ISMARA results: tal1

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PRJNA207719: Tissue specific transcriptome profiling

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Results for tal1

Z-value: 2.11

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Transcription factors associated with tal1

Gene Symbol	Gene ID	Gene Info
tal1 NCBI UniProt	ENSDARG00000019930	T-cell acute lymphocytic leukemia 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
tal1	dr11_v1_chr22_+_16535575_16535575	-0.42	4.8e-01	Click!

Activity profile of tal1 motif

Sorted Z-values of tal1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_+_19790962 Show fit	1.83	ENSDART00000142228	flna NCBI UniProt Show fit	filamin A, alpha (actin binding protein 280)
chr25_-_18470695 Show fit	1.77	ENSDART00000034377	cpa5 NCBI UniProt Show fit	carboxypeptidase A5
chr3_-_3209432 Show fit	1.59	ENSDART00000140635	si:ch211-229i14.2 NCBI UniProt Show fit	si:ch211-229i14.2
chr10_-_342564 Show fit	1.58	ENSDART00000157633	vaspa NCBI UniProt Show fit	vasodilator stimulated phosphoprotein a
chr3_+_58833306 Show fit	1.55	ENSDART00000113223	igl1c3 NCBI UniProt Show fit	immunoglobulin light 1 constant 3
chr16_-_41990421 Show fit	1.38	ENSDART00000055921	pycard NCBI UniProt Show fit	PYD and CARD domain containing
chr22_-_10541372 Show fit	1.38	ENSDART00000179708	si:dkey-42i9.4 NCBI UniProt Show fit	si:dkey-42i9.4
chr21_+_5531138 Show fit	1.31	ENSDART00000163825	ly6m6 NCBI UniProt Show fit	lymphocyte antigen 6 family member M6
chr13_+_669177 Show fit	1.19	ENSDART00000190085	CU462915.1 NCBI UniProt Show fit
chr7_+_71535045 Show fit	1.15	ENSDART00000047069	tyms NCBI UniProt Show fit	thymidylate synthetase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of tal1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.8	GO:0060046	binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1	2.5	GO:0006910	phagocytosis, recognition(GO:0006910)
0.1	2.2	GO:0016584	nucleosome positioning(GO:0016584)
0.1	2.0	GO:0001843	neural tube closure(GO:0001843)
0.1	1.8	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	1.7	GO:0002548	monocyte chemotaxis(GO:0002548)
0.0	1.7	GO:0045930	negative regulation of mitotic cell cycle(GO:0045930)
0.0	1.4	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.4	1.2	GO:0009162	deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.0	1.2	GO:0046785	microtubule polymerization(GO:0046785)

Showing 1 to 10 of 98 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	2.3	GO:0000786	nucleosome(GO:0000786)
0.0	1.5	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	1.5	GO:0005581	collagen trimer(GO:0005581)
0.3	1.4	GO:0061702	inflammasome complex(GO:0061702)
0.0	1.2	GO:0044853	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0	1.1	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	1.1	GO:0005861	troponin complex(GO:0005861)
0.2	1.0	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	1.0	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.8	GO:0035804	structural constituent of egg coat(GO:0035804)
0.1	2.5	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	2.4	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.1	1.9	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.2	1.6	GO:0005522	profilin binding(GO:0005522)
0.1	1.4	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1	1.2	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	1.2	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1	1.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	1.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)

Showing 1 to 10 of 92 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	1.7	PID E2F PATHWAY	E2F transcription factor network
0.0	0.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.8	PID PLK1 PATHWAY	PLK1 signaling events
0.0	0.4	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	0.3	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.3	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.3	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	0.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.3	1.4	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	1.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	0.8	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.7	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.5	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.5	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
0.0	0.5	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Showing 1 to 10 of 18 entries

Results for tal1

Z-value: 2.11

Motif logo

Transcription factors associated with tal1

Activity-expression correlation:

Activity profile of tal1 motif

Sorted Z-values of tal1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of tal1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: