PRJNA207719: Tissue specific transcriptome profiling


Results for tefa+tefb

Z-value: 1.73

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Transcription factors associated with tefa+tefb

Gene Symbol Gene ID Gene Info
ENSDARG00000039117 TEF transcription factor, PAR bZIP family member a
ENSDARG00000098103 TEF transcription factor, PAR bZIP family member b
ENSDARG00000109532 TEF transcription factor, PAR bZIP family member a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of tefa+tefb motif

Sorted Z-values of tefa+tefb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_15354095 2.70 ENSDART00000090397
KIAA1549-like a
chr1_+_31112436 2.59 ENSDART00000075340
eukaryotic translation elongation factor 1 alpha 1b
chr16_+_39146696 2.25 ENSDART00000121756
syntabulin (syntaxin-interacting)
chr12_-_26383242 2.09 ENSDART00000152941
ubiquitin specific peptidase 54b
chr16_+_34523515 2.09 ENSDART00000041007
stathmin 1b
chr17_-_43466317 2.05 ENSDART00000155313
heat shock protein 4 like
chr4_-_5302866 1.95 ENSDART00000138590
chr16_+_46111849 1.94 ENSDART00000172232
synaptic vesicle glycoprotein 2A
chr3_-_46818001 1.94 ENSDART00000166505
ELAV like neuron-specific RNA binding protein 3
chr17_-_20979077 1.83 ENSDART00000006676
phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr3_-_28665291 1.80 ENSDART00000151670
F-box and leucine-rich repeat protein 16
chr11_-_10770053 1.80 ENSDART00000179213
solute carrier family 4, sodium bicarbonate transporter, member 10a
chr5_-_22001003 1.74 ENSDART00000134393
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr5_-_21970881 1.71 ENSDART00000182907
Cdc42 guanine nucleotide exchange factor (GEF) 9a
chr4_-_5302162 1.64 ENSDART00000177099
chr7_+_38717624 1.63 ENSDART00000132522
synaptotagmin XIII
chr10_-_24371312 1.61 ENSDART00000149362
phosphatidylinositol transfer protein, alpha b
chr2_+_24177190 1.54 ENSDART00000099546
microtubule associated protein 4 like
chr20_+_38201644 1.38 ENSDART00000022694
EH-domain containing 3
chr20_-_45661049 1.36 ENSDART00000124582
N-ethylmaleimide-sensitive factor attachment protein, beta b
chr10_+_33895315 1.36 ENSDART00000142881
furry homolog b (Drosophila)
chr9_+_17862858 1.36 ENSDART00000166566
diacylglycerol kinase, eta
chr20_-_40717900 1.32 ENSDART00000181663
connexin 43
chr5_+_1278092 1.26 ENSDART00000147972
dynamin 1a
chr14_+_34971554 1.26 ENSDART00000184271
ring finger protein 145a
chr25_-_11088839 1.22 ENSDART00000154748
synaptic vesicle glycoprotein 2Bb
chr7_+_38278860 1.13 ENSDART00000016265
low density lipoprotein receptor-related protein 3
chr24_-_39772045 1.12 ENSDART00000087441
chr22_-_11438627 1.09 ENSDART00000007649
MID1 interacting protein 1b
chr9_+_46644633 1.06 ENSDART00000160285
solute carrier family 4 (anion exchanger), member 3
chr7_-_6604623 1.06 ENSDART00000172874
potassium inwardly-rectifying channel, subfamily J, member 10a
chr21_-_32467799 1.04 ENSDART00000007675
chr11_+_6819050 1.00 ENSDART00000104289
RAB3A, member RAS oncogene family, b
chr20_+_1121458 1.00 ENSDART00000064472
proline-rich nuclear receptor coactivator 1
chr1_+_54673846 0.99 ENSDART00000145018
G protein-coupled receptor, class C, group 5, member Bb
chr21_-_42202792 0.99 ENSDART00000124708
gamma-aminobutyric acid (GABA) A receptor, alpha 6b
chr5_+_15350954 0.99 ENSDART00000140990
phosphatidylethanolamine binding protein 1
chr8_+_8712446 0.97 ENSDART00000158674
ELK1, member of ETS oncogene family
chr18_-_39288894 0.92 ENSDART00000186216
mitogen-activated protein kinase 6
chr7_+_17716601 0.91 ENSDART00000173792
reticulon 3
chr16_-_45069882 0.86 ENSDART00000058384
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr14_+_36628131 0.85 ENSDART00000188625
chr3_-_21348478 0.83 ENSDART00000114906
family with sequence similarity 171, member A2a
chr5_-_21030934 0.83 ENSDART00000133461
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
chr21_-_32467099 0.82 ENSDART00000186354
chr19_+_7549854 0.79 ENSDART00000138866
pre-B-cell leukemia homeobox interacting protein 1a
chr25_-_13490744 0.77 ENSDART00000056721
lactate dehydrogenase D
chr7_-_32833153 0.77 ENSDART00000099871
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr20_-_1151265 0.72 ENSDART00000012376
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr18_-_1228688 0.72 ENSDART00000064403
neuroplastin b
chr8_-_29851706 0.67 ENSDART00000149297
solute carrier family 20 (phosphate transporter), member 2
chr20_+_3934516 0.67 ENSDART00000165732
C-type lectin domain containing 11A
chr20_-_44576949 0.65 ENSDART00000148639
UBX domain protein 2A
chr9_+_33788626 0.64 ENSDART00000088469
lysine (K)-specific demethylase 6A
chr24_+_18948665 0.62 ENSDART00000106186
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr10_-_26729930 0.60 ENSDART00000145532
fibroblast growth factor 13b
chr17_+_15845765 0.59 ENSDART00000130881
gamma-aminobutyric acid (GABA) A receptor, rho 2a
chr20_+_23083800 0.59 ENSDART00000132093
ubiquitin specific peptidase 46
chr6_-_29612269 0.52 ENSDART00000104293
peroxisomal biogenesis factor 5-like a
chr9_-_13871935 0.52 ENSDART00000146597
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1a
chr7_+_52761841 0.47 ENSDART00000111444
diphosphoinositol pentakisphosphate kinase 1a
chr15_-_20939579 0.45 ENSDART00000152371
ubiquitin specific peptidase 2a
chr12_-_20584413 0.45 ENSDART00000170923

chr9_-_9225980 0.45 ENSDART00000180301
cystathionine-beta-synthase b
chr14_+_23717165 0.44 ENSDART00000006373
Nedd4 family interacting protein 1
chr22_-_18491813 0.41 ENSDART00000105419
chr21_+_43178831 0.41 ENSDART00000151512
AF4/FMR2 family, member 4
chr7_-_38792543 0.41 ENSDART00000157416
chr17_-_8268406 0.40 ENSDART00000149873
Abelson helper integration site 1
chr7_-_40959667 0.40 ENSDART00000084070
RNA binding motif protein 33a
chr11_-_7078392 0.39 ENSDART00000112156
chr5_+_69808763 0.38 ENSDART00000143482
fibronectin type III and SPRY domain containing 1-like
chr21_-_39566854 0.36 ENSDART00000020174
dynein, light chain, LC8-type 2b
chr9_+_33788389 0.36 ENSDART00000144623
lysine (K)-specific demethylase 6A
chr12_+_36416173 0.35 ENSDART00000190278
unkempt family zinc finger
chr19_-_45650994 0.35 ENSDART00000163504
trichorhinophalangeal syndrome I
chr5_-_65153731 0.34 ENSDART00000171024
SH2 domain containing 3Cb
chr15_+_37559570 0.34 ENSDART00000085522
heat shock protein, alpha-crystallin-related, b6
chr1_+_19764995 0.33 ENSDART00000138276
chr23_-_21763598 0.33 ENSDART00000145408
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr20_-_44496245 0.33 ENSDART00000012229
FK506 binding protein 1b
chr23_+_33963619 0.33 ENSDART00000140666
pyridoxal phosphate binding protein
chr16_-_35427060 0.31 ENSDART00000172294
CTP synthase 1b
chr25_-_16826219 0.30 ENSDART00000191299
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr22_+_15973122 0.28 ENSDART00000144545
ring finger and CCCH-type domains 1a
chr23_+_19590006 0.28 ENSDART00000021231
sarcolemma associated protein b
chr12_+_15002757 0.28 ENSDART00000135036
myosin light chain, phosphorylatable, fast skeletal muscle b
chr23_+_9522781 0.26 ENSDART00000136486
oxysterol binding protein-like 2b
chr15_+_24737599 0.23 ENSDART00000078024
v-crk avian sarcoma virus CT10 oncogene homolog
chr18_-_2549198 0.21 ENSDART00000186516

chr3_-_15144067 0.20 ENSDART00000127738
family with sequence similarity 173, member A
chr17_-_31308658 0.16 ENSDART00000124505
bromo adjacent homology domain containing 1
chr5_-_69437422 0.16 ENSDART00000073676
iron-sulfur cluster assembly 1
chr6_-_14038804 0.15 ENSDART00000184606
ets variant 5b
chr13_+_30035253 0.15 ENSDART00000181303
DnaJ (Hsp40) homolog, subfamily B, member 12a
chr22_-_10605045 0.14 ENSDART00000184812
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr15_+_21882419 0.11 ENSDART00000157216
chr22_+_10606573 0.11 ENSDART00000192638
RAD54 like 2
chr8_+_21225064 0.10 ENSDART00000129210
cryptochrome circadian clock 1ba
chr3_+_24094581 0.09 ENSDART00000138270
coatomer protein complex, subunit zeta 2
chr25_-_18330503 0.09 ENSDART00000104496
dual specificity phosphatase 6
chr10_-_20523405 0.09 ENSDART00000114824
DDHD domain containing 2
chr25_-_12803723 0.07 ENSDART00000158787
carbonic anhydrase Va
chr4_+_21867522 0.07 ENSDART00000140400
acyl-CoA synthetase short chain family member 3
chr14_+_8174828 0.06 ENSDART00000167228
pleckstrin and Sec7 domain containing 2
chr20_-_20270191 0.05 ENSDART00000009356
protein phosphatase 2, regulatory subunit B', epsilon isoform a
chr5_-_54395488 0.04 ENSDART00000160781
zinc finger, MYND-type containing 19
chr10_-_25591194 0.04 ENSDART00000131640
T cell lymphoma invasion and metastasis 1a
chr8_-_37249813 0.03 ENSDART00000098634
RNA binding motif protein 39b
chr20_-_36617313 0.01 ENSDART00000172395
enabled homolog (Drosophila)
chr16_-_54800202 0.01 ENSDART00000059560
KH domain containing 4, pre-mRNA splicing factor

Network of associatons between targets according to the STRING database.

First level regulatory network of tefa+tefb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0060074 synapse maturation(GO:0060074)
0.3 1.4 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.3 1.0 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.3 0.8 GO:0006089 lactate metabolic process(GO:0006089)
0.2 0.7 GO:0045023 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.2 1.1 GO:0036268 swimming(GO:0036268)
0.1 0.4 GO:0050666 regulation of sulfur amino acid metabolic process(GO:0031335) regulation of homocysteine metabolic process(GO:0050666)
0.1 2.9 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.8 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 1.0 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.1 0.8 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 0.3 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.1 1.6 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.1 1.3 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 1.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.5 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.3 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 2.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.6 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.4 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.0 0.2 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.6 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 2.6 GO:0006414 translational elongation(GO:0006414)
0.0 0.4 GO:0044458 motile cilium assembly(GO:0044458)
0.0 1.6 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.5 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 1.4 GO:0032456 endocytic recycling(GO:0032456)
0.0 1.1 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.0 0.7 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 1.6 GO:0015914 phospholipid transport(GO:0015914)
0.0 1.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.7 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 1.1 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
0.0 2.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.3 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.9 GO:0006096 glycolytic process(GO:0006096)
0.0 0.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.4 GO:0031398 positive regulation of protein ubiquitination(GO:0031398) positive regulation of protein modification by small protein conjugation or removal(GO:1903322)
0.0 0.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0007520 myoblast fusion(GO:0007520)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.2 1.0 GO:0070062 extracellular exosome(GO:0070062)
0.1 0.3 GO:0097268 cytoophidium(GO:0097268)
0.1 2.3 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 1.3 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.1 1.4 GO:0060170 ciliary membrane(GO:0060170)
0.1 2.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.0 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.4 GO:0032783 ELL-EAF complex(GO:0032783)
0.1 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 3.2 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 2.0 GO:0030427 site of polarized growth(GO:0030427)
0.0 3.4 GO:0014069 postsynaptic density(GO:0014069)
0.0 2.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.4 GO:0030424 axon(GO:0030424)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.2 1.4 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.2 0.9 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 1.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 1.1 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.1 0.5 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.4 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 2.2 GO:0019894 kinesin binding(GO:0019894)
0.1 1.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 0.8 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.1 0.4 GO:0004122 cystathionine beta-synthase activity(GO:0004122)
0.1 0.4 GO:0050699 WW domain binding(GO:0050699)
0.1 0.3 GO:0003883 CTP synthase activity(GO:0003883)
0.1 1.0 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 1.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 0.5 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.4 GO:0098809 nitrite reductase activity(GO:0098809)
0.1 0.8 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.1 2.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.7 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 1.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.1 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.9 GO:0004707 MAP kinase activity(GO:0004707)
0.0 3.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.7 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.0 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 4.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 4.5 GO:0015631 tubulin binding(GO:0015631)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.0 PID AURORA B PATHWAY Aurora B signaling
0.0 0.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.1 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.2 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.7 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import