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PRJNA207719: Tissue specific transcriptome profiling
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Results for ptf1a+si:dkey-34f9.3
Z-value: 1.97
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Transcription factors associated with ptf1a+si:dkey-34f9.3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| si:dkey-34f9.3 | dr11_v1_chr9_+_45789887_45789887 | -0.87 | 5.7e-02 | Click! |
| ptf1a | dr11_v1_chr2_+_29710857_29710857 | -0.87 | 5.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_5490668 Show fit | 2.46 |
ENSDART00000167035
|
muscle-specific beta 1 integrin binding protein 2 |
|
| chr7_-_38644560 Show fit | 2.36 |
ENSDART00000114934
|
six-cysteine containing astacin protease 3 |
|
| chr7_-_38644287 Show fit | 2.27 |
ENSDART00000182307
|
six-cysteine containing astacin protease 3 |
|
| chr22_-_20695237 Show fit | 1.49 |
ENSDART00000112722
|
oogenesis-related gene |
|
| chr24_+_6353394 Show fit | 1.42 |
ENSDART00000165118
|
|
|
| chr13_+_33452096 Show fit | 1.35 |
ENSDART00000057370
|
finTRIM family, member 80 |
|
| chr16_+_35905031 Show fit | 1.34 |
ENSDART00000162411
|
SH3 domain containing 21 |
|
| chr10_-_45029041 Show fit | 1.31 |
ENSDART00000167878
|
polymerase (DNA directed), mu |
|
| chr3_-_4579214 Show fit | 1.29 |
ENSDART00000164456
|
finTRIM family, member 50 |
|
| chr2_-_40199780 Show fit | 1.24 |
ENSDART00000113901
|
chemokine (C-C motif) ligand 34a, duplicate 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ptf1a+si:dkey-34f9.3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.5 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.0 | 2.3 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.1 | 1.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 1.4 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
| 0.1 | 1.3 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
| 0.1 | 1.2 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.0 | 1.2 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 1.2 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.0 | 1.1 | GO:0048741 | myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741) |
| 0.1 | 1.0 | GO:0016556 | mRNA modification(GO:0016556) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.6 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 1.4 | GO:0005861 | troponin complex(GO:0005861) |
| 0.1 | 1.2 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.3 | 0.9 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.0 | 0.7 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 0.4 | GO:0034709 | methylosome(GO:0034709) |
| 0.1 | 0.4 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 0.4 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 0.4 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.9 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 6.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 2.5 | GO:0050262 | ribosylnicotinamide kinase activity(GO:0050262) |
| 0.0 | 2.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.5 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 1.4 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 1.3 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 1.2 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 1.0 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 0.5 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.4 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 0.6 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.5 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.5 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.4 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.0 | 0.4 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.0 | 0.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |