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PRJNA207719: Tissue specific transcriptome profiling
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Results for sox5
Z-value: 1.80
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Transcription factors associated with sox5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| sox5 | dr11_v1_chr4_-_17055782_17055782 | 0.83 | 8.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of sox5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.5 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.0 | 1.4 | GO:0016082 | synaptic vesicle priming(GO:0016082) |
| 0.0 | 1.3 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.0 | 1.2 | GO:0048570 | notochord morphogenesis(GO:0048570) |
| 0.0 | 1.2 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 1.2 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.1 | 1.1 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 1.1 | GO:0048484 | enteric nervous system development(GO:0048484) |
| 0.0 | 1.1 | GO:0008203 | cholesterol metabolic process(GO:0008203) |
| 0.0 | 1.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 2.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 1.6 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.2 | 1.5 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.0 | 1.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 1.2 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.1 | 1.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 1.1 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) |
| 0.1 | 0.9 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.8 | GO:0005637 | nuclear inner membrane(GO:0005637) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 2.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 1.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 1.2 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 1.2 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 1.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 1.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.3 | 1.1 | GO:0030228 | lipoprotein particle receptor activity(GO:0030228) |
| 0.0 | 1.1 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 1.0 | GO:0042056 | chemoattractant activity(GO:0042056) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.9 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.7 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.0 | 0.6 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 0.5 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 0.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.4 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.9 | REACTOME FRS2 MEDIATED CASCADE | Genes involved in FRS2-mediated cascade |
| 0.0 | 0.8 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.8 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.4 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.4 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.4 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |