ISMARA results: sp8a+sp8b_sp4_rsl1d1+sp3a

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PRJNA207719: Tissue specific transcriptome profiling

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Results for sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Z-value: 1.86

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Transcription factors associated with sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Gene Symbol	Gene ID	Gene Info
sp8a NCBI UniProt	ENSDARG00000011870	sp8 transcription factor a
sp8b NCBI UniProt	ENSDARG00000056666	sp8 transcription factor b
sp4 NCBI UniProt	ENSDARG00000005186	sp4 transcription factor
sp3a NCBI UniProt	ENSDARG00000001549	sp3a transcription factor
rsl1d1 NCBI UniProt	ENSDARG00000005846	Sp5 transcription factor b
klf4 NCBI UniProt	ENSDARG00000079922	Kruppel-like factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
FO704755.1	dr11_v1_chr6_+_3809346_3809346	-0.84	7.4e-02	Click!
klf4	dr11_v1_chr21_-_435466_435466	-0.48	4.2e-01	Click!
sp4	dr11_v1_chr19_+_2364552_2364552	-0.46	4.4e-01	Click!
sp8a	dr11_v1_chr19_-_2318391_2318391	0.17	7.8e-01	Click!
sp3a	dr11_v1_chr9_+_2762270_2762415	-0.06	9.3e-01	Click!
sp8b	dr11_v1_chr16_+_19537073_19537073	0.04	9.5e-01	Click!

Activity profile of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Sorted Z-values of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr24_+_37449893 Show fit	2.96	ENSDART00000164405	nlrc3 NCBI UniProt Show fit	NLR family, CARD domain containing 3
chr21_-_32436679 Show fit	2.59	ENSDART00000076974	gfpt2 NCBI UniProt Show fit	glutamine-fructose-6-phosphate transaminase 2
chr22_+_835728 Show fit	2.48	ENSDART00000003325	dennd2db NCBI UniProt Show fit	DENN/MADD domain containing 2Db
chr5_-_2689753 Show fit	2.47	ENSDART00000172699	gng10 NCBI UniProt Show fit	guanine nucleotide binding protein (G protein), gamma 10
chr12_+_46634736 Show fit	2.37	ENSDART00000008009	trim16 NCBI UniProt Show fit	tripartite motif containing 16
chr22_+_11756040 Show fit	2.31	ENSDART00000105808	krt97 NCBI UniProt Show fit	keratin 97
chr5_-_1047504 Show fit	2.26	ENSDART00000159346	mbd2 NCBI UniProt Show fit	methyl-CpG binding domain protein 2
chr15_+_17752928 Show fit	2.26	ENSDART00000155314	si:ch211-213d14.2 NCBI UniProt Show fit	si:ch211-213d14.2
chr3_+_1211242 Show fit	2.14	ENSDART00000171287 ENSDART00000165769	poldip3 NCBI UniProt Show fit	polymerase (DNA-directed), delta interacting protein 3
chr20_-_54564018 Show fit	2.07	ENSDART00000099832	zgc:153012 NCBI UniProt Show fit	zgc:153012

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.7	GO:0070830	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0	3.1	GO:0006954	inflammatory response(GO:0006954)
0.0	3.0	GO:0006334	nucleosome assembly(GO:0006334)
0.2	2.8	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.6	2.5	GO:0003228	atrial cardiac muscle tissue development(GO:0003228)
0.4	2.5	GO:0097341	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0	2.3	GO:0006414	translational elongation(GO:0006414)
0.7	2.0	GO:0036228	protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.1	1.9	GO:0007586	digestion(GO:0007586)
0.0	1.9	GO:0045732	positive regulation of protein catabolic process(GO:0045732)

Showing 1 to 10 of 322 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.1	GO:0005882	intermediate filament(GO:0005882)
0.0	5.0	GO:0000785	chromatin(GO:0000785)
0.2	4.8	GO:0090568	nuclear transcriptional repressor complex(GO:0090568)
0.0	4.1	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.3	3.7	GO:0045095	keratin filament(GO:0045095)
0.0	3.7	GO:0016459	myosin complex(GO:0016459)
0.0	3.4	GO:0000786	nucleosome(GO:0000786)
0.1	2.6	GO:0030057	desmosome(GO:0030057)
0.5	2.0	GO:0044611	nuclear pore inner ring(GO:0044611)
0.1	2.0	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)

Showing 1 to 10 of 95 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.5	GO:0005198	structural molecule activity(GO:0005198)
0.0	5.1	GO:0051015	actin filament binding(GO:0051015)
0.3	4.3	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	4.2	GO:0046982	protein heterodimerization activity(GO:0046982)
0.0	4.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.6	3.2	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.1	2.8	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1	2.6	GO:0042805	actinin binding(GO:0042805)
0.4	2.5	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1	2.4	GO:0048306	calcium-dependent protein binding(GO:0048306)

Showing 1 to 10 of 228 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.0	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	4.5	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.1	3.7	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	1.8	PID NECTIN PATHWAY	Nectin adhesion pathway
0.2	1.0	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.1	0.8	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.8	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.6	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	0.6	PID P53 REGULATION PATHWAY	p53 pathway
0.1	0.5	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway

Showing 1 to 10 of 42 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.6	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.2	2.8	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0	2.4	REACTOME SIGNALING BY ERBB4	Genes involved in Signaling by ERBB4
0.0	2.3	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
0.1	2.0	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.2	1.8	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.1	1.8	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.1	1.7	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	1.7	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	1.4	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)

Showing 1 to 10 of 68 entries

Results for sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Z-value: 1.86

Motif logo

Transcription factors associated with sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

Activity-expression correlation:

Activity profile of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Sorted Z-values of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sp8a+sp8b_sp4_rsl1d1+sp3a_klf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: