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PRJNA207719: Tissue specific transcriptome profiling

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Results for sox18

Z-value: 0.63

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Transcription factors associated with sox18

Gene Symbol Gene ID Gene Info
sox18
ENSDARG00000058598 SRY-box transcription factor 18

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox18dr11_v1_chr23_+_8797143_8797143-0.523.7e-01Click!

Activity profile of sox18 motif

Sorted Z-values of sox18 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_8030583 0.50 ENSDART00000113628
si:ch211-240l19.8
si:ch211-240l19.8
chr11_+_29671661 0.48 ENSDART00000024318
ENSDART00000165024
rnf207a
ring finger protein 207a
chr16_+_23404170 0.47 ENSDART00000170061
s100w
S100 calcium binding protein W
chr16_+_23398369 0.46 ENSDART00000037694
s100a10b
S100 calcium binding protein A10b
chr16_+_23403602 0.46 ENSDART00000159848
s100w
S100 calcium binding protein W
chr25_+_10416583 0.42 ENSDART00000073907
ehf
ets homologous factor
chr5_+_22459087 0.40 ENSDART00000134781
BX546499.1

chr8_+_23726708 0.38 ENSDART00000142395
mkrn4
makorin, ring finger protein, 4
chr24_+_20372497 0.35 ENSDART00000132340
ENSDART00000139989
ENSDART00000168751
ENSDART00000192909
plcd1a
phospholipase C, delta 1a
chr18_+_7204378 0.33 ENSDART00000142905
vwf
von Willebrand factor
chr16_+_29586468 0.33 ENSDART00000148926
mcl1b
MCL1, BCL2 family apoptosis regulator b
chr8_+_37700090 0.33 ENSDART00000187885
ENSDART00000127633
adrb3a
adrenoceptor beta 3a
chr24_-_40668208 0.32 ENSDART00000171543
smyhc1
slow myosin heavy chain 1
chr2_-_32262287 0.30 ENSDART00000056621
ENSDART00000039717
fam49ba
family with sequence similarity 49, member Ba
chr25_+_10987817 0.29 ENSDART00000156529
si:dkey-52p2.5
si:dkey-52p2.5
chr25_-_12982193 0.28 ENSDART00000159617
ccl39.5
chemokine (C-C motif) ligand 39, duplicate 5
chr5_-_71722257 0.27 ENSDART00000013404
ak1
adenylate kinase 1
chr12_+_18524953 0.27 ENSDART00000090332
neurl2
neuralized E3 ubiquitin protein ligase 2
chr13_+_25397098 0.26 ENSDART00000132953
gsto2
glutathione S-transferase omega 2
chr16_-_383664 0.26 ENSDART00000051693
irx4a
iroquois homeobox 4a
chr21_-_30166097 0.26 ENSDART00000130676
hbegfb
heparin-binding EGF-like growth factor b
chr3_+_25999477 0.26 ENSDART00000024316
mcm5
minichromosome maintenance complex component 5
chr3_-_34089310 0.25 ENSDART00000151774
ighv5-5
immunoglobulin heavy variable 5-5
chr13_+_25396896 0.24 ENSDART00000041257
gsto2
glutathione S-transferase omega 2
chr2_+_32016516 0.24 ENSDART00000135040
mycb
MYC proto-oncogene, bHLH transcription factor b
chr8_-_29677300 0.23 ENSDART00000032407
ENSDART00000143623
prf1.6
perforin 1.6
chr2_+_32016256 0.23 ENSDART00000005143
mycb
MYC proto-oncogene, bHLH transcription factor b
chr16_-_24819860 0.23 ENSDART00000183874
kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr25_-_35104083 0.23 ENSDART00000183252
ENSDART00000156727
si:dkey-108k21.21
si:dkey-108k21.21
chr10_-_42237304 0.23 ENSDART00000140341
tcf7l1a
transcription factor 7 like 1a
chr21_+_21012210 0.22 ENSDART00000190317
ndr1
nodal-related 1
chr6_+_49052741 0.22 ENSDART00000011876
sycp1
synaptonemal complex protein 1
chr3_-_31845816 0.22 ENSDART00000157028
map3k3
mitogen-activated protein kinase kinase kinase 3
chr21_-_5066462 0.21 ENSDART00000067733
zgc:77838
zgc:77838
chr7_+_4922104 0.21 ENSDART00000135154
si:dkey-28d5.11
si:dkey-28d5.11
chr15_+_29727799 0.21 ENSDART00000182006
zgc:153372
zgc:153372
chr22_+_9110998 0.21 ENSDART00000141520
nlrp15
NACHT, LRR and PYD domains-containing protein 15
chr25_+_25202213 0.20 ENSDART00000150744
ccl39a.10
chemokine (C-C motif) ligand 39, duplicate 10
chr8_+_14158021 0.20 ENSDART00000080832
si:dkey-6n6.2
si:dkey-6n6.2
chr24_+_38658334 0.20 ENSDART00000155735
si:ch73-70c5.1
si:ch73-70c5.1
chr19_+_15440841 0.20 ENSDART00000182329
lin28a
lin-28 homolog A (C. elegans)
chr23_+_42482137 0.19 ENSDART00000160199
cyp2aa3
cytochrome P450, family 2, subfamily AA, polypeptide 3
chr25_+_35061044 0.19 ENSDART00000111706
si:dkey-108k21.14
si:dkey-108k21.14
chr1_-_49434798 0.19 ENSDART00000150842
ENSDART00000150789
ATP5MD
si:dkeyp-80c12.10
chr7_+_24814866 0.19 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr3_-_34087394 0.19 ENSDART00000151344
ighv4-8
immunoglobulin heavy variable 4-8
chr12_-_44122412 0.18 ENSDART00000169094
si:ch73-329n5.3
si:ch73-329n5.3
chr22_+_25352530 0.18 ENSDART00000176742
ENSDART00000113186
si:dkey-240e12.6
si:dkey-240e12.6
chr20_+_37295006 0.18 ENSDART00000153137
cx23
connexin 23
chr2_+_33541928 0.18 ENSDART00000162852
BX548164.1

chr19_-_46777963 0.18 ENSDART00000046857
abrab
actin binding Rho activating protein b
chr5_-_68259747 0.18 ENSDART00000188756
CABZ01083944.1

chr18_+_39649660 0.18 ENSDART00000149859
gldn
gliomedin
chr5_-_7829657 0.17 ENSDART00000158374
pdlim5a
PDZ and LIM domain 5a
chr5_+_25317061 0.17 ENSDART00000170097
trpm6
transient receptor potential cation channel, subfamily M, member 6
chr10_-_29733194 0.17 ENSDART00000149252
si:ch73-261i21.2
si:ch73-261i21.2
chr11_-_396724 0.17 ENSDART00000184375
CR855375.3

chr9_-_9992697 0.17 ENSDART00000123415
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr1_-_2061419 0.17 ENSDART00000058878
oxgr1a.3
oxoglutarate (alpha-ketoglutarate) receptor 1a, tandem duplicate 3
chr12_-_26407092 0.16 ENSDART00000178687
myoz1b
myozenin 1b
chr22_+_1853999 0.16 ENSDART00000163288
znf1174
zinc finger protein 1174
chr23_+_4373360 0.15 ENSDART00000144061
ptpdc1b
protein tyrosine phosphatase domain containing 1b
chr3_-_33961589 0.15 ENSDART00000151533
ighd
immunoglobulin heavy constant delta
chr19_-_3255725 0.15 ENSDART00000105165
illr1
immune-related, lectin-like receptor 1
chr7_+_73807504 0.15 ENSDART00000166244
si:ch73-252p3.1
si:ch73-252p3.1
chr18_+_39649825 0.15 ENSDART00000087960
gldn
gliomedin
chr23_-_10831995 0.14 ENSDART00000142533
pdzrn3a
PDZ domain containing RING finger 3a
chr16_+_29586004 0.14 ENSDART00000149520
mcl1b
MCL1, BCL2 family apoptosis regulator b
chr11_+_17984354 0.14 ENSDART00000179986
rpusd4
RNA pseudouridylate synthase domain containing 4
chr21_+_14511685 0.14 ENSDART00000102099
CR392036.1

chr25_+_12849609 0.13 ENSDART00000168144
ccl33.2
chemokine (C-C motif) ligand 33, duplicate 2
chr15_-_31366742 0.13 ENSDART00000125585
or111-3
odorant receptor, family D, subfamily 111, member 3
chr4_-_37479395 0.13 ENSDART00000168299
ENSDART00000157864
si:dkey-106c17.2
si:dkey-106c17.2
chr4_+_38981587 0.13 ENSDART00000142713
si:dkey-66k12.3
si:dkey-66k12.3
chr5_-_62317496 0.13 ENSDART00000180089
zgc:85789
zgc:85789
chr24_+_9475809 0.13 ENSDART00000132688
si:ch211-285f17.1
si:ch211-285f17.1
chr8_-_17184482 0.13 ENSDART00000025803
pola2
polymerase (DNA directed), alpha 2
chr1_+_30551777 0.12 ENSDART00000112778
gpr183b
G protein-coupled receptor 183b
chr11_+_17984167 0.12 ENSDART00000020283
ENSDART00000188329
rpusd4
RNA pseudouridylate synthase domain containing 4
chr5_-_16475374 0.12 ENSDART00000134274
ENSDART00000136004
piwil2
piwi-like RNA-mediated gene silencing 2
chr9_+_45680802 0.12 ENSDART00000036369
asb1
ankyrin repeat and SOCS box containing 1
chr13_+_25412307 0.12 ENSDART00000175339
calhm1
calcium homeostasis modulator 1
chr7_+_4283299 0.12 ENSDART00000182026
klhl33
kelch-like family member 33
chr11_-_34097418 0.11 ENSDART00000028301
ENSDART00000138579
tdo2b
tryptophan 2,3-dioxygenase b
chr1_-_57839070 0.11 ENSDART00000152571
si:dkey-1c7.3
si:dkey-1c7.3
chr6_-_37460178 0.11 ENSDART00000153500
si:dkey-66a8.7
si:dkey-66a8.7
chr11_-_28614608 0.11 ENSDART00000065853
dhrs3b
dehydrogenase/reductase (SDR family) member 3b
chr9_+_32306862 0.11 ENSDART00000078513
mob4
MOB family member 4, phocein
chr22_-_910926 0.11 ENSDART00000180075
FP016205.1

chr3_-_23470986 0.10 ENSDART00000113135
msl1a
male-specific lethal 1 homolog a (Drosophila)
chr7_+_73827805 0.10 ENSDART00000109316
zgc:173587
zgc:173587
chr9_+_44994214 0.10 ENSDART00000141434
retsatl
retinol saturase (all-trans-retinol 13,14-reductase) like
chr1_-_43987873 0.10 ENSDART00000108821
CR385050.1

chr8_-_13454281 0.10 ENSDART00000141959
CR354547.2

chr22_-_8499778 0.10 ENSDART00000142219
si:ch73-27e22.4
si:ch73-27e22.4
chr6_-_37459759 0.10 ENSDART00000190666
si:dkey-66a8.7
si:dkey-66a8.7
chr2_-_27900518 0.09 ENSDART00000109561
ENSDART00000077720
zgc:163121
zgc:163121
chr11_+_5565082 0.09 ENSDART00000112590
ENSDART00000183207
si:ch73-40i7.5
si:ch73-40i7.5
chr6_+_59029485 0.09 ENSDART00000050140
CABZ01088367.1

chr12_+_20618336 0.08 ENSDART00000084007
si:dkey-220f10.4
si:dkey-220f10.4
chr9_+_44832032 0.08 ENSDART00000002633
frzb
frizzled related protein
chr21_+_43171013 0.08 ENSDART00000151362
zcchc10
zinc finger, CCHC domain containing 10
chr3_-_40976463 0.08 ENSDART00000128450
ENSDART00000018676
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr22_+_2533514 0.08 ENSDART00000147967
si:ch73-92e7.4
si:ch73-92e7.4
chr8_-_13486258 0.08 ENSDART00000137459
pimr104
Pim proto-oncogene, serine/threonine kinase, related 104
chr19_+_43753995 0.07 ENSDART00000058504
SLC17A3
si:ch1073-513e17.1
chr3_+_34986837 0.07 ENSDART00000190341
smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr7_+_22853788 0.07 ENSDART00000148502
clcn5b
chloride channel, voltage-sensitive 5b
chr8_-_25600888 0.07 ENSDART00000193860
stk38a
serine/threonine kinase 38a
chr7_+_69459759 0.07 ENSDART00000160500
ctdnep1b
CTD nuclear envelope phosphatase 1b
chr14_+_6962271 0.07 ENSDART00000148447
ENSDART00000149114
ENSDART00000149492
ENSDART00000148394
hnrnpaba
heterogeneous nuclear ribonucleoprotein A/Ba
chr15_+_17722054 0.06 ENSDART00000191390
ENSDART00000169550
si:ch211-213d14.1
si:ch211-213d14.1
chr19_-_31035155 0.06 ENSDART00000161882
bzw2
basic leucine zipper and W2 domains 2
chr16_-_40508624 0.06 ENSDART00000075718
ndufaf6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr7_-_47282853 0.06 ENSDART00000169299
si:ch211-186j3.3
si:ch211-186j3.3
chr10_+_23441488 0.05 ENSDART00000100783
si:ch73-122g19.1
si:ch73-122g19.1
chr14_+_30272891 0.05 ENSDART00000017122
asah1a
N-acylsphingosine amidohydrolase (acid ceramidase) 1a
chr2_+_31942390 0.05 ENSDART00000138684
ENSDART00000146758
ENSDART00000137921
otulinb
OTU deubiquitinase with linear linkage specificity b
chr5_+_61863996 0.05 ENSDART00000082879
sympk
symplekin
chr17_+_51682429 0.04 ENSDART00000004379
nol10
nucleolar protein 10
chr23_-_10745288 0.04 ENSDART00000140745
ENSDART00000013768
eif4e3
eukaryotic translation initiation factor 4E family member 3
chr24_+_11334733 0.04 ENSDART00000147552
ENSDART00000143171
si:dkey-12l12.1
si:dkey-12l12.1
chr7_+_22688781 0.04 ENSDART00000173509
ugt5g1
UDP glucuronosyltransferase 5 family, polypeptide G1
chr18_-_7400075 0.04 ENSDART00000101250
si:dkey-30c15.13
si:dkey-30c15.13
chr24_-_25184553 0.04 ENSDART00000166917
plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr20_+_18992679 0.03 ENSDART00000147105
ENSDART00000152811
tdh
L-threonine dehydrogenase
chr17_+_16423721 0.03 ENSDART00000064233
efcab11
EF-hand calcium binding domain 11
chr6_+_27304503 0.03 ENSDART00000154759
espnla
espin like a
chr17_+_50564070 0.03 ENSDART00000075150
bmp4
bone morphogenetic protein 4
chr21_-_1012269 0.03 ENSDART00000159835
CABZ01057159.1

chr15_+_29728377 0.03 ENSDART00000099958
zgc:153372
zgc:153372
chr1_-_35924495 0.03 ENSDART00000184424
smad1
SMAD family member 1
chr5_-_38107741 0.02 ENSDART00000156853
si:ch211-284e13.14
si:ch211-284e13.14
chr16_-_9449712 0.02 ENSDART00000136522
prpf3
PRP3 pre-mRNA processing factor 3 homolog (yeast)
chr10_+_15511885 0.02 ENSDART00000165663
erbin
erbb2 interacting protein
chr20_-_13640598 0.02 ENSDART00000128823
ENSDART00000103394
rsph3
radial spoke 3 homolog
chr2_-_51521079 0.02 ENSDART00000165504
LO018493.1

chr14_-_35400671 0.02 ENSDART00000129676
lsm11
LSM11, U7 small nuclear RNA associated
chr3_+_52145511 0.02 ENSDART00000078485
adgre14
adhesion G protein-coupled receptor E14
chr12_-_35105670 0.02 ENSDART00000153034
si:ch73-127m5.2
si:ch73-127m5.2
chr2_-_51593835 0.01 ENSDART00000168072
si:ch211-9d9.7
si:ch211-9d9.7
chr4_+_33012407 0.01 ENSDART00000151873
si:dkey-26h11.2
si:dkey-26h11.2
chr1_+_49435017 0.01 ENSDART00000124833
pdcd11
programmed cell death 11
chr5_+_3892551 0.01 ENSDART00000134396
rpain
RPA interacting protein
chr2_+_3428357 0.00 ENSDART00000125967
CU633991.1

chr4_+_30776883 0.00 ENSDART00000169519
si:dkey-11d20.1
si:dkey-11d20.1

Network of associatons between targets according to the STRING database.

First level regulatory network of sox18

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.1 0.2 GO:0051026 meiotic DNA repair synthesis(GO:0000711) chiasma assembly(GO:0051026)
0.1 0.3 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.1 0.2 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.0 0.3 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.3 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.0 0.3 GO:0006172 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.0 0.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.3 GO:2000273 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.0 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.3 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.3 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.0 0.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.2 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.1 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0043073 germ cell nucleus(GO:0043073)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0045174 glutathione dehydrogenase (ascorbate) activity(GO:0045174)
0.1 0.3 GO:0051380 norepinephrine binding(GO:0051380)
0.1 0.2 GO:0030792 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.0 1.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.6 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.2 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.3 GO:0043142 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.3 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates