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PRJNA207719: Tissue specific transcriptome profiling
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Results for stat1a+stat2-1_stat1b
Z-value: 1.61
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Transcription factors associated with stat1a+stat2-1_stat1b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000006266 | signal transducer and activator of transcription 1a | |
| ENSDARG00000031647 | signal transducer and activator of transcription 2 | |
| ENSDARG00000076182 | signal transducer and activator of transcription 1b |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| stat1b | dr11_v1_chr9_+_41224100_41224100 | 0.77 | 1.3e-01 | Click! |
| stat1a | dr11_v1_chr22_+_12798569_12798569 | -0.36 | 5.6e-01 | Click! |
| stat2 | dr11_v1_chr6_-_39160422_39160422 | -0.13 | 8.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_+_45626136 Show fit | 2.93 |
ENSDART00000158742
|
interferon regulatory factor 1b |
|
| chr9_-_32813177 Show fit | 2.29 |
ENSDART00000012694
|
myxovirus (influenza virus) resistance C |
|
| chr21_-_27338639 Show fit | 2.22 |
ENSDART00000130632
|
hypoxia-inducible factor 1, alpha subunit, like 2 |
|
| chr9_-_54304684 Show fit | 2.02 |
ENSDART00000109512
|
interleukin 13 |
|
| chr22_+_7480465 Show fit | 1.97 |
ENSDART00000034545
|
zgc:92745 |
|
| chr15_-_29598679 Show fit | 1.91 |
ENSDART00000155153
|
si:ch211-207n23.2 |
|
| chr24_-_38197040 Show fit | 1.80 |
ENSDART00000137949
ENSDART00000105639 |
immunoglobulin light iota constant 1, s1 |
|
| chr5_+_1911814 Show fit | 1.79 |
ENSDART00000172233
|
si:ch73-55i23.1 |
|
| chr20_-_37813863 Show fit | 1.71 |
ENSDART00000147529
|
basic leucine zipper transcription factor, ATF-like 3 |
|
| chr15_+_20239141 Show fit | 1.60 |
ENSDART00000101152
ENSDART00000152473 |
serine peptidase inhibitor, Kunitz type, 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of stat1a+stat2-1_stat1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:1990266 | neutrophil migration(GO:1990266) |
| 0.1 | 3.0 | GO:0071219 | cellular response to molecule of bacterial origin(GO:0071219) cellular response to lipopolysaccharide(GO:0071222) |
| 0.3 | 2.9 | GO:0050688 | regulation of defense response to virus(GO:0050688) |
| 0.3 | 2.5 | GO:0043330 | response to exogenous dsRNA(GO:0043330) |
| 0.4 | 2.4 | GO:0045063 | neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
| 0.3 | 2.2 | GO:0046426 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.1 | 2.2 | GO:0071456 | cellular response to hypoxia(GO:0071456) |
| 0.1 | 1.8 | GO:0046475 | glycerophospholipid catabolic process(GO:0046475) |
| 0.0 | 1.8 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 1.5 | GO:0048821 | erythrocyte development(GO:0048821) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.5 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 3.3 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 3.1 | GO:0019814 | immunoglobulin complex(GO:0019814) |
| 0.2 | 3.0 | GO:0098844 | postsynaptic endocytic zone membrane(GO:0098844) |
| 0.2 | 2.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.2 | 1.4 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 1.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.4 | GO:0030055 | cell-substrate junction(GO:0030055) |
| 0.0 | 1.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 1.1 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 3.3 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.4 | 2.4 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.0 | 1.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 1.8 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 1.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 1.8 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.3 | 1.4 | GO:0019863 | IgE binding(GO:0019863) immunoglobulin binding(GO:0019865) |
| 0.1 | 1.3 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 1.2 | GO:0019838 | growth factor binding(GO:0019838) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.0 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.1 | 1.8 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.1 | 1.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.3 | 1.6 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.7 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 0.6 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.6 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.1 | 0.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 1.4 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 1.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 1.1 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 1.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 1.0 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 0.9 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.0 | 0.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.7 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |