PRJNA207719: Tissue specific transcriptome profiling


Results for sox5

Z-value: 1.80

Motif logo

Transcription factors associated with sox5

Gene Symbol Gene ID Gene Info
ENSDARG00000011582 SRY-box transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of sox5 motif

Sorted Z-values of sox5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_21832441 1.97 ENSDART00000151272
myelin basic protein a
chr5_+_37837245 1.62 ENSDART00000171617
chr13_+_38520927 1.46 ENSDART00000137299
adhesion G protein-coupled receptor B3
chr12_-_3756405 1.46 ENSDART00000150839
family with sequence similarity 57, member Bb
chr5_+_58397646 1.41 ENSDART00000180759
hepatic and glial cell adhesion molecule
chr20_+_34915945 1.24 ENSDART00000153064
synaptosomal-associated protein, 25a
chr17_-_39185336 1.17 ENSDART00000050534
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr15_-_33933790 1.16 ENSDART00000165162
myelin associated glycoprotein
chr14_-_33872092 1.06 ENSDART00000111903
chr1_-_38709551 1.06 ENSDART00000128794
glycoprotein M6Ab
chr16_-_28856112 1.06 ENSDART00000078543
synaptotagmin XIb
chr22_-_26945493 1.05 ENSDART00000077411
chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)
chr4_-_74367912 1.03 ENSDART00000174199
protein tyrosine phosphatase, receptor type, b
chr10_-_26163989 1.02 ENSDART00000136472
tripartite motif containing 3b
chr13_-_22771708 1.02 ENSDART00000112900
chr16_+_10318893 1.01 ENSDART00000055380
tubulin, beta 5
chr24_+_24461341 1.00 ENSDART00000147658
basic helix-loop-helix family, member e22
chr19_-_103289 1.00 ENSDART00000143118
adhesion G protein-coupled receptor B1b
chr20_+_54383838 0.94 ENSDART00000157737
leucine rich repeat and fibronectin type III domain containing 5b
chr15_+_18863875 0.90 ENSDART00000062603
cell adhesion molecule 1b
chr23_-_3681026 0.89 ENSDART00000192128
protein kinase C and casein kinase substrate in neurons 1a
chr16_+_5678071 0.89 ENSDART00000011166
chr3_-_42086577 0.87 ENSDART00000083111
tweety family member 3a
chr5_-_18446483 0.84 ENSDART00000180027
chr16_+_23811554 0.84 ENSDART00000114336
chr11_+_39672874 0.81 ENSDART00000046663
calmodulin binding transcription activator 1b
chr15_+_28685892 0.81 ENSDART00000155815
neuro-oncological ventral antigen 2
chr24_+_24461558 0.79 ENSDART00000182424
basic helix-loop-helix family, member e22
chr10_+_22003750 0.78 ENSDART00000109420
Kv channel interacting protein 1 b
chr6_-_21873266 0.77 ENSDART00000151658
chr7_+_47287307 0.77 ENSDART00000114669
dpy-19 like C-mannosyltransferase 3
chr3_-_31804481 0.75 ENSDART00000028270
glial fibrillary acidic protein
chr17_-_33289304 0.74 ENSDART00000135118
EFR3 homolog Ba (S. cerevisiae)
chr23_+_19590006 0.74 ENSDART00000021231
sarcolemma associated protein b
chr1_+_9708801 0.74 ENSDART00000189621
extracellular leucine-rich repeat and fibronectin type III domain containing 1b
chr19_-_38872650 0.73 ENSDART00000146641
adhesion G protein-coupled receptor B2
chr11_+_6819050 0.73 ENSDART00000104289
RAB3A, member RAS oncogene family, b
chr6_+_40587551 0.73 ENSDART00000155554
fibroblast growth factor receptor substrate 3
chr20_-_47704973 0.73 ENSDART00000174808
transcription factor AP-2 beta
chr8_-_9118958 0.72 ENSDART00000037922
solute carrier family 6 (neurotransmitter transporter), member 8
chr2_+_50626476 0.71 ENSDART00000018150
neuronal differentiation 6b
chr6_-_38418862 0.71 ENSDART00000104135
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr8_-_22639794 0.70 ENSDART00000188029
IQ motif and Sec7 domain 2a
chr13_-_20518632 0.69 ENSDART00000165310
gdnf family receptor alpha 1a
chr14_-_18671334 0.69 ENSDART00000182381
SLIT and NTRK-like family, member 4
chr25_-_29134654 0.68 ENSDART00000067066
poly (ADP-ribose) polymerase family, member 6b
chr19_-_868187 0.68 ENSDART00000186626
eomesodermin homolog a
chr2_-_50372467 0.68 ENSDART00000108900
contactin associated protein like 2b
chr7_-_52849913 0.68 ENSDART00000174133
microtubule-associated protein 1Aa
chr19_+_24872159 0.66 ENSDART00000158490
chr13_+_11440389 0.66 ENSDART00000186463
zinc finger and BTB domain containing 18
chr23_-_33654889 0.65 ENSDART00000146180
cysteine-serine-rich nuclear protein 2
chr4_-_19016396 0.64 ENSDART00000166160
chr5_-_28606916 0.64 ENSDART00000026107
tenascin C
chr8_-_51635930 0.64 ENSDART00000015833
neuropeptide Y receptor Y8b
chr2_+_21855036 0.64 ENSDART00000140012
carbonic anhydrase VIII
chr3_-_35602233 0.64 ENSDART00000055269
guanine nucleotide binding protein (G protein), gamma 13b
chr6_+_18520859 0.63 ENSDART00000158263
chr3_+_29714775 0.63 ENSDART00000041388
calcium channel, voltage-dependent, gamma subunit 2a
chr18_+_38900092 0.63 ENSDART00000148541
myosin VAa
chr4_-_16412084 0.61 ENSDART00000188460
chr8_-_34051548 0.61 ENSDART00000105204
pre-B-cell leukemia homeobox 3b
chr7_+_23515966 0.59 ENSDART00000186893
chr10_+_23022263 0.59 ENSDART00000138955
chr8_+_23093155 0.59 ENSDART00000063075
chr10_+_15255012 0.59 ENSDART00000023766
very low density lipoprotein receptor
chr10_+_4095917 0.58 ENSDART00000114533
meningioma 1a
chr13_+_28854438 0.58 ENSDART00000193407

chr18_-_1185772 0.57 ENSDART00000143245
neuroplastin b
chr16_-_43025885 0.57 ENSDART00000193146
chr5_+_20147830 0.57 ENSDART00000098727
SV2 related protein a
chr24_-_19719240 0.56 ENSDART00000135405
cysteine-serine-rich nuclear protein 1b
chr5_-_46273938 0.56 ENSDART00000080033
chr7_+_27898091 0.55 ENSDART00000186451
tubby bipartite transcription factor
chr10_+_15255198 0.55 ENSDART00000139047
very low density lipoprotein receptor
chr19_+_37848830 0.55 ENSDART00000042276
neurexophilin 1
chr8_+_31941650 0.55 ENSDART00000138217
5-hydroxytryptamine (serotonin) receptor 1A a
chr24_+_32411753 0.55 ENSDART00000058530
neuronal differentiation 6a
chr2_+_38556195 0.54 ENSDART00000138769
cadherin 24, type 2b
chr13_+_29773153 0.54 ENSDART00000144443
paired box 2a
chr17_-_14966384 0.53 ENSDART00000105064
thioredoxin domain containing 16
chr19_-_15335787 0.52 ENSDART00000187131
human immunodeficiency virus type I enhancer binding protein 3a
chr12_+_48340133 0.52 ENSDART00000152899
DNA-damage-inducible transcript 4
chr23_-_30787932 0.52 ENSDART00000135771
myelin transcription factor 1a
chr8_-_39978767 0.52 ENSDART00000083066
aspartate beta-hydroxylase domain containing 2
chr9_+_49659114 0.52 ENSDART00000189643
cysteine and serine rich nuclear protein 3
chr2_+_56463167 0.52 ENSDART00000123392
RAB11B, member RAS oncogene family, b
chr19_+_7549854 0.51 ENSDART00000138866
pre-B-cell leukemia homeobox interacting protein 1a
chr19_-_45960191 0.51 ENSDART00000052434
eukaryotic translation initiation factor 3, subunit H, b
chr5_-_38342992 0.51 ENSDART00000140337
misshapen-like kinase 1
chr7_-_38861741 0.51 ENSDART00000173629
PHD finger protein 21Aa
chr6_+_54358529 0.51 ENSDART00000153704
ankyrin repeat and sterile alpha motif domain containing 1Ab
chr23_+_30730121 0.51 ENSDART00000134141
additional sex combs like transcriptional regulator 1
chr4_-_8902406 0.50 ENSDART00000192962
metallophosphoesterase domain containing 1
chr2_-_30668580 0.50 ENSDART00000087270
catenin (cadherin-associated protein), delta 2b
chr8_+_25267903 0.49 ENSDART00000093090
adenosine monophosphate deaminase 2b
chr7_+_30970045 0.49 ENSDART00000155974
tight junction protein 1a
chr15_-_14467394 0.48 ENSDART00000191944
numb homolog (Drosophila)-like
chr8_+_31799410 0.48 ENSDART00000141226
3-oxoacid CoA transferase 1a
chr24_+_26039464 0.48 ENSDART00000131017
tyrosine kinase, non-receptor, 2a
chr24_-_20658446 0.47 ENSDART00000127923
natural killer cell triggering receptor
chr8_+_8291492 0.47 ENSDART00000151314
SRSF protein kinase 3
chr18_-_12327426 0.47 ENSDART00000136992
family with sequence similarity 107, member B
chr15_+_29662401 0.47 ENSDART00000135540
nuclear receptor interacting protein 1a
chr5_-_50748081 0.47 ENSDART00000113985
multiple C2 domains, transmembrane 1a
chr21_-_25573064 0.46 ENSDART00000134310

chr23_+_22819971 0.46 ENSDART00000111345
arginine-glutamic acid dipeptide (RE) repeats a
chr16_-_21047872 0.46 ENSDART00000131582
chromobox homolog 3b
chr17_+_33495194 0.46 ENSDART00000033691
parathyroid hormone 2
chr15_-_20949692 0.45 ENSDART00000185548
tubulin folding cofactor E-like a
chr23_-_33944597 0.45 ENSDART00000133223
chr2_+_31957554 0.45 ENSDART00000012413
ANKH inorganic pyrophosphate transport regulator b
chr19_-_10196370 0.45 ENSDART00000091707
D site albumin promoter binding protein a
chr14_+_31529958 0.45 ENSDART00000053026
family with sequence similarity 122B
chr11_+_25010491 0.44 ENSDART00000167285
chr13_-_20519001 0.44 ENSDART00000168955
gdnf family receptor alpha 1a
chr21_-_35853245 0.43 ENSDART00000172245
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr11_-_30611814 0.43 ENSDART00000089803
solute carrier family 8 (sodium/calcium exchanger), member 1a
chr6_+_11250316 0.42 ENSDART00000137122
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr7_-_18601206 0.42 ENSDART00000111636
chr20_-_31238313 0.42 ENSDART00000028471
hippocalcin-like 1
chr6_+_39812475 0.42 ENSDART00000067063
complement component 1, q subcomponent-like 4b
chr2_-_32505091 0.42 ENSDART00000141884
Fas apoptotic inhibitory molecule 2a
chr18_+_45571378 0.42 ENSDART00000077251
kinesin family member C3
chr13_+_7292061 0.42 ENSDART00000179504
Danio rerio neuroblast differentiation-associated protein AHNAK-like (LOC795051), mRNA.
chr3_-_25369557 0.42 ENSDART00000055491
SMAD specific E3 ubiquitin protein ligase 2
chr22_-_16443199 0.42 ENSDART00000006290
pleckstrin homology domain containing, family B (evectins) member 2
chr18_-_21267103 0.42 ENSDART00000136285
purine nucleoside phosphorylase 6
chr17_-_21418340 0.42 ENSDART00000007021
ATPase, H+ transporting, lysosomal, V1 subunit B, member a
chr12_+_27704015 0.41 ENSDART00000153256
calcium channel, voltage-dependent, T type, alpha 1G subunit
chr16_+_19033554 0.41 ENSDART00000182430
Rap guanine nucleotide exchange factor (GEF) 5b
chr16_+_30117798 0.41 ENSDART00000135723
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E
chr5_-_19036164 0.41 ENSDART00000099378
family with sequence similarity 214, member B
chr13_+_13770980 0.40 ENSDART00000113089
solute carrier family 4, sodium borate transporter, member 11
chr24_-_6647275 0.40 ENSDART00000161494
Rho GTPase activating protein 21a
chr3_+_54047342 0.40 ENSDART00000178486
olfactomedin 2a
chr20_+_27331008 0.40 ENSDART00000141486
protein phosphatase 4, regulatory subunit 4
chr3_+_24134418 0.39 ENSDART00000156204
chr1_-_30689004 0.39 ENSDART00000018827
dachshund c
chr9_+_42607138 0.39 ENSDART00000138133
GULP, engulfment adaptor PTB domain containing 1a
chr1_+_53321878 0.39 ENSDART00000143909
TBC1 domain family, member 9 (with GRAM domain)
chr21_+_10782013 0.39 ENSDART00000146248
zinc finger protein 532
chr10_+_31244619 0.39 ENSDART00000145562
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr22_-_15602760 0.39 ENSDART00000009054
tropomyosin 4a
chr12_-_33357655 0.39 ENSDART00000066233
solute carrier family 16 (monocarboxylate transporter), member 3
chr23_-_33640959 0.39 ENSDART00000187599
cysteine-serine-rich nuclear protein 2
chr6_+_32382743 0.38 ENSDART00000190009
dedicator of cytokinesis 7
chr4_-_6567355 0.38 ENSDART00000134820
forkhead box P2
chr5_+_17624463 0.38 ENSDART00000183869
fibrosin-like 1
chr21_+_37357578 0.38 ENSDART00000143621
nuclear receptor binding SET domain protein 1b
chr3_+_40407352 0.38 ENSDART00000155112
trinucleotide repeat containing 18
chr17_-_945883 0.37 ENSDART00000158837
dynein, cytoplasmic 1, heavy chain 1
chr17_-_24564674 0.37 ENSDART00000105435
ATP-binding cassette, sub-family H, member 1
chr23_-_36003282 0.37 ENSDART00000103150
calcium binding and coiled-coil domain 1a
chr13_+_3667230 0.36 ENSDART00000131553
QKI, KH domain containing, RNA binding b
chr9_-_27649406 0.36 ENSDART00000181270
syntaxin binding protein 5-like
chr21_+_7605803 0.35 ENSDART00000121813
WD repeat domain 41
chr18_+_36066389 0.35 ENSDART00000059347
branched chain keto acid dehydrogenase E1, alpha polypeptide
chr5_-_67911111 0.34 ENSDART00000051833
GS homeobox 1
chr12_+_33403694 0.34 ENSDART00000124083
fatty acid synthase
chr11_-_1967438 0.34 ENSDART00000155844
nuclear receptor subfamily 1, group D, member 4b
chr22_-_20342260 0.34 ENSDART00000161610
transcription factor 3b
chr12_+_26621906 0.33 ENSDART00000158440
Rho GTPase activating protein 12b
chr17_+_28005763 0.33 ENSDART00000155838
leucine zipper protein 1
chr3_+_52999962 0.33 ENSDART00000104683
pre-B-cell leukemia transcription factor 4
chr15_+_5028608 0.33 ENSDART00000092809
ATP-binding cassette, sub-family G (WHITE), member 1
chr2_-_21170517 0.32 ENSDART00000135417
bmi1 polycomb ring finger oncogene 1b
chr14_-_24761132 0.32 ENSDART00000146299
slit homolog 3 (Drosophila)
chr9_-_33749556 0.32 ENSDART00000149383
Norrie disease (pseudoglioma)
chr11_-_33857911 0.32 ENSDART00000165370
neurexophilin 2b
chr23_+_17102960 0.32 ENSDART00000053414
COMM domain containing 7
chr13_+_3938526 0.32 ENSDART00000012759
Yip1 domain family, member 3
chr12_+_32729470 0.32 ENSDART00000175712
RNA binding fox-1 homolog 3a
chr20_-_35246150 0.32 ENSDART00000090549
frizzled class receptor 3a
chr9_-_43213229 0.32 ENSDART00000139775
SEC14 and spectrin domains 1
chr6_+_42819337 0.32 ENSDART00000046498
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr21_+_27283054 0.32 ENSDART00000139058
chr5_+_31860043 0.31 ENSDART00000036235
iron-sulfur cluster assembly enzyme b
chr10_+_33744098 0.31 ENSDART00000147775
relaxin/insulin-like family peptide receptor 2a
chr2_-_48966431 0.31 ENSDART00000147948
potassium inwardly-rectifying channel, subfamily J, member 9
chr3_-_30186296 0.31 ENSDART00000134395
TBC1 domain family, member 17
chr24_+_21540842 0.30 ENSDART00000091529
WAS protein family, member 3b
chr19_+_42694211 0.30 ENSDART00000180153
cytoplasmic linker associated protein 2
chr18_+_48428713 0.30 ENSDART00000076861
Fli-1 proto-oncogene, ETS transcription factor a
chr2_+_24867534 0.30 ENSDART00000158050
RAB3A, member RAS oncogene family, a
chr22_-_15602593 0.30 ENSDART00000036075
tropomyosin 4a
chr10_+_21807497 0.30 ENSDART00000164634
protocadherin 1 gamma 32
chr6_-_12900154 0.30 ENSDART00000080408
islet cell autoantigen 1-like
chr2_+_16696052 0.30 ENSDART00000022356
protein phosphatase 1, regulatory (inhibitor) subunit 7
chr2_-_36819624 0.29 ENSDART00000140844
SLIT and NTRK-like family, member 3b
chr2_+_42112503 0.29 ENSDART00000136022
corticotropin releasing hormone a
chr14_+_35023923 0.29 ENSDART00000172171
early B cell factor 3a
chr23_+_20523617 0.29 ENSDART00000176404
activity-dependent neuroprotector homeobox b
chr19_+_43969363 0.29 ENSDART00000051712
GATA zinc finger domain containing 1
chr13_+_12045475 0.29 ENSDART00000163053
guanine nucleotide binding protein (G protein), gamma 2
chr18_+_16246806 0.29 ENSDART00000142584
ALX homeobox 1
chr19_+_15571290 0.29 ENSDART00000131134
forkhead box O6 b
chr17_+_23968214 0.29 ENSDART00000183053
exportin 1 (CRM1 homolog, yeast) b
chr14_-_2217285 0.28 ENSDART00000157949
protocadherin 2 alpha b2
protocadherin 2 alpha b2
chr9_+_38163876 0.28 ENSDART00000137955
cytoplasmic linker associated protein 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of sox5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.3 1.5 GO:0016322 neuron remodeling(GO:0016322)
0.3 1.0 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
0.3 0.8 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.3 1.0 GO:0090386 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.2 0.7 GO:0060571 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.2 0.6 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.1 0.7 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.1 0.4 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.1 0.5 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.8 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.5 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.7 GO:0021588 cerebellum formation(GO:0021588)
0.1 0.3 GO:1990403 embryonic brain development(GO:1990403)
0.1 0.3 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.1 0.9 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 0.5 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.4 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 0.6 GO:0050909 sensory perception of taste(GO:0050909)
0.1 0.9 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.1 0.5 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 0.3 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 0.3 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 1.1 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 0.2 GO:1902895 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 0.4 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 1.2 GO:0048570 notochord morphogenesis(GO:0048570)
0.0 0.9 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.3 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.0 0.2 GO:0071548 cellular response to cortisol stimulus(GO:0071387) response to dexamethasone(GO:0071548)
0.0 1.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.5 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.2 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.0 0.4 GO:0044805 late nucleophagy(GO:0044805)
0.0 0.5 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:1904871 positive regulation of protein localization to nucleus(GO:1900182) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 0.3 GO:0003160 endocardium morphogenesis(GO:0003160)
0.0 0.6 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.4 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.5 GO:0032264 IMP salvage(GO:0032264)
0.0 0.2 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.2 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 1.2 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.5 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0032530 regulation of microvillus organization(GO:0032530) regulation of microvillus assembly(GO:0032534)
0.0 0.7 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.8 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.0 0.8 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 1.2 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.3 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.7 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.8 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 1.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0043388 positive regulation of DNA binding(GO:0043388) positive regulation of binding(GO:0051099)
0.0 0.9 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.3 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.4 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.4 GO:0045471 response to ethanol(GO:0045471)
0.0 0.3 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.5 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.4 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.3 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.7 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.1 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.6 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.1 GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.0 0.5 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 0.3 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.4 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.5 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 1.1 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.2 GO:0003315 heart rudiment formation(GO:0003315)
0.0 0.2 GO:0070828 heterochromatin organization(GO:0070828)
0.0 0.7 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.5 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.7 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.0 GO:0021549 cerebellum development(GO:0021549)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.3 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.1 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.7 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 1.0 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.1 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.0 0.2 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0003222 ventricular trabecula myocardium morphogenesis(GO:0003222)
0.0 0.6 GO:0030901 midbrain development(GO:0030901)
0.0 0.2 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.7 GO:0061512 protein localization to cilium(GO:0061512)
0.0 0.1 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.6 GO:0090307 establishment of mitotic spindle localization(GO:0040001) mitotic spindle assembly(GO:0090307) microtubule cytoskeleton organization involved in mitosis(GO:1902850)
0.0 1.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.6 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.2 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.1 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.3 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.0 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 1.3 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.6 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.0 0.1 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.1 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.1 GO:0061056 sclerotome development(GO:0061056)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0043083 synaptic cleft(GO:0043083)
0.2 1.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.4 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1 0.3 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 2.0 GO:0043209 myelin sheath(GO:0043209)
0.1 0.7 GO:0033010 paranodal junction(GO:0033010)
0.1 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.1 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.1 0.5 GO:0035517 PR-DUB complex(GO:0035517)
0.1 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.9 GO:0031209 SCAR complex(GO:0031209)
0.1 0.3 GO:0071203 WASH complex(GO:0071203)
0.1 0.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 1.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.2 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0031213 RSF complex(GO:0031213)
0.0 0.4 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.8 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.4 GO:0005771 multivesicular body(GO:0005771)
0.0 0.3 GO:0043195 terminal bouton(GO:0043195)
0.0 0.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.8 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0071914 prominosome(GO:0071914)
0.0 3.1 GO:0030424 axon(GO:0030424)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.2 0.9 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.1 2.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 0.8 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 0.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.9 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.5 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.1 0.4 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.1 0.3 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.1 1.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.4 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.7 GO:0008503 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.5 GO:0048039 ubiquinone binding(GO:0048039)
0.0 1.0 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.3 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.5 GO:0005522 profilin binding(GO:0005522)
0.0 1.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0004394 heparan sulfate 2-O-sulfotransferase activity(GO:0004394)
0.0 0.4 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.5 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 1.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.6 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 1.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.7 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.6 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 1.0 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.5 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.5 GO:0048018 receptor activator activity(GO:0030546) receptor agonist activity(GO:0048018)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.8 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.4 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.3 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0 1.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.4 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 2.1 GO:0045296 cadherin binding(GO:0045296)
0.0 0.4 GO:0045159 myosin II binding(GO:0045159)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 1.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.3 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.4 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.0 GO:0000810 diacylglycerol diphosphate phosphatase activity(GO:0000810)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.4 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.2 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 0.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID ATM PATHWAY ATM pathway
0.0 0.7 PID SHP2 PATHWAY SHP2 signaling
0.0 0.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.4 PID BMP PATHWAY BMP receptor signaling
0.0 0.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.1 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.9 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.4 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.1 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.0 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis