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PRJNA207719: Tissue specific transcriptome profiling
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Results for srfa+srfb
Z-value: 3.59
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Transcription factors associated with srfa+srfb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| srfb | dr11_v1_chr13_-_51922290_51922290 | 0.72 | 1.7e-01 | Click! |
| srfa | dr11_v1_chr22_+_35089031_35089031 | -0.48 | 4.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_26064480 Show fit | 4.82 |
ENSDART00000158215
ENSDART00000171206 ENSDART00000171212 ENSDART00000182956 ENSDART00000186779 |
LIM domain binding 3b |
|
| chr12_-_26064105 Show fit | 4.63 |
ENSDART00000168825
|
LIM domain binding 3b |
|
| chr20_+_53577502 Show fit | 4.43 |
ENSDART00000126983
|
myosin, heavy chain 6, cardiac muscle, alpha |
|
| chr15_-_551177 Show fit | 4.05 |
ENSDART00000066774
ENSDART00000154617 |
transgelin |
|
| chr13_+_24279021 Show fit | 3.98 |
ENSDART00000058629
|
actin, alpha 1b, skeletal muscle |
|
| chr20_-_9980318 Show fit | 3.95 |
ENSDART00000080664
|
zgc:86709 |
|
| chr22_-_15602593 Show fit | 3.42 |
ENSDART00000036075
|
tropomyosin 4a |
|
| chr20_-_29420713 Show fit | 3.39 |
ENSDART00000147464
|
ryanodine receptor 3 |
|
| chr22_-_15602760 Show fit | 3.38 |
ENSDART00000009054
|
tropomyosin 4a |
|
| chr7_-_71758613 Show fit | 3.29 |
ENSDART00000166724
|
myomesin 1b |
Network of associatons between targets according to the STRING database.
First level regulatory network of srfa+srfb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.9 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.0 | 9.9 | GO:0061061 | muscle structure development(GO:0061061) |
| 0.3 | 6.8 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 1.1 | 6.3 | GO:0055005 | ventricular cardiac myofibril assembly(GO:0055005) |
| 0.1 | 5.6 | GO:0048747 | muscle fiber development(GO:0048747) |
| 1.8 | 5.5 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.2 | 5.3 | GO:0051209 | release of sequestered calcium ion into cytosol(GO:0051209) |
| 0.9 | 4.4 | GO:0055014 | atrial cardiac muscle cell development(GO:0055014) |
| 0.7 | 2.9 | GO:0003413 | plasma membrane repair(GO:0001778) chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413) growth plate cartilage chondrocyte differentiation(GO:0003418) |
| 0.1 | 2.7 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.1 | GO:0016459 | myosin complex(GO:0016459) |
| 0.2 | 12.4 | GO:0005884 | actin filament(GO:0005884) |
| 0.2 | 10.3 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.6 | 9.5 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.4 | 9.0 | GO:0031430 | M band(GO:0031430) |
| 0.8 | 5.3 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.1 | 4.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 2.9 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.2 | 2.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 2.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.5 | 9.4 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 1.1 | 5.3 | GO:0048763 | ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763) |
| 0.9 | 2.7 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.2 | 2.7 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.2 | 1.9 | GO:0015250 | water channel activity(GO:0015250) |
| 0.1 | 1.9 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.3 | 1.7 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.0 | 1.7 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.2 | 1.4 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 2.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 1.7 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 0.8 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.7 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 0.6 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 0.4 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 0.4 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 0.4 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 4.8 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.1 | 2.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.3 | 1.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 1.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 0.9 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 0.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 0.7 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 0.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 0.4 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |