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PRJNA207719: Tissue specific transcriptome profiling
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Results for smarcc1a+smarcc1b
Z-value: 1.52
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Transcription factors associated with smarcc1a+smarcc1b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000017397 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a | |
| ENSDARG00000098919 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1b |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| smarcc1b | dr11_v1_chr19_-_19379084_19379084 | -0.53 | 3.6e-01 | Click! |
| smarcc1a | dr11_v1_chr16_-_42461263_42461263 | -0.51 | 3.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_61185746 Show fit | 1.18 |
ENSDART00000028219
|
parvalbumin 4 |
|
| chr21_+_25765734 Show fit | 0.89 |
ENSDART00000021664
|
claudin b |
|
| chr21_+_10866421 Show fit | 0.84 |
ENSDART00000137858
|
alpha-kinase 2 |
|
| chr3_-_32818607 Show fit | 0.82 |
ENSDART00000075465
|
myosin light chain, phosphorylatable, fast skeletal muscle a |
|
| chr25_-_22187397 Show fit | 0.81 |
ENSDART00000123211
ENSDART00000139110 |
plakophilin 3a |
|
| chr17_-_5583345 Show fit | 0.79 |
ENSDART00000035944
|
chloride intracellular channel 5a |
|
| chr13_-_33134611 Show fit | 0.77 |
ENSDART00000026280
|
pleckstrin 2 |
|
| chr16_-_22303130 Show fit | 0.75 |
ENSDART00000142181
|
si:dkey-92i15.4 |
|
| chr1_-_59252973 Show fit | 0.73 |
ENSDART00000167061
|
si:ch1073-286c18.5 |
|
| chr7_+_7048245 Show fit | 0.70 |
ENSDART00000001649
|
actinin alpha 3b |
Network of associatons between targets according to the STRING database.
First level regulatory network of smarcc1a+smarcc1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0048246 | macrophage chemotaxis(GO:0048246) |
| 0.0 | 1.2 | GO:0070830 | apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830) |
| 0.0 | 1.2 | GO:0008203 | cholesterol metabolic process(GO:0008203) |
| 0.1 | 1.1 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 1.0 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.1 | 0.9 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 0.9 | GO:0006958 | humoral immune response mediated by circulating immunoglobulin(GO:0002455) complement activation, classical pathway(GO:0006958) |
| 0.2 | 0.8 | GO:0071962 | mitotic sister chromatid cohesion, centromeric(GO:0071962) |
| 0.1 | 0.8 | GO:1902975 | cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975) |
| 0.1 | 0.8 | GO:0014034 | neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 2.0 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 1.2 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.9 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 0.8 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.2 | 0.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.7 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 0.6 | GO:0000811 | GINS complex(GO:0000811) |
| 0.0 | 0.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0051393 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 0.0 | 1.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 1.5 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 1.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.4 | 1.1 | GO:0008397 | sterol 12-alpha-hydroxylase activity(GO:0008397) |
| 0.2 | 0.7 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.2 | 0.7 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.1 | 0.7 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.1 | 0.7 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.1 | 0.6 | GO:0045735 | nutrient reservoir activity(GO:0045735) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.5 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 0.3 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 0.2 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.1 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 0.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.4 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 0.3 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 0.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.3 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.3 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.2 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |