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PRJNA207719: Tissue specific transcriptome profiling

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Results for srebf2

Z-value: 1.15

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Transcription factors associated with srebf2

Gene Symbol Gene ID Gene Info
srebf2
ENSDARG00000063438 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
srebf2dr11_v1_chr3_+_1107102_1107102-0.069.3e-01Click!

Activity profile of srebf2 motif

Sorted Z-values of srebf2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_7539297 0.75 ENSDART00000081550
ENSDART00000081553
desma
desmin a
chr4_-_20511595 0.74 ENSDART00000185806
rassf8b
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8b
chr19_-_25113660 0.74 ENSDART00000035538
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr21_+_28445052 0.67 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr10_-_31782616 0.64 ENSDART00000128839
fez1
fasciculation and elongation protein zeta 1 (zygin I)
chr18_-_21271373 0.62 ENSDART00000060001
pnp6
purine nucleoside phosphorylase 6
chr14_-_21618005 0.62 ENSDART00000043162
reep2
receptor accessory protein 2
chr16_+_41873708 0.61 ENSDART00000084631
ENSDART00000084639
ENSDART00000058611
scn1ba
sodium channel, voltage-gated, type I, beta a
chr13_-_33398735 0.58 ENSDART00000182601
ENSDART00000103628
btbd6a
BTB (POZ) domain containing 6a
chr7_+_44445595 0.58 ENSDART00000108766
cdh5
cadherin 5
chr14_-_29826659 0.57 ENSDART00000138413
sorbs2b
sorbin and SH3 domain containing 2b
chr22_-_11614973 0.55 ENSDART00000063135
pcyt2
phosphate cytidylyltransferase 2, ethanolamine
chr23_-_20258490 0.55 ENSDART00000147326
lamb2
laminin, beta 2 (laminin S)
chr21_-_19006631 0.52 ENSDART00000080269
ENSDART00000191682
pgam2
phosphoglycerate mutase 2 (muscle)
chr2_+_24203229 0.51 ENSDART00000138088
map4l
microtubule associated protein 4 like
chr9_-_4075620 0.50 ENSDART00000046903
mylka
myosin, light chain kinase a
chr16_-_29164379 0.49 ENSDART00000132589
mef2d
myocyte enhancer factor 2d
chr20_-_27311675 0.47 ENSDART00000026088
ENSDART00000148361
asb2a.1
ankyrin repeat and SOCS box containing 2a, tandem duplicate 1
chr21_-_43550120 0.46 ENSDART00000151627
si:ch73-362m14.2
si:ch73-362m14.2
chr4_+_19535946 0.45 ENSDART00000192342
ENSDART00000183740
ENSDART00000180812
ENSDART00000180017
lrrc4.1
leucine rich repeat containing 4.1
chr8_-_26961779 0.44 ENSDART00000099214
slc16a1b
solute carrier family 16 (monocarboxylate transporter), member 1b
chr3_-_61099004 0.41 ENSDART00000112043
cacng4b
calcium channel, voltage-dependent, gamma subunit 4b
chr1_+_41690402 0.41 ENSDART00000177298
fbxo41
F-box protein 41
chr12_-_23009312 0.41 ENSDART00000111801
mkxa
mohawk homeobox a
chr9_-_43082945 0.41 ENSDART00000142257
ccdc141
coiled-coil domain containing 141
chr17_-_48915427 0.40 ENSDART00000054781
lgals8b
galectin 8b
chr24_+_9590188 0.39 ENSDART00000137092
si:dkey-96n2.1
si:dkey-96n2.1
chr22_-_13466246 0.35 ENSDART00000134035
cntnap5b
contactin associated protein-like 5b
chr17_+_15041647 0.34 ENSDART00000108999
samd4a
sterile alpha motif domain containing 4A
chr3_+_26288981 0.32 ENSDART00000163500
rhot1a
ras homolog family member T1a
chr8_+_52491436 0.32 ENSDART00000164298
si:ch1073-392o20.1
si:ch1073-392o20.1
chr3_-_48612078 0.30 ENSDART00000169923
ndel1b
nudE neurodevelopment protein 1-like 1b
chr19_-_10196370 0.29 ENSDART00000091707
dbpa
D site albumin promoter binding protein a
chr14_-_33894915 0.28 ENSDART00000143290
urp1
urotensin-related peptide 1
chr9_+_54417141 0.27 ENSDART00000056810
drd1b
dopamine receptor D1b
chr7_-_30082931 0.25 ENSDART00000075600
tspan3b
tetraspanin 3b
chr10_-_35220285 0.25 ENSDART00000180439
ypel2a
yippee-like 2a
chr5_+_45976130 0.24 ENSDART00000175670
sv2c
synaptic vesicle glycoprotein 2C
chr17_-_7436766 0.23 ENSDART00000162002
grm1b
glutamate receptor, metabotropic 1b
chr5_-_36328688 0.20 ENSDART00000011399
efnb1
ephrin-B1
chr5_-_37871526 0.19 ENSDART00000136450
arhgap35b
Rho GTPase activating protein 35b
chr8_-_13678415 0.18 ENSDART00000134153
ENSDART00000143331
si:dkey-258f14.3
si:dkey-258f14.3
chr10_-_31563049 0.18 ENSDART00000023575
robo3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr14_-_46117345 0.18 ENSDART00000172166
NDUFC1
si:ch211-235e9.6
chr13_-_992458 0.18 ENSDART00000114655
BFSP1
beaded filament structural protein 1
chr18_-_39188664 0.18 ENSDART00000162983
mapk6
mitogen-activated protein kinase 6
chr1_-_30689004 0.17 ENSDART00000018827
dachc
dachshund c
chr12_+_33395748 0.16 ENSDART00000129458
fasn
fatty acid synthase
chr5_-_12524996 0.16 ENSDART00000142258
si:ch73-263f13.1
si:ch73-263f13.1
chr3_-_45308394 0.15 ENSDART00000155324
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr13_+_4409294 0.15 ENSDART00000146437
si:ch211-130h14.4
si:ch211-130h14.4
chr6_-_19351495 0.15 ENSDART00000164287
grb2a
growth factor receptor-bound protein 2a
chr16_+_41874001 0.15 ENSDART00000161278
scn1ba
sodium channel, voltage-gated, type I, beta a
chr3_-_34296361 0.15 ENSDART00000181485
ENSDART00000113726
tnrc6c1
trinucleotide repeat containing 6C1
chr18_+_8231138 0.14 ENSDART00000140193
arsa
arylsulfatase A
chr19_+_20785724 0.13 ENSDART00000038942
adnp2b
ADNP homeobox 2b
chr6_-_15757867 0.13 ENSDART00000063665
ackr3b
atypical chemokine receptor 3b
chr11_-_3334248 0.13 ENSDART00000154314
ENSDART00000121861
prph
peripherin
chr7_-_41013575 0.12 ENSDART00000150139
insig1
insulin induced gene 1
chr1_+_9557212 0.12 ENSDART00000111131
elfn1b
extracellular leucine-rich repeat and fibronectin type III domain containing 1b
chr25_+_3008263 0.12 ENSDART00000160484
neo1b
neogenin 1b
chr6_-_15101477 0.11 ENSDART00000187713
ENSDART00000124132
fhl2b
four and a half LIM domains 2b
chr18_+_39649825 0.11 ENSDART00000087960
gldn
gliomedin
chr20_+_39223235 0.10 ENSDART00000132132
reps1
RALBP1 associated Eps domain containing 1
chr13_+_30572172 0.10 ENSDART00000010052
ENSDART00000144417
ppifa
peptidylprolyl isomerase Fa
chr9_-_30363770 0.09 ENSDART00000147030
sytl5
synaptotagmin-like 5
chr4_+_646154 0.09 ENSDART00000171138
xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr3_-_6417328 0.09 ENSDART00000160979
jpt1b
Jupiter microtubule associated homolog 1b
chr23_-_29878643 0.08 ENSDART00000058407
slc25a33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr8_+_4745340 0.08 ENSDART00000182894
ufd1l
ubiquitin recognition factor in ER associated degradation 1
chr10_-_5053589 0.08 ENSDART00000193579
tmem150c
transmembrane protein 150C
chr4_+_41311345 0.07 ENSDART00000151905
si:dkey-16p19.8
si:dkey-16p19.8
chr23_-_27694960 0.07 ENSDART00000135129
IKZF4
si:dkey-166n8.9
chr22_+_17286841 0.07 ENSDART00000133176
FAM163A
si:dkey-171o17.8
chr5_+_37032038 0.06 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr3_-_51109286 0.06 ENSDART00000172010
si:ch211-148f13.1
si:ch211-148f13.1
chr5_-_14344647 0.06 ENSDART00000188456
tet3
tet methylcytosine dioxygenase 3
chr2_+_34138376 0.05 ENSDART00000137170
dars2
aspartyl-tRNA synthetase 2, mitochondrial
chr20_-_7176809 0.05 ENSDART00000012247
ENSDART00000125019
dhcr24
24-dehydrocholesterol reductase
chr14_-_30390145 0.05 ENSDART00000045423
slc7a2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr7_-_5640822 0.05 ENSDART00000143767
BX000524.1

chr8_+_22916536 0.05 ENSDART00000136403
cacna1fb
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr18_+_14342326 0.04 ENSDART00000181013
ENSDART00000138372
si:dkey-246g23.2
si:dkey-246g23.2
chr2_-_48539673 0.04 ENSDART00000168202
CR391991.4

chr22_-_13165186 0.04 ENSDART00000105762
ahr2
aryl hydrocarbon receptor 2
chr7_+_25920792 0.03 ENSDART00000026295
arrb2b
arrestin, beta 2b
chr5_-_15321451 0.03 ENSDART00000139203
txnrd2.1
thioredoxin reductase 2, tandem duplicate 1
chr24_-_3477103 0.02 ENSDART00000143723
idi1
isopentenyl-diphosphate delta isomerase 1
chr13_+_21826096 0.02 ENSDART00000056432
zswim8
zinc finger, SWIM-type containing 8
chr12_+_21684239 0.01 ENSDART00000043546
mrpl27
mitochondrial ribosomal protein L27
chr24_-_28229618 0.01 ENSDART00000145290
bcl2a
BCL2, apoptosis regulator a

Network of associatons between targets according to the STRING database.

First level regulatory network of srebf2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0052576 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.2 0.7 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.1 0.8 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
0.1 0.6 GO:0001955 blood vessel maturation(GO:0001955) regulation of establishment of cell polarity(GO:2000114)
0.1 0.7 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 0.6 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.3 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.1 GO:0036314 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.3 GO:0042311 vasodilation(GO:0042311)
0.0 0.5 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.3 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.1 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
0.0 0.5 GO:0016203 muscle attachment(GO:0016203)
0.0 0.1 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.2 GO:0003404 optic vesicle morphogenesis(GO:0003404)
0.0 0.5 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0 0.4 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.4 GO:0045445 myoblast differentiation(GO:0045445)
0.0 0.5 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.4 GO:0019226 transmission of nerve impulse(GO:0019226)
0.0 0.1 GO:0032656 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.5 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.6 GO:0016342 catenin complex(GO:0016342)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.1 0.5 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.1 0.8 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.3 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.1 0.6 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.3 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.0 GO:0031701 angiotensin receptor binding(GO:0031701)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.7 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases