:ch73-215d9.1
si:ch73-215d9.1
chr16_-_17162485 0.35 ENSDART00000123011
iffo1b
intermediate filament family orphan 1b
chr12_+_19036380 0.35 ENSDART00000153086
ENSDART00000181060
kctd17
potassium channel tetramerization domain containing 17
chr7_+_39011852 0.34 ENSDART00000093009
dgkza
diacylglycerol kinase, zeta a
chr11_+_30253968 0.34 ENSDART00000157272
ENSDART00000003475
ppef1
protein phosphatase, EF-hand calcium binding domain 1
chr18_+_34478959 0.33 ENSDART00000059394
kcnab1a
potassium voltage-gated channel, shaker-related subfamily, beta member 1 a
chr19_-_31707892 0.32 ENSDART00000088427
ripor2
RHO family interacting cell polarization regulator 2
chr14_-_31465905 0.32 ENSDART00000173108
gpc3
glypican 3
chr11_+_1657221 0.30 ENSDART00000164394
lrp1aa
low density lipoprotein receptor-related protein 1Aa
chr23_+_2760573 0.30 ENSDART00000129719
top1
DNA topoisomerase I
chr19_+_47311869 0.29 ENSDART00000136647
ext1c
exostoses (multiple) 1c
chr11_+_13067028 0.29 ENSDART00000186126
zfyve9b
zinc finger, FYVE domain containing 9b
chr2_-_15041846 0.28 ENSDART00000139050
si:dkey-10f21.4
si:dkey-10f21.4
chr5_+_27267186 0.27 ENSDART00000182238
ENSDART00000087857
unc5db
unc-5 netrin receptor Db
chr10_+_36029537 0.27 ENSDART00000165386
hmgb1a
high mobility group box 1a
chr23_-_35347714 0.25 ENSDART00000161770
ENSDART00000165615
cpne9
copine family member IX
chr9_+_32978302 0.25 ENSDART00000007630
nhlh2
nescient helix loop helix 2
chr22_+_110158 0.24 ENSDART00000143698
prkar2ab
protein kinase, cAMP-dependent, regulatory, type II, alpha, B
chr23_-_18668836 0.22 ENSDART00000138792
ENSDART00000051182
arhgap4b
Rho GTPase activating protein 4b
chr19_-_27462720 0.21 ENSDART00000135901
si:ch73-25f10.6
si:ch73-25f10.6
chr19_-_30510930 0.21 ENSDART00000088760
ENSDART00000181043
bag6l
BCL2 associated athanogene 6, like
chr13_+_16342926 0.21 ENSDART00000105496
ENSDART00000124710
dlg5a
discs, large homolog 5a (Drosophila)
chr11_-_26180714 0.18 ENSDART00000173597
kaznb
kazrin, periplakin interacting protein b
chr21_-_39577517 0.17 ENSDART00000143566
srsf1b
serine/arginine-rich splicing factor 1b
chr10_+_5135842 0.16 ENSDART00000132627
ENSDART00000162434
zgc:113274
zgc:113274
chr7_+_39011355 0.15 ENSDART00000173855
dgkza
diacylglycerol kinase, zeta a
chr16_-_39859119 0.13 ENSDART00000138388
rbms3
RNA binding motif, single stranded interacting protein
chr5_+_63302660 0.12 ENSDART00000142131
si:ch73-376l24.2
si:ch73-376l24.2
chr16_-_46393154 0.11 ENSDART00000132154
si:ch73-59c19.1
si:ch73-59c19.1
chr25_+_36405021 0.11 ENSDART00000152801
ankrd27
ankyrin repeat domain 27 (VPS9 domain)
chr23_+_27778670 0.10 ENSDART00000053863
kmt2d
lysine (K)-specific methyltransferase 2D
chr11_+_31323746 0.09 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr5_+_25736979 0.09 ENSDART00000175959
abhd17b
abhydrolase domain containing 17B
chr23_-_9965148 0.09 ENSDART00000137308
plxnb1a
plexin b1a
chr21_+_39941875 0.08 ENSDART00000190414
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr21_+_39941559 0.08 ENSDART00000189718
ENSDART00000160875
ENSDART00000135235
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr20_-_20312789 0.08 ENSDART00000114779
si:ch211-212g7.6
si:ch211-212g7.6
chr22_-_57177 0.08 ENSDART00000163959
CABZ01085139.1

chr21_-_39058490 0.08 ENSDART00000114885
aldh3a2b
aldehyde dehydrogenase 3 family, member A2b
chr8_-_11004726 0.07 ENSDART00000192594
ENSDART00000020116
trim33
tripartite motif containing 33
chr23_-_27647769 0.07 ENSDART00000059974
wnt10b
wingless-type MMTV integration site family, member 10b
chr22_+_1440702 0.06 ENSDART00000165677
si:dkeyp-53d3.3
si:dkeyp-53d3.3
chr8_+_48943009 0.05 ENSDART00000180763
rer1
retention in endoplasmic reticulum sorting receptor 1
chr25_+_258883 0.05 ENSDART00000155256
zgc:92481
zgc:92481
chr18_+_34181655 0.05 ENSDART00000130831
ENSDART00000109535
gmps
guanine monophosphate synthase
chr3_-_54607166 0.04 ENSDART00000021977
dnmt1
DNA (cytosine-5-)-methyltransferase 1
chr2_+_1988036 0.04 ENSDART00000155956
ssx2ipa
synovial sarcoma, X breakpoint 2 interacting protein a
chr2_+_11205795 0.04 ENSDART00000019078
lhx8a
LIM homeobox 8a
chr19_+_10799929 0.04 ENSDART00000159152
lipea
lipase, hormone-sensitive a
chr25_-_19574146 0.04 ENSDART00000156811
si:ch211-59o9.10
si:ch211-59o9.10
chr4_+_26972862 0.04 ENSDART00000011519
ENSDART00000138830
slc6a1l
solute carrier family 6 (neurotransmitter transporter, GABA), member 1, like
chr1_+_16548733 0.03 ENSDART00000048855
mtus1b
microtubule associated tumor suppressor 1b
chr8_+_48942470 0.03 ENSDART00000005464
ENSDART00000132035
rer1
retention in endoplasmic reticulum sorting receptor 1
chr15_+_44929497 0.02 ENSDART00000111373
pdgfd
platelet derived growth factor d
chr1_+_33328857 0.02 ENSDART00000137151
mxra5a
matrix-remodelling associated 5a
chr7_-_33921366 0.02 ENSDART00000052397
pias1a
protein inhibitor of activated STAT, 1a
chr14_+_39258569 0.00 ENSDART00000103298
diaph2
diaphanous-related formin 2
chr21_-_32680638 0.00 ENSDART00000147203
adamts2
ADAM metallopeptidase with thrombospondin type 1 motif, 2

Network of associatons between targets according to the STRING database.

First level regulatory network of tfap2e

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.3 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.1 0.3 GO:2000405 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.1 0.3 GO:1901380 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 1.1 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 0.6 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 1.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.4 GO:0040038 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.0 0.3 GO:0060976 coronary vasculature development(GO:0060976)
0.0 0.6 GO:0060034 notochord cell differentiation(GO:0060034)
0.0 0.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.6 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.0 0.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.2 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.3 GO:0009409 response to cold(GO:0009409)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.1 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060171 stereocilium membrane(GO:0060171)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.1 GO:0031201 SNARE complex(GO:0031201)
0.0 0.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.3 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.4 GO:0030507 spectrin binding(GO:0030507)
0.0 0.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.6 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.0 1.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.5 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.2 GO:0042910 xenobiotic transporter activity(GO:0042910)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters