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PRJNA207719: Tissue specific transcriptome profiling
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Results for si:dkey-149i17.7_zic1
Z-value: 1.63
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Transcription factors associated with si:dkey-149i17.7_zic1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| zic1 | dr11_v1_chr24_-_4973765_4973765 | 0.87 | 5.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_51855047 Show fit | 1.95 |
ENSDART00000088912
|
complexin 1 |
|
| chr3_+_24482999 Show fit | 1.62 |
ENSDART00000059179
|
neuronal pentraxin receptor a |
|
| chr18_+_49411417 Show fit | 1.52 |
ENSDART00000028944
|
zmp:0000001073 |
|
| chr21_+_3093419 Show fit | 1.49 |
ENSDART00000162520
|
SHC adaptor protein 3 |
|
| chr24_-_3419998 Show fit | 1.43 |
ENSDART00000066839
|
solute carrier family 35, member G2b |
|
| chr10_-_2526526 Show fit | 1.43 |
ENSDART00000191726
ENSDART00000192767 |
|
|
| chr18_+_7345417 Show fit | 1.31 |
ENSDART00000041429
|
GLI pathogenesis-related 1b |
|
| chr13_-_11667661 Show fit | 1.14 |
ENSDART00000102411
|
dynactin 1b |
|
| chr14_+_7140997 Show fit | 1.14 |
ENSDART00000170994
ENSDART00000129898 |
cathepsin F |
|
| chr16_-_27640995 Show fit | 1.12 |
ENSDART00000019658
|
NAC alpha domain containing |
Network of associatons between targets according to the STRING database.
First level regulatory network of si:dkey-149i17.7_zic1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 0.2 | 2.0 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.4 | 1.8 | GO:0021557 | oculomotor nerve development(GO:0021557) |
| 0.1 | 1.8 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.0 | 1.8 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 1.4 | GO:0099645 | protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645) |
| 0.0 | 1.3 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.0 | 1.2 | GO:0051781 | positive regulation of cell division(GO:0051781) |
| 0.1 | 1.1 | GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108) |
| 0.0 | 1.1 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.2 | 1.1 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.0 | 1.1 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.9 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 0.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.8 | GO:0044853 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.1 | 0.7 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.1 | 0.6 | GO:0090533 | sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.2 | 2.0 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.0 | 1.6 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 1.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 1.1 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 1.1 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 1.1 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.1 | 1.0 | GO:0004309 | exopolyphosphatase activity(GO:0004309) |
| 0.1 | 0.9 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.9 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 1.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 1.0 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.1 | 0.7 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 0.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.3 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.2 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.1 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 1.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.1 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 1.0 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 0.8 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 0.7 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 0.6 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.6 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 0.5 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.3 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |