PRJNA207719: Tissue specific transcriptome profiling


Results for si:dkey-149i17.7_zic1

Z-value: 1.63

Motif logo

Transcription factors associated with si:dkey-149i17.7_zic1

Gene Symbol Gene ID Gene Info
ENSDARG00000094684 si_dkey-149i17.7
ENSDARG00000015567 zic family member 1 (odd-paired homolog, Drosophila)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of si:dkey-149i17.7_zic1 motif

Sorted Z-values of si:dkey-149i17.7_zic1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_51855047 1.95 ENSDART00000088912
complexin 1
chr3_+_24482999 1.62 ENSDART00000059179
neuronal pentraxin receptor a
chr18_+_49411417 1.52 ENSDART00000028944
chr21_+_3093419 1.49 ENSDART00000162520
SHC adaptor protein 3
chr24_-_3419998 1.43 ENSDART00000066839
solute carrier family 35, member G2b
chr10_-_2526526 1.43 ENSDART00000191726

chr18_+_7345417 1.31 ENSDART00000041429
GLI pathogenesis-related 1b
chr13_-_11667661 1.14 ENSDART00000102411
dynactin 1b
chr14_+_7140997 1.14 ENSDART00000170994
cathepsin F
chr16_-_27640995 1.12 ENSDART00000019658
NAC alpha domain containing
chr19_+_46259619 1.11 ENSDART00000158032
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding)
chr8_+_8845932 1.09 ENSDART00000112028
chr23_-_46217134 1.09 ENSDART00000189477

chr4_-_1324141 1.09 ENSDART00000180720
chr14_-_3031810 1.07 ENSDART00000090213
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a
chr24_-_30096666 1.05 ENSDART00000183285
phospholipid phosphatase related 4b
chr22_+_5106751 1.04 ENSDART00000138967
ataxia, cerebellar, Cayman type a
chr1_+_45085194 1.04 ENSDART00000193863
chr13_+_27314795 1.02 ENSDART00000128726
eukaryotic translation elongation factor 1 alpha 1a
chr7_-_24699985 0.93 ENSDART00000052802
calbindin 2b
chr14_-_3032016 0.91 ENSDART00000183461
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1a
chr13_-_226109 0.91 ENSDART00000161705
reticulon 4b
chr8_-_7386978 0.90 ENSDART00000058321
LHFPL tetraspan subfamily member 4b
chr8_+_54055390 0.87 ENSDART00000102696
membrane associated guanylate kinase, WW and PDZ domain containing 1a
chr17_+_13664442 0.87 ENSDART00000171689
leucine rich repeat and fibronectin type III domain containing 5a
chr16_-_55028740 0.86 ENSDART00000156368
chr21_+_18353703 0.85 ENSDART00000181396
chr4_-_2162688 0.85 ENSDART00000148900
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr13_-_226393 0.85 ENSDART00000172677
reticulon 4b
chr6_-_13308813 0.85 ENSDART00000065372
potassium inwardly-rectifying channel, subfamily J, member 3b
chr1_-_625875 0.79 ENSDART00000167331
amyloid beta (A4) precursor protein a
chr16_-_13004166 0.79 ENSDART00000133735
calcium channel, voltage-dependent, gamma subunit 7b
chr19_-_32641725 0.78 ENSDART00000165006
chr4_-_22671469 0.78 ENSDART00000050753
CD36 molecule (thrombospondin receptor)
chr3_+_14317802 0.77 ENSDART00000162023
phospholipid phosphatase related 2a
chr10_+_7182423 0.76 ENSDART00000186788
pleckstrin and Sec7 domain containing 3, like
chr10_-_22918214 0.76 ENSDART00000163908
ribonuclease, RNase K b
chr11_-_18799827 0.74 ENSDART00000185438
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr23_+_216012 0.74 ENSDART00000181115
chr12_-_35393211 0.73 ENSDART00000137139
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1
chr3_+_54047342 0.72 ENSDART00000178486
olfactomedin 2a
chr20_-_18731268 0.72 ENSDART00000183893
ectonucleotide pyrophosphatase/phosphodiesterase 5
chr7_-_67842997 0.69 ENSDART00000169763
polyamine modulated factor 1 binding protein 1
chr5_-_45651548 0.68 ENSDART00000097645
neuropeptide FF receptor 2a
chr12_+_9342502 0.68 ENSDART00000152808
potassium voltage-gated channel, subfamily H (eag-related), member 6b
chr15_-_16323750 0.68 ENSDART00000028500
chr25_+_27923846 0.68 ENSDART00000047007
solute carrier family 13 member 1
chr25_-_10564721 0.67 ENSDART00000154776
galanin/GMAP prepropeptide
chr1_-_57280585 0.66 ENSDART00000152220
chr21_-_45588720 0.65 ENSDART00000186642

chr16_+_50755133 0.65 ENSDART00000029283
chr16_-_25393699 0.64 ENSDART00000149445
par-6 family cell polarity regulator gamma a
chr17_+_5915875 0.63 ENSDART00000184179
fibronectin type III domain containing 4b
chr23_+_44741500 0.61 ENSDART00000166421
ATPase Na+/K+ transporting subunit beta 2a
chr23_+_22267374 0.61 ENSDART00000079035
RAP1 GTPase activating protein
chr25_-_37205061 0.61 ENSDART00000155620
chr16_+_50741154 0.60 ENSDART00000101627
chr6_+_29923593 0.58 ENSDART00000169687
discs, large homolog 1 (Drosophila)
chr25_-_10565006 0.58 ENSDART00000130608
galanin/GMAP prepropeptide
chr14_+_36521553 0.58 ENSDART00000136233
chr23_-_28294763 0.58 ENSDART00000139537
zinc finger protein 385A
chr25_-_29134654 0.58 ENSDART00000067066
poly (ADP-ribose) polymerase family, member 6b
chr9_+_55075526 0.55 ENSDART00000139555
G protein-coupled receptor 143
chr10_+_37182626 0.54 ENSDART00000137636
kinase suppressor of ras 1a
chr4_-_26322834 0.54 ENSDART00000170709
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr7_-_35126374 0.54 ENSDART00000141211
hydroxysteroid (11-beta) dehydrogenase 2
chr15_+_47386939 0.54 ENSDART00000128224

chr16_+_14029283 0.54 ENSDART00000146165
RUN and SH3 domain containing 1
chr15_+_45591669 0.54 ENSDART00000157459
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr19_-_9472893 0.53 ENSDART00000045565
vesicle-associated membrane protein 1
chr3_-_21061931 0.53 ENSDART00000036741
family with sequence similarity 57, member Ba
chr8_-_50346246 0.52 ENSDART00000025008
stanniocalcin 1
chr21_-_4793686 0.52 ENSDART00000158232
notch 1a
chr4_-_4795205 0.51 ENSDART00000039313
chr17_-_3303805 0.50 ENSDART00000169136

chr7_-_24994722 0.50 ENSDART00000131671
REST corepressor 2
chr18_+_3169579 0.50 ENSDART00000164724
p21 protein (Cdc42/Rac)-activated kinase 1
chr9_+_34380299 0.49 ENSDART00000131705
lysosomal-associated membrane protein 1
chr18_+_3243292 0.49 ENSDART00000166580
p21 protein (Cdc42/Rac)-activated kinase 1
chr15_-_32383529 0.47 ENSDART00000028349
complement component 4
chr4_-_4535189 0.47 ENSDART00000057519
chr17_-_44584811 0.47 ENSDART00000165059
solute carrier family 35, member F4
chr14_+_7939216 0.46 ENSDART00000171657
CXXC finger protein 5b
chr21_+_29077509 0.45 ENSDART00000128561
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr22_+_15438513 0.45 ENSDART00000010846
glypican 5b
chr23_+_35759843 0.44 ENSDART00000047082
ganglioside induced differentiation associated protein 1-like 1
chr10_+_33990572 0.44 ENSDART00000138547
furry homolog b (Drosophila)
chr1_+_41690402 0.42 ENSDART00000177298
F-box protein 41
chr1_+_40562540 0.42 ENSDART00000122059
short coiled-coil protein a
chr18_+_907266 0.41 ENSDART00000171729
pyruvate kinase M1/2a
chr3_+_46479705 0.41 ENSDART00000181564
tyrosine kinase 2
chr7_-_24994568 0.40 ENSDART00000002961
REST corepressor 2
chr13_-_41482064 0.40 ENSDART00000188322
protocadherin-related 15a
chr10_-_20481763 0.40 ENSDART00000091156
transforming, acidic coiled-coil containing protein 1
chr14_+_7939398 0.39 ENSDART00000189773
CXXC finger protein 5b
chr22_+_15438872 0.38 ENSDART00000139800
glypican 5b
chr6_+_42587637 0.38 ENSDART00000179964
CaM kinase-like vesicle-associated a
chr4_-_5077158 0.38 ENSDART00000155915
adenosylhomocysteinase-like 2
chr11_-_37411492 0.37 ENSDART00000166468
ELKS/RAB6-interacting/CAST family member 2
chr20_+_20731633 0.36 ENSDART00000191952
protein phosphatase 1, regulatory subunit 13Bb
chr5_-_21044693 0.36 ENSDART00000140298
chr23_+_2361184 0.36 ENSDART00000184469

chr14_+_14224730 0.36 ENSDART00000180112
neuroligin 3a
chr8_-_44015210 0.36 ENSDART00000186879
RIMS binding protein 2
RIMS binding protein 2
chr13_+_7292061 0.35 ENSDART00000179504
Danio rerio neuroblast differentiation-associated protein AHNAK-like (LOC795051), mRNA.
chr3_-_19899914 0.35 ENSDART00000134969
Rho family GTPase 2
chr21_-_40557281 0.35 ENSDART00000172327
TAO kinase 1b
chr17_+_33296852 0.35 ENSDART00000154580
DnaJ (Hsp40) homolog, subfamily C, member 27
chr1_+_44906517 0.35 ENSDART00000142820
chr19_+_37620342 0.34 ENSDART00000158960
thrombospondin, type I, domain containing 7Aa
chr22_-_237651 0.34 ENSDART00000075210
chr21_+_1381276 0.34 ENSDART00000192907
transcription factor 4
chr24_-_28711176 0.33 ENSDART00000105753
olfactomedin 3a
chr6_+_518979 0.33 ENSDART00000151012
chr17_-_20979077 0.33 ENSDART00000006676
phytanoyl-CoA 2-hydroxylase interacting protein-like a
chr20_-_52846212 0.33 ENSDART00000040265
TBC1 domain family, member 7
chr15_-_25613114 0.32 ENSDART00000182431
TAO kinase 1a
chr5_-_29112956 0.32 ENSDART00000132726
whirlin b
chr6_+_11026354 0.32 ENSDART00000065433
ATP-binding cassette, sub-family C (CFTR/MRP), member 6a
chr12_+_48634927 0.32 ENSDART00000168441
chr20_+_1960092 0.32 ENSDART00000191892

chr14_-_4043818 0.32 ENSDART00000179870
sorting nexin 25
chr3_+_14339728 0.31 ENSDART00000184127
phospholipid phosphatase related 2a
chr22_-_20924564 0.31 ENSDART00000100642
elongation factor RNA polymerase II
chr6_-_33707278 0.31 ENSDART00000188103
microtubule associated serine/threonine kinase 2
chr21_-_13225402 0.31 ENSDART00000080347
WD repeat domain 34
chr14_+_19258702 0.31 ENSDART00000187087
SLIT and NTRK-like family, member 2
chr18_+_50278858 0.31 ENSDART00000014582
chr10_-_41450367 0.30 ENSDART00000122682
calcium binding protein 1b
chr12_+_31735159 0.30 ENSDART00000185442
chr5_-_72178739 0.30 ENSDART00000050971
RAB14, member RAS oncogene family, like
chr9_-_6208067 0.30 ENSDART00000032368
teleost multiple tissue opsin 2b
chr14_+_14225048 0.30 ENSDART00000168749
neuroligin 3a
chr16_-_20492799 0.30 ENSDART00000014769
chimerin 2
chr9_+_25832329 0.29 ENSDART00000130059
zinc finger E-box binding homeobox 2a
chr2_+_28889936 0.29 ENSDART00000078232
cadherin 10, type 2a (T2-cadherin)
chr10_+_41765944 0.29 ENSDART00000171484
ring finger protein 34b
chr9_+_54891962 0.29 ENSDART00000148620
chr23_+_45611649 0.28 ENSDART00000169521
doublecortin-like kinase 2b
chr7_+_58843700 0.28 ENSDART00000159500
lysophospholipase I
chr6_-_44711942 0.28 ENSDART00000055035
contactin 3b
chr1_-_21529641 0.28 ENSDART00000135905
WD repeat domain 19
chr23_+_16620801 0.27 ENSDART00000189859
syntaphilin b
chr13_+_31172833 0.27 ENSDART00000176378

chr12_+_40905427 0.27 ENSDART00000170526
cadherin 18
chr7_-_32599669 0.27 ENSDART00000173752
potassium voltage-gated channel, shaker-related subfamily, member 4
chr3_+_46479913 0.26 ENSDART00000149755
tyrosine kinase 2
chr8_+_31777633 0.26 ENSDART00000142519
3-oxoacid CoA transferase 1a
chr24_-_37877743 0.26 ENSDART00000105658
transmembrane protein 204
chr9_+_307863 0.26 ENSDART00000163474
SH3 and cysteine rich domain 3
chr8_+_7756893 0.26 ENSDART00000191894
FYVE, RhoGEF and PH domain containing 1
chr1_-_1627487 0.26 ENSDART00000166094
chloride intracellular channel 6
chr14_+_8328645 0.25 ENSDART00000127494
neuregulin 2b
chr6_-_3978919 0.25 ENSDART00000167753
solute carrier family 25 (aspartate/glutamate carrier), member 12
chr2_+_3472832 0.25 ENSDART00000115278
connexin 47.1
chr15_+_25681044 0.24 ENSDART00000077853
hypermethylated in cancer 1
chr9_-_53920959 0.24 ENSDART00000149618
midline 1
chr22_+_12431608 0.24 ENSDART00000108609
Rho family GTPase 3a
chr1_-_17693273 0.24 ENSDART00000146258
cilia and flagella associated protein 97
chr23_-_32334208 0.24 ENSDART00000053472
ring finger protein 41
chr5_-_5326010 0.24 ENSDART00000161946
pre-B-cell leukemia homeobox 3a
chr11_+_30057762 0.24 ENSDART00000164139
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr10_+_16092671 0.23 ENSDART00000182761
multiple EGF-like-domains 10
chr1_+_23230459 0.23 ENSDART00000147857
chr7_-_52842007 0.23 ENSDART00000182710
microtubule-associated protein 1Aa
chr2_-_15041846 0.23 ENSDART00000139050
chr8_+_26874924 0.23 ENSDART00000141794
ribosomal modification protein rimK-like family member A
chr22_+_12366516 0.23 ENSDART00000157802
R3H domain containing 1
chr21_+_33311622 0.22 ENSDART00000163808
chr25_+_31264155 0.22 ENSDART00000012256
troponin I type 2a (skeletal, fast), tandem duplicate 3
chr22_-_29586608 0.22 ENSDART00000059869
adrenoceptor alpha 2A
chr3_-_61592417 0.22 ENSDART00000155082
neuronal pentraxin 2a
chr2_-_51095743 0.22 ENSDART00000184646
chr7_-_36358303 0.21 ENSDART00000130028
fat mass and obesity associated
chr15_+_24691088 0.21 ENSDART00000110618
chr22_+_35275206 0.21 ENSDART00000112234
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr2_+_5245692 0.21 ENSDART00000108990
peroxisomal biogenesis factor 5-like b
chr7_-_36358735 0.21 ENSDART00000188392
fat mass and obesity associated
chr2_+_41526904 0.21 ENSDART00000127520
activin A receptor, type 1 like
chr4_+_8376362 0.20 ENSDART00000138653
ELKS/RAB6-interacting/CAST family member 1b
chr14_-_47882706 0.20 ENSDART00000188772
Rap guanine nucleotide exchange factor (GEF) 2
chr8_-_54304381 0.20 ENSDART00000184177
chr11_+_30058139 0.20 ENSDART00000112254
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr11_+_43363075 0.20 ENSDART00000179934

chr15_-_32383340 0.20 ENSDART00000185632
complement component 4
chr25_-_21092222 0.20 ENSDART00000154765
proline rich 5a (renal)
chr9_+_29430432 0.20 ENSDART00000125632
UDP-glucose glycoprotein glucosyltransferase 2
chr13_-_25632756 0.19 ENSDART00000077627
ret proto-oncogene receptor tyrosine kinase
chr12_+_47909026 0.19 ENSDART00000192472
thymus, brain and testes associated
chr17_-_37052622 0.19 ENSDART00000186408
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr12_-_6551681 0.19 ENSDART00000145413
chr9_+_33340311 0.19 ENSDART00000140064
DEAD (Asp-Glu-Ala-Asp) box helicase 3a
chr7_-_40959867 0.19 ENSDART00000174009
RNA binding motif protein 33a
chr13_-_10727550 0.18 ENSDART00000190925
protein phosphatase, Mg2+/Mn2+ dependent, 1Ba
chr4_+_38344 0.18 ENSDART00000170197
putative homeodomain transcription factor 2
chr12_-_9084640 0.18 ENSDART00000125230
exocyst complex component 6
chr23_-_32892441 0.18 ENSDART00000147998
plexin A2
chr12_-_4651988 0.18 ENSDART00000182836
chr24_-_39772045 0.18 ENSDART00000087441
chr11_-_35975026 0.18 ENSDART00000186219
inositol 1,4,5-trisphosphate receptor, type 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of si:dkey-149i17.7_zic1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0021557 oculomotor nerve development(GO:0021557)
0.2 0.9 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.2 2.0 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.2 0.5 GO:0021531 spinal cord radial glial cell differentiation(GO:0021531)
0.2 1.0 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 0.4 GO:0042245 RNA repair(GO:0042245)
0.1 0.5 GO:0019079 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.1 1.1 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.1 1.0 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.1 1.8 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.6 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)
0.1 0.8 GO:0034381 plasma lipoprotein particle clearance(GO:0034381)
0.1 0.5 GO:0034650 cortisol metabolic process(GO:0034650)
0.1 0.3 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.1 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.1 0.3 GO:0032655 interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.1 0.2 GO:0003403 optic vesicle formation(GO:0003403)
0.1 0.7 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 0.4 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.3 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.1 0.3 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.2 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.1 0.3 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.1 0.3 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 0.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 1.4 GO:0099645 protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
0.0 0.7 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.2 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 1.1 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.3 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.0 0.3 GO:1900118 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.5 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.0 0.1 GO:1904871 positive regulation of protein localization to nucleus(GO:1900182) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 0.2 GO:1901166 branchiomeric skeletal muscle development(GO:0014707) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.0 0.1 GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine(GO:0019284)
0.0 0.7 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.0 0.5 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.1 GO:0015695 organic cation transport(GO:0015695)
0.0 0.1 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.6 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.1 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.0 0.3 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.7 GO:0008272 sulfate transport(GO:0008272)
0.0 0.1 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.0 0.3 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.3 GO:0015740 C4-dicarboxylate transport(GO:0015740) acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0006740 NADPH regeneration(GO:0006740)
0.0 2.1 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.4 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.1 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.0 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.3 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.1 GO:1901004 ubiquinone-6 metabolic process(GO:1901004) ubiquinone-6 biosynthetic process(GO:1901006)
0.0 0.7 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 1.2 GO:0051781 positive regulation of cell division(GO:0051781)
0.0 0.4 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.2 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.4 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.8 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.6 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.9 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.1 GO:0007624 ultradian rhythm(GO:0007624)
0.0 0.3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.8 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.8 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.1 GO:1903729 regulation of plasma membrane organization(GO:1903729)
0.0 0.1 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0 0.1 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.0 1.1 GO:0006612 protein targeting to membrane(GO:0006612)
0.0 0.1 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661)
0.0 0.2 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 0.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.8 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.3 GO:0030500 regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167)
0.0 1.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.8 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.3 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 0.7 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.6 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.9 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.3 GO:0032426 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.0 0.6 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.1 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0070724 BMP receptor complex(GO:0070724)
0.0 0.9 GO:0043195 terminal bouton(GO:0043195)
0.0 0.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0032420 stereocilium(GO:0032420)
0.0 1.4 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.6 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.8 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.0 0.5 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.1 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.3 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 0.8 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.2 0.6 GO:0072545 tyrosine binding(GO:0072545)
0.2 0.7 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.4 GO:0043734 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.1 1.0 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.1 0.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.9 GO:0016805 dipeptidase activity(GO:0016805)
0.1 2.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 0.2 GO:0072591 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.1 0.4 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.5 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.3 GO:0031420 potassium ion binding(GO:0030955) alkali metal ion binding(GO:0031420)
0.1 0.7 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.3 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.0 0.5 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.0 0.2 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.0 0.2 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.2 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.0 1.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.6 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.5 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0 0.1 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0 1.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.3 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.3 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0015250 water channel activity(GO:0015250)
0.0 1.6 GO:0008201 heparin binding(GO:0008201)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.3 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.1 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 1.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 1.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.2 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.4 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 0.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 0.7 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 1.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.1 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.3 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing