PRJNA207719: Tissue specific transcriptome profiling


Results for smad2_smad10a+smad4a_smad1

Z-value: 1.50

Motif logo

Transcription factors associated with smad2_smad10a+smad4a_smad1

Gene Symbol Gene ID Gene Info
ENSDARG00000006389 SMAD family member 2
ENSDARG00000045094 si_dkey-222b8.1
ENSDARG00000070428 si_dkey-222b8.1
ENSDARG00000075226 SMAD family member 4a
ENSDARG00000027199 SMAD family member 1
ENSDARG00000112617 SMAD family member 1
ENSDARG00000115674 SMAD family member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of smad2_smad10a+smad4a_smad1 motif

Sorted Z-values of smad2_smad10a+smad4a_smad1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_4932619 1.20 ENSDART00000103293
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr24_-_28243186 1.19 ENSDART00000105691
cytochrome c oxidase subunit IV isoform 1, like
chr20_-_7648325 1.04 ENSDART00000186541

chr23_-_39849155 0.90 ENSDART00000115330
protein phosphatase 1, regulatory (inhibitor) subunit 14C
chr4_-_16412084 0.77 ENSDART00000188460
chr19_-_41069573 0.68 ENSDART00000111982
sarcoglycan, epsilon
chr21_-_43616586 0.66 ENSDART00000036537
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 2
chr13_+_31648271 0.64 ENSDART00000006648
MNAT CDK-activating kinase assembly factor 1
chr23_+_36460239 0.64 ENSDART00000172441
LIM domain and actin binding 1a
chr13_+_25433774 0.63 ENSDART00000141255
chr5_+_64900223 0.61 ENSDART00000191677
prostaglandin-endoperoxide synthase 1
chr19_-_5380770 0.55 ENSDART00000000221
keratin 91
chr10_-_10018794 0.55 ENSDART00000130734
spermatid perinuclear RNA binding protein
chr19_+_42219165 0.50 ENSDART00000163192

chr4_-_21466825 0.50 ENSDART00000066897
PRKC, apoptosis, WT1, regulator
chr11_-_13152524 0.48 ENSDART00000181440
ELOVL fatty acid elongase 1b
chr10_+_20364009 0.48 ENSDART00000186139
golgin A7
chr11_-_497854 0.46 ENSDART00000104520
CCHC-type zinc finger, nucleic acid binding protein b
chr11_+_45255774 0.45 ENSDART00000172838
alveolar soft part sarcoma chromosome region, candidate 1
chr15_+_28303161 0.44 ENSDART00000087926
myosin Ic, paralog b
chr23_+_41831224 0.44 ENSDART00000171885
sterol carrier protein 2b
chr23_-_24263474 0.43 ENSDART00000160312
heat shock protein family, member 7 (cardiovascular)
chr3_+_26813058 0.39 ENSDART00000055537
suppressor of cytokine signaling 1a
chr18_+_49225552 0.39 ENSDART00000135026
chr8_-_32497815 0.39 ENSDART00000122359
chr9_-_35875051 0.38 ENSDART00000013432
DnaJ (Hsp40) homolog, subfamily C, member 28
chr8_-_32497581 0.37 ENSDART00000176298
chr11_+_40032790 0.36 ENSDART00000158809
chr25_-_31433512 0.35 ENSDART00000067028
chr14_-_237130 0.34 ENSDART00000164988
biorientation of chromosomes in cell division 1-like 1
chr22_+_35068046 0.32 ENSDART00000161660
chr7_-_18508815 0.31 ENSDART00000173539
regulator of G protein signaling 12a
chr7_+_9290929 0.30 ENSDART00000128530
small nuclear ribonucleoprotein polypeptide A'
chr18_+_5549672 0.29 ENSDART00000184970
nicotinamide nucleotide transhydrogenase 2
chr7_+_22767678 0.29 ENSDART00000137203
plac8 onzin related protein 6
chr12_-_4070058 0.28 ENSDART00000042200
aldolase a, fructose-bisphosphate, b
chr15_+_11427620 0.28 ENSDART00000168688
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
chr11_+_77526 0.27 ENSDART00000193521

chr13_+_33703784 0.26 ENSDART00000173361
MACRO domain containing 2
chr9_+_45605410 0.26 ENSDART00000136444
TNF receptor-associated factor 3 interacting protein 1
chr18_+_25003207 0.25 ENSDART00000099476
family with sequence similarity 174, member B
chr24_-_4768955 0.24 ENSDART00000066834
angiotensin II receptor, type 1b
chr4_-_797831 0.24 ENSDART00000158970
microtubule-associated protein, RP/EB family, member 3b
chr2_-_42628028 0.24 ENSDART00000179866
myosin X
chr19_-_43819582 0.23 ENSDART00000160879
kelch-like family member 43
chr2_+_54755172 0.23 ENSDART00000097864
ankyrin repeat domain 12
chr10_-_10018120 0.22 ENSDART00000132375
spermatid perinuclear RNA binding protein
chr12_+_15165736 0.22 ENSDART00000180398
ADP-ribosylarginine hydrolase
chr22_+_30446987 0.22 ENSDART00000146471
chr14_-_25949951 0.22 ENSDART00000141304
secreted protein, acidic, cysteine-rich (osteonectin)
chr14_+_45608576 0.22 ENSDART00000173248
chr19_-_11425542 0.22 ENSDART00000177875
septin 7a
chr3_-_56569968 0.21 ENSDART00000165317
Danio rerio uncharacterized LOC797202 (LOC797202), mRNA.
chr14_-_736575 0.21 ENSDART00000168611
toll-like receptor 1
chr15_+_37545855 0.21 ENSDART00000099456
presenilin enhancer gamma secretase subunit
chr3_-_21242460 0.20 ENSDART00000007293
titin-cap (telethonin)
chr20_+_23625387 0.20 ENSDART00000147945
palladin, cytoskeletal associated protein
chr17_-_14671098 0.20 ENSDART00000037371
protein phosphatase 1, regulatory subunit 13Ba
chr8_+_30742898 0.20 ENSDART00000018475
small nuclear ribonucleoprotein D3 polypeptide
chr25_+_32496877 0.19 ENSDART00000132698
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr9_-_21904695 0.19 ENSDART00000134768
LIM domain 7a
chr6_+_8172227 0.18 ENSDART00000146106
nuclear factor, interleukin 3 regulated, member 5
chr5_+_24287927 0.18 ENSDART00000143563
zinc finger, DHHC-type containing 23a
chr10_-_34976812 0.18 ENSDART00000170625
SMAD family member 9
chr9_-_21936841 0.18 ENSDART00000144843
LIM domain 7a
chr21_-_13751535 0.18 ENSDART00000111666
neural proliferation, differentiation and control, 1a
chr23_+_40908583 0.18 ENSDART00000180933

chr5_+_18047111 0.18 ENSDART00000132164
histone cell cycle regulator a
chr16_+_31542645 0.18 ENSDART00000163724
Src like adaptor
chr3_-_36846496 0.17 ENSDART00000055237
receptor (G protein-coupled) activity modifying protein 2
chr17_+_33433576 0.17 ENSDART00000077581
synaptosomal-associated protein 23.2
chr7_-_72269049 0.17 ENSDART00000161497

chr25_+_32496723 0.17 ENSDART00000087978
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr13_+_23157053 0.17 ENSDART00000162359
sorbin and SH3 domain containing 1
chr18_+_50461981 0.17 ENSDART00000158761

chr19_-_3574060 0.17 ENSDART00000105120
transmembrane protein 170B
chr2_+_26240339 0.17 ENSDART00000191006
paralemmin 1b
chr24_-_37272116 0.16 ENSDART00000022999
ubiquitin-conjugating enzyme E2Ib
chr17_+_50524573 0.16 ENSDART00000187974

chr23_+_19790962 0.16 ENSDART00000142228
filamin A, alpha (actin binding protein 280)
chr24_-_28245872 0.16 ENSDART00000167861
cytochrome c oxidase subunit IV isoform 1, like
chr13_+_45980163 0.16 ENSDART00000074547
BSD domain containing 1
chr7_-_26601307 0.16 ENSDART00000188934
phospholipid scramblase 3b
chr9_+_23900703 0.16 ENSDART00000127859
tripartite motif containing 63b
chr23_+_45734011 0.16 ENSDART00000062415

chr6_-_33925381 0.16 ENSDART00000137268
aldo-keto reductase family 1, member A1b (aldehyde reductase)
chr9_-_21230999 0.16 ENSDART00000150160
phospholipase A1 member A
chr19_-_5369486 0.16 ENSDART00000105004
keratin 17
chr3_-_29928695 0.15 ENSDART00000151275
granulin a
chr19_+_20177208 0.15 ENSDART00000166807
transformer 2 alpha homolog
chr6_-_15653494 0.15 ENSDART00000038133
tripartite motif containing 63a
chr4_+_76957765 0.15 ENSDART00000129607
chr1_+_59073203 0.15 ENSDART00000149937
chr13_+_281214 0.15 ENSDART00000137572
mitochondrial pyruvate carrier 1
chr19_+_46113828 0.15 ENSDART00000159331
RNA binding motif protein 24a
chr21_-_17603182 0.15 ENSDART00000020048
gelsolin a
chr5_-_25583125 0.15 ENSDART00000031665
annexin A1a
chr6_-_29195642 0.15 ENSDART00000078625
chr19_+_4061699 0.15 ENSDART00000158309
bloodthirsty-related gene family, member 25
bloodthirsty-related gene family, member 26
chr13_+_22295905 0.14 ENSDART00000180133
ubiquitin specific peptidase 54a
chr15_+_28106498 0.14 ENSDART00000041707
unc-119 homolog a (C. elegans)
chr2_-_59265521 0.14 ENSDART00000146341
finTRIM family, member 33
chr10_-_24759616 0.14 ENSDART00000079528
integrin-linked kinase
chr20_+_35085224 0.14 ENSDART00000040456
CDC42 binding protein kinase alpha (DMPK-like) b
chr8_+_554531 0.14 ENSDART00000193623

chr18_-_14337065 0.14 ENSDART00000135703
heat shock factor binding protein 1b
chr5_+_3892551 0.14 ENSDART00000134396
RPA interacting protein
chr6_-_52757276 0.14 ENSDART00000159154

chr4_-_76488581 0.14 ENSDART00000174291
finTRIM family, member 51
chr16_-_13595027 0.14 ENSDART00000060004
ntl-dependent gene 5
chr6_-_35439406 0.14 ENSDART00000073784
regulator of G protein signaling 5a
chr16_+_40340222 0.14 ENSDART00000190631
methyltransferase like 6
chr25_-_27819838 0.14 ENSDART00000067106
leiomodin 2 (cardiac) a
chr4_+_70351760 0.13 ENSDART00000159832
chr14_+_6546516 0.13 ENSDART00000097214
ADAM metallopeptidase domain 19b
chr14_-_12307522 0.13 ENSDART00000163900
chr22_-_11136625 0.13 ENSDART00000016873
ATPase H+ transporting accessory protein 2
chr19_-_43757568 0.13 ENSDART00000058491
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr14_+_51098036 0.13 ENSDART00000184118

chr20_-_7293837 0.13 ENSDART00000100060
desmocollin 2 like
chr4_+_5156117 0.13 ENSDART00000067392
tp53-induced glycolysis and apoptosis regulator b
chr11_-_3646793 0.13 ENSDART00000077344
inter-alpha-trypsin inhibitor heavy chain 1
chr16_+_40301056 0.13 ENSDART00000058578
R-spondin 3
chr20_+_26349002 0.13 ENSDART00000152842
spectrin repeat containing, nuclear envelope 1a
chr10_+_5268054 0.13 ENSDART00000114491
receptor tyrosine kinase-like orphan receptor 2
chr25_-_3892686 0.13 ENSDART00000043172
transmembrane protein 258
chr24_+_6353394 0.13 ENSDART00000165118

chr6_-_55423220 0.13 ENSDART00000158929
cathepsin A
chr19_+_4068134 0.12 ENSDART00000158285
bloodthirsty-related gene family, member 26
chr8_-_26388090 0.12 ENSDART00000147912
chr6_-_42049350 0.12 ENSDART00000022949
poly (ADP-ribose) polymerase family, member 3
chr8_-_2230128 0.12 ENSDART00000140427
chr13_+_22480496 0.12 ENSDART00000136863
LIM domain binding 3a
chr23_-_874418 0.12 ENSDART00000133906
RNA binding motif protein 10
chr17_-_52091999 0.12 ENSDART00000019766
transforming growth factor, beta 3
chr13_+_23176330 0.12 ENSDART00000168351
sorbin and SH3 domain containing 1
chr20_-_15922986 0.11 ENSDART00000189421
family with sequence similarity 20, member B (H. sapiens)
chr17_+_53311618 0.11 ENSDART00000166517
ankyrin repeat and SOCS box containing 2b
chr12_+_48581588 0.11 ENSDART00000114996

chr24_-_12958668 0.11 ENSDART00000178982
Danio rerio fat storage inducing transmembrane protein 1 (LOC792443), mRNA.
chr4_+_11458078 0.11 ENSDART00000037600
ankyrin repeat domain 16
chr11_-_3647014 0.11 ENSDART00000171786
inter-alpha-trypsin inhibitor heavy chain 1
chr15_-_47468085 0.11 ENSDART00000164438
inositol polyphosphate phosphatase-like 1a
chr11_+_141504 0.11 ENSDART00000086166
chr4_+_41602 0.11 ENSDART00000159640
putative homeodomain transcription factor 2
chr7_-_25895189 0.11 ENSDART00000173599
CD99 molecule-like 2
chr22_-_506522 0.11 ENSDART00000106645
dual serine/threonine and tyrosine protein kinase
chr25_+_37340722 0.11 ENSDART00000137025
peptidase domain containing associated with muscle regeneration 1
chr6_+_49881864 0.11 ENSDART00000075040
tubulin, beta 1 class VI
chr9_-_34191627 0.11 ENSDART00000142664
ddb1 and cul4 associated factor 6
chr1_-_9104631 0.11 ENSDART00000146642
chr14_+_2243 0.11 ENSDART00000191193
cytokine like 1
chr18_-_49020066 0.11 ENSDART00000174394

chr6_-_24103666 0.11 ENSDART00000164915
scinderin like a
chr24_-_28306484 0.11 ENSDART00000148618
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr3_-_1434135 0.11 ENSDART00000149622
matrix Gla protein
chr13_+_22480857 0.11 ENSDART00000078721
LIM domain binding 3a
chr5_+_36661058 0.11 ENSDART00000125653
calpain, small subunit 1 a
chr6_+_60036767 0.10 ENSDART00000155009
transglutaminase 8
chr17_+_23968214 0.10 ENSDART00000183053
exportin 1 (CRM1 homolog, yeast) b
chr11_-_44647286 0.10 ENSDART00000169329
translocase of outer mitochondrial membrane 20b
chr3_+_28594713 0.10 ENSDART00000179799
septin 12
chr19_-_7144548 0.10 ENSDART00000147177
proteasome subunit beta 8A
proteasome subunit beta 13a
chr14_-_29799993 0.10 ENSDART00000133775
PDZ and LIM domain 3b
chr2_-_42128714 0.10 ENSDART00000047055
tripartite motif containing 55a
chr12_+_8822717 0.10 ENSDART00000021628
receptor accessory protein 3b
chr9_-_23922011 0.10 ENSDART00000145734
collagen, type VI, alpha 3
chr24_+_41610068 0.10 ENSDART00000159507

chr18_-_5509616 0.10 ENSDART00000142945
biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
chr8_+_22359881 0.10 ENSDART00000187867
chr10_-_43334914 0.10 ENSDART00000146660
hyaluronan and proteoglycan link protein 1b
chr6_+_41463786 0.10 ENSDART00000065006
twinfilin actin-binding protein 2a
chr16_-_39859119 0.10 ENSDART00000138388
RNA binding motif, single stranded interacting protein
chr19_-_32487469 0.10 ENSDART00000050130
guanosine monophosphate reductase
chr13_+_42124566 0.10 ENSDART00000074707
CDC42 effector protein (Rho GTPase binding) 3
chr9_+_24095677 0.10 ENSDART00000150443
leucine rich repeat (in FLII) interacting protein 1a
chr2_-_43135700 0.10 ENSDART00000098284
finTRIM family, member 14
chr14_+_9421510 0.10 ENSDART00000123652
high mobility group nucleosome binding domain 6
chr14_-_34700633 0.10 ENSDART00000150358
actin binding LIM protein family, member 3
chr22_-_30935510 0.10 ENSDART00000133335
chr20_+_34151670 0.10 ENSDART00000152870
actin related protein 2/3 complex, subunit 5B
chr15_-_419597 0.10 ENSDART00000058993
phosphoserine phosphatase
chr12_-_628024 0.10 ENSDART00000158563
chr12_-_9132682 0.10 ENSDART00000066471
ADAM metallopeptidase domain 8b
chr18_-_44129151 0.10 ENSDART00000087339
cell adhesion associated, oncogene regulated
chr23_-_27479558 0.09 ENSDART00000013563
activating transcription factor 7a
chr23_+_25893020 0.09 ENSDART00000144769
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr5_+_8964926 0.09 ENSDART00000091397
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b
chr4_+_50401133 0.09 ENSDART00000150644
chr19_-_38611814 0.09 ENSDART00000151958
collagen, type XVI, alpha 1
chr12_-_5505205 0.09 ENSDART00000092319
ABI family, member 3b
chr19_-_24218942 0.09 ENSDART00000189198

chr20_+_54356540 0.09 ENSDART00000143591
zinc finger protein 410
chr19_-_12193622 0.09 ENSDART00000041960
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr5_-_26466169 0.09 ENSDART00000144035
ARVCF, delta catenin family member b
chr18_+_8912113 0.09 ENSDART00000147467
transmembrane protein 243, mitochondrial a
chr2_-_43151358 0.09 ENSDART00000061170
finTRIM family, member 15
chr22_+_81799 0.09 ENSDART00000163661
chr21_-_45728069 0.09 ENSDART00000185101

chr20_-_15922210 0.09 ENSDART00000152412
family with sequence similarity 20, member B (H. sapiens)

Network of associatons between targets according to the STRING database.

First level regulatory network of smad2_smad10a+smad4a_smad1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.2 0.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.5 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.1 0.4 GO:0032370 positive regulation of lipid transport(GO:0032370)
0.1 0.2 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 0.3 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.4 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 0.4 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 0.2 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.2 GO:0035994 response to muscle stretch(GO:0035994)
0.1 0.4 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.1 GO:0043455 regulation of secondary metabolic process(GO:0043455)
0.0 0.3 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.2 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.0 0.3 GO:0031113 regulation of microtubule polymerization(GO:0031113) cerebrospinal fluid circulation(GO:0090660)
0.0 0.6 GO:0043114 regulation of vascular permeability(GO:0043114)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.0 0.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.5 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.2 GO:0090024 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:2000378 negative regulation of reactive oxygen species metabolic process(GO:2000378)
0.0 0.8 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 1.5 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.2 GO:0045064 T-helper 2 cell differentiation(GO:0045064)
0.0 0.1 GO:0090299 regulation of neural crest formation(GO:0090299)
0.0 0.1 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.5 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0032206 positive regulation of telomere maintenance(GO:0032206) regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355)
0.0 0.2 GO:0034205 Notch receptor processing(GO:0007220) beta-amyloid formation(GO:0034205) amyloid precursor protein catabolic process(GO:0042987)
0.0 0.1 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.7 GO:0007631 feeding behavior(GO:0007631)
0.0 0.1 GO:0035989 tendon development(GO:0035989)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 0.2 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.2 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 0.1 GO:0051031 tRNA transport(GO:0051031)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.1 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.0 0.1 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.0 0.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.1 GO:2001286 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.1 GO:1903723 negative regulation of centriole elongation(GO:1903723)
0.0 0.1 GO:0010660 negative regulation of muscle cell apoptotic process(GO:0010656) muscle cell apoptotic process(GO:0010657) striated muscle cell apoptotic process(GO:0010658) regulation of muscle cell apoptotic process(GO:0010660) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.0 0.1 GO:0033632 cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.1 GO:0061614 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 0.2 GO:2000403 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.0 0.2 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.0 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.0 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.1 GO:0051182 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.0 0.2 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.0 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.0 0.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:0060036 notochord cell vacuolation(GO:0060036)
0.0 0.1 GO:0097341 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.0 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.0 0.0 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.0 0.0 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.0 GO:0065001 specification of axis polarity(GO:0065001)
0.0 0.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0033986 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 1.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.6 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 1.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.4 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.1 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0044609 DBIRD complex(GO:0044609)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.0 GO:0008352 katanin complex(GO:0008352)
0.0 0.1 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.0 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.0 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.7 GO:0042641 actomyosin(GO:0042641)
0.0 0.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.0 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 0.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.2 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.1 0.3 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 1.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.2 GO:0004945 angiotensin type I receptor activity(GO:0001596) angiotensin type II receptor activity(GO:0004945)
0.1 0.3 GO:0030620 U2 snRNA binding(GO:0030620)
0.1 1.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:1990825 mRNA CDS binding(GO:1990715) sequence-specific mRNA binding(GO:1990825)
0.0 0.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.2 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.0 0.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 0.1 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.4 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.5 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0 0.3 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.1 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.1 GO:0043185 vascular endothelial growth factor receptor 3 binding(GO:0043185)
0.0 1.4 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0008119 thiopurine S-methyltransferase activity(GO:0008119)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 0.0 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.0 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.0 0.1 GO:0051380 norepinephrine binding(GO:0051380)
0.0 0.0 GO:0004557 alpha-galactosidase activity(GO:0004557)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.0 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.0 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.5 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.0 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.0 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.2 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 0.1 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.6 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.0 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.0 0.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions