ISMARA results: tcf7l1a+tcf7l1b+tcf7l2

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PRJNA207719: Tissue specific transcriptome profiling

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Results for tcf7l1a+tcf7l1b+tcf7l2

Z-value: 2.16

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Transcription factors associated with tcf7l1a+tcf7l1b+tcf7l2

Gene Symbol	Gene ID	Gene Info
tcf7l2 NCBI UniProt	ENSDARG00000004415	transcription factor 7 like 2
tcf7l1b NCBI UniProt	ENSDARG00000007369	transcription factor 7 like 1b
tcf7l1a NCBI UniProt	ENSDARG00000038159	transcription factor 7 like 1a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tcf7l2	dr11_v1_chr12_-_31012741_31012741	0.92	2.8e-02	Click!
tcf7l1b	dr11_v1_chr8_-_52229462_52229462	0.66	2.2e-01	Click!
tcf7l1a	dr11_v1_chr10_-_42237304_42237304	-0.30	6.2e-01	Click!

Activity profile of tcf7l1a+tcf7l1b+tcf7l2 motif

Sorted Z-values of tcf7l1a+tcf7l1b+tcf7l2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_39011514 Show fit	3.31	ENSDART00000075123	pcp4a NCBI UniProt Show fit	Purkinje cell protein 4a
chr25_+_21829777 Show fit	1.94	ENSDART00000027393	ckmt1 NCBI UniProt Show fit	creatine kinase, mitochondrial 1
chr13_+_27073901 Show fit	1.84	ENSDART00000146227	slc24a3 NCBI UniProt Show fit	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr9_+_7548533 Show fit	1.83	ENSDART00000081543	ptprna NCBI UniProt Show fit	protein tyrosine phosphatase, receptor type, Na
chr24_+_11105786 Show fit	1.79	ENSDART00000175182	prlh2 NCBI UniProt Show fit	prolactin releasing hormone 2
chr4_+_69619 Show fit	1.73	ENSDART00000164425	mansc1 NCBI UniProt Show fit	MANSC domain containing 1
chr22_-_21150845 Show fit	1.66	ENSDART00000027345	tmem59l NCBI UniProt Show fit	transmembrane protein 59-like
chr2_-_34483597 Show fit	1.64	ENSDART00000133224	brinp2 NCBI UniProt Show fit	bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr14_+_22172047 Show fit	1.62	ENSDART00000114750 ENSDART00000148259	gabrb2 NCBI UniProt Show fit	gamma-aminobutyric acid (GABA) A receptor, beta 2
chr19_+_31771270 Show fit	1.61	ENSDART00000147474	stmn2b NCBI UniProt Show fit	stathmin 2b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tcf7l1a+tcf7l1b+tcf7l2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.1	GO:0070588	calcium ion transmembrane transport(GO:0070588)
0.0	2.8	GO:0048675	axon extension(GO:0048675)
0.6	2.4	GO:0060074	synapse maturation(GO:0060074)
0.1	2.2	GO:0060079	excitatory postsynaptic potential(GO:0060079) chemical synaptic transmission, postsynaptic(GO:0099565)
0.1	2.2	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2	2.0	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1	1.9	GO:0042396	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1	1.9	GO:0031114	regulation of microtubule depolymerization(GO:0031114)
0.0	1.9	GO:0061512	protein localization to cilium(GO:0061512)
0.3	1.7	GO:0060784	regulation of cell proliferation involved in tissue homeostasis(GO:0060784)

Showing 1 to 10 of 94 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.0	GO:0043025	neuronal cell body(GO:0043025)
0.1	2.4	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.1	2.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	2.2	GO:0030133	transport vesicle(GO:0030133)
0.0	1.9	GO:0030658	transport vesicle membrane(GO:0030658)
0.1	1.6	GO:0034706	voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0	1.6	GO:0030426	growth cone(GO:0030426)
0.0	1.5	GO:0031594	neuromuscular junction(GO:0031594)
0.0	1.5	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	1.3	GO:0044295	axonal growth cone(GO:0044295)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.7	GO:0005516	calmodulin binding(GO:0005516)
0.0	3.8	GO:0042802	identical protein binding(GO:0042802)
0.0	3.0	GO:0005179	hormone activity(GO:0005179)
0.1	2.8	GO:0019894	kinesin binding(GO:0019894)
0.0	2.4	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.1	2.2	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.1	2.1	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1	1.9	GO:0004111	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.2	1.8	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.1	1.7	GO:0008301	DNA binding, bending(GO:0008301)

Showing 1 to 10 of 68 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	2.0	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	2.0	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	1.7	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	1.6	PID NOTCH PATHWAY	Notch signaling pathway
0.0	1.6	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	1.3	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	1.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.0	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	0.8	PID S1P S1P1 PATHWAY	S1P1 pathway

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	2.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	1.9	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	1.6	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	1.6	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	1.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	1.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	1.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	1.1	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.1	1.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression

Showing 1 to 10 of 19 entries

Results for tcf7l1a+tcf7l1b+tcf7l2

Z-value: 2.16

Motif logo

Transcription factors associated with tcf7l1a+tcf7l1b+tcf7l2

Activity-expression correlation:

Activity profile of tcf7l1a+tcf7l1b+tcf7l2 motif

Sorted Z-values of tcf7l1a+tcf7l1b+tcf7l2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tcf7l1a+tcf7l1b+tcf7l2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: