PRJNA207719: Tissue specific transcriptome profiling


Results for tcf7l1a+tcf7l1b+tcf7l2

Z-value: 2.16

Motif logo

Transcription factors associated with tcf7l1a+tcf7l1b+tcf7l2

Gene Symbol Gene ID Gene Info
ENSDARG00000004415 transcription factor 7 like 2
ENSDARG00000007369 transcription factor 7 like 1b
ENSDARG00000038159 transcription factor 7 like 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of tcf7l1a+tcf7l1b+tcf7l2 motif

Sorted Z-values of tcf7l1a+tcf7l1b+tcf7l2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_39011514 3.31 ENSDART00000075123
Purkinje cell protein 4a
chr25_+_21829777 1.94 ENSDART00000027393
creatine kinase, mitochondrial 1
chr13_+_27073901 1.84 ENSDART00000146227
solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
chr9_+_7548533 1.83 ENSDART00000081543
protein tyrosine phosphatase, receptor type, Na
chr24_+_11105786 1.79 ENSDART00000175182
prolactin releasing hormone 2
chr4_+_69619 1.73 ENSDART00000164425
MANSC domain containing 1
chr22_-_21150845 1.66 ENSDART00000027345
transmembrane protein 59-like
chr2_-_34483597 1.64 ENSDART00000133224
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr14_+_22172047 1.62 ENSDART00000114750
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr19_+_31771270 1.61 ENSDART00000147474
stathmin 2b
chr15_-_12545683 1.61 ENSDART00000162807
sodium channel, voltage-gated, type II, beta
chr12_+_40905427 1.61 ENSDART00000170526
cadherin 18
chr20_+_22666548 1.56 ENSDART00000147520
ligand of numb-protein X 1
chr8_+_36803415 1.51 ENSDART00000111680
IQ motif and Sec7 domain 2b
chr17_+_27176243 1.50 ENSDART00000162527
chr1_-_8428736 1.49 ENSDART00000138435
synaptogyrin 3b
chr5_+_44190974 1.48 ENSDART00000182634
chr24_+_32411753 1.48 ENSDART00000058530
neuronal differentiation 6a
chr16_+_32559821 1.46 ENSDART00000093250
POU class 3 homeobox 2b
chr4_+_10366532 1.46 ENSDART00000189901
potassium voltage-gated channel, Shal-related subfamily, member 2
chr1_-_42779075 1.44 ENSDART00000133917
leucine rich repeat transmembrane neuronal 1
chr20_+_41549200 1.42 ENSDART00000135715
family with sequence similarity 184, member A
chr7_+_27977065 1.42 ENSDART00000089574
tubby bipartite transcription factor
chr3_-_19091024 1.41 ENSDART00000188485
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
chr1_-_42778510 1.39 ENSDART00000190172
leucine rich repeat transmembrane neuronal 1
chr11_+_19068442 1.36 ENSDART00000171766
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr21_-_25522906 1.34 ENSDART00000110923
connector enhancer of kinase suppressor of Ras 2b
chr13_-_31441042 1.34 ENSDART00000076571
reticulon 1a
chr25_-_19395476 1.32 ENSDART00000182622
microtubule-associated protein 1Ab
chr23_+_16620801 1.30 ENSDART00000189859
syntaphilin b
chr25_+_7229046 1.29 ENSDART00000149965
leucine rich repeat and Ig domain containing 1a
chr8_+_14778292 1.29 ENSDART00000089971
calcium channel, voltage-dependent, R type, alpha 1E subunit a
chr16_+_39159752 1.28 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr22_+_3045495 1.25 ENSDART00000164061

chr1_+_32528097 1.23 ENSDART00000128317
neuroligin 4a
chr18_-_34143189 1.22 ENSDART00000079341
phospholipase C, eta 1
chr18_+_16330720 1.19 ENSDART00000080638
chr3_-_30861177 1.16 ENSDART00000154811
SH3 and multiple ankyrin repeat domains 1
chr16_+_39146696 1.15 ENSDART00000121756
syntabulin (syntaxin-interacting)
chr23_-_26077038 1.15 ENSDART00000126299
GDP dissociation inhibitor 1
chr18_+_45796096 1.13 ENSDART00000087070
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr20_+_30445971 1.13 ENSDART00000153150
myelin transcription factor 1-like, a
chr17_-_20897250 1.13 ENSDART00000088106
ankyrin 3b
chr15_+_40188076 1.12 ENSDART00000063779
EF-hand domain family, member D1
chr9_-_35155089 1.12 ENSDART00000077901
amyloid beta (A4) precursor protein b
chr3_-_55650771 1.12 ENSDART00000162413
axin 2 (conductin, axil)
chr2_-_30784198 1.12 ENSDART00000182523
regulator of G protein signaling 20
chr1_+_49814461 1.10 ENSDART00000132405
lymphoid enhancer-binding factor 1
chr15_-_10341048 1.09 ENSDART00000171013
teneurin transmembrane protein 4
chr12_+_35203091 1.09 ENSDART00000153022
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2b
chr1_-_29045426 1.05 ENSDART00000019770
glycoprotein M6Ba
chr20_-_40451115 1.04 ENSDART00000075092
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr5_-_18474486 1.03 ENSDART00000090580
chr14_+_22591624 1.03 ENSDART00000108987
GDNF family receptor alpha 4b
chr21_-_37889727 1.03 ENSDART00000163612
gamma-aminobutyric acid (GABA) A receptor, beta 4
chr25_+_26921480 1.03 ENSDART00000155949
glutamate receptor, metabotropic 8b
chr2_-_22230326 1.02 ENSDART00000127810
family with sequence similarity 110, member B
chr21_-_17482465 1.02 ENSDART00000004548
BarH-like homeobox 1b
chr24_-_24848612 1.01 ENSDART00000190941
corticotropin releasing hormone b
chr9_-_37613792 0.98 ENSDART00000138345
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr24_-_32408404 0.98 ENSDART00000144157
chr17_-_8638713 0.98 ENSDART00000148971
C-terminal binding protein 2a
chr5_-_22082918 0.98 ENSDART00000020908
zinc finger, C4H2 domain containing
chr8_-_50346246 0.97 ENSDART00000025008
stanniocalcin 1
chr4_-_77432218 0.97 ENSDART00000158683
solute carrier organic anion transporter family, member 1D1
chr6_-_53143667 0.96 ENSDART00000079694
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr9_-_12034444 0.95 ENSDART00000038651
zinc finger protein 804A
chr12_-_31103187 0.94 ENSDART00000005562
transcription factor 7 like 2
chr21_-_25522510 0.93 ENSDART00000162711
connector enhancer of kinase suppressor of Ras 2b
chr6_-_26559921 0.93 ENSDART00000104532
SRY (sex determining region Y)-box 14
chr3_-_55650417 0.92 ENSDART00000171441
axin 2 (conductin, axil)
chr17_-_4245311 0.92 ENSDART00000055379
growth differentiation factor 3
chr11_+_34522554 0.91 ENSDART00000109833
zinc finger, matrin-type 3
chr8_-_34051548 0.91 ENSDART00000105204
pre-B-cell leukemia homeobox 3b
chr6_-_15604157 0.90 ENSDART00000141597
leucine rich repeat (in FLII) interacting protein 1b
chr2_-_30784502 0.90 ENSDART00000056735
regulator of G protein signaling 20
chr23_-_20764227 0.90 ENSDART00000089750
zinc finger protein 362b
chr9_-_3671911 0.89 ENSDART00000102900
Sp5 transcription factor a
chr9_+_32431666 0.88 ENSDART00000187614
phospholipase C like 1
chr16_-_18702249 0.87 ENSDART00000191595
formin homology 2 domain containing 3b
chr6_-_29105727 0.86 ENSDART00000184355
family with sequence similarity 69, member Ab
chr3_-_2589704 0.84 ENSDART00000187239
chr14_-_47963115 0.84 ENSDART00000003826
Rap guanine nucleotide exchange factor (GEF) 2
chr24_+_15897717 0.81 ENSDART00000105956
neuropilin (NRP) and tolloid (TLL)-like 1, like
chr15_+_22722684 0.80 ENSDART00000156760
glutamate receptor, ionotropic, kainate 4
chr18_+_36806545 0.80 ENSDART00000098958
tetratricopeptide repeat domain 9B
chr20_+_36730049 0.79 ENSDART00000045948
nuclear receptor coactivator 1
chr16_+_34493987 0.79 ENSDART00000138374
chr10_-_31562695 0.79 ENSDART00000186456
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr3_-_33573252 0.79 ENSDART00000191339

chr20_-_9436521 0.79 ENSDART00000133000
chr22_-_16042243 0.78 ENSDART00000062633
sphingosine-1-phosphate receptor 1
chr12_+_10115964 0.77 ENSDART00000152369
chr2_+_9822319 0.76 ENSDART00000144078
annexin A13, like
chr11_+_34523132 0.76 ENSDART00000192257
zinc finger, matrin-type 3
chr2_-_43083749 0.72 ENSDART00000084303
potassium voltage-gated channel, KQT-like subfamily, member 3
chr20_+_36234335 0.72 ENSDART00000193484
cornichon family AMPA receptor auxiliary protein 3
chr8_-_22739757 0.72 ENSDART00000182167
IQ motif and Sec7 domain 2a
chr3_-_32299892 0.72 ENSDART00000181472
chr18_+_10907999 0.71 ENSDART00000133555
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr16_+_17389116 0.71 ENSDART00000103750
family with sequence similarity 131, member Bb
chr15_-_2188332 0.71 ENSDART00000138941
short stature homeobox 2
chr17_+_26611929 0.70 ENSDART00000166450
tetratricopeptide repeat domain 7B
chr15_+_24691088 0.70 ENSDART00000110618
chr21_-_31241254 0.69 ENSDART00000065365
tyrosylprotein sulfotransferase 1, like
chr15_-_163586 0.69 ENSDART00000163597
chr13_+_4505232 0.68 ENSDART00000007500
phosphodiesterase 10A
chr19_+_29798064 0.68 ENSDART00000167803
MARCKS-like 1b
chr8_-_34052019 0.68 ENSDART00000040126
pre-B-cell leukemia homeobox 3b
chr1_-_36151377 0.67 ENSDART00000037516
zinc finger protein 827
chr6_-_57938043 0.67 ENSDART00000171073
TOX high mobility group box family member 2
chr1_+_2190714 0.66 ENSDART00000132126
muscleblind-like splicing regulator 2
chr7_-_42206720 0.66 ENSDART00000110907
integrin alpha FG-GAP repeat containing 1
chr1_-_39976492 0.66 ENSDART00000181680
storkhead box 2a
chr17_-_4245902 0.65 ENSDART00000151851
growth differentiation factor 3
chr7_-_37622153 0.64 ENSDART00000052379
naked cuticle homolog 1 (Drosophila)
chr7_-_37622370 0.64 ENSDART00000173523
naked cuticle homolog 1 (Drosophila)
chr21_-_25722834 0.64 ENSDART00000101208
abhydrolase domain containing 11
chr13_+_15656042 0.64 ENSDART00000134240
MAP/microtubule affinity-regulating kinase 3a
chr24_-_6546479 0.63 ENSDART00000160538
Rho GTPase activating protein 21a
chr1_+_49814942 0.63 ENSDART00000164936
lymphoid enhancer-binding factor 1
chr6_-_7208119 0.62 ENSDART00000105148
heparan sulfate 6-O-sulfotransferase 3a
chr17_-_24714837 0.61 ENSDART00000154871
chr6_+_15762647 0.60 ENSDART00000127133
IQ motif containing with AAA domain 1
chr5_+_15992655 0.60 ENSDART00000182148
zinc and ring finger 3
chr12_+_48340133 0.60 ENSDART00000152899
DNA-damage-inducible transcript 4
chr8_+_17009199 0.60 ENSDART00000139452
phosphodiesterase 4D, cAMP-specific
chr9_+_28693592 0.60 ENSDART00000110198
chr19_-_8880688 0.59 ENSDART00000039629
cugbp, Elav-like family member 3a
chr6_-_53144336 0.59 ENSDART00000154429
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr7_-_31940590 0.58 ENSDART00000131009
brain-derived neurotrophic factor
chr25_-_19395156 0.57 ENSDART00000155335
microtubule-associated protein 1Ab
chr19_-_8732037 0.57 ENSDART00000138971
chr3_+_15809098 0.56 ENSDART00000183023
phosphatase, orphan 1
chr3_+_15773991 0.55 ENSDART00000089923
zinc finger protein 652
chr15_-_31588162 0.55 ENSDART00000153598
heat shock 105/110 protein 1
chr14_+_34495216 0.54 ENSDART00000147756
wingless-type MMTV integration site family, member 8a
chr2_+_33368414 0.54 ENSDART00000077462
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr17_-_50010121 0.53 ENSDART00000122747
transmembrane protein 30Aa
chr13_-_24906307 0.53 ENSDART00000148191
K(lysine) acetyltransferase 6B
chr4_-_16658514 0.52 ENSDART00000133837
DENN/MADD domain containing 5B
chr21_-_40782393 0.52 ENSDART00000075808
amyloid beta (A4) precursor protein-binding, family B, member 3
chr12_-_31995840 0.52 ENSDART00000112881
glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb
chr22_+_35930526 0.52 ENSDART00000169242

chr1_+_26356360 0.51 ENSDART00000113020
tet methylcytosine dioxygenase 2
chr15_+_28106498 0.51 ENSDART00000041707
unc-119 homolog a (C. elegans)
chr1_+_26356205 0.51 ENSDART00000190064
tet methylcytosine dioxygenase 2
chr16_+_16933002 0.50 ENSDART00000173163
myosin, heavy chain 14, non-muscle
chr9_+_10014817 0.50 ENSDART00000132065
neurexophilin 2a
chr2_-_42396592 0.50 ENSDART00000127136
solute carrier organic anion transporter family member 5A1b
chr6_-_21616659 0.49 ENSDART00000074256
protein phosphatase 1, regulatory subunit 12C
chr19_-_44801918 0.49 ENSDART00000108507
chr21_+_25068215 0.49 ENSDART00000167523
DIX domain containing 1b
chr23_+_25201077 0.49 ENSDART00000136675
chr6_-_15603675 0.48 ENSDART00000143502
leucine rich repeat (in FLII) interacting protein 1b
chr13_+_4505079 0.48 ENSDART00000144312
phosphodiesterase 10A
chr19_-_23895839 0.47 ENSDART00000174834
chr17_-_26507289 0.46 ENSDART00000155616
coiled-coil serine-rich protein 2a
chr17_+_3379673 0.46 ENSDART00000176354
syntrophin, gamma 2
chr1_-_19233890 0.46 ENSDART00000127145
protein tyrosine phosphatase, receptor type, D, b
chr19_-_32940040 0.46 ENSDART00000179947
antizyme inhibitor 1b
chr7_+_27976448 0.46 ENSDART00000181026
tubby bipartite transcription factor
chr5_+_34407763 0.46 ENSDART00000188849
laminin, gamma 3
chr20_+_43942278 0.46 ENSDART00000100571
chloride intracellular channel 5b
chr7_+_57836841 0.45 ENSDART00000136175
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr11_+_14622379 0.45 ENSDART00000112589
chr17_+_26352372 0.45 ENSDART00000155177
glutamate receptor, ionotropic, delta 1a
chr13_-_18835254 0.43 ENSDART00000147579
leucine zipper, putative tumor suppressor 2a
chr7_-_34062301 0.43 ENSDART00000052404
mitogen-activated protein kinase kinase 5
chr15_-_43768776 0.43 ENSDART00000170398
glutamate receptor, metabotropic 5b
chr20_-_9194257 0.43 ENSDART00000133012
YLP motif containing 1
chr7_-_72423666 0.41 ENSDART00000191214
rabphilin 3A homolog (mouse), b
chr14_+_24277556 0.41 ENSDART00000122660
heterogeneous nuclear ribonucleoprotein A0a
chr9_+_10014514 0.41 ENSDART00000185590
neurexophilin 2a
chr15_+_1705167 0.40 ENSDART00000081940
otolin 1b
chr7_-_32895668 0.40 ENSDART00000141828
anoctamin 5b
chr5_+_26156079 0.40 ENSDART00000088141
ankyrin repeat domain 34Bb
chr7_-_31941330 0.40 ENSDART00000144682
brain-derived neurotrophic factor
chr17_-_20897407 0.39 ENSDART00000149481
ankyrin 3b
chr11_-_18604317 0.39 ENSDART00000182081
zinc finger, MYND-type containing 8
chr18_-_44888375 0.39 ENSDART00000160506
chr15_+_6109861 0.38 ENSDART00000185154
Purkinje cell protein 4
chr11_-_18323059 0.37 ENSDART00000182590
Scm like with four mbt domains 1
chr24_-_35269991 0.36 ENSDART00000185424
syntrophin, gamma 1
chr4_-_2036620 0.35 ENSDART00000150490
chr6_-_14038804 0.35 ENSDART00000184606
ets variant 5b
chr11_+_28107632 0.33 ENSDART00000177721
neuromedin U receptor 3
chr15_-_16384184 0.33 ENSDART00000154504
family with sequence similarity 222, member Bb
chr2_+_2503396 0.33 ENSDART00000168418
corticotropin releasing hormone receptor 2
chr2_+_22042745 0.33 ENSDART00000132039
thymocyte selection-associated high mobility group box
chr11_+_41135055 0.32 ENSDART00000173252
calmodulin binding transcription activator 1
chr3_+_28831622 0.32 ENSDART00000184130
chr23_-_24226533 0.32 ENSDART00000109134
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr13_+_28702104 0.32 ENSDART00000135481
chr6_-_54111928 0.31 ENSDART00000083880
hyaluronoglucosaminidase 2a
chr12_+_32323098 0.31 ENSDART00000188722
chr4_-_20511595 0.31 ENSDART00000185806
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8b
chr13_-_23264724 0.31 ENSDART00000051886
chr7_+_42206543 0.30 ENSDART00000112543
phosphorylase kinase, beta
chr9_-_27410597 0.30 ENSDART00000135652
KDEL (Lys-Asp-Glu-Leu) containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of tcf7l1a+tcf7l1b+tcf7l2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0060074 synapse maturation(GO:0060074)
0.4 1.1 GO:0051580 regulation of neurotransmitter uptake(GO:0051580) negative regulation of anion transport(GO:1903792)
0.3 1.7 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.3 1.0 GO:0035902 response to immobilization stress(GO:0035902)
0.3 1.3 GO:0042306 regulation of protein import into nucleus(GO:0042306) negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of protein localization to nucleus(GO:1900181) regulation of protein import(GO:1904589) negative regulation of protein import(GO:1904590)
0.3 1.6 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.3 0.8 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.3 1.3 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.2 0.9 GO:0010226 response to lithium ion(GO:0010226)
0.2 1.2 GO:0010754 negative regulation of cGMP-mediated signaling(GO:0010754)
0.2 1.1 GO:0032289 central nervous system myelin formation(GO:0032289)
0.2 1.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 0.5 GO:0039015 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.2 1.5 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.2 1.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.2 2.0 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.2 0.6 GO:0032801 receptor catabolic process(GO:0032801)
0.1 1.9 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 1.0 GO:0006211 5-methylcytosine catabolic process(GO:0006211) 5-methylcytosine metabolic process(GO:0019857)
0.1 0.4 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.1 1.0 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.1 0.5 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.1 1.1 GO:1901678 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 2.2 GO:0060079 excitatory postsynaptic potential(GO:0060079) chemical synaptic transmission, postsynaptic(GO:0099565)
0.1 0.9 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.1 0.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 1.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 1.0 GO:0050975 sensory perception of touch(GO:0050975)
0.1 1.0 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 0.7 GO:0006477 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.1 1.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.3 GO:0006530 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.1 0.5 GO:1902269 polyamine transport(GO:0015846) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269)
0.1 1.9 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.1 0.4 GO:0038065 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 0.5 GO:1900186 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.2 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.1 0.4 GO:0051013 microtubule severing(GO:0051013)
0.1 1.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 2.2 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0010039 response to iron ion(GO:0010039)
0.0 0.1 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.0 0.3 GO:0036372 opsin transport(GO:0036372)
0.0 0.2 GO:0010586 miRNA metabolic process(GO:0010586)
0.0 1.9 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.3 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.9 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.7 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 1.0 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.8 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
0.0 0.2 GO:0044209 AMP salvage(GO:0044209)
0.0 0.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.5 GO:0010765 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.1 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 1.3 GO:0031103 axon regeneration(GO:0031103)
0.0 0.3 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 1.0 GO:0048665 neuron fate specification(GO:0048665)
0.0 0.3 GO:1903729 regulation of plasma membrane organization(GO:1903729)
0.0 0.3 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.3 GO:1903318 negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.0 0.2 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.0 0.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 1.0 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.0 0.1 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.0 0.8 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.2 GO:0021634 optic nerve formation(GO:0021634)
0.0 0.1 GO:0048569 post-embryonic organ development(GO:0048569)
0.0 0.4 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 0.6 GO:0070167 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 0.4 GO:0030316 osteoclast differentiation(GO:0030316)
0.0 1.3 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.0 2.8 GO:0048675 axon extension(GO:0048675)
0.0 1.4 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.2 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 1.5 GO:0050769 positive regulation of neurogenesis(GO:0050769)
0.0 0.1 GO:0019532 oxalate transport(GO:0019532)
0.0 0.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.2 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.3 GO:0007622 rhythmic behavior(GO:0007622) circadian behavior(GO:0048512)
0.0 0.2 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.0 0.7 GO:0001885 endothelial cell development(GO:0001885)
0.0 3.1 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.1 GO:0061011 hepatic duct development(GO:0061011)
0.0 0.2 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.0 0.1 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.2 GO:0006144 purine nucleobase metabolic process(GO:0006144)
0.0 1.4 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.2 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.2 GO:0008272 sulfate transport(GO:0008272)
0.0 0.8 GO:0030042 actin filament depolymerization(GO:0030042)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.2 0.8 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.2 0.5 GO:0097189 apoptotic body(GO:0097189)
0.1 2.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.3 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.7 GO:0043194 axon initial segment(GO:0043194)
0.1 0.2 GO:1902560 GMP reductase complex(GO:1902560)
0.1 1.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.4 GO:0098645 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 0.3 GO:0005879 axonemal microtubule(GO:0005879)
0.1 2.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.5 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.2 GO:0070724 BMP receptor complex(GO:0070724)
0.0 1.6 GO:0030426 growth cone(GO:0030426)
0.0 0.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 5.0 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 1.0 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.4 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.9 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 0.2 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 1.3 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 2.2 GO:0030133 transport vesicle(GO:0030133)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.2 1.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 1.0 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 1.2 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.2 1.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 1.8 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.2 0.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.6 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 1.9 GO:0004111 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 1.0 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.1 1.0 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 1.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 2.8 GO:0019894 kinesin binding(GO:0019894)
0.1 0.3 GO:0001607 neuromedin U receptor activity(GO:0001607)
0.1 1.0 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 2.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.3 GO:0070735 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.1 0.6 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.8 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 1.7 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 0.7 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 0.3 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.1 0.5 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 1.0 GO:0005163 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.1 0.2 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.3 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.3 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.4 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 2.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 1.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.2 GO:0003994 aconitate hydratase activity(GO:0003994)
0.1 1.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 1.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 0.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.2 GO:0004001 adenosine kinase activity(GO:0004001)
0.0 0.5 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 1.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 5.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.0 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 1.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.5 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 1.0 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.4 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.6 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 3.0 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.6 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.4 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 3.8 GO:0042802 identical protein binding(GO:0042802)
0.0 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 1.0 GO:0051287 NAD binding(GO:0051287)
0.0 0.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.2 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 2.4 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 1.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 0.8 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 2.0 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 1.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.6 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.1 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 1.1 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 2.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 1.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.0 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 1.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.8 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events