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PRJNA207719: Tissue specific transcriptome profiling
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Results for smad3a+smad3b
Z-value: 1.90
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Transcription factors associated with smad3a+smad3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| smad3a | dr11_v1_chr7_-_34149263_34149263 | -0.82 | 8.6e-02 | Click! |
| smad3b | dr11_v1_chr18_+_19772874_19772874 | -0.57 | 3.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_59073203 Show fit | 2.32 |
ENSDART00000149937
ENSDART00000162201 |
si:zfos-2330d3.3 zgc:173915 |
|
| chr22_+_661711 Show fit | 1.80 |
ENSDART00000113795
|
E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
|
| chr22_+_661505 Show fit | 1.75 |
ENSDART00000149460
|
E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
|
| chr5_+_22459087 Show fit | 1.58 |
ENSDART00000134781
|
|
|
| chr19_-_5332784 Show fit | 1.55 |
ENSDART00000010373
|
keratin, type 1, gene 19d |
|
| chr1_-_59104145 Show fit | 1.48 |
ENSDART00000132495
ENSDART00000152457 |
si:zfos-2330d3.1 si:zfos-2330d3.7 |
|
| chr23_+_44614056 Show fit | 1.47 |
ENSDART00000188379
|
enolase 3, (beta, muscle) |
|
| chr14_+_38786298 Show fit | 1.39 |
ENSDART00000164440
|
si:ch211-195b11.3 |
|
| chr18_+_13164325 Show fit | 1.34 |
ENSDART00000189057
|
tyrosine aminotransferase |
|
| chr1_+_59073436 Show fit | 1.34 |
ENSDART00000161642
|
si:zfos-2330d3.3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of smad3a+smad3b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.3 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.0 | 4.2 | GO:0006954 | inflammatory response(GO:0006954) |
| 0.0 | 2.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 2.5 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.2 | 1.5 | GO:0032889 | regulation of vacuole fusion, non-autophagic(GO:0032889) |
| 0.4 | 1.3 | GO:0098581 | detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581) |
| 0.2 | 1.3 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.1 | 1.3 | GO:0097535 | lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) |
| 0.1 | 1.3 | GO:1900107 | regulation of nodal signaling pathway(GO:1900107) |
| 0.0 | 1.3 | GO:0030574 | collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 1.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.2 | 1.5 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 0.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.3 | 0.8 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.0 | 0.8 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.1 | 0.6 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.0 | 0.5 | GO:0000780 | condensed nuclear chromosome kinetochore(GO:0000778) condensed nuclear chromosome, centromeric region(GO:0000780) |
| 0.0 | 0.5 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 0.3 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 2.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 2.2 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.2 | 1.5 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.4 | 1.3 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.0 | 1.3 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.0 | 1.3 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 1.3 | GO:0030295 | kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295) |
| 0.0 | 1.2 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.4 | 1.1 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.4 | PID CONE PATHWAY | Visual signal transduction: Cones |
| 0.0 | 0.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.1 | 0.3 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 1.2 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 1.0 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.8 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.1 | 0.4 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.4 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.3 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |