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PRJNA207719: Tissue specific transcriptome profiling
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Results for snai1a
Z-value: 3.44
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Transcription factors associated with snai1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| snai1a | dr11_v1_chr11_-_25257595_25257595 | -0.75 | 1.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of snai1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.5 | GO:0031175 | neuron projection development(GO:0031175) |
| 0.1 | 13.8 | GO:0043087 | regulation of GTPase activity(GO:0043087) |
| 0.1 | 10.7 | GO:0071805 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.1 | 10.1 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.1 | 8.2 | GO:0051966 | regulation of synaptic transmission, glutamatergic(GO:0051966) |
| 0.0 | 7.1 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.4 | 6.9 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.2 | 6.9 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.2 | 6.7 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 6.7 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.0 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 26.7 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 18.2 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 10.3 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 10.0 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 9.3 | GO:0045202 | synapse(GO:0045202) |
| 0.2 | 7.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.4 | 7.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.5 | 7.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 7.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 12.5 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.2 | 10.4 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 10.3 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.1 | 8.7 | GO:0060090 | binding, bridging(GO:0060090) |
| 0.4 | 7.9 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.2 | 6.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 6.0 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.3 | 5.7 | GO:0098882 | structural constituent of presynaptic active zone(GO:0098882) |
| 0.1 | 5.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.3 | 5.8 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 4.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.4 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 3.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 3.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 3.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.3 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 2.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 2.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 5.6 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.3 | 4.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 4.1 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 4.1 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 3.5 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.2 | 3.3 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.2 | 2.3 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.3 | 2.2 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.1 | 2.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |