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PRJNA207719: Tissue specific transcriptome profiling
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Results for sox10
Z-value: 1.41
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Transcription factors associated with sox10
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| sox10 | dr11_v1_chr3_+_1492174_1492174 | -0.85 | 6.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_3629201 Show fit | 1.62 |
ENSDART00000136577
ENSDART00000132121 |
inter-alpha-trypsin inhibitor heavy chain 3a |
|
| chr1_-_19845378 Show fit | 1.16 |
ENSDART00000139314
ENSDART00000132958 ENSDART00000147502 |
glyoxylate reductase/hydroxypyruvate reductase b |
|
| chr2_-_39017838 Show fit | 1.16 |
ENSDART00000048838
|
retinol binding protein 2b, cellular |
|
| chr20_-_25518488 Show fit | 0.97 |
ENSDART00000186993
|
cytochrome P450, family 2, subfamily N, polypeptide 13 |
|
| chr16_+_26732086 Show fit | 0.95 |
ENSDART00000138496
|
RAD54 homolog B (S. cerevisiae) |
|
| chr21_+_20771082 Show fit | 0.85 |
ENSDART00000079732
|
3-oxoacid CoA transferase 1b |
|
| chr15_-_108414 Show fit | 0.83 |
ENSDART00000170044
|
apolipoprotein A-Ib |
|
| chr16_-_45917322 Show fit | 0.82 |
ENSDART00000060822
|
antifreeze protein type IV |
|
| chr16_-_26731928 Show fit | 0.82 |
ENSDART00000135860
|
ring finger protein 41, like |
|
| chr15_-_32365940 Show fit | 0.82 |
ENSDART00000155371
|
complement component 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of sox10
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | GO:0006941 | striated muscle contraction(GO:0006941) |
| 0.0 | 2.0 | GO:0006956 | complement activation(GO:0006956) |
| 0.0 | 1.3 | GO:0017144 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 0.0 | 1.2 | GO:0002088 | lens development in camera-type eye(GO:0002088) |
| 0.0 | 0.9 | GO:0009395 | phospholipid catabolic process(GO:0009395) |
| 0.0 | 0.9 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) |
| 0.2 | 0.8 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.2 | 0.8 | GO:0010873 | regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873) |
| 0.2 | 0.8 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.1 | 0.8 | GO:0015746 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 1.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.4 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.1 | 1.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 1.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 0.8 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 0.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.6 | GO:0008305 | integrin complex(GO:0008305) |
| 0.1 | 0.5 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 0.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.4 | 1.2 | GO:0030267 | hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267) |
| 0.0 | 1.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 0.9 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.2 | 0.8 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 0.2 | 0.8 | GO:0008260 | 3-oxoacid CoA-transferase activity(GO:0008260) |
| 0.2 | 0.8 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.1 | 0.7 | GO:0016728 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 0.7 | GO:0004568 | chitinase activity(GO:0004568) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 0.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.6 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.4 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.3 | PID EPO PATHWAY | EPO signaling pathway |
| 0.0 | 0.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.2 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 0.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.6 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.5 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.4 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.3 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 0.3 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |