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PRJNA207719: Tissue specific transcriptome profiling
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Results for tcf21
Z-value: 1.63
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Transcription factors associated with tcf21
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tcf21 | dr11_v1_chr23_-_31555696_31555696 | -0.26 | 6.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_34794829 Show fit | 1.78 |
ENSDART00000009698
ENSDART00000075089 ENSDART00000173456 |
epithelial splicing regulatory protein 2 |
|
| chr3_+_1055588 Show fit | 1.72 |
ENSDART00000143220
|
zgc:153921 |
|
| chr5_+_28830643 Show fit | 1.57 |
ENSDART00000051448
|
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 |
|
| chr6_+_112579 Show fit | 1.50 |
ENSDART00000034505
|
adaptor-related protein complex 1, mu 2 subunit |
|
| chr11_-_5865744 Show fit | 1.39 |
ENSDART00000104360
|
guanidinoacetate N-methyltransferase |
|
| chr5_+_28849155 Show fit | 1.38 |
ENSDART00000079090
|
zgc:174259 |
|
| chr5_+_28858345 Show fit | 1.12 |
ENSDART00000111180
|
si:ch211-186e20.2 |
|
| chr7_+_6652967 Show fit | 0.96 |
ENSDART00000102681
|
purine nucleoside phosphorylase 5a |
|
| chr9_-_35633827 Show fit | 0.96 |
ENSDART00000077745
|
zona pellucida glycoprotein 2, like 1 |
|
| chr19_+_43119014 Show fit | 0.89 |
ENSDART00000023156
|
eukaryotic translation elongation factor 1 alpha 1, like 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of tcf21
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.0 | 1.5 | GO:0006414 | translational elongation(GO:0006414) |
| 0.5 | 1.4 | GO:0006600 | creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601) |
| 0.1 | 1.3 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.0 | 1.3 | GO:0006892 | post-Golgi vesicle-mediated transport(GO:0006892) |
| 0.2 | 1.0 | GO:0048260 | positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946) |
| 0.0 | 1.0 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 0.9 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.3 | 0.8 | GO:0050995 | negative regulation of lipid transport(GO:0032369) negative regulation of lipid catabolic process(GO:0050995) |
| 0.3 | 0.8 | GO:0015695 | organic cation transport(GO:0015695) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 1.3 | GO:0005657 | replication fork(GO:0005657) |
| 0.1 | 1.1 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 1.0 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 0.8 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) |
| 0.0 | 0.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.6 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.6 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.5 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 1.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.3 | 1.3 | GO:0043139 | 5'-3' DNA helicase activity(GO:0043139) |
| 0.0 | 1.1 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.0 | 1.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 1.0 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 0.1 | 1.0 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 1.0 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.2 | 0.9 | GO:0016823 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.6 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.4 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 1.5 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 1.0 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.2 | 0.9 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.3 | 0.8 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.8 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 0.7 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 0.7 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 0.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |