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PRJNA207719: Tissue specific transcriptome profiling
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Results for tcf12
Z-value: 3.08
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Transcription factors associated with tcf12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| tcf12 | dr11_v1_chr7_-_52709759_52709935 | 0.69 | 2.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_233143 Show fit | 4.72 |
ENSDART00000175273
|
synaptic Ras GTPase activating protein 1a |
|
| chr11_-_101758 Show fit | 4.20 |
ENSDART00000173015
|
engulfment and cell motility 2 |
|
| chr4_-_14328997 Show fit | 3.64 |
ENSDART00000091151
|
neural EGFL like 2b |
|
| chr13_-_36911118 Show fit | 3.30 |
ENSDART00000048739
|
tripartite motif containing 9 |
|
| chr15_-_15357178 Show fit | 3.28 |
ENSDART00000106120
|
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2 |
|
| chr5_+_22098591 Show fit | 3.01 |
ENSDART00000143676
|
zinc finger CCCH-type containing 12B |
|
| chr19_+_30633453 Show fit | 2.82 |
ENSDART00000052124
|
family with sequence similarity 49, member A-like |
|
| chr1_+_59154521 Show fit | 2.60 |
ENSDART00000130089
ENSDART00000152456 |
heme-binding protein soul5, like |
|
| chr10_+_15777258 Show fit | 2.46 |
ENSDART00000140511
|
amyloid beta (A4) precursor protein-binding, family A, member 1b |
|
| chr4_+_12617108 Show fit | 2.35 |
ENSDART00000134362
ENSDART00000112860 |
LIM domain only 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of tcf12
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.8 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.3 | 6.6 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.0 | 6.2 | GO:0043087 | regulation of GTPase activity(GO:0043087) |
| 0.0 | 5.6 | GO:0015698 | inorganic anion transport(GO:0015698) |
| 0.1 | 5.5 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.1 | 4.9 | GO:0032012 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.4 | 4.8 | GO:0006798 | polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798) |
| 0.0 | 4.7 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.2 | 4.6 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.0 | 4.6 | GO:0030705 | cytoskeleton-dependent intracellular transport(GO:0030705) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 41.0 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 14.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.2 | 7.0 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 6.1 | GO:0005768 | endosome(GO:0005768) |
| 0.0 | 4.5 | GO:0005938 | cell cortex(GO:0005938) |
| 0.1 | 4.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 4.3 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 4.2 | GO:0005770 | late endosome(GO:0005770) |
| 0.1 | 4.0 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.1 | 3.9 | GO:0005940 | septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 11.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 6.4 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.0 | 5.7 | GO:0060090 | binding, bridging(GO:0060090) |
| 0.0 | 5.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.4 | 4.8 | GO:0004309 | exopolyphosphatase activity(GO:0004309) |
| 0.2 | 4.7 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.3 | 4.6 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 4.4 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 4.1 | GO:0045499 | chemorepellent activity(GO:0045499) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 1.7 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 1.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 1.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 1.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 1.1 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 3.7 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.2 | 2.7 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.0 | 2.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 1.8 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 1.7 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.7 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.0 | 1.6 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |